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Review

Factors Affecting Preparation of Molecularly Imprinted Polymer and Methods on Finding Template-Monomer Interaction as the Key of Selective Properties of the Materials

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Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21.5, Sumedang 45363, Indonesia
2
Drug Development Study Center, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21.5, Sumedang 45363, Indonesia
*
Author to whom correspondence should be addressed.
Academic Editors: Victoria Samanidou and Irene Panderi
Molecules 2021, 26(18), 5612; https://doi.org/10.3390/molecules26185612
Received: 22 August 2021 / Revised: 14 September 2021 / Accepted: 14 September 2021 / Published: 16 September 2021
Molecular imprinting is a technique for creating artificial recognition sites on polymer matrices that complement the template in terms of size, shape, and spatial arrangement of functional groups. The main advantage of Molecularly Imprinted Polymers (MIP) as the polymer for use with a molecular imprinting technique is that they have high selectivity and affinity for the target molecules used in the molding process. The components of a Molecularly Imprinted Polymer are template, functional monomer, cross-linker, solvent, and initiator. Many things determine the success of a Molecularly Imprinted Polymer, but the Molecularly Imprinted Polymer component and the interaction between template-monomers are the most critical factors. This review will discuss how to find the interaction between template and monomer in Molecularly Imprinted Polymer before polymerization and after polymerization and choose the suitable component for MIP development. Computer simulation, UV-Vis spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), Proton-Nuclear Magnetic Resonance (1H-NMR) are generally used to determine the type and strength of intermolecular interaction on pre-polymerization stage. In turn, Suspended State Saturation Transfer Difference High Resolution/Magic Angle Spinning (STD HR/MAS) NMR, Raman Spectroscopy, and Surface-Enhanced Raman Scattering (SERS) and Fluorescence Spectroscopy are used to detect chemical interaction after polymerization. Hydrogen bonding is the type of interaction that is becoming a focus to find on all methods as this interaction strongly contributes to the affinity of molecularly imprinted polymers (MIPs). View Full-Text
Keywords: molecular imprinted polymer; interaction mechanism; template-monomer interaction; MIP-template interaction molecular imprinted polymer; interaction mechanism; template-monomer interaction; MIP-template interaction
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MDPI and ACS Style

Hasanah, A.N.; Safitri, N.; Zulfa, A.; Neli, N.; Rahayu, D. Factors Affecting Preparation of Molecularly Imprinted Polymer and Methods on Finding Template-Monomer Interaction as the Key of Selective Properties of the Materials. Molecules 2021, 26, 5612. https://doi.org/10.3390/molecules26185612

AMA Style

Hasanah AN, Safitri N, Zulfa A, Neli N, Rahayu D. Factors Affecting Preparation of Molecularly Imprinted Polymer and Methods on Finding Template-Monomer Interaction as the Key of Selective Properties of the Materials. Molecules. 2021; 26(18):5612. https://doi.org/10.3390/molecules26185612

Chicago/Turabian Style

Hasanah, Aliya N., Nisa Safitri, Aulia Zulfa, Neli Neli, and Driyanti Rahayu. 2021. "Factors Affecting Preparation of Molecularly Imprinted Polymer and Methods on Finding Template-Monomer Interaction as the Key of Selective Properties of the Materials" Molecules 26, no. 18: 5612. https://doi.org/10.3390/molecules26185612

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