32,776 Results Found

Understanding the structural intricacies of RNA molecules is essential for deciphering numerous biological processes. Traditionally, scientists have relied on experimental methods to gain insights and draw conclusions. However, the recent advent of a...

This study investigates the structural and magnetic properties of La–Mg co-substituted M-type strontium hexaferrites with the compositions Sr_1−xLa_xFe_12−xMg_xO₁₉ (x = 0, 0.05, 0.1, 0.15), synthesized via a conventional solid-state rea...

Background: Corylin (3-(2,2-dimethylchromen-6-yl)-7-hydroxychromen-4-one), a bioactive flavonoid, has been reported to exercise anti-inflammatory, antineoplastic, and antioxidant effects, and may also possess lifespan-extending properties. Objectives...

The core subunits of the K_V7.2, K_V7.3, and K_V7.5 channels, encoded by the KCNQ2, KCNQ3, and KCNQ5 genes, are expressed across various cell types and play a key role in generating the M-type K⁺ current (I_K(M)). This current is characterized by an acti...

We report enhanced permanent magnet performance for multi-cation–substituted M-type Sr-hexaferrites (SrM) prepared using conventional ceramic processes. The final cation composition, Sr_0.4Ca_0.3La_0.3Fe_10.2Co_0.1Mn_0.1Si_0.05Mg_0.05O₁₉, could be deri...

Kynurenic acid (KYNA, 4-oxoquinoline-2-carboxylic acid), an intermediate of the tryptophan metabolism, has been recognized to exert different neuroactive actions; however, the need of how it or its aminoalkylated amide derivative N-(2-(dimethylamino)...

Cannabidiol (CBD) is a naturally occurring compound found in the Cannabis plant that is known for its potential therapeutic effects. However, its impact on membrane ionic currents remains a topic of debate. This study aimed to investigate how CBD mod...

M-type Sr_0.1Ca_0.4La_0.5Fe₁₂O₁₉ powder specimens doped with different precursors RFe₂O₄(R = Co, Ni, Cu, Zn, and Mg) were prepared via a traditional solid-state reaction method. The structural and magnetic properties of the specimens were studied. Only...

La-Ca-Co substituted M-type Sr-hexaferrites (Sr_0.3Ca_0.4La_0.3Fe_9.8Co_0.2O_19-δ) were prepared by a solid-state reaction using two different procedures, where the SiO₂ additive was mixed either before calcination (pre-Si) or after calcination (post...

Perampanel (PER) is a selective blocker of AMPA receptors showing efficacy in treating various epileptic disorders including brain tumor-related epilepsy and also potential in treating motor neuron disease. However, besides its inhibition of AMPA-ind...

A series of charge-balanced Si⁴⁺-M^1+,2+ (M = Mg²⁺, K⁺, Li⁺) substitution compositions with the chemical formulae of SrFe_12−2xSi_xMg_xO₁₉ (x = 0, 0.05, 0.1, 0.2), Sr_1−yFe_12−ySi_yK_yO₁₉ (y = 0.05, 0.1, 0.2), and SrFe_12−z(Si_0.6Li_0.6)...

Gastrodigenin (HBA) and gastrodin (GAS) are phenolic ingredients found in Gastrodia elata Blume (GEB), a traditional Chinese herbal medicine. These compounds have been previously used to treat cognitive dysfunction, convulsion, and dizziness. However...

A cobalt-free compositional strategy was pursued to promote Ce incorporation in M-type SrFe₁₂O₁₉ and thereby enhance its hard magnetic performance. In Sr_1−xCe_xFe_12−xMg_xO₁₉ (x = 0–0.15), the highest coercivity and finest microstructu...

M-type optical fibers in which a core is surrounded by a thin ring layer with a higher refractive index have attracted increasing attention in recent years. One of their advantageous features is the ability to operate a non-fundamental LP₀₂ mode poss...

Solifenacin (Vesicare^®, SOL), known to be a member of isoquinolines, is a muscarinic antagonist that has anticholinergic effect, and it has been beneficial in treating urinary incontinence and neurogenic detrusor overactivity. However, the informatio...

Obtaining reliable dynamic mechanical properties through experiments is essential for developing and validating constitutive models in material selection and structural design. This study introduces a dynamic tensile method using a modified M-type sp...

Enhanced hard magnetic properties were achieved in M-type hexaferrite by optimizing the substitution levels of Mn, Al, and Si for Fe, and Ca for Sr within SrFe₁₂O₁₉. The addition of Al–Si–Mn effectively controlled crystallite growth, resu...

Ba_1−xSr_xFe₁₂O₁₉ (x = 0.0, 0.5 and 1.0) hard-magnetic nanohexaferrites prepared by autocombustion were primarily investigated using Mössbauer spectroscopy and optical studies. Morphological examination by electron scanning microscopy reveal...

The theory of convexity has a rich and paramount history and has been the interest of intense research for longer than a century in mathematics. It has not just fascinating and profound outcomes in different branches of engineering and mathematical s...

In order to improve the microwave-absorption performance of barium ferrite and broaden its microwave-absorption band, BaFe₁₂O₁₉, Ba_0.95Ca_0.05Fe₁₂O₁₉, and Ba_0.95Ca_0.05Fe_12−xCo_xO₁₉ (x = 0.1, 0.2, 0.3 and 0.4, respectively) hexaferrites were synth...

Bisoprolol (BIS) is a selective antagonist of β₁ adrenergic receptors. We examined the effects of BIS on M-type K⁺ currents (I_K(M)) or erg-mediated K⁺ currents (I_K(erg)) in pituitary GH_3, R1220 cells, and hippocampal mHippoE-14 cells. As GH₃ cel...

QO-58 (5-(2,6-dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)-1H-pyrazolol[1,5-a]pyrimidin-7-one) has been regarded to be an activator of K_V7 channels with analgesic properties. However, whether and how the presence of this compound can r...

Mn–Ti, Zn–Ti, Zn–Zr substituted M-type Sr-hexaferrites (SrM), SrFe_12−2xM_1xM_2xO₁₉ (0 ≤ x ≤ 2.0, M₁ = Mn or Zn; M₂ = Ti or Zr) were synthesized, and their solubility, crystalline structure, and high-frequency properties were studied. Zn–Zr substitution...

SrFe_12−xNb_xO₁₉ (x = 0.00–0.15) was here synthesized by a conventional solid-state reaction method. Thermogravimetry and differential scanning calorimetry curves revealed the sample reactions at four temperature ranges, and the optimal rea...

M-type barium hexaferrites, BaFe_(12−x)La_xO₁₉ (x = 0.0, 0.05, 0.1, 0.15, and 0.2), were prepared by a low-cost solid-state reaction method. The specimens crystallized in a non-centrosymmetric hexagonal magnetoplumbite structure that belonged to...

Post-weld evaluation does not readily capture the dynamic evolution of nugget formation in resistance spot welding. In this study, an embedded ultrasonic probe was used to acquire A-scan signals during resistance spot welding of stainless steel. Cons...

Artificial reefs are effective measures to improve the marine ecological environment and increase fishery production. However, there are several geometries being investigated nowadays and their setup, including the spacing between groups of them, can...

Reliable clinical and laboratory research requires clearly defined methodological processes, appropriate statistical evaluation, and careful interpretation of findings. Null hypothesis significance testing (NHST), derived from Fisher’s concept...

Phenobarbital (PHB, Luminal Sodium^®) is a medication of the barbiturate and has long been recognized to be an anticonvulsant and a hypnotic because it can facilitate synaptic inhibition in the central nervous system through acting on the γ-...

Brivaracetam (BRV) is recognized as a novel third-generation antiepileptic drug approved for the treatment of epilepsy. Emerging evidence has demonstrated that it has potentially better efficacy and tolerability than its analog, Levetiracetam (LEV)....

Differentiating primary and secondary membranous glomerulonephritis (MGN) using biomarkers for MGN is essential in patients’ diagnosis, treatment and follow-up. Although biopsy has been the primary tool in making the diagnosis, not all patients can w...

M-type hexaferrites are widely used in magnetic applications, and tailoring their properties via aliovalent substitution requires a detailed understanding of charge compensation and cation distribution. In this work, Mg²⁺/M⁴⁺ (M = Zr, Hf) co-substitu...

Sesamin (SSM) and sesamolin (SesA) are the two major furofuran lignans of sesame oil and they have been previously noticed to exert various biological actions. However, their modulatory actions on different types of ionic currents in electrically exc...

The study investigates Co²⁺/M⁴⁺ (Sn, Zr, Hf)-substituted M-type barium ferrites to understand phase formation, structural evolution and magnetic behavior. Ferrites with the general composition BaFe_12−x−yCo_xM_yO₁₉ were synthesized via sodiu...

This report is on Co and Ti substituted M-type barium and strontium hexagonal ferrites that are reported to be single phase multiferroics due to a transition from Neel type ferrimagnetic order to a spiral spin structure that is accompanied by a ferro...

Ribociclib (RIB, LE011, Kisqali^®), an orally administered inhibitor of cyclin-dependent kinase-4/6 (CDK-4/6) complex, is clinically effective for the treatment of several malignancies, including advanced breast cancer. However, information regard...

GAL-021 has recently been developed as a novel breathing control modulator. However, modifications of ionic currents produced by this agent remain uncertain, although its efficacy in suppressing the activity of big-conductance Ca²⁺-activated K⁺ (BK_Ca...

The non-linear voltage-dependent hysteresis (Hys_(V)) of voltage-gated ionic currents can be robustly activated by the isosceles-triangular ramp voltage (V_ramp) through digital-to-analog conversion. Perturbations on this Hys_(V) behavior play a role in...

The concerted regulation of chloroplast biosynthetic pathways and NADPH extrusion via malate valve depends on f and m thioredoxins (Trxs). The finding that decreased levels of the thiol-peroxidase 2-Cys peroxiredoxin (Prx) suppress the severe phenoty...

The M-type barium hexaferrite substituted with titanium, BaFe${}_{12-x}$Ti${}_x$O${}_{19}$, was synthesized from sodium carbonate flux and the obtained single crystals with a maximum degree of substitution of up to about x = 0.9 were characterized. XPS measuremen...

Mass sensitivity plays a crucial role in the practical application of quartz crystal microbalances (QCMs)-based quantitative analysis. n-m type QCMs have many applications, so it is necessary to clarify the relationship between the mass sensitivity a...

We consider an irreducible discrete-time Markov process with states represented as (k, i) where k is an M-dimensional vector with non-negative integer entries, and i indicates the state (phase) of the external environment. The number n of phases may...

This article intends to initiate the study of Pompeiu–Hausdorff distance induced by an M-metric. The Nadler and Kannan type fixed point theorems for set-valued mappings are also established in the said spaces. Moreover, the discussion is suppor...

The current work records for the first time the rare-metal pegmatites with mixed NYF-LCT located at Wadi Sikait, south Eastern Desert of the Egyptian Nubian Shield. Most of the Sikait pegmatites are associated with sheared granite and are surrounded...

Neutral lipid storage disease type M (NLSD-M) is an ultra-rare, autosomal recessive disorder that causes severe skeletal and cardiac muscle damage and lipid accumulation in all body tissues. In this hereditary pathology, the defective action of the a...

In differential geometry, relations between curves are a large and important area of study for many researchers. Frame areas are an important tool when studying curves, specially the Frenet–Serret frame along a space curve and the Darboux frame along...

In this manuscript, we investigate original fixed-point (fp) and fixed-disc results in quasi M-metric spaces. First, we present a Hardy–Rogers-type fp result for self-mappings satisfying a specific contractive condition in $m_q$-complete quasi M-m...

In this work, we discover a new version of Hermite–Hadamard quantum integrals inequality via m-preinvex functions. Moreover, the authors present a quantum integrals identity and drive some new quantum integrals of Hermite–Hadamard-type in...

In the present paper, regular spacelike spatial Minkowski Pythagorean hodograph (MPH) curves are characterized with rational rotation-minimizing frames (RRMFs). We define an Euler–Rodrigues frame (ERF) for MPH curves and by means of this concep...

Integral inequalities play critical roles in measure theory and probability theory. Given recent profound discoveries in the field of fuzzy set theory, fuzzy inequality has become a hot research topic in recent years. For classical Sandor type inequa...