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2,092 Results Found

  • Project Report
  • Open Access
6 Citations
3,990 Views
13 Pages

According to attachment theory, security providing attachment figures fulfill two main functions: (1) safe haven—providing safety and comfort and reducing stress—helping people regain a sense of security; and (2) secure base—providi...

  • Article
  • Open Access
11 Citations
2,887 Views
18 Pages

17 April 2021

This paper aims to improve the stability and robustness of the state-of-charge estimation algorithm for lithium-ion batteries. A new internal resistance-polarization circuit model is constructed on the basis of the Thevenin equivalent circuit to char...

  • Article
  • Open Access
2 Citations
1,562 Views
18 Pages

Currently, protein–protein interaction (PPI) networks have become an essential data source for protein function prediction. However, methods utilizing graph neural networks (GNNs) face significant challenges in modeling PPI networks. A primary...

  • Feature Paper
  • Article
  • Open Access
53 Citations
8,554 Views
29 Pages

Towards Marine Dual Fuel Engines Digital Twins—Integrated Modelling of Thermodynamic Processes and Control System Functions

  • Sokratis Stoumpos,
  • Gerasimos Theotokatos,
  • Christoforos Mavrelos and
  • Evangelos Boulougouris

This study aims at developing an integrated model that combines detailed engine thermodynamic modelling and the control system functional modelling paving the way towards the development of high-fidelity digital twins. To sufficiently represent the c...

  • Article
  • Open Access
4 Citations
3,955 Views
13 Pages

A Novel Dual-Function Nitric Oxide Donor Therapy for Preeclampsia—A Proof-of-Principle Study in a Murine Model

  • Diana Pintye,
  • Réka E. Sziva,
  • Lauren A. Biwer,
  • Esilida Sula Karreci,
  • Sonako Jacas,
  • Maxim Mastyugin,
  • Marianna Török,
  • Brett C. Young,
  • Prakash Jagtap and
  • Zsuzsanna K. Zsengellér
  • + 2 authors

23 November 2023

Background: Preeclampsia (PE) is a hypertensive disorder of pregnancy that is associated with substantial morbidity and mortality for the mother and fetus. Reduced nitric oxide bioavailability and oxidative stress contribute to the maternal and fetal...

  • Article
  • Open Access
29 Citations
2,465 Views
16 Pages

Fractional Dual-Phase-Lag Model for Nonlinear Viscoelastic Soft Tissues

  • Mohamed Abdelsabour Fahmy and
  • Mohammed M. Almehmadi

The primary goal of this paper is to create a new fractional boundary element method (BEM) model for bio-thermomechanical problems in functionally graded anisotropic (FGA) nonlinear viscoelastic soft tissues. The governing equations of bio-thermomech...

  • Article
  • Open Access
974 Views
19 Pages

Dual ROCK1/2–MYLK4 Kinase Inhibition Preserves Visual Function in a Rat Model of Neuromyelitis Optica Spectrum Disorder Optic Neuritis

  • Chin-Te Huang,
  • Monir Hossen,
  • Tu-Wen Chen,
  • Chih-Wei Fu,
  • Yi-Hsun Chen,
  • Tzu-Lun Huang and
  • Rong-Kung Tsai

31 October 2025

Background: Neuromyelitis optica spectrum disorder (NMOSD) causes severe optic nerve (ON) inflammation and vision loss. Current treatments remain limited, prompting exploration of new therapeutic strategies. This study evaluated the efficacy of ITRI-...

  • Article
  • Open Access
6 Citations
2,966 Views
22 Pages

DECT-CLUST: Dual-Energy CT Image Clustering and Application to Head and Neck Squamous Cell Carcinoma Segmentation

  • Faicel Chamroukhi,
  • Segolene Brivet,
  • Peter Savadjiev,
  • Mark Coates and
  • Reza Forghani

6 December 2022

Dual-energy computed tomography (DECT) is an advanced CT computed tomography scanning technique enabling material characterization not possible with conventional CT scans. It allows the reconstruction of energy decay curves at each 3D image voxel, re...

  • Article
  • Open Access
11 Citations
4,323 Views
18 Pages

The Thermal Behavior of a Dual-Function Solar Collector Integrated with Building: An Experimental and Numerical Study on the Air Heating Mode

  • Jinwei Ma,
  • Qiang Zhao,
  • Yuehong Su,
  • Jie Ji,
  • Wei He,
  • Zhongting Hu,
  • Tingyong Fang and
  • Haitao Wang

11 September 2018

This paper presented a novel solar collector that can work in air or water heating mode depending on the seasonal requirement. The dual-function solar collector (DFSC) integrated with a building as well as a reference building without the DFSC were b...

  • Article
  • Open Access
6 Citations
2,365 Views
14 Pages

Levosimendan Ameliorates Cardiopulmonary Function but Not Inflammatory Response in a Dual Model of Experimental ARDS

  • René Rissel,
  • Moritz Gosling,
  • Jens Kamuf,
  • Miriam Renz,
  • Robert Ruemmler,
  • Alexander Ziebart and
  • Erik K. Hartmann

The calcium sensitiser levosimendan, which is used as an inodilator to treat decompensated heart failure, may also exhibit anti-inflammatory properties. We examined whether treatment with levosimendan improves cardiopulmonary function and is substant...

  • Feature Paper
  • Article
  • Open Access
16 Citations
8,021 Views
11 Pages

28 March 2019

Adults with an Autism Spectrum Disorder (ASD) are characterized by impairments in social interaction and communication, repetitive and stereotyped interests and behaviours as well as hyper- and/or hyposensitivities. These disorder specific symptoms c...

  • Feature Paper
  • Article
  • Open Access

Model Validation for Multivariate Functional Responses via Autoencoder-Based Dual-Layer Feature Extraction

  • Dengyu Wu,
  • Xiaodong Zhang,
  • Daobo Sun,
  • Haidong Lin,
  • Jinhui Li and
  • Baoqiang Zhang

13 February 2026

Model validation for complex simulation models with multivariate functional responses poses significant challenges, as it involves the dual coupling of physical correlations among variables and field correlations in time-series data. A novel Autoenco...

  • Article
  • Open Access
1 Citations
1,346 Views
25 Pages

A Dual Filter Based on Radial Basis Function Neural Networks and Kalman Filters with Application to Numerical Wave Prediction Models

  • Athanasios Donas,
  • Ioannis Kordatos,
  • Alex Alexandridis,
  • George Galanis and
  • Ioannis Th. Famelis

15 December 2024

The aim of this study is to introduce and evaluate a dual filter that combines Radial Basis Function neural networks and Kalman filters to enhance the accuracy of numerical wave prediction models. Unlike the existing methods, which focus solely on sy...

  • Article
  • Open Access
1 Citations
2,628 Views
14 Pages

Several of the integrin family of cell adhesion receptors have been popular targets for the development of anticancer agents, but with little clinical success to date. Cancer cells usually express multiple redundant integrins; one hypothesis for the...

  • Article
  • Open Access
25 Citations
4,502 Views
19 Pages

The application of intra-articular injections in osteoarthritis management has gained great attention lately. In this work, novel intra-articular injectable hyaluronic acid gel-core vesicles (hyaluosomes) loaded with diacerein (DCN), a structural mod...

  • Article
  • Open Access
4 Citations
3,041 Views
15 Pages

Calculation of the Dangerous Failure Rate of the Safety Function

  • Karol Rástočný,
  • Juraj Ždánsky,
  • Jozef Hrbček and
  • Milan Medvedík

24 February 2022

Each safety-related function must be implemented with a defined safety integrity level (SIL) if the control system implements safety-related functions (SFs) in addition to the standard control functions. The required SIL of the SF depends on the quan...

  • Article
  • Open Access
16 Citations
7,244 Views
17 Pages

Risk Decision Making and Executive Function among Adolescents and Young Adults

  • Francisco Marquez-Ramos,
  • David Alarcon,
  • Josue G. Amian,
  • Cristina Fernandez-Portero,
  • Maria J. Arenilla-Villalba and
  • Jose Sanchez-Medina

8 February 2023

The dual theory establishes that the decision-making process relies on two different systems, the affective system and the executive function (EF), developed during adolescence. This study analyzes the relationship between the decision-making and EF...

  • Article
  • Open Access
3 Citations
1,712 Views
15 Pages

Design and Numerical Modeling of Terahertz Metasurface with Dual Functions of Sensing and Filtering

  • Lu Zhang,
  • Huayan Sun,
  • Zhe Chen,
  • Runfeng Tang,
  • Jinxiao Yang and
  • Weilin Li

25 July 2024

This study proposes a dual-functional terahertz device based on the Dirac semimetal, serving as both a sensing element and a band-pass filter. The device’s operating mode can switch between these two functions by utilizing the phase transition...

  • Article
  • Open Access
9 Citations
11,170 Views
26 Pages

3 November 2010

Ionocovalency (IC), a quantitative dual nature of the atom, is defined and correlated with quantum-mechanical potential to describe quantitatively the dual properties of the bond. Orbiotal hybrid IC model scale, IC, and IC electronegativity scale, XI...

  • Article
  • Open Access
1 Citations
2,192 Views
17 Pages

Decomposition–Coordination of Double-Layer MPC for Constrained Systems

  • Hongrui Wang,
  • Pengbin Zhang,
  • Zhijia Yang and
  • Tao Zou

22 December 2022

Large-scale industrial processes usually adopt centralized control and optimization methods. However, with the growth of the scale of industrial processes leading to increasing computational complexity, the online optimization capability of the doubl...

  • Article
  • Open Access
23 Citations
5,389 Views
22 Pages

7 July 2021

To meet the high-accuracy position/force control requirements of dual-arm robots for handling a target object, a control algorithm for dual-arm robots based on the modified sliding mode impedance controller MSMIC(tanh) is proposed. First, the combina...

  • Article
  • Open Access
6 Citations
3,185 Views
31 Pages

23 September 2024

Currently, key factors hindering application of steer-by-wire systems are their inadequate safety and reliability, which are significant criteria for evaluating automotive active safety. Based on the steer-by-wire platform, a dual-redundant steering...

  • Article
  • Open Access
477 Views
28 Pages

1 November 2025

This paper investigates the dual-functional broadband properties of an asymmetric piezoelectric metamaterial beam for simultaneous vibration reduction and energy harvesting. Firstly, a grading method is proposed, and an asymmetric piezoelectric metam...

  • Feature Paper
  • Article
  • Open Access
13 Citations
5,114 Views
16 Pages

In Vivo Assessment of Hypoxia Levels in Pancreatic Tumors Using a Dual-Modality Ultrasound/Photoacoustic Imaging System

  • Yuhling Wang,
  • De-Fu Jhang,
  • Chia-Hua Tsai,
  • Nai-Jung Chiang,
  • Chia-Hui Tsao,
  • Chiung-Cheng Chuang,
  • Li-Tzong Chen,
  • Wun-Shaing Wayne Chang and
  • Lun-De Liao

Noninvasive anatomical and functional imaging has become an essential tool to evaluate tissue oxygen saturation dynamics in preclinical or clinical studies of hypoxia. Our dual-wavelength technique for photoacoustic (PA) imaging based on the differen...

  • Review
  • Open Access
318 Views
37 Pages

The Cortico-Cortical and Subcortical Circuits of the Human Brain Language Centers Including the Dual Limbic and Language Functioning Fiber Tracts

  • Arash Kamali,
  • Nithya P. Narayana,
  • Anastasia Loiko,
  • Anusha Gandhi,
  • Paul E. Schulz,
  • Nitin Tandon,
  • Manish N. Shah,
  • Vinodh A. Kumar,
  • Larry A. Kramer and
  • Khader M. Hasan
  • + 3 authors

28 January 2026

Background/Objectives: In recent years, MRI-based diffusion-weighted tractography techniques have uncovered additional white matter pathways that have significant roles in language processing and production. In this review, we aim to outline the majo...

  • Article
  • Open Access
2 Citations
1,898 Views
20 Pages

24 June 2023

To achieve river channel detection in SAR (synthetic aperture radar) images, we developed a level-set-based model (LSBM) guided by a designed data-fitting energy which is called the SoDEF (sum of dual exponential functions)-fitting energy. Firstly, w...

  • Article
  • Open Access
9 Citations
3,622 Views
24 Pages

9 October 2017

We examine three point functions with two scalar operators and a higher spin current in 2d W N minimal model to the next non-trivial order in 1 / N expansion. The minimal model was proposed to be dual to a 3d higher spin gauge theory,...

  • Article
  • Open Access
3 Citations
2,253 Views
18 Pages

Mixed Type Nondifferentiable Higher-Order Symmetric Duality over Cones

  • Izhar Ahmad,
  • Khushboo Verma and
  • Suliman Al-Homidan

11 February 2020

A new mixed type nondifferentiable higher-order symmetric dual programs over cones is formulated. As of now, in the literature, either Wolfe-type or Mond–Weir-type nondifferentiable symmetric duals have been studied. However, we present a unifi...

  • Article
  • Open Access
2 Citations
2,838 Views
10 Pages

24 December 2021

This paper is devoted to the dual superconductor model of confinement in the 4D Yang–Mills theory. In the first part, we consider the latter theory compactified on a torus, and use the dual superconductor model in order to obtain the Polchinski...

  • Article
  • Open Access
446 Views
19 Pages

5 May 2025

This paper introduces a new class of multiple-objective control models driven by path-independent curvilinear integrals involving the partial derivatives of the control variable. We investigate its solution set by considering a dual problem. Various...

  • Article
  • Open Access
326 Views
13 Pages

Dual Targeting of IDH2 and the Ubiquitin-Proteasome System Reveals a Functional Vulnerability in Breast Cancer Models

  • Nariman Gharari,
  • Elisabetta Mereu,
  • Beatrice Luciano,
  • Bahareh Heidari,
  • Sylvie Mader and
  • Roberto Piva

24 January 2026

Background/Objectives: Breast cancer cells rely on both mitochondrial metabolism and proteostatic mechanisms for cell fitness. The mitochondrial enzyme IDH2 supports redox balance and biosynthesis, while the ubiquitin-proteasome system (UPS) preserve...

  • Article
  • Open Access
37 Citations
8,771 Views
15 Pages

Dual-Labeled Near-Infrared/99mTc Imaging Probes Using PAMAM-Coated Silica Nanoparticles for the Imaging of HER2-Expressing Cancer Cells

  • Haruka Yamaguchi,
  • Makoto Tsuchimochi,
  • Kazuhide Hayama,
  • Tomoyuki Kawase and
  • Norio Tsubokawa

We sought to develop dual-modality imaging probes using functionalized silica nanoparticles to target human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer cells and achieve efficient target imaging of HER2-expressing tumors. P...

  • Article
  • Open Access
647 Views
21 Pages

Accurate prediction of urban grid-scale population inflow is crucial for smart city management and emergency response. However, existing methods struggle to model spatial heterogeneity and quantify prediction uncertainty, limiting their accuracy and...

  • Article
  • Open Access
4 Citations
2,593 Views
25 Pages

Quantum Particle on Dual Weight Lattice in Weyl Alcove

  • Adam Brus,
  • Jiří Hrivnák and
  • Lenka Motlochová

24 July 2021

Families of discrete quantum models that describe a free non-relativistic quantum particle propagating on rescaled and shifted dual weight lattices inside closures of Weyl alcoves are developed. The boundary conditions of the presented discrete quant...

  • Article
  • Open Access
1 Citations
2,116 Views
22 Pages

Conic Duality for Multi-Objective Robust Optimization Problem

  • Khoirunnisa Rohadatul Aisy Muslihin,
  • Endang Rusyaman and
  • Diah Chaerani

24 October 2022

Duality theory is important in finding solutions to optimization problems. For example, in linear programming problems, the primal and dual problem pairs are closely related, i.e., if the optimal solution of one problem is known, then the optimal sol...

  • Article
  • Open Access
1 Citations
1,612 Views
18 Pages

Modeling Dual-Task Performance: Identifying Key Predictors Using Artificial Neural Networks

  • Arash Mohammadzadeh Gonabadi,
  • Farahnaz Fallahtafti,
  • Judith Heselton,
  • Sara A. Myers,
  • Ka-Chun Siu and
  • Julie Blaskewicz Boron

Dual-task paradigms that combine cognitive and motor tasks offer a valuable lens for detecting subtle impairments in cognitive and physical functioning, especially in older adults. This study used artificial neural network (ANN) modeling to predict c...

  • Article
  • Open Access
6 Citations
4,318 Views
19 Pages

27 December 2019

In this paper, the effects of strategic consumer behaviors have been investigated and analyzed with regard to online retailers and offline retailers in a dual-channel supply chain. Four channel structures (i.e., no-promotion, a direct online channel,...

  • Article
  • Open Access
21 Citations
9,552 Views
15 Pages

22 May 2023

The dual-continua model of mental health suggests that psychological distress and mental wellbeing operate on two distinct yet related continua, both uniquely contributing to overall mental health. Previous literature provides support for the dual-co...

  • Article
  • Open Access
28 Citations
3,618 Views
13 Pages

Dual Extended Hesitant Fuzzy Sets

  • José Carlos R. Alcantud,
  • Gustavo Santos-García,
  • Xindong Peng and
  • Jianming Zhan

26 May 2019

Hesitant fuzzy sets extend fuzzy sets by considering many-valued sets of membership degrees. Real applications validate this model and decision making approaches of various forms permit to act in a flexible manner. If we can avail ourselves of hesita...

  • Article
  • Open Access
1,971 Views
15 Pages

21 January 2024

The feature extraction problem of coupled vibration signals with multiple fault modes of planetary gears has not been solved effectively. At present, kernel principal component analysis (KPCA) is usually used to solve nonlinear feature extraction pro...

  • Article
  • Open Access
3 Citations
1,727 Views
30 Pages

24 December 2022

This article develops dual variational formulations for a large class of models in variational optimization. The results are established through basic tools of functional analysis, convex analysis and duality theory. The main duality principle is dev...

  • Review
  • Open Access
4 Citations
4,829 Views
27 Pages

Dual-Specificity Phosphatases in Regulation of Tumor-Associated Macrophage Activity

  • Marina R. Patysheva,
  • Elizaveta A. Prostakishina,
  • Arina A. Budnitskaya,
  • Olga D. Bragina and
  • Julia G. Kzhyshkowska

16 December 2023

The regulation of protein kinases by dephosphorylation is a key mechanism that defines the activity of immune cells. A balanced process of the phosphorylation/dephosphorylation of key protein kinases by dual-specificity phosphatases is required for t...

  • Communication
  • Open Access
8 Citations
2,694 Views
9 Pages

Iodotyrosine deiodinase (IYD) is a type of deiodinase enzyme that scavenges iodide from the thyroid gland. Previously, we showed that H3 Ab acts as an agonist on IYD to induce migration of cells to the heart and differentiate human stem cells into br...

  • Article
  • Open Access
10 Citations
7,108 Views
16 Pages

12 December 2024

Telecom fraud has emerged as one of the most pressing challenges in the criminal field. With advancements in artificial intelligence, telecom fraud texts have become increasingly covert and deceptive. Existing prevention methods, such as mobile numbe...

  • Article
  • Open Access
2 Citations
2,958 Views
18 Pages

Integration of Functional Link Neural Networks into a Parameter Estimation Methodology

  • Tuan-Ho Le,
  • Mengyuan Tang,
  • Jun Hyuk Jang,
  • Hyeonae Jang and
  • Sangmun Shin

2 October 2021

In the field of robust design, most estimation methods for output responses of input factors are based on the response surface methodology (RSM), which makes several assumptions regarding the input data. However, these assumptions may not consistentl...

  • Article
  • Open Access
2 Citations
4,443 Views
19 Pages

A Dual-Payload Bispecific ADC Improved Potency and Efficacy over Single-Payload Bispecific ADCs

  • Nicole A. Wilski,
  • Peter Haytko,
  • Zhengxia Zha,
  • Simin Wu,
  • Ying Jin,
  • Peng Chen,
  • Chao Han and
  • Mark L. Chiu

Background/Objectives: All current FDA-approved antibody–drug conjugates (ADCs) are single-target and single-payload molecules that have limited efficacy in patients due to drug resistance. Therefore, our goal was to generate a novel ADC that w...

  • Article
  • Open Access
9 Citations
3,526 Views
18 Pages

Synthesis of the Energy-Saving Dry Dual Clutch Control Mechanism

  • Nikolay Sergienko,
  • Pavel Kalinin,
  • Ivan Pavlenko,
  • Marek Ochowiak,
  • Vitalii Ivanov,
  • Anton Sergienko,
  • Natalia Pavlova,
  • Yevheniia Basova,
  • Oksana Titarenko and
  • Sylwia Włodarczak
  • + 3 authors

6 January 2023

A promising direction in developing up-to-date transport vehicles is the use of transmissions, an essential element of which is a dual-clutch. Improving functional performance, energy efficiency, and environmental friendliness are relevant and requir...

  • Article
  • Open Access
5 Citations
3,224 Views
22 Pages

Engineered Dual Antioxidant Enzyme Complexes Targeting ICAM-1 on Brain Endothelium Reduce Brain Injury-Associated Neuroinflammation

  • Brian M. Leonard,
  • Vladimir V. Shuvaev,
  • Trent A. Bullock,
  • Kalpani N. Udeni Galpayage Dona,
  • Vladimir R. Muzykantov,
  • Allison M. Andrews and
  • Servio H. Ramirez

The neuroinflammatory cascade triggered by traumatic brain injury (TBI) represents a clinically important point for therapeutic intervention. Neuroinflammation generates oxidative stress in the form of high-energy reactive oxygen and nitrogen species...

  • Article
  • Open Access
6 Citations
3,113 Views
19 Pages

15 December 2021

Global Navigation Satellite System (GNSS) Precise Point Positioning (PPP) enables the estimation the ionospheric vertical total electron content (VTEC) as well as the by-product of the satellite Pseudorange observable-specific signal bias (OSB). The...

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