molecules-logo

Journal Browser

Journal Browser

Special Issue "New Approach in Multicomponent Reactions"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Ana Maria Gomez Neo
E-Mail Website
Guest Editor
Universidad de Extremadura, Badajoz, Spain
Interests: organic chemistry; synthetic organic chemistry; multicomponet reactions; heterocyclic chemistry; green chemistry; materials chemistry; bioorganic chemistry
Special Issues and Collections in MDPI journals
Dr. Carlos Fernández Marcos
E-Mail Website
Co-Guest Editor
Department of Organic and Inorganic Chemistry, Universidad de Extremadura, Badajoz, Spain
Interests: synthetic methodology; multicomponet reactions; heterocyclic chemistry; bioactive molecules
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Multicomponent reactions are highly convergent processes that permit the synthesis of complex molecules in a simple procedure. This synthetic methodology has been widely used in different research fields, such as medicinal chemistry, combinatorial chemistry, green chemistry, or materials chemistry. Particularly, multicomponent reactions are outstandingly suited for diversity diversity-oriented chemistry, constituting an excellent tool in order to explore the chemical molecular space. Multicomponent chemistry is now more active than ever, and new approaches are being developed every day to give response to the challenges of contemporary organic chemistry.

You may choose our Joint Special Issue in Chemistry.

Dr. Ana Maria Gomez Neo
Dr. Carlos M. Fernández Marcos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Multicomponent reaction
  • MCR
  • New synthetic methodologies
  • Isocyanides
  • Green chemistry
  • Diversity-oriented chemistry

Related Special Issue

Published Papers (6 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

Article
Three-Component Suzuki–Knoevenagel Synthesis of Merocyanine Libraries and Correlation Analyses of Their Oxidation Potentials and Optical Band Gaps
Molecules 2021, 26(17), 5149; https://doi.org/10.3390/molecules26175149 - 25 Aug 2021
Viewed by 327
Abstract
The Suzuki coupling Knoevenagel condensation one-pot synthesis of boronic acids/esters, (hetero)aromatic bromo aldehydes and methylene active compounds is a highly practical consecutive three-component process to provide substance libraries with 60 donor-π-bridge-acceptor molecules, i.e., merocyanines in a broader sense, in moderate to excellent yield. [...] Read more.
The Suzuki coupling Knoevenagel condensation one-pot synthesis of boronic acids/esters, (hetero)aromatic bromo aldehydes and methylene active compounds is a highly practical consecutive three-component process to provide substance libraries with 60 donor-π-bridge-acceptor molecules, i.e., merocyanines in a broader sense, in moderate to excellent yield. As already seen with the naked eye, a broad variation of the optical properties becomes accessible using this practical synthetic tool. More systematically, correlation analyses upon plotting the optical band gaps against the first oxidation potentials of redox active systems of consanguineous series furnishes linear correlations and, by extension, two parameter plots (oxidation potential and emission maximum) planar correlations with the optical band gaps. Full article
(This article belongs to the Special Issue New Approach in Multicomponent Reactions)
Show Figures

Figure 1

Article
Cyanovinylation of Aldehydes: Organocatalytic Multicomponent Synthesis of Conjugated Cyanomethyl Vinyl Ethers
Molecules 2021, 26(14), 4120; https://doi.org/10.3390/molecules26144120 - 06 Jul 2021
Viewed by 586
Abstract
A novel organocatalytic multicomponent cyanovinylation of aldehydes was designed for the synthesis of conjugated cyanomethyl vinyl ethers. The reaction was implemented for the synthesis of a 3-substituted 3-(cyanomethoxy)acrylates, using aldehydes as substrates, acetone cyanohydrin as the cyanide anion source, and methyl propiolate as [...] Read more.
A novel organocatalytic multicomponent cyanovinylation of aldehydes was designed for the synthesis of conjugated cyanomethyl vinyl ethers. The reaction was implemented for the synthesis of a 3-substituted 3-(cyanomethoxy)acrylates, using aldehydes as substrates, acetone cyanohydrin as the cyanide anion source, and methyl propiolate as the source of the vinyl component. The multicomponent reaction is catalyzed by N-methyl morpholine (2.5 mol%) to deliver the 3-(cyanomethoxy)acrylates in excellent yields and with preponderance of the E-isomer. The multicomponent reaction manifold is highly tolerant to the structure and composition of the aldehyde (aliphatic, aromatic, heteroaromatics), and it is instrumentally simple (one batch, open atmospheres), economic (2.5 mol% catalyst, stoichiometric reagents), environmentally friendly (no toxic waste), and sustainable (easy scalability). Full article
(This article belongs to the Special Issue New Approach in Multicomponent Reactions)
Show Figures

Scheme 1

Communication
Ugi Reaction on α-Phosphorated Ketimines for the Synthesis of Tetrasubstituted α-Aminophosphonates and Their Applications as Antiproliferative Agents
Molecules 2021, 26(6), 1654; https://doi.org/10.3390/molecules26061654 - 16 Mar 2021
Viewed by 681
Abstract
An Ugi three-component reaction using preformed α-phosphorated N-tosyl ketimines with different isocyanides in the presence of a carboxylic acid affords tetrasubstituted α-aminophosphonates. Due to the high steric hindrance, the expected acylated amines undergo a spontaneous elimination of the acyl group. The reaction [...] Read more.
An Ugi three-component reaction using preformed α-phosphorated N-tosyl ketimines with different isocyanides in the presence of a carboxylic acid affords tetrasubstituted α-aminophosphonates. Due to the high steric hindrance, the expected acylated amines undergo a spontaneous elimination of the acyl group. The reaction is applicable to α-aryl ketimines bearing a number of substituents and several isocyanides. In addition, the densely substituted α-aminophosphonate substrates showed in vitro cytotoxicity, inhibiting the growth of carcinoma human tumor cell line A549 (carcinomic human alveolar basal epithelial cell). Full article
(This article belongs to the Special Issue New Approach in Multicomponent Reactions)
Show Figures

Graphical abstract

Article
Synthesis of Chromeno[3,4-b]piperazines by an Enol-Ugi/Reduction/Cyclization Sequence
Molecules 2021, 26(5), 1287; https://doi.org/10.3390/molecules26051287 - 27 Feb 2021
Viewed by 599
Abstract
Keto piperazines and aminocoumarins are privileged building blocks for the construction of geometrically constrained peptides and therefore valuable structures in drug discovery. Combining these two heterocycles provides unique rigid polycyclic peptidomimetics with drug-like properties including many points of diversity that could be modulated [...] Read more.
Keto piperazines and aminocoumarins are privileged building blocks for the construction of geometrically constrained peptides and therefore valuable structures in drug discovery. Combining these two heterocycles provides unique rigid polycyclic peptidomimetics with drug-like properties including many points of diversity that could be modulated to interact with different biological receptors. This work describes an efficient multicomponent approach to condensed chromenopiperazines based on the novel enol-Ugi reaction. Importantly, this strategy involves the first reported post-condensation transformation of an enol-Ugi adduct. Full article
(This article belongs to the Special Issue New Approach in Multicomponent Reactions)
Show Figures

Graphical abstract

Article
Keto-Enol Tautomerism in Passerini and Ugi Adducts
Molecules 2021, 26(4), 919; https://doi.org/10.3390/molecules26040919 - 09 Feb 2021
Viewed by 830
Abstract
The use of arylglyoxal as starting material in Passerini and Ugi reactions affords β-ketoamides. This has allowed to study keto-enol tautomerism in these systems and assess the way in which the presence of acyloxy or aminoacyl groups bound to the C2 position affects [...] Read more.
The use of arylglyoxal as starting material in Passerini and Ugi reactions affords β-ketoamides. This has allowed to study keto-enol tautomerism in these systems and assess the way in which the presence of acyloxy or aminoacyl groups bound to the C2 position affects such tautomerism, and to investigate the reactivity of both the enol and carbonyl forms. In this work we also prove the versatility of the Passerini reaction, since depending on the conditions to which the corresponding adducts are subjected different products of synthetic interest can be obtained. Full article
(This article belongs to the Special Issue New Approach in Multicomponent Reactions)
Show Figures

Figure 1

Review

Jump to: Research

Review
Petasis vs. Strecker Amino Acid Synthesis: Convergence, Divergence and Opportunities in Organic Synthesis
Molecules 2021, 26(6), 1707; https://doi.org/10.3390/molecules26061707 - 18 Mar 2021
Viewed by 737
Abstract
α-Amino acids find widespread applications in various areas of life and physical sciences. Their syntheses are carried out by a multitude of protocols, of which Petasis and Strecker reactions have emerged as the most straightforward and most widely used. Both reactions are three-component [...] Read more.
α-Amino acids find widespread applications in various areas of life and physical sciences. Their syntheses are carried out by a multitude of protocols, of which Petasis and Strecker reactions have emerged as the most straightforward and most widely used. Both reactions are three-component reactions using the same starting materials, except the nucleophilic species. The differences and similarities between these two important reactions are highlighted in this review. Full article
(This article belongs to the Special Issue New Approach in Multicomponent Reactions)
Show Figures

Graphical abstract

Back to TopTop