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8.7
4.6
Journals
Antibiotics
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Antibiotic Therapy in Infectious Diseases
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Antibiotic Therapy in Infectious Diseases

A section of Antibiotics (ISSN 2079-6382).

Section Information

Antibiotics play a vital role in modern medicine. Their discovery and use after World War II significantly increased human life expectancy. They are used primarily to treat bacterial infections, but also sometimes used to prevent them, mainly in the surgical setting.

From 1940 to 1990, the discovery of new antibiotics was very dynamic, making it possible to control most bacterial infectious diseases in developed countries. However, antibiotics should only be prescribed in cases of proven or strongly suspected bacterial infection, because their overuse has led to the emergence of resistant bacteria, making treatments less effective. Thus, bacterial resistance appeared quickly after the introduction of each new antibiotic, driving continuous innovation.

From the 1990s onwards, the discovery of new molecules slowed down, while resistance increased, first affecting hospitals. Since the 2000s, very few new antibiotics have been introduced, while the effectiveness of some older treatments is decreasing due to growing resistance resulting from bacterial adaptation. Major pharmaceutical companies are turning away from antibiotic research, which is considered unprofitable compared to other fields such as oncology. New antibiotics, when developed, are reserved for last-resort use to limit the development of resistance, limiting their use and therefore profitability.

The aim of this Section is to improve the use of antibiotics in order to limit bacterial resistance and preserve their role in the future.

The Section's main topics include the following:

  • Antibiotic resistance: resistance mechanisms, their impact on drug efficacy, and strategies to limit this phenomenon.
  • Studies on new therapeutic strategies: new molecules or optimization of existing treatments and antibiotic combinations.
  • Antibiotic stewardship: strategies to avoid overuse and inappropriate use, and promote the optimal duration of use.
  • Alternatives to antibiotics: phage therapy, vaccination to prevent bacterial infections, and other innovative approaches.
  • Epidemiologic studies on antibiotic use.

Promoting optimal strategies for antibiotic prescription and limiting the impact of antibiotic resistance on public health remain the Section’s main goals.

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