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Spatial Linkages Between Geographical Environments and Health Indicators: From Water Quality Parameters to Regional Health Status

A special issue of Water (ISSN 2073-4441). This special issue belongs to the section "Water Quality and Contamination".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 360

Special Issue Editor

College for Water Research, Beijing Normal University, Zhuhai, China
Interests: advanced oxidation technology; control of emerging contaminants; water chemistry; radicals; photolysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As urbanization accelerates and climate change intensifies, the global water crisis has reached critical levels, driven by both water scarcity and deteriorating water quality. Addressing these challenges requires innovative solutions in water management and environmental health. This Special Issue seeks to explore the vital connections between water quality parameters, regional geographical factors, and public health outcomes. This Special Issue also emphasizes how spatial factors—including hydrological conditions, soil composition, and climatic variables—mediate the effects of water quality on human health biomarkers. The Special Issue aims to address the growing need to understand how water pollution impacts health across various regions, focusing particularly on cardiovascular and metabolic health indicators. It seeks to bridge the gap between environmental science and medical research by investigating the following critical areas:

(1) Spatial distribution of water pollutants (e.g., heavy metals, sulfates, and organic compounds) and their influence on human health biomarkers, such as cardiac troponin I;

(2) Geographical correlations between regional water quality parameters (e.g., pH, dissolved oxygen, and mineral content) and health outcomes;

(3) Innovative technologies for water treatment, optimized by GIS, to mitigate health risks posed by poor water quality;

(4) Transport and transformation of pollutants across hydrological systems and their associated health risks, with a focus on spatial heterogeneity.

This Special Issue brings together interdisciplinary research from environmental toxicology, GIS analysis, water engineering, and environmental medicine to offer a comprehensive perspective on the geographical factors influencing water quality and public health. The research aims to provide actionable insights for developing region-specific water quality standards, targeted treatment strategies, and health risk assessments. By investigating the spatial dynamics of pollutant distribution and their health impacts, we hope to foster synergistic governance of the water–soil–health system, contributing to better health outcomes globally.

We welcome both fundamental and applied research, as well as review papers, that address the pressing challenges and prospects of understanding and mitigating the health impacts of water quality across diverse geographical contexts.

  • Environmental health biomarkers;
  • Water treatment technologies;
  • Spatial heterogeneity;
  • Water quality parameters;
  • Cardiovascular and metabolic health;
  • Geographic information systems (GISs);
  • Regional health disparities;
  • Pollutant transport and transformation;
  • Environmental medicine interdisciplinarity;
  • Health risk

Dr. Zihao Wu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Water is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • environmental health biomarkers
  • spatial heterogeneity
  • regional health disparities
  • pollutant transport and transformation
  • health risk assessment
  • environmental medicine interdisciplinarity

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Published Papers (1 paper)

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Research

14 pages, 1970 KiB  
Article
Geographic Exposomics of Cardiac Troponin I Reference Intervals in Chinese Adults: Climate-Topography Coupling-Driven Spatial Prediction and Health Risk Assessment
by Tianyu Li, Jiayu Zhang, Xinfeng Zhao and Zihao Wu
Water 2025, 17(10), 1426; https://doi.org/10.3390/w17101426 - 9 May 2025
Viewed by 278
Abstract
This study elucidates soil–climate regulatory mechanisms on regional health baselines in China and hydrogeochemical roles in cardiovascular biomarker differentiation. Utilizing data from 26,759 healthy adult samples across 286 Chinese cities/counties, seven core factors were identified via Pearson correlation analysis from 25 indicators, including [...] Read more.
This study elucidates soil–climate regulatory mechanisms on regional health baselines in China and hydrogeochemical roles in cardiovascular biomarker differentiation. Utilizing data from 26,759 healthy adult samples across 286 Chinese cities/counties, seven core factors were identified via Pearson correlation analysis from 25 indicators, including longitude (X1, r = −0.192, p = 0.009), elevation (X3, r = 0.377, p = 0.001), and precipitation (X7, r = −0.200, p = 0.006). Ridge regression analysis (R2 = 0.714) was subsequently applied to simulate predicted values for 2232 cities/counties. The synergistic effects of soil calcium sulfate content and salinity (X25) on serum cardiac troponin I (cTnI) reference values were rigorously validated, explaining 25.5% of regional cTnI elevation (ΔR2 = 0.183). The findings demonstrate that precipitation leaching and groundwater recharge processes collectively drive a 25.5% elevation in cTnI levels in northwestern regions (e.g., Nagqu, Tibet: altitude > 4500 m, annual sunshine > 3000 h) compared to southeastern areas. To mitigate salinity transport dynamics, optimization strategies targeting soil cation exchange capacity (X18/X19) were proposed, providing a theoretical foundation for designing gradient water treatment schemes in high-calcium-sulfate zones (CaSO4 > 150 mg/L). Crucially, regression equations derived from the predictive model enable the construction of a geographically stratified reference framework for cTnI in Chinese adults, with spatial analysis delineating its latitudinal (R2 = 0.83) and longitudinal (R2 = 0.88) distribution patterns. We propose targeted strategies optimizing soil cation exchange capacity to mitigate sulfate transport in groundwater, informing geographically tailored water treatment and cardiovascular disease prevention efforts. Our findings provide localized empirical evidence critical for refining WHO drinking water sulfate guidelines, demonstrating direct integration of hydrogeochemistry, water quality management, and public health. Full article
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