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  • Article
  • Open Access
31 Citations
10,222 Views
19 Pages

14 April 2018

Sponge City research has been attracting extensive attention both in practical and theoretical research field, as the increased threat of flood risk and environmental safety due to urbanization. Varies names of Sponge City prevalent in different coun...

(This article belongs to the Special Issue Urban Water Management)
  • Review
  • Open Access
8 Citations
5,120 Views
26 Pages

28 June 2022

The field of industry–university research cooperation policy is about to enter a new stage. It is necessary to systematically sort and summarize the literature, both at home and abroad, that has been produced in recent years. Through knowledge...

  • Article
  • Open Access
1 Citations
2,892 Views
10 Pages

Galectinology of Equine Pregnancy

  • Carleigh E. Fedorka,
  • Hossam El-Sheikh Ali and
  • Mats H. T. Troedsson

29 December 2022

Galectins are a family of proteins that bind to glycans, acting in a cytokine-like manner throughout the body. In the majority of mammalians, galectins have been found to be involved in pregnancy maintenance, but few studies have evaluated this in th...

(This article belongs to the Section Animal Reproduction)
  • Article
  • Open Access
9 Citations
3,562 Views
25 Pages

Oxidant-Induced Alterations in the Adipocyte Transcriptome: Role of the Na,K-ATPase Oxidant Amplification Loop

  • Komal Sodhi,
  • James Denvir,
  • Jiang Liu,
  • Juan R. Sanabria,
  • Yiliang Chen,
  • Roy Silverstein,
  • Zijian Xie,
  • Nader G. Abraham and
  • Joseph I. Shapiro

18 August 2020

(1) Background: Recently we have noted that adipocyte specific expression of the peptide, NaKtide, which was developed to attenuate the Na,K-ATPase oxidant amplification loop, could ameliorate the phenotypical features of uremic cardiomyopathy. We pe...

(This article belongs to the Special Issue Cardiotonic Steroids: From Toxins to Hormones)
  • Article
  • Open Access
2 Citations
2,924 Views
19 Pages

2 November 2021

Craniofacial development including palatogenesis is a complex process which requires an orchestrated and spatiotemporal expression of various genes and factors for proper embryogenesis and organogenesis. One such group of genes essential for craniofa...

(This article belongs to the Special Issue Precision Medicine in Oral Science and Dentistry)
  • Proceeding Paper
  • Open Access
1,464 Views
6 Pages

Experimental Identification of Aberrantly Expressed Long Non-Coding RNAs in Breast Cancer

  • Irina Pronina,
  • Svetlana Lukina,
  • Vitaly Loginov,
  • Aleksey Burdennyy,
  • Tatiana Kazubskaya,
  • Eleonora Braga and
  • Elena Filippova

Breast cancer (BC) remains one of the leading causes of cancer deaths among women worldwide. Recently, studies of long non-coding RNAs (lncRNAs) involved in the regulation of various signaling pathways in cells have become increasingly important, sin...

(This article belongs to the Proceedings of The 2nd International Electronic Conference on Biomedicines)
  • Article
  • Open Access
41 Citations
7,932 Views
13 Pages

A Study of Proline Metabolism in Canola (Brassica napus L.) Seedlings under Salt Stress

  • Mubshara Saadia,
  • Amer Jamil,
  • Nudrat Aisha Akram and
  • Muhammad Ashraf

16 May 2012

Expression analysis of crop plants has improved our knowledge about the veiled underlying mechanisms for salt tolerance. In order to observe the time course effects of salinity stress on gene expression for enzymes regulating proline metabolism, we c...

  • Article
  • Open Access
9 Citations
5,291 Views
16 Pages

Breast Cancer and p16: Role in Proliferation, Malignant Transformation and Progression

  • Dalibor V. Jovanovic,
  • Slobodanka L. Mitrovic,
  • Milos Z. Milosavljevic,
  • Milena B. Ilic,
  • Vesna D. Stankovic,
  • Milena S. Vuletic,
  • Milica N. Dimitrijevic Stojanovic,
  • Danijela B. Milosev,
  • Goran L. Azanjac and
  • Dragce Radovanovic
  • + 1 author

21 September 2021

The definition of new molecular biomarkers could provide a more reliable approach in predicting the prognosis of invasive breast cancers (IBC). The aim of this study is to analyze the expression of p16 protein in IBC, as well as its participation in...

  • Article
  • Open Access
3 Citations
2,998 Views
20 Pages

Impact of Nutritional Status of Patients with Head and Neck Squamous Cell Carcinoma on the Expression Profile of Ghrelin, Irisin, and Titin

  • Agata Andruszko,
  • Jarosław Szydłowski,
  • Beniamin Oskar Grabarek,
  • Katarzyna Mazur,
  • Tomasz Sirek,
  • Piotr Ossowski,
  • Mieszko Kozikowski,
  • Konrad Kaminiów,
  • Ariadna Zybek-Kocik and
  • Jacek Banaszewski

19 January 2024

The goal of this paper was the evaluation of the changes in the expression profile of irisin, ghrelin, and titin in the carcinoma tissue and in the blood of patients with head and neck squamous cell carcinoma (HNSCC), including determining the profil...

(This article belongs to the Special Issue Advances in Head and Neck Squamous Cell Carcinoma)
  • Communication
  • Open Access
1 Citations
2,323 Views
14 Pages

Influence of Clinical Factors on miR-3613-3p Expression in Colorectal Cancer

  • Paulina Gil-Kulik,
  • Alicja Petniak,
  • Natalia Kluz,
  • Grzegorz Wallner,
  • Tomasz Skoczylas,
  • Aleksander Ciechański and
  • Janusz Kocki

13 September 2023

Colorectal cancer (CRC) is the second most common cause of cancer-related death globally. Because of a tendency to be an asymptomatic primary tumor and therefore resulting in late detection, most CRC patients are diagnosed in the advanced stage. Seve...

(This article belongs to the Special Issue Advanced Research on Biomarkers in Gastrointestinal Cancer)
  • Article
  • Open Access
5 Citations
4,943 Views
14 Pages

Epithelial Cell Adhesion Molecule (EpCAM) Expression Can Be Modulated via NFκB

  • Saadiya Zia,
  • Komal Tehreem,
  • Sidra Batool,
  • Mehreen Ishfaq,
  • Shaher Bano Mirza,
  • Shahrukh Khan,
  • Majed N. Almashjary,
  • Mohannad S. Hazzazi,
  • Husam Qanash and
  • Ramla Shahid
  • + 6 authors

20 November 2022

The epithelial cell adhesion molecule (EpCAM) is considered an essential proliferation signature in cancer. In the current research study, qPCR induced expression of EpCAM was noted in acute lymphoblastic leukemia (ALL) cases. Costunolide, a sesquite...

(This article belongs to the Special Issue Women’s Special Issue Series: Biomedicines)
  • Article
  • Open Access
15 Citations
7,692 Views
12 Pages

13 December 2013

Golgi protein 73 (GP73), which is up-regulated in hepatocellular carcinoma (HCC), has recently been identified as a novel serum marker for HCC diagnosis. Several reports also noted the increased levels of GP73 expression in chronic liver disease in p...

(This article belongs to the Special Issue Molecular Mechanisms of Human Liver Diseases)
  • Article
  • Open Access
5 Citations
4,358 Views
15 Pages

Corrected Tilt Calculation for Atmospheric Pressure-Induced Seismic Noise

  • Richard Raspet,
  • Craig J. Hickey and
  • Bipin Koirala

25 January 2022

In a literature search on the coupling of wind-generated pressure fluctuations into seismic noise, it was noticed that the expression for the angular tilt induced by pressure fluctuations in the seminal paper “A preliminary investigation into t...

(This article belongs to the Section Acoustics and Vibrations)
  • Article
  • Open Access
1 Citations
2,725 Views
13 Pages

The Influence of Intravaginal Gestagens Treatment on the Morphological Features and Endometrial Steroid Hormone Receptors Content during Anestrus Type II in Dairy Cattle

  • Michał Trela,
  • Olga Witkowska-Piłaszewicz,
  • Dominika Domańska,
  • Monika M. Kaczmarek,
  • Bartosz Pawliński,
  • Zdzisław Gajewski and
  • Małgorzata Domino

22 January 2022

Background: Gestagens are the most widely used therapy in anestrus type II. The aim of this research is to evaluate the effectiveness of the vaginal progesterone inserts therapy in anestrus type II in cows. Methods: The study was conducted on 33 cows...

(This article belongs to the Section Bioactives and Nutraceuticals)
  • Comment
  • Open Access
2 Citations
2,169 Views
4 Pages

We have noted the views expressed by the authors of the article “The Missed Opportunity of Patient-Centered Medical Homes (PCMH) to Thrive in an Asian Context” by Surendran et al. [...]

(This article belongs to the Special Issue Chronic Disease Prevention and Management in Primary Health Care)
  • Article
  • Open Access
5 Citations
3,162 Views
16 Pages

The Role of miR-155 in Modulating Gene Expression in CD4+ T Cells: Insights into Alternative Immune Pathways in Autoimmune Encephalomyelitis

  • Maria Cichalewska-Studzinska,
  • Jacek Szymanski,
  • Emilia Stec-Martyna,
  • Ewelina Perdas,
  • Miroslawa Studzinska,
  • Hanna Jerczynska,
  • Dominika Kulczycka-Wojdala,
  • Robert Stawski and
  • Marcin P. Mycko

22 October 2024

CD4+ T cells are considered the main orchestrators of autoimmune diseases. Their disruptive effect on CD4+ T cell differentiation and the imbalance between T helper cell populations can be most accurately determined using experimental autoimmune ence...

(This article belongs to the Section Molecular Immunology)
  • Article
  • Open Access
18 Citations
4,543 Views
25 Pages

The BIRC Family Genes Expression in Patients with Triple Negative Breast Cancer

  • Anna Makuch-Kocka,
  • Janusz Kocki,
  • Anna Brzozowska,
  • Jacek Bogucki,
  • Przemysław Kołodziej,
  • Bartosz J. Płachno and
  • Anna Bogucka-Kocka

12 February 2021

The BIRC (baculoviral IAP repeat-containing; BIRC) family genes encode for Inhibitor of Apoptosis (IAP) proteins. The dysregulation of the expression levels of the genes in question in cancer tissue as compared to normal tissue suggests that the apop...

(This article belongs to the Special Issue Animal and Plant Cell–Tissue, Organ Specialization and Function: Investigational, Experimental and Medical Aspects)
  • Article
  • Open Access
2 Citations
1,148 Views
20 Pages

Genome-Wide Identification and Expression Analysis of LOX-HPL-ADH Pathway Genes Contributing to C6 Volatile Diversity in Chinese Plum (Prunus salicina)

  • Menghan Wu,
  • Gaigai Du,
  • Mengmeng Zhang,
  • Siyu Li,
  • Yanke Geng,
  • Yuan Wang,
  • Danfeng Bai,
  • Shaobin Yang,
  • Gaopu Zhu and
  • Taishan Li
  • + 1 author

The characteristic green-note aroma of Chinese plum (Prunus salicina) is largely defined by C6 aldehydes and alcohols synthesized through the fatty acid pathway involving lipoxygenase (LOX), hydroperoxide lyase (HPL), and alcohol dehydrogenase (ADH)....

(This article belongs to the Collection Recent Scientific Developments in Genetics, Genomics, and Breeding of Fruit Trees)
  • Article
  • Open Access
19 Citations
3,961 Views
17 Pages

Rickettsial Pathogen Perturbs Tick Circadian Gene to Infect the Vertebrate Host

  • Supreet Khanal,
  • Vikas Taank,
  • John F. Anderson,
  • Hameeda Sultana and
  • Girish Neelakanta

Ixodes scapularis is a medically important tick that transmits several microbes to humans, including rickettsial pathogen Anaplasma phagocytophilum. In nature, these ticks encounter several abiotic factors including changes in temperature, humidity,...

(This article belongs to the Special Issue Human Animal Tick-Borne Diseases)
  • Article
  • Open Access
2 Citations
3,025 Views
17 Pages

Melatonin Receptor Expression in Primary Uveal Melanoma

  • Anna Hagström,
  • Ruba Kal Omar,
  • Hans Witzenhausen,
  • Emma Lardner,
  • Oran Abdiu and
  • Gustav Stålhammar

Melatonin, noted for its anti-cancer properties in various malignancies, including cutaneous melanoma, shows promise in Uveal melanoma (UM) treatment. This study aimed to evaluate melatonin receptor expression in primary UM and its association with U...

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
  • Article
  • Open Access
2 Citations
2,594 Views
12 Pages

Development of a Novel Weighted Ranking Method for Immunohistochemical Quantification of a Heterogeneously Expressed Protein in Gastro-Esophageal Cancers

  • Cathy E. Richards,
  • Katherine M. Sheehan,
  • Elaine W. Kay,
  • Charlotta Hedner,
  • David Borg,
  • Joanna Fay,
  • Anthony O’Grady,
  • Arnold D. K. Hill,
  • Karin Jirström and
  • Ann M. Hopkins

13 March 2021

High expression of Junctional Adhesion Molecule-A (JAM-A) has been linked with poor prognosis in several cancers, including breast cancers overexpressing the human epidermal growth factor receptor-2 (HER2). Furthermore, JAM-A expression has been link...

(This article belongs to the Section Molecular Cancer Biology)
  • Article
  • Open Access
7 Citations
2,969 Views
14 Pages

Analysis of HLA-G 14 bp Insertion/Deletion Polymorphism and HLA-G, ILT2 and ILT4 Expression in Head and Neck Squamous Cell Carcinoma Patients

  • Vladimira Durmanova,
  • Miroslav Tedla,
  • Dusan Rada,
  • Helena Bandzuchova,
  • Daniel Kuba,
  • Magda Suchankova,
  • Agata Ocenasova and
  • Maria Bucova

8 February 2024

HLA-G is the checkpoint molecule involved in the suppression of the immune response. Increased expression of HLA-G and its ILTs receptors have been correlated with tumor progression in various cancer types. In head and neck squamous cell carcinoma (H...

  • Article
  • Open Access
3 Citations
3,845 Views
9 Pages

Detection of Pathogenic Isoforms of IKZF1 in Leukemic Cell Lines and Acute Lymphoblastic Leukemia Samples: Identification of a Novel Truncated IKZF1 Transcript in SUP-B15

  • Weiqiang Zhao,
  • Ying Li,
  • Chenjiao Yao,
  • Guojuan Zhang,
  • Kevin Y. Zhao,
  • Wei Chen,
  • Peng Ru,
  • Xiaokang Pan,
  • Huolin Tu and
  • Daniel Jones

28 October 2020

Leukemia-associated alternative splicing of IKZF1 can result in proteins with loss of one to four copies of its N-terminal zinc finger domains (N-ZnF). The best characterized pathogenic splice isoforms, Ik-6 and Ik-8, have been commonly found in BCR-...

(This article belongs to the Special Issue Recent Developments of Hematologic Diagnostics in the Interplay with Evolving Treatment Developments)
  • Article
  • Open Access
16 Citations
4,088 Views
17 Pages

The Long Noncoding RNA LOC441461 (STX17-AS1) Modulates Colorectal Cancer Cell Growth and Motility

  • Jui-Ho Wang,
  • Tzung-Ju Lu,
  • Mei-Lang Kung,
  • Yi-Fang Yang,
  • Chung-Yu Yeh,
  • Ya-Ting Tu,
  • Wei-Shone Chen and
  • Kuo-Wang Tsai

28 October 2020

Colorectal carcinoma (CRC) is one of the most prevalent cancers worldwide and has a high mortality rate. Long noncoding RNAs (lncRNAs) have been noted to play critical roles in cell growth; cell apoptosis; and metastasis in CRC. This study determined...

(This article belongs to the Special Issue Recent Research on Gastrointestinal Carcinoma)
  • Comment
  • Open Access
4,092 Views
3 Pages

7 April 2016

The purpose of this note is to express my concerns about the published paper by Quarati et al. (Entropy 2016, 18, 63). It is hoped that these comments will stimulate a constructive discussion of the issues involved.

(This article belongs to the Section Quantum Information)
  • Article
  • Open Access
14 Citations
3,358 Views
13 Pages

Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies

  • Lukasz Jaskiewicz,
  • Karolina Hejne,
  • Blazej Szostak,
  • Karolina Osowiecka,
  • Mariusz T. Skowronski,
  • Ewa Lepiarczyk,
  • Anna Doboszynska,
  • Marta Majewska,
  • Pawel Kordowitzki and
  • Agnieszka Skowronska

9 October 2022

Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most com...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
20 Citations
4,933 Views
10 Pages

Epigenome-Wide Study Identified Methylation Sites Associated with the Risk of Obesity

  • Majid Nikpay,
  • Sepehr Ravati,
  • Robert Dent and
  • Ruth McPherson

9 June 2021

Here, we performed a genome-wide search for methylation sites that contribute to the risk of obesity. We integrated methylation quantitative trait locus (mQTL) data with BMI GWAS information through a SNP-based multiomics approach to identify genomic...

(This article belongs to the Section Nutrigenetics and Nutrigenomics)
  • Article
  • Open Access
1 Citations
2,914 Views
20 Pages

Cognitive Networks and Text Analysis Identify Anxiety as a Key Dimension of Distress in Genuine Suicide Notes

  • Massimo Stella,
  • Trevor James Swanson,
  • Andreia Sofia Teixeira,
  • Brianne N. Richson,
  • Ying Li,
  • Thomas T. Hills,
  • Kelsie T. Forbush and
  • David Watson

Understanding the mindset of people who die by suicide remains a key research challenge. We map conceptual and emotional word–word co-occurrences in 139 genuine suicide notes and in reference word lists, an Emotional Recall Task, from 200 indiv...

  • Article
  • Open Access
10 Citations
3,665 Views
13 Pages

miR-10 and Its Negative Correlation with Serum IL-35 Concentration and Positive Correlation with STAT5a Expression in Patients with Rheumatoid Arthritis

  • Agnieszka Paradowska-Gorycka,
  • Anna Wajda,
  • Ewa Rzeszotarska,
  • Tomasz Kmiolek,
  • Barbara Stypinska,
  • Ewa Dudek,
  • Katarzyna Romanowska-Prochnicka and
  • Piotr Syrowka

Circulating free-cell miRNAs are increasingly important as potential non-invasive biomarkers due to the easy accessibility of clinical materials. Moreover, their epigenetic role may provide insight into the mechanisms of pathogenesis. Nevertheless, t...

(This article belongs to the Special Issue miRNAs in the Era of Personalized Medicine: From Biomarkers to Therapeutics 2.0)
  • Article
  • Open Access
6 Citations
3,393 Views
13 Pages

High Pregnane X Receptor (PXR) Expression Is Correlated with Poor Prognosis in Invasive Breast Carcinoma

  • Stamatios Theocharis,
  • Constantinos Giaginis,
  • Stefania Gourzi,
  • Paraskevi Alexandrou,
  • Gerasimos Tsourouflis,
  • Panagiotis Sarantis,
  • Eugene Danas,
  • Artemis Michail,
  • Nikolaos Tsoukalas and
  • Lydia Nakopoulou
  • + 2 authors

20 October 2021

Pregnane X Receptor (PXR) is involved in human cancer, either by directly affecting carcinogenesis or by inducing drug-drug interactions and chemotherapy resistance. The clinical significance of PXR expression in invasive breast carcinoma was evaluat...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Communication
  • Open Access
1 Citations
6,605 Views
9 Pages

20 February 2014

In several cases (e.g., thermal noise, weather echoes, …), the incoming signal to a radar receiver can be assumed to be Rayleigh distributed. When estimating the mean power from the inherently fluctuating Rayleigh signals, it is necessary to average...

(This article belongs to the Special Issue Cloud and Precipitation)
  • Article
  • Open Access
9 Citations
2,770 Views
14 Pages

A Comparative Analysis on the Innate Immune Responses of Cirrhinus mrigala Challenged with Pseudomonas aeruginosa and Fusarium oxysporum

  • Zaeema Usman,
  • Zakia Kanwal,
  • Asima Tayyeb,
  • Iqra Noshair,
  • Imran Haider,
  • Naushad Ahmad and
  • Suliman Yousef Alomar

3 August 2023

Microbes are the most significant ubiquitous pathogens that cause serious infections in freshwater fish, leading to tremendous economic losses. The present study was designed to investigate the extent of changes in cytokine expression, hemato-biochem...

(This article belongs to the Special Issue Fish Immunology: 4th Edition)
  • Article
  • Open Access
4 Citations
1,465 Views
24 Pages

25 December 2025

The present study models the deflection of nonlinear waves over a Kirchhoff plate underlying a Pasternak-like elastic foundation. A promising version of the tanh expansion analytical method has been deployed for the construction of regular exact solu...

(This article belongs to the Special Issue Nonlinear Wave Dynamics: Theory and Application)
  • Article
  • Open Access
6 Citations
2,478 Views
14 Pages

None of our investigations have identified stress in response to the HSP70 and HO-1 proteins in metals under stress in our study, which aimed to understand the genetic basis of the metal tolerance of Arundo donax. Thus, the present work aimed to inve...

  • Article
  • Open Access
36 Citations
5,830 Views
21 Pages

Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC

  • Robert N. Hawthorne,
  • Adriana Blazeski,
  • Justin Lowenthal,
  • Suraj Kannan,
  • Roald Teuben,
  • Deborah DiSilvestre,
  • Justin Morrissette-McAlmon,
  • Jeffrey E. Saffitz,
  • Kenneth R. Boheler and
  • Leslie Tung
  • + 3 authors

10 July 2021

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive heart condition which causes fibro-fatty myocardial scarring, ventricular arrhythmias, and sudden cardiac death. Most cases of ARVC can be linked to pathogenic mutations in the c...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
17 Citations
3,225 Views
16 Pages

Super Enhancer-Regulated LINC00094 (SERLOC) Upregulates the Expression of MMP-1 and MMP-13 and Promotes Invasion of Cutaneous Squamous Cell Carcinoma

  • Minna Piipponen,
  • Pilvi Riihilä,
  • Jaakko S. Knuutila,
  • Markku Kallajoki,
  • Veli-Matti Kähäri and
  • Liisa Nissinen

17 August 2022

Long non-coding RNAs (lncRNAs) have emerged as important regulators of cancer progression. Super enhancers (SE) play a role in tumorigenesis and regulate the expression of specific lncRNAs. We examined the role of BRD3OS, also named LINC00094, in cut...

(This article belongs to the Special Issue Novel Biomarkers and Therapeutic Targets for Skin Cancer)
  • Article
  • Open Access
15 Citations
3,456 Views
14 Pages

Immunomodulatory Effects Mediated by Nano Amorphous Calcium Phosphate/Chitosan Oligosaccharide Lactate Coatings Decorated with Selenium on Titanium Implants

  • Marijana R. Pantović Pavlović,
  • Nenad L. Ignjatović,
  • Vladimir V. Panić,
  • Ivana I. Mirkov,
  • Jelena B. Kulaš,
  • Anastasija Lj. Malešević and
  • Miroslav M. Pavlović

The aim of this work is in situ anodization/anaphoretic deposition of a nano amorphous calcium phosphate (ACP)/chitosan oligosaccharide lactate (ChOL) multifunctional hybrid coating decorated with selenium (Se) on a titanium substrate and in vivo inv...

(This article belongs to the Section Dental Biomaterials)
  • Article
  • Open Access
26 Citations
4,621 Views
14 Pages

mRNA and miRNA Expression Analyses of the MYC/E2F/miR-17-92 Network in the Most Common Pediatric Brain Tumors

  • Renata Gruszka,
  • Krzysztof Zakrzewski,
  • Paweł Piotr Liberski and
  • Magdalena Zakrzewska

Numerous molecular factors disrupt the correctness of the cell cycle process leading to the development of cancer due to increased cell proliferation. Among known causative factors of such process is abnormal gene expression. Nowadays in the light of...

(This article belongs to the Special Issue Molecular Biology and Translational Aspects in CNS Tumors 2.0)
  • Article
  • Open Access
48 Citations
7,747 Views
13 Pages

23 February 2020

Probiotic bacteria have beneficial effects to the development and maintenance of a healthy microflora that subsequently has health benefits to humans. Some of the health benefits attributed to probiotics have been noted to be via their immune modulat...

(This article belongs to the Special Issue Advances in Multiple Sclerosis Research—Series I)
  • Article
  • Open Access
1 Citations
3,122 Views
22 Pages

Placental Neutrophil Infiltration Associated with Tobacco Exposure but Not Development of Bronchopulmonary Dysplasia

  • David M. Box,
  • Abhishek Makkar,
  • Zhongxin Yu,
  • Hala Chaaban,
  • Henry H. Tran,
  • Kathryn Y. Burge and
  • Jeffrey V. Eckert

Objective: In utero inflammation is associated with bronchopulmonary dysplasia (BPD) in preterm infants. We hypothesized that maternal tobacco exposure (TE) might induce placental neutrophil infiltration, increasing the risk for BPD. Study design: We...

(This article belongs to the Section Pediatric Neonatology)
  • Article
  • Open Access
2 Citations
1,901 Views
16 Pages

Altered Expression of m6A-Associated Genes Is Linked with Poor Prognosis in Pediatric Acute Myeloid Leukemia Patients

  • Parminder Kaur,
  • Bollipogu Rajitha,
  • Richa Jain,
  • Pankaj Sharma,
  • Prateek Bhatia,
  • Shano Naseem,
  • Amita Trehan and
  • Minu Singh

27 August 2025

The dysregulation of m6A-related genes recognized as ‘writers’, ‘readers’, and ‘erasers’ is reported to be involved in the initiation, progression, and drug resistance of acute myeloid leukemia (AML). In the presen...

(This article belongs to the Section Molecular Medicine)
  • Article
  • Open Access
9 Citations
3,457 Views
16 Pages

Autophagy Blockage Up-Regulates HLA-Class-I Molecule Expression in Lung Cancer and Enhances Anti-PD-L1 Immunotherapy Efficacy

  • Erasmia Xanthopoulou,
  • Ioannis Lamprou,
  • Achilleas G. Mitrakas,
  • Georgios D. Michos,
  • Christos E. Zois,
  • Alexandra Giatromanolaki,
  • Adrian L. Harris and
  • Michael I. Koukourakis

26 September 2024

Background/Objectives: Immune checkpoint inhibitors have an established role in non-small cell lung cancer (NSCLC) therapy. The loss of HLA-class-I expression allows cancer cell evasion from immune surveillance, disease progression, and failure of im...

(This article belongs to the Special Issue Lung Cancer: Molecular Pathways, Current Therapies and New Targeted Treatments)
  • Review
  • Open Access
5 Citations
4,656 Views
9 Pages

Differential Allelic Expression among Long Non-Coding RNAs

  • Michael B. Heskett,
  • Paul T. Spellman and
  • Mathew J. Thayer

Long non-coding RNAs (lncRNA) comprise a diverse group of non-protein-coding RNAs >200 bp in length that are involved in various normal cellular processes and disease states, and can affect coding gene expression through mechanisms in cis or in tr...

(This article belongs to the Section Long Non-Coding RNA)
  • Article
  • Open Access
15 Citations
3,062 Views
18 Pages

24 September 2022

Neuropathic pain is well known to occur after damage to the somatosensory system. Aryl hydrocarbon receptor (AhR) has neuroprotective effects when the central nervous system is subjected to internal and external stimulations. However, the exact mecha...

(This article belongs to the Special Issue Pharmacology in Pain Management)
  • Proceeding Paper
  • Open Access
1,834 Views
3 Pages

Protein Expressions of the Small GTPase Rho Proteins in Pterygial Tissue and Leukocytes of Patients with Pterygium

  • Ahmet Saracaloglu,
  • Seniz Demiryürek,
  • Sabit Kimyon,
  • Alper Mete,
  • Ebru Temiz,
  • Gülper Nacarkahya,
  • Betül Düzen,
  • Oguzhan Saygili,
  • Kıvanc Güngör and
  • Abdullah Tuncay Demiryürek

6 December 2018

Pterygium is a benign fibrovascular proliferation that develops from the conjunctiva and invades the cornea. The etiology of this disorder remains unclear. Current treatment of pterygium is surgical. The postoperative recurrence rate of pterygium is...

(This article belongs to the Proceedings of The 2nd International Cell Death Research Congress)
  • Feature Paper
  • Article
  • Open Access
10 Citations
3,812 Views
15 Pages

Ralph Kenna’s Scaling Relations in Critical Phenomena

  • Leïla Moueddene,
  • Arnaldo Donoso and
  • Bertrand Berche

29 February 2024

In this note, we revisit the scaling relations among “hatted critical exponents”, which were first derived by Ralph Kenna, Des Johnston, and Wolfhard Janke, and we propose an alternative derivation for some of them. For the scaling relati...

(This article belongs to the Special Issue Violations of Hyperscaling in Phase Transitions and Critical Phenomena—in Memory of Prof. Ralph Kenna)
  • Article
  • Open Access
1 Citations
3,050 Views
15 Pages

Expression of Prostaglandin Genes and β-Catenin in Whole Blood as Potential Markers of Muscle Degeneration

  • Anna Wajda,
  • Diana Bogucka,
  • Barbara Stypińska,
  • Marcin Jerzy Radkowski,
  • Tomasz Targowski,
  • Ewa Dudek,
  • Tomasz Kmiołek,
  • Ewa Modzelewska and
  • Agnieszka Paradowska-Gorycka

17 August 2023

Prostaglandin signaling pathways are closely related to inflammation, but also muscle regeneration and processes associated with frailty and sarcopenia, whereas β-catenin (CTNNB1 gene) as a part of Wnt signaling is also involved in the different...

(This article belongs to the Section Molecular Endocrinology and Metabolism)
  • Article
  • Open Access
9 Citations
11,053 Views
26 Pages

14 September 2021

Pure land comes from the Indian term “sukha,” which means welfare and happiness. However, in East Asia, Buddhism has been associated with the theological concepts of the immortal realm in the bond of death and afterlife. This study reviews detailed c...

(This article belongs to the Special Issue Buddhist Architecture in East Asia)
  • Case Report
  • Open Access
1 Views
2 Pages

31 January 2012

Expression profiling has shown great promise in matching cancers of unknown primary to likely primary tumors of origin based on patterns of mRNA expression. However, it remains uncertain as to whether even well matched tumors will demonstrate the cli...

  • Article
  • Open Access
22 Citations
4,063 Views
15 Pages

In recent years, a significant increase in the consumption of products containing large amounts of acrylamide (e.g., chips, fries, coffee), especially among young people has been noted. The present study was created to establish the impact of acrylam...

(This article belongs to the Special Issue Peptides for Health Benefits 2019)

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