Regulation of calcineurin, a Ca2+/calmodulin-regulated phosphatase, is important for the nervous system, and its abnormal activity is associated with various pathologies, including neurodegenerative disorders. In yeast cells lacking the VPS13 gene (v...
The prerequisite for breeding a plant to be used in phytoremediation is its high tolerance to grow normally in soil contaminated by certain heavy metals. As mechanisms of plant uptake and transport of nickel (Ni) are not fully understood, it is of si...
Reticulocalbin-2 (RCN2), encoded by the human RCN2 gene (HGNC:9935) and historically identified as E6-binding protein, is a CREC-family EF-hand Ca2+-binding protein. Although first characterized as an endoplasmic reticulum (ER)-associated protein, cu...
Soil salinity severely restricts castor (Ricinus communis L.) seed germination, yet the molecular basis of this trait remains poorly understood. Here, we identified and functionally characterized RcnsLTPC, a nonspecific lipid transfer protein gene st...
Cellular senescence is characterized by the accumulation of reactive oxygen species (ROS), and the selective elimination of excessive ROS remains a key therapeutic challenge. Through antioxidant screening, we identified the pyrazole-based small molec...
Reticulocalbin 1 (RCN1) is an endoplasmic reticulum (ER)-residing protein, involved in promoting cell survival during pathophysiological conditions that lead to ER stress. However, the key upstream receptor tyrosine kinase that regulates RCN1 express...
Regenerated cellulose nanoparticles (RCNs) reinforced waterborne polyurethanes (WPU) were developed to improve mechanical properties as well as biodegradability by using a facile, eco-friendly approach, and introducing much stronger chemical bonding...
The neonatal heart possesses a unique capacity for reparative healing after myocardial injury, unlike the adult heart. While immune cells, particularly T cells, regulate post-infarction inflammation, their role in age-dependent cardiac repair remains...
This study identified 13 endoplasmic reticulum stress (ERS)-related biomarkers associated with multiple sclerosis (MS) through integrated bioinformatics analysis (including weighted gene co-expression network analysis and machine learning algorithms)...
Alternative splicing (AS) is an important molecular mechanism by which single genes can generate multiple mRNA isoforms. We reported previously that, in Oryza sativa, the cyclophilin 19-4 (OsCYP19-4.1) transcript was significantly upregulated in resp...
Advances in visual recognition have relied on increasingly deep and wide convolutional neural networks (CNNs), which often introduce substantial computational and memory costs. This review summarizes recent progress in parameter-efficient CNN design...
Polarimetric synthetic aperture radar (PolSAR) image classification has become more and more widely used in recent years. It is well known that PolSAR image classification is a dense prediction problem. The recently proposed fully convolutional netwo...
Aspergillus species, especially A. fumigatus, and to a lesser extent others (A. flavus, A. niger, A. terreus), although rarely pathogenic to healthy humans, can be very aggressive to immunocompromised patients (they are opportunistic pathogens). Alth...
Single-frame circulation aquaculture belongs to the important category of sustainable agriculture development. In light of the visual-detection problem related to survival rate of Portunus in single-frame three-dimensional aquaculture, a fusion recog...
Pedestrian-future-trajectory prediction is a critical task in intelligent driving, traffic-scene understanding, and active safety decision-making. In real-world road environments, pedestrians’ historical trajectories are frequently affected by...
Vascular inflammation initiated by oxidized lipoproteins drives initiation, progression, and even rupture of atherosclerotic plaques. Yet, to date, no biomarker is directly linked to oxidized lipid-induced vascular inflammation. Reticulocalbin 2 (RCN...
Rabies is an ancient disease that is responsible for approximately 59,000 human deaths annually. Bats (Order Chiroptera) are thought to be the original hosts of rabies virus (RABV) and currently account for most rabies cases in wildlife in the Americ...
Glioblastoma is the most common malignant primary brain tumor. Molecular mechanisms underlying the pathobiology of glioblastoma are incompletely understood, emphasizing an unmet need for the identification of new therapeutic candidates. Reticulocalbi...
Lung and colon cancers are among the leading causes of cancer-related mortality worldwide. Early and accurate detection of these cancers is crucial for effective treatment and improved patient outcomes. False or incorrect detection is harmful. Accura...
Metal corrosion and microbial contamination cause severe damage to marine facilities and result in immeasurable economic losses. Highly efficient and durable anti-corrosion and anti-fouling coatings represent the most effective solution strategy wide...
Rapid landslide motions control impact area, flow velocity, deposition pattern, and, in extreme cases, are a river-blocking hazard; therefore, reliable dynamic simulations are of direct importance to engineering–geological hazard assessments. D...
Background/Objectives: For surgical candidates with metastatic renal cell carcinoma with a tumor thrombus (mRCC-TT), surgery is cytoreductive nephrectomy with tumor thrombectomy (CN-TT). This is carried out through an open (OCN-TT), laparoscopic (LCN...
This study introduces a global land cover clustering using an unsupervised algorithm, incorporating the novel step of filtering data to retain only temporally stable pixels before applying K-means clustering. Unlike previous approaches that did not a...
In previous studies, we demonstrated in mice and prairie dogs that simultaneous administration of two recombinant raccoon poxviruses (rRCN) expressing Yersinia pestis antigens (F1 and V307—a truncated version of the V protein) provided superior prote...
Background: Radiation-induced cystic brain necrosis (RCN) can progress rapidly to life-threatening cerebral herniation. This study aimed to develop a predictive model integrating radiomic features and clinical variables to assess the risk of cerebral...
The COVID-19 epidemic has created highly unprocessed emotions that trigger stress, anxiety, or panic attacks. These attacks exhibit physical symptoms that may easily lead to misdiagnosis. Deep-learning (DL)-based classification approaches for emotion...
A cloud image can provide significant information, such as precipitation and solar irradiation. Predicting short-time cloud motion from images is the primary means of making intra-hour irradiation forecasts for solar-energy production and is also imp...
The development of waterborne polyurethane (WPU) has been stimulated as an alternative to solvent-based polyurethanes due to low-VOC alternatives and reduced exposure to solvents. However, their relatively low mechanical performance and degradation h...
Given a query language, a Detection-based Vision-Language Understanding (DVLU) system needs to respond based on the detected regions (i.e.,bounding boxes). With the significant advancement in object detection, DVLU has witnessed great improvements in...
This study develops a bottom-up cost optimization model (DC-DECOM) to evaluate decarbonization pathways for Japan’s data center industry, targeting carbon neutrality of the information and communications technology (ICT) sector by 2040. The mod...
In recent years, vision transformers have demonstrated remarkable superiority to CNNs in single image super-resolution (SISR), yet their heavy computational and storage costs hinder practical deployment. In this work, we revisit CNN-based residual le...
Video captioning is a popular task which automatically generates a natural-language sentence to describe video content. Previous video captioning works mainly use the encoder–decoder framework and exploit special techniques such as attention mechanis...
Cardiac disorders in cancer patients pose significant challenges to disease prognosis. While it has been established that these disorders are linked to cancer cells, the precise underlying mechanisms remain elusive. In this study, we investigated the...
This study analyzed the resistome, virulome and mobilome of an MCR-9-producing Enterobacter sp. identified in a muscle sample of seabream (Sparus aurata), collected in a land tank from multitrophic fish farming production. Average Nucleotide Identity...
In dairy-based imitation mozzarella cheese (IMC) formulations, intact casein is critical and imparts IMC with a firm and elastic, stringy, melted texture. Rennet casein (RCN) is the desired ingredient to provide intact casein in IMC and is preferred...
P index is a management tool commonly used to identify critical source areas (CSAs) in agro-catchments. We tested the applicability of several P-index models adjusted to Eastern Mediterranean conditions. On the basis of model structure and data requi...
A pseudo-three-component synthesis of N-aroylmethylimidazoles 3 with three new C–N bonds formed regioselectively under microwave conditions was developed. Products were obtained by reacting two equivalents of aroylmethyl bromide (ArCOCH2Br, 1)...
Background/Objectives: Cerebral small vessel disease (cSVD) is one of the leading causes of gait disorders (GDs) in the elderly. Clinical diversity and lack of standardization in assessment of GDs in cSVD patients are associated with late diagnosis....
Calcineurin, a key regulator of the calcium signaling pathway, is involved in calcium signal transduction and calcium ion homeostasis. Magnaporthe oryzae is a devastating filamentous phytopathogenic fungus in rice, yet little is known about the funct...
Medical image registration is an essential technique to achieve spatial consistency geometric positions of different medical images obtained from single- or multi-sensor, such as computed tomography (CT), magnetic resonance (MR), and ultrasound (US)...
Research projects combining different disciplines are increasingly common and sought after by funding agencies looking for ways to achieve environmental, social, and economic sustainability. Creating and running a truly integrated research project th...
In recent years, metal biomaterials have emerged one after another, and have many excellent properties, playing a great role in medicine. However, these coatings cannot meet the medical needs in every aspect. Schiff base is an important organic synth...
Dairy proteins are potential and multipurpose ingredients used to prepare various food products. It exhibits many beneficial functionalities and bioactivities in the processing of food products. All the functionalities of different dairy proteins dep...
In this study, two different ITFs sources were incorporated into a cereal-based diet to evaluate possible aortic protein and gene changes in nursery pigs. The animals were fed two different experimental diets from the 10th day of life, supplemented w...
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignant tumors in the digestive tract, characterized by a high recurrence rate and inadequate immunotherapy options. We analyzed mutation data of ESCC from public databases and...
Mutations in human VPS13A-D genes result in rare neurological diseases, including chorea-acanthocytosis. The pathogenesis of these diseases is poorly understood, and no effective treatment is available. As VPS13 genes are evolutionarily conserved, th...
20 December 2025
Arboviruses spread in urban tropics under climate change. At Aedes aegypti breeding sites in Recife, Brazil, we linked surveillance and climate data from the Pernambuco Water and Climate Agency (APAC), the Brazilian National Institute of Meteorology...
Oral squamous cell carcinoma (OSCC) is a malignancy with a poor prognosis, and early diagnosis is essential for improving patient survival and quality of life. This study aimed to develop a non-invasive screening method based on salivary gene express...
In this paper, we provide an approach for analyzing cyber security threats and attacks in digital substations, which is based on several steps we performed within our work on two Research Council of Norway (RCN) projects. In the literature, there are...
This study focused on the “Xinlu” walnut and explored the molecular regulatory mechanism of lignin synthesis in the endocarp, aiming to explain the formation of bared-nut walnuts through morphological, metabolomic, and transcriptomic tech...
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