Medical Sciences Forum, Volume 21, Issue 1

In submitting conference proceedings to Medical Sciences Forum, the volume editors of the proceedings certify to the publisher that all papers published in this volume have been subjected to peer review administered by the volume editors [...]

In the present study was to determine the anti-inflammatory activity of the aqueous extract of the bark and root of Myrica esculenta and their active phytoconstituents through in vitro and in silico studies. The bioactive phytoconstituent of Myrica e...

Dermatological diseases of the scalp such as seborrheic dermatitis (SD) significantly affect the quality of life of a population. Medical shampoos with synthetic substances have adverse effects that can be alleviated by use of medical shampoos with p...

Background and Objectives: The international protocol used to diagnose non-small cell lung cancer (NSCLC) usually faces an inappropriate result due to the poor diagnostic ability in the early stages. Carcinoembryonic Antigen (CEA), an established ser...

Resistance to presently available antifungals and their toxicities is a serious concern throughout the world. It is necessary to investigate innovative, more effective molecules especially derived from medicinally active plants with lesser side effec...

Acute localized irradiation accidents may evolve into a musculocutaneous radiation-induced syndrome that leaves a significant underlying muscle defect despite standard treatment. The identification of new therapeutic targets is, therefore, necessary...

Soybeans are one of the primary dietary sources of isoflavones - phytoestrogens with numerous benefits to human health, including alleviating menopausal symptoms, reducing the risk of certain types of cancer and many others. This research provides a...

The endocrine disorder polycystic ovarian syndrome (PCOS) is complicated. In India, two out of every ten women have PCOS. PCOS can also be identified with a polycystic ovary morphology and an ovulatory hyperandrogenism. PCOS, defined as one of the mo...

Aim: In the present study, we performed an in silico study on the triterpenoid compounds from the mangrove plant as potential COVID-19 main protease (Mpro) inhibitors, which can be used as a potential medicine target. Methods: In this study we perfor...

The term neuroimmunomodulation defines the modulating role of the nervous system in relation to immune functions. This phenomenon is possible due to the existence of receptors for neurotransmitters in immune cells. The neuronal mediators are also abl...

Primary biliary cholangitis (PBC) is a slowly progressive cholestatic autoimmune liver disease which leads to fibrosis, cirrhosis, and liver failure. Oxidative stress seems to play an important role in the pathogenesis of chronic liver diseases. The...

In the last few decades, natural products from plants have developed immense importance in human health due to their therapeutic multi-functionality. They have also been reported to enhance human gut health, which is another important factor in overa...

The strong link between coagulation and inflammation has recently been investigated in multiple sclerosis (MS) in the light of coagulant serine proteases as pro-inflammatory mediators in MS animal models. Our work attempted to enlighten the role of I...

We have developed an approach to reprogramming immune cells by inhibiting the MAPK/ERK pathway through MEKi and the PD-1/PD-L1 immune checkpoint signaling pathway. We hypothesized that reprogramming of spleen CD8⁺ T-cells could also create a populati...

The problem of pharmacologically correcting CNS hypoxic disorders is one of priority. HSP70, an endogenous regulator of cytoprotective processes, can be considered as an effective pharmacological target. The aim of this research was to study the abil...

We show that an extract from catmint (Nepeta nuda L.) flowers is not hemotoxic and does not alter erythrocytes’ morphology. H₂O₂-induced oxidative stress leads to an increase in lipid peroxidation, accompanied by a reduction in the number of bi...

Lung cancer is one of the deadliest cancers, responsible for more than 1.80 million deaths annually worldwide, and it is on the priority list of the WHO. In the current scenario, when cancer cells become resistant to drugs, making them less effective...

Medicinal plants with favorable therapeutic effects have gained interest over conventional drugs in the treatment of oxidative stress and inflammatory-mediated diseases. The antioxidant and anti-inflammatory activities of Combretum paniculatum ethano...

In this study, novel potential inhibitors of SARS-CoV-2 variants were designed de novo using generative neural networks. The top-performing ligand based on docking performance and ADMET profiles was CID #526. It forms several hydrogen bonds with wild...

Here, potential inhibitors of the SARS-CoV-2 papain-like protease (PL^pro) are reported. A drug molecule (PL^pro-50), designed de novo using generative neural networks, interacts with PL^pro via hydrogen bonding, forming a salt bridge, and π–&p...

Diabetes mellitus (DM) is a widespread, long-term illness recognised as elevated blood sugar. Infection, inadequate blood flow, neuropathy and insufficient proliferative and cytokine signalling slow down wound healing in diabetics. Recent research ha...

Uterine leiomyoma (UL) is the most common benign tumor causing considerable morbidity during the reproductive years in women with contributions from environmental and genetic factors. According to the GWAS studies, there are many genes and polymorphi...

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder. Acetylcholinesterase (AChE) inhibitors constitute a pharmacotherapeutic strategy for AD treatment. Resveratrol has anti-inflammatory, neuroprotective, anticarcinogenic, an...

Childhood (pediatric) obesity is becoming increasingly common at an alarming rate. Obese children are more likely to develop insulin resistance, relative insulin insufficiency, and type 2 diabetes. Recent research suggests that mitochondrial dysfunct...

Age-related neurodegenerative diseases have drawn the interest of the scientific community due to the gradual increase in the average age in the world’s population. Recent studies have indicated an altered cell cycle in the triggering of neurod...

The purpose of this review is to delve into the essence of Annona muricata Linn. A. muricata, also known as soursop, guanabana, and graviola, is a member of the Annonaceae family and has a long history of traditional uses. This is an evergreen plant...

Wound healing consists of a sequence of coordinated phases: inflammation, proliferation, and remodeling. In skin lesions, neutrophils and keratinocytes are the main cell types participating in the inflammatory phase, during which the release of media...

Fibroblasts play a crucial role in wound healing and skin fibrosis. It is also probably the cell model used to study in vitro photobiomodulation. Our previous in vivo results evidenced a faster recovery in blue-light-treated wounds (410–430 nm)...

Enteroaggregative Escherichia coli (EAEC) has been widely recognized as one of the leading causes of infantile diarrhoea and nutrient malabsorption in developing as well as developed countries. In recent years, drug resistance, particularly multi-dru...

Diabetes mellitus (DM) is a chronic metabolic disorder and is associated with impaired wound healing. Non-healing leg and foot ulcers are a frequent significant consequence of diabetes and are caused by a combination of inadequate tissue perfusion, s...

The following study investigated the effects of blue LED light (410–430 nm) on wound healing in mice with superficial and full-thickness skin wounds. The wounds were treated with blue LED light (20.6 J/cm², 30 s), and biopsies were collected ov...

In today’s busy lifestyle, people are experiencing a constant shortage of time for their personal care. Focus on personal health and hygiene has reduced to a significant extent. In such situations, health and hygiene of people are continuously...

Chronic wound resulting from diabetes mellitus is a significant cause of amputation worldwide. Secondary infections, lowering of nitric oxide synthase level, reduction of glucose-6-phosphate dehydrogenase levels, improper extracellular matrix remodel...

The health-promoting properties of Silybum marianum have been acknowledged since antiquity. This plant is credited with substantial hepatoprotective properties and is also protective in cardiovascular diseases, diabetes mellitus, and neurodegeneratio...

Cissus quadrangularis (Vitaceae) is a common perennial succulent climber plant belonging to the Vitaceae family. The plant has a strong pharmacological profile with a variety of phytoconstituents and is geographically distributed throughout tropical...

This study aimed to formulate polymer-based chitosan nanoparticles as a drug (miltefosine) delivery system for treating leishmaniasis. Miltefosine-loaded chitosan nanoparticles (MLCNPs) have been synthesized and then characterized by the use of UV-vi...

Glioblastoma is an aggressive type of CNS tumor. The aim was to evaluate the antitumor activity of Taraxacum officinale (TO) extracts on U-138 MG glial cells and correlate it with the concentration of chicoric (ChA), chlorogenic (CGA), and caftaric (...

Insulin affects wound healing by reducing inflammation, regulating oxidative reactions, and increasing collagen deposition. Despite the many benefits of insulin, there is still no topical product for insulin delivery through the skin on the market. T...

Mangrove is an opulent and untapped ecosystem with great phytochemical diversity, making it suitable for the discovery of novel antimicrobial compounds. The goal of the study was to explore the pharmaceutical antibacterial and antioxidant resources f...

We have found a logical way to prove a mechanism that allows us to demonstrate the relationship between the restoration of arterial blood flow through the cervical vertebral arteries to the rhomboid fossa and the normalization of left ventricular hyp...

In the world of data, there is an urgent need to find ways to extract knowledge and information for improving patient care. Artificial intelligence (AI) is an emerging tool that has the potential to provide cardiologists with new insights and knowled...

Inflammatory bowel disease is a term used for chronic inflammatory condition that includes two diseases, i.e., ulcerative colitis and Crohn’s disease; both mostly affect the colon, as well as the mouth, oesophagus, stomach, small intestine, and...

Enteroaggregative Escherichia coli (EAEC) is a neglected, though emerging, bacterial pathogen associated with gastrointestinal illnesses worldwide. Recently, a surprising surge in the multi-drug resistance pattern among EAEC strains has been observed...

The drugs currently available as cyclooxygenase-2 (COX-2) inhibitors increase the risk of cardiovascular events, which justifies the search for new alternative anti-inflammatory molecules. This work aimed to evaluate the anti-inflammatory activity of...

Depression is a serious psychological disorder with high prevalence rates, especially among university students. Serum proteins related to the immune system and oxygen and lipid transfer could have contributing roles in the development of depression...

Integral membrane proteins, known as Transient Receptor Potential (TRP), channels are cellular sensors for various physical and chemical stimuli in the nervous system, respiratory airways, colon, pancreas, bladder, skin, cardiovascular system, and ey...

Santolina chamaecyparissus, commonly known as cotton lavender, is a plant with recognized medicinal properties that has been traditionally used for several conditions, including providing relief in premenstrual syndrome and the treatment of infection...

Breast cancer (BC) is one of the leading causes of death in Canadian women, with an average survival rate of 5 years after diagnosis. Early detection of BC can greatly improve patient outcomes and survival. However, a non-invasive BC detection method...

Breast cancer (BC) remains one of the leading causes of cancer deaths among women worldwide. Recently, studies of long non-coding RNAs (lncRNAs) involved in the regulation of various signaling pathways in cells have become increasingly important, sin...

The survival and cytotoxicity of reprogrammed human CD8⁺ T-cells (hrT-cells) were evaluated in a culture of cancer stem cells (CSCs) isolated from a patient with small-cell lung cancer (SCLC). T-cells were isolated from the blood of healthy volunteer...