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1,017 Results Found

  • Review
  • Open Access
30 Citations
7,993 Views
38 Pages

27 March 2023

Extrusion-based 3D concrete printing (E3DCP) has been appreciated by academia and industry as the most plausible candidate for prospective concrete constructions. Considerable research efforts are dedicated to the material design to improve the extru...

(This article belongs to the Special Issue Design and Properties of 3D Printing Concrete)
  • Article
  • Open Access
10 Citations
7,024 Views
10 Pages

This paper developed a multi-nozzle pneumatic extrusion-based additive manufacturing (AM) system and applied it to print multi-material polymers and conductive sensing pads. We used pneumatic extrusion nozzles to extrude the liquid material and then...

(This article belongs to the Section Inventions and Innovation in Advanced Manufacturing)
  • Article
  • Open Access
30 Citations
4,233 Views
16 Pages

Poor bioavailability hampers the use of curcumin and piperine as biologically active agents. It can be improved by enhancing the solubility as well as by using bioenhancers to inhibit metabolic transformation processes. Obtaining an amorphous system...

(This article belongs to the Special Issue Biologically Active Plant-Derived Pharmaceuticals: Recent Advances and Future Prospects)
  • Article
  • Open Access
36 Citations
6,808 Views
16 Pages

A Hot-Melt Extrusion Risk Assessment Classification System for Amorphous Solid Dispersion Formulation Development

  • Samuel O. Kyeremateng,
  • Kristin Voges,
  • Stefanie Dohrn,
  • Ekaterina Sobich and ,
  • Ute Lander,
  • Stefan Weber,
  • David Gessner,
  • Rachel C. Evans and
  • Matthias Degenhardt
  • + 4 authors+ 0 author

Several literature publications have described the potential application of active pharmaceutical ingredient (API)–polymer phase diagrams to identify appropriate temperature ranges for processing amorphous solid dispersion (ASD) formulations vi...

(This article belongs to the Special Issue Amorphous Solid Dispersions: Rational Selection of a Manufacturing Process)
  • Article
  • Open Access
170 Citations
13,752 Views
13 Pages

This study was performed to develop novel core-shell gastroretentive floating pulsatile drug delivery systems using a hot-melt extrusion-paired fused deposition modeling (FDM) 3D printing and direct compression method. Hydroxypropyl cellulose (HPC) a...

(This article belongs to the Special Issue 3D Printing of Pharmaceuticals and Drug Delivery Devices)
  • Article
  • Open Access
593 Views
26 Pages

Extrusion-based bioprinting is governed by coupled material, extrusion, and motion parameters, yet printability is often assessed using isolated rheological tests or qualitative geometric inspection. This study developed a systems-engineering framewo...

(This article belongs to the Special Issue Multimodal AI‑Assisted Bioprinting: From Material Selection to Automated Fabrication)
  • Article
  • Open Access
4 Citations
1,696 Views
19 Pages

Effects of Isolated Pea Protein on Extrusion-Induced Gelation and Gel-like Network Formation in Low-Moisture Meat Analog Systems

  • Hyun-Woo Choi,
  • Yu Zhang,
  • Yunju Lee,
  • Hyerim Jeon and ,
  • Gi-Hyung Ryu and
  • Bon-Jae Gu
  • + 1 author+ 0 author

16 February 2026

Low-moisture meat analogs (LMMAs) typically exhibit highly expanded structures with large air cells, which differ from the dense and fibrous architecture observed in high-moisture systems. This study investigated the role of isolated pea protein (IPP...

(This article belongs to the Section Gel Applications)
  • Article
  • Open Access
9 Citations
3,521 Views
10 Pages

Comparative Evaluation of Extrusion of Apical Debris in Primary Maxillary Anterior Teeth Using Two Different Rotary Systems and Hand Files: An In Vitro Study

  • Balaji Suresh,
  • Ganesh Jeevanandan,
  • Vignesh Ravindran,
  • Mohammed Mashyakhy and ,
  • Noura Alessa,
  • Ather Ahmed Syed,
  • Suman Panda,
  • Ali Ahmed Assiry,
  • Prabhadevi C. Maganur and
  • Satish Vishwanathaiah
  • + 5 authors+ 0 author

Successful outcome of pulp therapy depends on good chemomechanical preparation of the canals. This is completed with the help of various upcoming rotary and hand files. However, during this preparation, there might be an apical extrusion of the debri...

(This article belongs to the Special Issue New Research Progress of Clinical Pediatric Dentistry)
  • Review
  • Open Access
40 Citations
7,703 Views
26 Pages

3D Printing Direct Powder Extrusion in the Production of Drug Delivery Systems: State of the Art and Future Perspectives

  • Ángela Aguilar-de-Leyva,
  • Marta Casas,
  • Carmen Ferrero,
  • Vicente Linares and
  • Isidoro Caraballo

The production of tailored, on-demand drug delivery systems has gained attention in pharmaceutical development over the last few years, thanks to the application of 3D printing technology in the pharmaceutical field. Recently, direct powder extrusion...

(This article belongs to the Section Pharmaceutical Technology, Manufacturing and Devices)
  • Article
  • Open Access
422 Views
31 Pages

3 September 2026

An integrated Model-Opti-Scale (MOPS) computer system for the modeling, optimization, and scaling-up of plastic extrusion has been built. This enabled simulations of single-screw extrusion with conventional, gravitational feeding of the extruder and...

(This article belongs to the Section Polymeric Materials)
  • Article
  • Open Access
4 Citations
2,783 Views
13 Pages

Hot-Melt Extrusion Drug Delivery System-Formulated Haematococcus pluvialis Extracts Regulate Inflammation and Oxidative Stress in Lipopolysaccharide-Stimulated Macrophages

  • Tae-Young Gil,
  • Ha-Yeon Sim,
  • Ha-Yeon Lee,
  • Suji Ryu and ,
  • Jong-Suep Baek,
  • Dae Geun Kim,
  • Jaehoon Sim and
  • Hyo-Jin An
  • + 3 authors+ 0 author

13 November 2024

Haematococcus pluvialis contains valuable bioactive compounds, including astaxanthin, proteins, and fatty acids. Astaxanthin is known for its various health benefits, such as preserving the redox balance and reducing inflammation. However, its low st...

(This article belongs to the Section Marine Pharmacology)
  • Article
  • Open Access
2 Citations
2,587 Views
14 Pages

13 July 2023

Polymer science plays a crucial role in the understanding and numerical study of material extrusion processes that have revolutionized additive manufacturing (AM). This study investigated the impact of high-gravity conditions on material extrusion an...

(This article belongs to the Special Issue 3D Printing Technology and Additive Manufacturing in Polymer Materials)
  • Article
  • Open Access

A Low-Cost, Modular Active-Mixing Extrusion System for Functionally Graded Direct Ink Writing

  • Anirud Chakkarapani,
  • Rebecca Anne A. Ang,
  • Arnav A. Rao,
  • Ashe Lothamer and ,
  • Marissa A. Capelli,
  • Dominick R. Scholten and
  • Guang Yang
  • + 2 authors+ 0 author

Functionally graded materials (FGMs) replace the discrete interfaces of multi-material additive manufacturing with continuous compositional gradients, mitigating delamination and cracking, but reported systems for FGM direct ink writing (DIW) rely on...

  • Article
  • Open Access
4 Citations
2,553 Views
20 Pages

Comparing Low-Dose Carvedilol Continuous Manufacturing by Solid and Liquid Feeding in Self-Emulsifying Delivery Systems via Hot Melt EXtrusion (SEDEX)

  • Ožbej Zupančič,
  • Josip Matić,
  • Aygün Doğan,
  • Alessio Gaggero and ,
  • Johannes Khinast and
  • Amrit Paudel
  • + 1 author+ 0 author

28 September 2024

Background/Objectives: This study compared two pilot scale continuous manufacturing methods of solid self-emulsifying drug delivery systems (SEDDSs) via hot melt extrusion (HME). Methods: A model poorly water-soluble drug carvedilol in low dose (0.5&...

(This article belongs to the Special Issue Pharmaceutical Excipients in Formulation Design and Drug Delivery)
  • Article
  • Open Access
149 Citations
13,836 Views
16 Pages

Process Parameter Optimization of Extrusion-Based 3D Metal Printing Utilizing PW–LDPE–SA Binder System

  • Luquan Ren,
  • Xueli Zhou,
  • Zhengyi Song,
  • Che Zhao and ,
  • Qingping Liu,
  • Jingze Xue and
  • Xiujuan Li
  • + 2 authors+ 0 author

16 March 2017

Recently, with a broadening range of available materials and alteration of feeding processes, several extrusion-based 3D printing processes for metal materials have been developed. An emerging process is applicable for the fabrication of metal parts...

  • Article
  • Open Access
45 Citations
6,747 Views
22 Pages

Formulation Development of Solid Self-Nanoemulsifying Drug Delivery Systems of Quetiapine Fumarate via Hot-Melt Extrusion Technology: Optimization Using Central Composite Design

  • Prateek Uttreja,
  • Ahmed Adel Ali Youssef,
  • Indrajeet Karnik,
  • Kavish Sanil and ,
  • Nagarjuna Narala,
  • Honghe Wang,
  • Rasha M. Elkanayati,
  • Sateesh Kumar Vemula and
  • Michael A. Repka
  • + 4 authors+ 0 author

Quetiapine fumarate (QTF) was approved for the treatment of schizophrenia and acute manic episodes. QTF can also be used as an adjunctive treatment for major depressive disorders. QTF oral bioavailability is limited due to its poor aqueous solubility...

(This article belongs to the Section Drug Delivery and Controlled Release)
  • Article
  • Open Access
6 Citations
3,013 Views
24 Pages

Tailored Supersaturable Immediate Release Behaviors of Hypotensive Supersaturating Drug-Delivery Systems Combined with Hot-Melt Extrusion Technique and Self-Micellizing Polymer

  • Huan Yu,
  • Yinghui Ma,
  • Yanfei Zhang,
  • Huifeng Zhang and ,
  • Lili Zuo,
  • Chengyi Hao,
  • Weilun Yu,
  • Xiaoying Lin,
  • Yong Zhang and
  • Nianqiu Shi
  • + 6 authors+ 1 author

8 November 2022

The short-term immediate release of supersaturated drug-delivery systems (SDDSs) presents an interesting process that can be tailored to multi-stage release events including initial release after dosing and dissolution, evolved release over longer di...

(This article belongs to the Special Issue Advanced Properties in Amorphous Polymers)
  • Proceeding Paper
  • Open Access
1,380 Views
7 Pages

29 October 2024

Stereolithography (SLA) is a 3D printing technology that uses a laser to cure liquid resin from a tank, layer by layer, to create highly detailed and precise objects. However, this 3D printing technique requires a large amount of resin material to be...

(This article belongs to the Proceedings of 1st International Conference on Industrial, Manufacturing, and Process Engineering (ICIMP-2024))
  • Proceeding Paper
  • Open Access
971 Views
9 Pages

Development of an Automated Filament Extrusion System Using Recycled Thermoplastics for 3D Printing in Caraga State University, Cabadbaran Campus

  • Marisol Jane M. Beray,
  • Raffy V. Cosicol,
  • Reymark C. Capunong,
  • Larry Merl G. Caldoza and
  • Matt Alfred A. Villahermosa

Additive manufacturing offers transformative opportunities but faces barriers due to costly, imported filaments. This study at Caraga State University, Cabadbaran Campus, developed a prototype automated filament extrusion system using recycled thermo...

  • Article
  • Open Access
2 Citations
2,720 Views
12 Pages

30 October 2022

Graphene oxide-carbon fiber/epoxy (GO-CF/EP) composites with extrusion temperatures of 30, 40, 50, 60 and 70 °C were prepared by a vacuum infiltration hot-press-forming experimental system (VIHPS). The effects of extrusion temperature on the micr...

(This article belongs to the Topic Advanced Polymeric Composites: Processing, Characterization and Mechanical Behavior)
  • Article
  • Open Access
6 Citations
2,621 Views
22 Pages

20 July 2022

The article discusses the effect of modification of the plasticizing system of a single-screw extruder on selected physicochemical properties of rapeseed straw and buckwheat straw. A TS-45 single-screw extruder (ZMCh Metalchem, Gliwice, Poland) with...

(This article belongs to the Special Issue Bio-Based Materials and Their Environmental Applications)
  • Article
  • Open Access
2 Citations
1,314 Views
29 Pages

Design of a Novel Integrated Solid–Liquid Separation and Mixing Pin Screw for CF-PLA Particle-Based 3D Printing: Fluid Simulation and Performance Evaluation

  • Jun Wang,
  • Xinke Liu,
  • Guanjun Fu,
  • Xipeng Luo and ,
  • Hang Hu,
  • Shuisheng Chen and
  • Yizhe Huang
  • + 2 authors+ 0 author

22 September 2025

Particle-based 3D printing shows great potential in high-performance composite fabrication due to high raw material utilization and flexible material compatibility. However, constrained by conventional extrusion system structures, critical issues (no...

(This article belongs to the Section Additive Manufacturing Technologies)
  • Article
  • Open Access
5 Citations
1,727 Views
17 Pages

Research on Optimizing Forming Accuracy in Food 3D Printing Based on Temperature–Pressure Dual Closed-Loop Control

  • Junhua Wang,
  • Hao Cao,
  • Jianan Shen,
  • Xu Duan and ,
  • Yanwei Xu,
  • Tancheng Xie and
  • Ruijie Gu
  • + 2 authors+ 0 author

12 October 2025

In this paper, a new 3D printing system based on temperature–pressure double closed-loop collaborative control is proposed to solve the problem of 3D printing accuracy of starch food. The rapid and accurate adjustment of the nozzle temperature...

(This article belongs to the Special Issue Advanced Micro- and Nano-Manufacturing Technologies, 2nd Edition)
  • Article
  • Open Access
3 Citations
1,285 Views
20 Pages

Kinetics and Mechanical Performance of Bio-Based Polyurethane Wood Composites for Sustainable 3D-Printed Construction Materials

  • Lucila M. Carias Duron,
  • Jesus Granero Garcia,
  • Chetna Mandurai,
  • Jordon Hoyer and ,
  • Japneet Kukal,
  • Manish Sakhakarmy,
  • Sushil Adhikari,
  • Brian Via,
  • Iris Beatriz Vega Erramuspe and
  • Maria L. Auad
  • + 6 authors+ 1 author

21 November 2025

Developing bio-based polyurethane (BPU) composites that incorporate bio-oil and wood dust as sources of hydroxyl groups (-OH) presents a compelling approach to advancing sustainable polymer systems. This study examines the impact of isocyanate-to-hyd...

  • Article
  • Open Access
5 Citations
3,025 Views
16 Pages

5 January 2023

Laboratory-scale data on a component level are frequently used for prognostics because acquiring them is time and cost efficient. However, they do not reflect actual field conditions. As prognostics is for an in-service system, the developed prognost...

(This article belongs to the Special Issue Structural Health Monitoring: Advanced Sensing, Diagnostics and Prognostics)
  • Feature Paper
  • Article
  • Open Access
177 Citations
15,597 Views
17 Pages

6 January 2021

The high moisture extrusion of plant proteins is well suited for the production of protein-rich products that imitate meat in their structure and texture. The desired anisotropic product structure of these meat analogues is achieved by extrusion at h...

(This article belongs to the Special Issue Latest Advances in Plant-Based Food Processing to Improve the Sustainability in the Food Supply Chain)
  • Article
  • Open Access
12 Citations
5,198 Views
10 Pages

Apical Debris Extrusion by Adaptive Root Canal Instrumentation in Oval Canals: Full-Sequence SAF System vs. the XP-Endo Shaper Plus Sequence

  • Ajinkya M. Pawar,
  • Bhaggyashri A. Pawar,
  • Anuj Bhardwaj,
  • Alexander Maniangat Luke and ,
  • Zvi Metzger and
  • Anda Kfir
  • + 1 author+ 0 author

16 August 2020

Apical extrusion of debris (AED) by the full sequence of the self-adjusting file (SAF) system was compared with that of the XP-endo shaper plus sequence. Sixty permanent mandibular incisors were randomly assigned to two groups (n = 30) for root canal...

(This article belongs to the Special Issue Predictable Restorative Dentistry)
  • Article
  • Open Access
3 Citations
1,744 Views
23 Pages

Formulation and Characterization of Edible Bigel Inks for Structuring Fat Alternatives in 3D-Printed Foods

  • Konstantina Zampouni,
  • Theocharis Salamandrakis,
  • Triantafyllia Biza,
  • Thomas Moschakis and
  • Eugenios Katsanidis

18 March 2026

Bigels (BGs) are promising biphasic systems for extrusion-based 3D food printing inks. In this study, BG inks were formulated by combining a 6% beeswax—4% monoglycerides oleogel (OG) with a 4% gelatin—1% guar gum hydrogel (HG). The BGs we...

(This article belongs to the Special Issue Food Hydrocolloids and Hydrogels: Rheology and Texture Analysis)
  • Article
  • Open Access
3 Citations
4,609 Views
10 Pages

Quantitative Evaluation of Apically Extruded Debris of Root Canal Dentin Layer with WaveOne, ProTaper Next, ProTaper Gold Rotary File Systems

  • Muhammad Ali,
  • Muhammad Adeel Ahmed,
  • Azeem Ul Yaqin Syed,
  • Asmat Jamil and ,
  • Seher Pervaiz Khan,
  • Ahmed A. AlMokhatieb,
  • Abdulaziz Abdulwahed,
  • Khulud A. Al-Aali,
  • Fahim Vohra and
  • Tariq Abduljabbar
  • + 5 authors+ 0 author

26 March 2022

Endodontic flare-up or post-operative pain occurs when debris such as necrotic pulp tissue, dentin chips, irrigants, and microorganisms are extruded from the apical foramen intraoperatively into the periradicular tissue during root canal instrumentat...

(This article belongs to the Special Issue Surface Coating for Biomedical Applications)
  • Proceeding Paper
  • Open Access
268 Views
10 Pages

2 September 2026

This study presents a system-level and subsystem-level evaluation of energy performance in an industrial polyethylene film production system based on real operational data. The analysis focuses on specific energy consumption (SEC) as a key performanc...

(This article belongs to the Proceedings of The International Conference on Electronics, Engineering Physics and Earth Science (EEPES2026))
  • Article
  • Open Access
21 Citations
5,839 Views
21 Pages

Polylactide as a Substitute for Conventional Polymers—Biopolymer Processing under Varying Extrusion Conditions

  • Daria Kosmalska,
  • Katarzyna Janczak,
  • Aneta Raszkowska-Kaczor,
  • Andrzej Stasiek and
  • Tomasz Ligor

The polymer processing industry is paying more attention to biodegradable materials synthesized from renewable sources. One of the most popular of them is polylactide (PLA). Except the material from which a given product is made, particularly importa...

  • Article
  • Open Access
10 Citations
2,308 Views
20 Pages

14 December 2023

The material extrusion 3D printing process known as fused deposition modeling (FDM) has recently gained relevance in the additive manufacturing industry for large-scale part production. However, improving the real-time monitoring of the process in te...

(This article belongs to the Special Issue Sensing Technology and Applications for Industrial Maintenance and Automation)
  • Article
  • Open Access
18 Citations
5,055 Views
17 Pages

15 December 2020

In the present study, melt-mixed composites based of poly (vinylidene fluoride) (PVDF) and fillers with different aspect ratios (carbon nanotubes (CNTs), carbon black (CB)) and their mixtures in composites were investigated whereby compression-molded...

(This article belongs to the Special Issue Polymer Nanocomposites II)
  • Article
  • Open Access
3 Citations
1,367 Views
22 Pages

Application of Hot-Melt Extrusion in Modifying the Solubility of Lycopene

  • Anna Kulawik,
  • Kamil Wdowiak,
  • Maciej Kulawik,
  • Natalia Rosiak and ,
  • Magdalena Paczkowska-Walendowska,
  • Judyta Cielecka-Piontek and
  • Przemysław Zalewski
  • + 2 authors+ 0 author

19 December 2025

Lycopene is a potent antioxidant carotenoid with significant health-promoting properties. However, its practical application is limited by poor water solubility. This study aimed to enhance lycopene dispersibility through the development of solid dis...

(This article belongs to the Special Issue Bioactive Natural Compounds: From Discovery to Applications)
  • Article
  • Open Access
3 Citations
2,838 Views
14 Pages

Development of a NC-Controlled GTAW-Based Wire Arc Additive Manufacturing System for Using Friction Stir Extrusion Recycled Wires

  • Gustavo H. S. F. L. Carvalho,
  • Gianni Campatelli,
  • Bruno Silva Cota,
  • Davide Campanella and
  • Rosa Di Lorenzo

28 December 2024

This study investigates the feasibility of using friction stir extrusion (FSE) recycled aluminum wires as filler metals for gas tungsten arc welding (GTAW) and additive manufacturing applications. A NC-controlled GTAW feeding system was developed to...

(This article belongs to the Section Advanced Manufacturing)
  • Article
  • Open Access
1 Citations
3,293 Views
11 Pages

Monitoring the Capillary Jet Breakage by Vibration Using a Fast-Video Camera

  • Marcella Chalella Mazzocato,
  • Sylvie Chevallier,
  • Carmen S. Fávaro-Trindade and
  • Denis Poncelet

1 November 2021

The production of beads by simple extrusion dropwise of an alginate solution in a calcium bath is a simple method. It may be done at room temperature without any toxic compound. However, simple extrusion drop by drop from a needle may result in large...

(This article belongs to the Section Biomedical Engineering)
  • Article
  • Open Access
25 Citations
4,532 Views
23 Pages

Expandable Drug Delivery Systems Based on Shape Memory Polymers: Impact of Film Coating on Mechanical Properties and Release and Recovery Performance

  • Marco Uboldi,
  • Chiara Pasini,
  • Stefano Pandini,
  • Francesco Baldi and ,
  • Francesco Briatico-Vangosa,
  • Nicoletta Inverardi,
  • Alessandra Maroni,
  • Saliha Moutaharrik,
  • Alice Melocchi and
  • Lucia Zema
  • + 6 authors+ 1 author

Retentive drug delivery systems (DDSs) are intended for prolonged residence and release inside hollow muscular organs, to achieve either local or systemic therapeutic goals. Recently, formulations based on shape memory polymers (SMPs) have gained att...

(This article belongs to the Section Drug Delivery and Controlled Release)
  • Article
  • Open Access
575 Views
25 Pages

Design and Development of a Laboratory-Scale 3D Printing Platform for Sustainable Construction Materials Using Model-Based Systems Engineering

  • Yassine Ilzen,
  • Erroumayssae Sabani,
  • Amine Ennawaoui,
  • Ihssane Bouiba and ,
  • Mohamed Amine Daoud,
  • El Mehdi Loualid,
  • Hicham Mastouri and
  • Chouaib Ennawaoui
  • + 3 authors+ 0 author

14 August 2026

This paper presents the design and development of a laboratory-scale 3D printing platform intended for research on sustainable construction materials. The growing interest in low-carbon and locally available materials, including clay, geopolymers, re...

(This article belongs to the Section Building Materials, and Repair & Renovation)
  • Article
  • Open Access
9 Citations
6,707 Views
21 Pages

11 August 2022

An approach for improving and maintaining consistent fusion quality of the deposited material during FDM 3d-printing is proposed. This approach is based on the nozzle temperature control during the printing process to adjust the polymer extrusion tem...

  • Review
  • Open Access
111 Citations
29,199 Views
33 Pages

Self-Emulsifying Drug Delivery Systems (SEDDS): Transition from Liquid to Solid—A Comprehensive Review of Formulation, Characterization, Applications, and Future Trends

  • Prateek Uttreja,
  • Indrajeet Karnik,
  • Ahmed Adel Ali Youssef,
  • Nagarjuna Narala and ,
  • Rasha M. Elkanayati,
  • Srikanth Baisa,
  • Nouf D. Alshammari,
  • Srikanth Banda,
  • Sateesh Kumar Vemula and
  • Michael A. Repka
  • + 5 authors+ 0 author

Self-emulsifying drug delivery systems (SEDDS) represent an innovative approach to improving the solubility and bioavailability of poorly water-soluble drugs, addressing significant challenges associated with oral drug delivery. This review highlight...

(This article belongs to the Section Physical Pharmacy and Formulation)
  • Article
  • Open Access
26 Citations
7,711 Views
10 Pages

Filament Advance Detection Sensor for Fused Deposition Modelling 3D Printers

  • Enrique Soriano Heras,
  • Fernando Blaya Haro,
  • José M. De Agustín del Burgo,
  • Manuel Islán Marcos and
  • Roberto D’Amato

9 May 2018

The main purpose of this paper is to present a system to detect extrusion failures in fused deposition modelling (FDM) 3D printers by sensing that the filament is moving forward properly. After several years using these kind of machines, authors dete...

(This article belongs to the Section Physical Sensors)
  • Article
  • Open Access
6 Citations
3,182 Views
14 Pages

27 September 2023

In this study, a material extrusion (MEX) nozzle for fabricating bond magnets was designed to form a unidirectional magnetic field with a solenoid. The hard magnetic properties of the bonded magnets were enhanced by induced magnetic anisotropy. The m...

(This article belongs to the Section Additive Manufacturing)
  • Article
  • Open Access
16 Citations
4,787 Views
17 Pages

During the last years, many evidences have been accumulating about the phytohormone indole-3-acetic acid (IAA) as a multifaceted compound in the microbial world, with IAA playing a role as a bacterial intra and intercellular signaling molecule or as...

(This article belongs to the Special Issue Macro and Microorganism Interactions)
  • Article
  • Open Access
2 Citations
652 Views
25 Pages

Rational Design of Multicomponent Polymeric Systems Based on a Transient Plasticization Window for Hot-Melt Extrusion

  • Mark Mandrik,
  • Veronika Makarova,
  • Ludmila Korol,
  • Ivan Krasnyuk and
  • Sergey Antonov

Background: Hot-melt extrusion (HME) is a promising technology for the manufacturing of drug products; however, its application is limited by elevated thermal and shear stresses that may induce degradation of thermolabile active pharmaceutical ingred...

(This article belongs to the Section Pharmaceutical Technology, Manufacturing and Devices)
  • Article
  • Open Access
6 Citations
4,074 Views
16 Pages

SEDEX—Self-Emulsifying Delivery Via Hot Melt Extrusion: A Continuous Pilot-Scale Feasibility Study

  • Ožbej Zupančič,
  • Aygün Doğan,
  • Josip Matić,
  • Varun Kushwah and ,
  • Carolina Alva,
  • Martin Spoerk and
  • Amrit Paudel
  • + 2 authors+ 0 author

The aim of this study was to develop a continuous pilot-scale solidification and characterization of self-emulsifying drug delivery systems (SEDDSs) via hot melt extrusion (HME) using Soluplus® and Kollidon® VA-64. First, an oil-binding capac...

(This article belongs to the Special Issue Strategies for Enhancing the Bioavailability of Poorly Soluble Drugs)
  • Article
  • Open Access
6 Citations
4,873 Views
19 Pages

6 August 2021

Systematic deflection of drainage systems along strike-slip faults is the combination of repeated faulting slipping and continuous headward erosion accumulated on the stream channels. The measurement and analysis of systematically deflected stream ch...

  • Review
  • Open Access
156 Views
29 Pages

3D-Printing Drug Delivery Systems for the Treatment of Infectious Diseases: Current Advances and Future Perspectives

  • Santiago Nicolás Campos,
  • Cintia Alejandra Briones Nieva,
  • Alicia Graciela Cid,
  • Claudia Elizabeth Llanos and ,
  • Mercedes Villegas,
  • Eva Carolina Arrúa,
  • Santiago Daniel Palma and
  • José María Bermúdez
  • + 3 authors+ 0 author

Background/Objectives: Infectious diseases remain a major burden on global public health, exacerbated by the serious threat of antimicrobial resistance and the limitations of conventional pharmaceutical formulations. This narrative review aims to ana...

(This article belongs to the Special Issue The Development of Drug Delivery Systems and Pharmaceutical Formulations for the Treatment of Infectious Diseases, 2nd Edition)
  • Article
  • Open Access
7 Citations
3,633 Views
30 Pages

Regulation of Intestinal Barrier Function and Gut Microbiota by Hot Melt Extrusion-Drug Delivery System-Prepared Mulberry Anthocyanin in an Inflammatory Bowel Disease Model

  • Eun-Ji Go,
  • Byeong Ryeol Ryu,
  • Gyeong Ju Gim,
  • Ye Rim Shin and ,
  • Min Ji Kang,
  • Min Jun Kim,
  • Jong-Suep Baek and
  • Jung Dae Lim
  • + 3 authors+ 0 author

27 March 2025

Background/Objectives: Anthocyanins (ACNs) derived from mulberry (Morus alba L.) exhibit potent antioxidant and anti-inflammatory activities. However, their low stability and bioavailability in physiological environments limit their therapeutic poten...

(This article belongs to the Special Issue Pharmacological Activities of Flavonoids and Their Analogues 2024)
  • Article
  • Open Access
14 Citations
6,442 Views
20 Pages

Due to stricter emission targets in the mobility sector and the resulting trend towards lightweight construction in order to reduce weight and consequently emissions, multi-material systems that allow a material to be placed in the right quantity and...

(This article belongs to the Special Issue Metal Forming and Joining)
  • Article
  • Open Access
1 Citations
1,887 Views
22 Pages

Objectives: Although 3D-printing has been identified as a promising technique for personalised medicine manufacturing, developing complex formulations that are suitable for the process can be challenging. This study evaluates the use of a mixture des...

(This article belongs to the Section Physical Pharmacy and Formulation)

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