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Open AccessArticle

Streptococcus thermophilus ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice

1
Institute for Health and Sport, Victoria University, Melbourne VIC 3030, Australia
2
NewDrug, Patras Science Park, 26500 Patras, Greece
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(2), 126; https://doi.org/10.3390/brainsci10020126
Received: 28 November 2019 / Revised: 20 February 2020 / Accepted: 21 February 2020 / Published: 23 February 2020
(This article belongs to the Special Issue Advances in Multiple Sclerosis Research)
Probiotic bacteria have beneficial effects to the development and maintenance of a healthy microflora that subsequently has health benefits to humans. Some of the health benefits attributed to probiotics have been noted to be via their immune modulatory properties suppressing inflammatory conditions. Hence, probiotics have become prominent in recent years of investigation with regard to their health benefits. As such, in the current study, we determined the effects of Streptococcus thermophilus to agonist MBP83–99 peptide immunized mouse spleen cells. It was noted that Streptococcus thermophilus induced a significant increase in the expression of anti-inflammatory IL-4, IL-5, IL-10 cytokines, and decreased the secretion of pro-inflammatory IL-1β and IFN-γ. Regular consumption of Streptococcus thermophilus may therefore be beneficial in the management and treatment of autoimmune diseases such as multiple sclerosis. View Full-Text
Keywords: probiotics; Streptococcus thermophilus; ST285; MBP83–99 peptide; mannan; immune modulation; multiple sclerosis; agonist peptide probiotics; Streptococcus thermophilus; ST285; MBP83–99 peptide; mannan; immune modulation; multiple sclerosis; agonist peptide
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Dargahi, N.; Matsoukas, J.; Apostolopoulos, V. Streptococcus thermophilus ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice. Brain Sci. 2020, 10, 126.

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