A healthy, latently infected, diseased (HLD) plant model for botanical epidemics was defined for tomato bacterial canker (TBC) caused by the pathogenic plant bacteria, Clavibacter michiganensis subsp. michiganensis (Cmm). To estimate the infection pr...
Using microemulsions (µEs) as preservation media for cells was pursued in the 1990s; however, the difficulty in formulating biocompatible µEs and keeping unacclimatized cells alive for more than three days hindered developments in this ar...
Hypomyelinating leukodystrophies (HLDs) represent a group of congenital rare diseases for which the responsible genes have been identified in recent studies. In this review, we briefly describe the genetic/molecular mechanisms underlying the pathogen...
Clove oil is an essential oil used in food and pharmaceutical applications, with a market value of 300+ million dollars per year. Microemulsions have been used as effective clove oil delivery vehicles and could also be used to develop new extraction...
Hypomyelinating leukodystrophy 10 (HLD10) is an autosomal recessive disease related to myelin sheaths in the central nervous system (CNS). In the CNS, myelin sheaths are derived from differentiated plasma membranes of oligodendrocytes (oligodendrogli...
Hypomyelinating leukodystrophy 7 (HLD7) is an autosomal recessive oligodendroglial cell-related myelin disease, which is associated with some nucleotide mutations of the RNA polymerase 3 subunit a (polr3a) gene. POLR3A is composed of the catalytic co...
POLR3B and POLR3A are the major subunits of RNA polymerase III, which synthesizes non-coding RNAs such as tRNAs and rRNAs. Nucleotide mutations of the RNA polymerase 3 subunit b (polr3b) gene are responsible for hypomyelinating leukodystrophy 8 (HLD8...
Introduction: In the central nervous system (CNS), proper interaction between neuronal and glial cells is crucial for the development of mature nervous tissue. Hypomyelinating leukodystrophies (HLDs) are a group of genetic CNS disorders characterized...
Myelin sheaths created by oligodendroglial cells encase neuronal axons to achieve saltatory conduction and protect axons. Pelizaeus-Merzbacher disease (PMD) is a prototypic, hereditary demyelinating oligodendroglial disease of the central nervous sys...
Optimal condition-based microemulsion is key to achieving great efficiency in oil removal. One useful empirical equation to predict an optimal condition is a hydrophilic–lipophilic deviation (HLD). However, the K constants of each surfactant should b...
Hypomyelinating leukodystrophies (HLDs) are a group of hereditary CNS disorders characterized by hypomyelination and, sometimes, repeated cycles of demyelination and remyelination. In HLDs, various genetic mutations in the responsible genes disrupt t...
The effects of surfactant molecules involved in macro-, mini-, nano-, and microemulsions used in cosmetics and pharmaceuticals are related to their amphiphilic interactions with oil and water phases. Basic ideas on their behavior when they are put to...
This work introduces a Targeted Emulsified-Solvent Injection (TESI) process for extracting bitumen from oil sands. In TESI, a solvent is emulsified near the emulsion phase inversion point (PIP), where the interfacial tension and the emulsion stabilit...
Soap applications for cleaning and personal care have been used for more than 4000 years, dating back to the pharaonic period, and have widely proliferated with the appearance of synthetic surfactants a century ago. Synthetic surfactants used to make...
Formulation is an ancient concept, although the word has been used only recently. The first formulations made our civilization advance by inventing bronze, steel, and gunpowder; then, it was used in medieval alchemy. When chemistry became a science a...
Hypomyelinating leukodystrophy 1 (HLD1), also known as Pelizaeus–Merzbacher disease (PMD), is a severe X-linked hereditary hypomyelinating/demyelinating disorder caused primarily by genomic duplications or multiplications that lead to the incre...
Pelizaeus–Merzbacher disease (PMD), also known as hypomyelinating leukodystrophy 1 (HLD1), is an X-linked recessive disease affecting in the central nervous system (CNS). The gene responsible for HLD1 encodes proteolipid protein 1 (plp1), which is th...
Transmembrane protein 106B (TMEM106B), which is a type II transmembrane protein, is believed to be involved in intracellular dynamics and morphogenesis in the lysosome. TMEM106B is known to be a risk factor for frontotemporal lobar degeneration and h...
Background: The aim of this study was to investigate whether the use of three-dimensional (3-D) computed tomography (CT)-based head-lesser trochanter distance (HLD) could reduce leg length discrepancy (LLD) more than the use of a two-dimensional (2-D...
This work provides a comprehensive review of experimental methods used to measure rheological properties of interfacial layers stabilized by surfactants, asphaltenes, and proteins that are relevant to systems with large interfacial areas, such as emu...
Ionic liquids attracted interest as green alternatives to replace conventional organic solvents in protein stability studies. They can play an important role in the stabilization of enzymes such as haloalkane dehalogenases that are used for biodegrad...
Background and Objectives: Oral isotretinoin has revolutionized the treatment of severe acne vulgaris. Isotretinoin is associated with multiple adverse effects, one of which is dyslipidemia (DLP). Materials and Methods: This single-center prospective...
Routine monitoring of ortho-phthalaldehyde (OPA) disinfectants is critical for endoscope reprocessing, yet commercial test strips suffer from subjective visual ambiguity, strict manual timing, and susceptibility to sample matrix dilution. This study...
Microemulsions are thermodynamically stable, transparent, isotropic single-phase mixtures of two immiscible liquids stabilized by surfactants (and possibly other compounds). The assortment of very different microstructures behind such a univocal macr...
Background: Genetic hypomyelinating diseases are a heterogeneous group of disorders involving the white matter. One infantile hypomyelinating leukoencephalopathy is associated with the homozygous variant (Cys4-to-Ser (C4S)) of the c11orf73 gene. Meth...
Cell-based interception and precision medicine is a novel approach aimed at improving healthcare through the early detection and treatment of diseased cells. Here, we describe our recent progress towards developing cell-based interception and precisi...
Connexins are members of a family of integral membrane proteins that provide a pathway for both electrical and metabolic coupling between cells. Astroglia express connexin 30 (Cx30)-GJB6 and Cx43-GJA1, while oligodendroglia express Cx29/Cx31.3-GJC3,...
Microemulsion flooding technology, known for significantly reducing interfacial tension, improving rock wettability, and providing strong driving forces at the microscopic level, has been widely applied in enhancing oil recovery in oil fields. This a...
Individuals with Lyme disease can be very symptomatic. This survey compares the burden of illness for individuals with a history of Lyme disease (HLD) with individuals with a HLD who have either contracted COVID-19 or who have taken the COVID-19 vacc...
Extreme prematurity (EPT, <28 weeks gestation) is associated with language problems. We previously reported hyperconnectivity in EPT children versus term children (TC) using magnetoencephalography (MEG). Here, we aim to ascertain whether functiona...
Heterogeneous ice nucleation is a key process for ice cloud formation, snowfall, and freezing of water bodies. Ice nucleating particle (INP) cloud feedbacks are one of the largest sources of uncertainties in Earth’s Energy Budget. Although INPs...
In the following, a brief overview on the recently found robust experimental evidence for the existence of the Fulde–Ferrell–Larkin–Ovchinnikov (FFLO) state in layered organic superconductors is given. These electronically quasi-two...
Quantum error correction (QEC) is indispensable for suppressing noise in near-term and future quantum processors. Most neural decoders proposed for the surface code exploit predominantly local syndrome neighborhoods, which limits their ability to cap...
This study investigated the effects of high-lipid diets (HLD) with methionine (Met) supplementations on golden pompano (Trachinotus ovatus). T. ovatus (initial weight 82 ± 0.04 g) were fed with a normal lipid control diet (11.30% crude lipid a...
Background/Objectives: Transforaminal epidural steroid injection (TFESI) is widely used to treat lumbosacral radicular pain caused by a herniated lumbar disc (HLD). However, therapeutic response varies substantially, and reliable outcome prediction r...
Background: Hyperlipidemia and inflammation are critical components in the pathophysiology of endothelial disorder, which can lead to vascular complications. Our study aimed to evaluate the effects of immunomodulatory therapy (methotrexate and inflix...
Hypomyelinating leukodystrophies (HLDs) are a rare group of heterogeneously genetic disorders characterized by persistent deficit of myelin observed on magnetic resonance imaging (MRI). To identify a new disease-associated gene of HLD, trio-based who...
Backround: The agr (accessory gene regulator) quorum sensing (QS) system of Staphylococcus aureus participates significantly in its virulence and biofilm formation—either through its activation or suppression. The aim of this study was to inves...
High Latitude Dust (HLD) deposition in the surface snow layer in two distant locations in Svalbard (Hornsund and Pyramiden) were collected during the June/July 2019 field campaign and examined in the laboratory. Despite the differences in their clima...
The Yersinia bacteriophages fPS-2, fPS-65, and fPS-90, isolated from pig stools, have long contractile tails and elongated heads, and they belong to genus Tequatroviruses in the order Caudovirales. The phages exhibited relatively wide host ranges amo...
Background: Hypomyelinating leukodystrophy 3 (HLD3), previously characterized as a congenital diseases associated with oligodendrocyte myelination, is increasingly regarded as primarily affecting neuronal cells. Methods: We used N1E-115 cells as the...
26 August 2024
Small GTP-binding proteins of the Rab family regulate intracellular vesicle trafficking across many aspects of the transport system. Among these, Rab9 is recognized for its role in controlling the transport system not only around the trans-Golgi netw...
Ulaanbaatar, the capital of Mongolia, operates one of the world’s largest district heating (DH) systems in the coldest national capital (heating degree-days ~5800). Despite serving over 60% of the city’s 1.6 million residents, the current...
Background: Mycosis fungoides (MF) is a cutaneous T-cell lymphoma. Previous reports have suggested MF is associated with inflammatory conditions such as psoriasis, increased cardiovascular risk factors as well as secondary neoplasms. Methods: A cross...
Recessive mutations in the POLR3A gene cause POLR3-HLD (the second-most-common form of childhood-onset hypomyelinating leukodystrophy), a neurodegenerative disorder featuring deficient cerebral myelin formation. To date, more than 140 POLR3A (NM_0070...
21 April 2022
With the rapid development of industrialization and urbanization, soil contamination with heavy metal (HM) has gradually become a global environmental problem. Lead (Pb) is one of the most abundant toxic metals in soil and high concentrations of Pb c...
Background: The post-acute sequelae of SARS-CoV-2 infection represent a growing public health concern. While associations between COVID-19 and metabolic disorders have been reported, less is known about this risk in young, healthy populations. This s...
Sulfonyl-containing compounds, which exhibit a broad spectrum of biological activities, comprise a substantial proportion of and play a vital role, not only in medicines but also in agrochemicals. As a result increasing attention has been paid to the...
Pedodiversity is generally neglected in studies concerning soil organic carbon (SOC). Therefore, this investigation aimed to explore the effect of soil types on the following: (1) soil processes related to organic matter (OM) dynamics along the profi...
2 March 2024
Background: There has been a trend to transit reprocessing of flexible endoscopes from a high-level disinfectant (HLD) centralized manner to sterilization performed by nursing staff in some Ear, Nose, and Throat (ENT) clinics. In doing so, the clinic...
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