The basic concept of this study is to investigate, by correlation analysis, the relationship between geomagnetic activity and Total Electron Content (TEC) for the period from 1994 to 2023. The global TEC data used have been recalculated to a coordina...
The capacity of the brain to adapt to experience has long been associated with synaptic plasticity; however, recent evidence demonstrates that experience-driven neural activity also modulates white matter organization through dynamic regulation of ol...
We focus on a queueing model in which the sizes of arriving jobs are stochastically dependent and each job may be denied service with a probability determined by the queue size (active management). Both of these effects are known to occur in computer...
One of the challenges of the mature nervous system is to maintain the stability of neural networks while providing a degree of plasticity to generate experience-dependent modifications. This plasticity–stability dynamism is regulated by perineu...
This paper investigates single-machine scheduling with a deteriorating maintenance activity, where the processing time of a job depends on whether it is handled before or after the maintenance activity. Under common and slack due date assignments, th...
Activity-dependent regulation of gene expression is critical in experience-mediated changes in the brain. Although less appreciated than transcriptional control, translational control is a crucial regulatory step of activity-mediated gene expression...
Loss of androgen receptor (AR) dependency in prostate cancer (PCa) cells is associated with progression to castration-resistant prostate cancer (CRPC). The tumor stroma is enriched in fibroblasts that secrete AR-activating factors. To investigate the...
The significant role of mast cells in the development of allergic and inflammatory diseases is well-established. Among the various mechanisms of mast cell activation, the interaction of antigens/allergens with IgE and the subsequent binding of this c...
Background/Objectives: Pulmonaria officinalis L., commonly known as lungwort, is a medicinal plant traditionally used for respiratory ailments, but its biological activities have not yet been sufficiently researched. The aim of this study was to...
We discuss an extension of the Single-Active-Electron (SAE) approximation in atoms by allowing the model potential to depend on the angular-momentum quantum number ℓ. We refer to this extension as the ℓ-SAE approximation. The main ideas b...
Human cytomegalovirus causes diseases in individuals with insufficient immunity. Cytomegaloviruses exploit the ubiquitin proteasome pathway to manipulate the proteome of infected cells. The proteasome degrades ubiquitinated proteins. The family of cu...
Protein kinases are key regulators of cell function, the abnormal activity of which may induce several human diseases, including cancers. Therefore, it is of great significance to develop a sensitive and reliable method for assaying protein kinase ac...
The spread of Human Immunodeficiency Virus (HIV) still represents a global public health issue of major concern, and would benefit from unveiling unique viral features as targets for drug design. In this respect, HIV-1 integrase (IN), due to the abse...
23 September 2026
Angiostrongylus cantonensis is the leading cause of eosinophilic meningitis worldwide, but therapeutic options remain limited. This study investigated the anthelmintic activity and preliminary selectivity of licarin A, a neolignan isolated from Necta...
Decades of research have illuminated the significant roles of gold/gold oxide clusters in small molecule catalytic oxidation. However, many fundamental questions, such as the actual sites to adsorb and activate O2 and the impact of charge, remain una...
Impaired glucose tolerance is a common feature associated with human aging, which is caused by defects in insulin secretion, insulin action or both. Recent studies have suggested that B-cell-activating factor (BAFF), a cytokine that modulates prolife...
This study evaluated the functional capacity measured by the Glittre-ADL test (TGlittre) in patients with nondialysis-dependent chronic kidney disease (NDD-CKD) and analyzed the test’s associations with muscle strength, physical activity level...
Deep representation learning has gained significant momentum in advancing text-dependent speaker verification (TD-SV) systems. When designing deep neural networks (DNN) for extracting bottleneck (BN) features, the key considerations include training...
5 August 2020
Investigating initial behavioral changes caused by irradiation of animals might provide important information to aid understanding of early health effects of radiation exposure and clinical features of radiation injury. Although previous studies in r...
A GalNAc/Gal-specific lectins named CGL and MTL were isolated and characterized from the edible mussels Crenomytilus grayanus and Mytilus trossulus. Amino acid sequence analysis of these lectins showed that they, together with another lectin MytiLec-...
Proteinase-activated receptor 2 is a G protein-coupled receptor that regulates vascular tone and inflammatory signalling in the circulatory system. The roles of PAR2 appear complex and sometimes opposing. Studies using PAR2-deficient mice provide a f...
Background. To date, a number of human pathogenic viruses are still unaddressed by the current repertoire of approved antiviral drugs. In order to widen this spectrum of preventive measures against virus infections, we have focused on additional host...
This study aimed to evaluate whether the type and degree of physical activity commitment (i.e., team sport athletes, highly active individuals, sedentary behavior) influence body image and exercise behavior. A total of 96 participants (46 women and 5...
30 November 2022
The purpose of this study was to identify the association between physical activity (PA), sedentary behavior (SB), satisfaction with sleep fatigue recovery (SSFR), and smartphone dependency in South Korean adults. We analyzed data from the National H...
In 2002, a new class of thymidylate synthase (TS) involved in the de novo synthesis of dTMP named Flavin-Dependent Thymidylate Synthase (FDTS) encoded by the thyX gene was discovered; FDTS is present only in 30% of prokaryote pathogens and not in hum...
A synthesis strategy for the manufacture of inexpensive highly efficient nanostructured catalysts has been developed. The developed unique nonplatinoid copper-based catalysts with different surface morphology were investigated as a functional layer w...
By catalyzing the hydrolysis of sphingomyelin into ceramide, acid sphingomyelinase (ASM) changes the local composition of the plasma membrane with effects on receptor-mediated signaling. Altered enzyme activities have been noted in common human disea...
CYP3A4 is the main xenobiotic metabolizing enzyme in the human body, as it is in volved in metabolism of ~30% of drugs on the market as well as of many other compounds, from small molecules such as ethanol to large drugs such as erythromycin and cycl...
Tumor cell metabolism differs from that of normal cells, conferring tumors with metabolic advantages but affording opportunities for therapeutic intervention. Accordingly, metabolism-targeting therapies have shown promise. However, drugs targeting si...
NETosis is a neutrophil process involving sequential steps from pathogen detection to the release of DNA harboring antimicrobial proteins, including the central generation of NADPH oxidase dependent or independent ROS. Previously, we reported that NE...
Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid), a hydrophilic analog of vitamin E, is known for its strong antioxidant activity, being a high radical scavenger of peroxyl and alkoxyl radicals. Under particular conditions, Trolox may...
Strontium titanates were prepared with different morphologies by varying the ratio of solvents used during the synthesis. The effects of morphology and solvent (ethylene glycol to water) ratio were investigated both on the structure and photocatalyti...
The ionosphere provides a channel that is able to propagate electromagnetic waves for long-haul communications, allowing Non-Line-Of-Sight (NLOS) radio communications in the high-frequency band (HF). Nonetheless, its performance as a communications c...
China’s religious social services complement the statutory welfare. Clarifying the situations and characteristics of different types of religious social services is conducive to promoting their better integration into public welfare. With the h...
Seeds sense temperature, nutrient levels and light conditions to inform decision making on the timing of germination. Limited light availability for photoblastic species results in irregular germination timing and losses of population germination per...
Hydroxyl radical (•OH) scavenging and the regeneration of Fe2+ may inhibit or enhance peroxidative damage induced by a Fenton system, respectively. Plant polyphenols reveal the afore-mentioned activities, and their cumulative net effect may dete...
Active hydraulic mounts with an inertia track, decoupler membrane, and oscillating coil actuator (AHM-IT-DM-OCAs) have been studied extensively due their compact structure and large damping in the low-frequency band. This paper focuses on a comprehen...
Amoebiasis is the second leading cause of death worldwide associated with parasitic disease and is becoming a critical health problem in low-income countries, urging new treatment alternatives. One of the most promising strategies is enhancing the re...
Background: People living with dementia (PLWD) may experience substantial cognitive decline as the disease progresses, which interferes with their daily activities. This study aimed to assess physical activity (PA) performance and care dependency (CD...
Hydrogen uptake/diffusivity in nitrile butadiene rubber (NBR) blended with carbon black (CB) and silica fillers was measured with a volumetric analysis method in the 258–323 K temperature range. The temperature-dependent H2 diffusivity was obta...
Identifying alterations caused by aging could be an important tool for improving the diagnosis of cardiovascular diseases. Changes in vascular tone regulation involve various mechanisms, like NO synthase activity, activity of the sympathetic nervous...
The strain-rate sensitivity of the yield stress for Acrylonitrile-Butadiene-Styrene (ABS) tensile samples processed via material extrusion additive manufacturing (ME-AM) was investigated. Such specimens show molecular orientation and interstitial voi...
This study focuses on the open question of the electron temperature (Te) variation with solar activity in the topside ionosphere at mid- and high latitudes. It takes advantage of in situ observations taken over a decade (2014–2023) from Langmui...
Distal-less 3 (Dlx3) is a homeobox-containing transcription factor and plays a crucial role in the development and differentiation process. Human Dlx3 consists of two transactivation domains and a homeobox domain (HD) that selectively binds to the co...
The cholinergic system has been proposed to participate in the development of dependence on opioids. The present study examined effects of dermal pretreatment with methyl parathion (MP), an acetylcholinesterase inhibitor, on the development of physic...
Activity-on-arc (AoA) and activity-on-node (AoN) project network representations have been used in construction scheduling for many decades. But due to the primary information that they emphasize—the activities themselves in the AoA graphs, and...
QO-58 (5-(2,6-dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)-1H-pyrazolol[1,5-a]pyrimidin-7-one) has been regarded to be an activator of KV7 channels with analgesic properties. However, whether and how the presence of this compound can r...
New 7-thio derivatives of 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione have been synthesized by the reaction of 3-cyclohexyl-7-thio-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione with alkylhalogenides. The synthesized compounds we...
A cancer-specific anti-PDPN mAb, LpMab-23 (mouse IgG1, kappa), was established in our previous study. We herein produced a humanized IgG1 version (humLpMab-23) and defucosylated form (humLpMab-23-f) of an anti-PDPN mAb to increase ADCC activity. humL...
Coupling glycolysis and mitochondrial tricarboxylic acid cycle, pyruvate dehydrogenase (PDH) complex (PDHC) is highly responsive to cellular demands through multiple mechanisms, including PDH phosphorylation. PDHC also produces acetyl-CoA for protein...
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