Oxidative Stress and Inflammation

Dear Colleagues,

Oxidative stress is viewed as an imbalance between the production of reactive oxygen species (ROS) and their elimination by protective mechanisms, which can lead to chronic inflammation. The incorrect lifestyle and the intake of external unhealthy chemicals are the major causes of age-related chronic diseases and cancer. Their study includes diseases pathology pathway, lifestyle, treatment, protection, and prevention of oxidative stress and inflammation. ROS are normally produced within the body in limited amount and are essential compounds involved in the regulation of processes capable of maintaining cell homeostasis and functions (signal transduction, gene expression, and activation of receptors). This imbalance may cause oxidative stress, which can lead to lipid peroxidation, gene mutation, inflammation and other complications. The harmful oxidative activity of ROS can be counteracted only by antioxidant/anti-inflammatory compounds, which may be both synthetic and natural, but are often characterized by several stability issues, such as poor water solubility and low bioavailability, that compromise their in vivo activities. The research papers of this Topic are looked forward to providing an overview of the status of research on both natural and synthetic products with antioxidant properties and capable of counteracting inflammatory diseases, including, but not necessarily restricted to, chemical compounds synthetic or of natural origin, vitamins, peptides, micronutrients, non-starch polysaccharides, probiotics, postbiotics, prebiotics formulations containing functional foods or nutraceutical or cosmeceutical products and their innovative oral, systemic or topical delivery capable to overcome their stability issues.

Dr. Maria Letizia Manca
Dr. Amparo Nacher
Dr. Mohamad Allaw
Dr. Matteo Perra
Dr. Ines Castangia
Topic Editors