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Open AccessArticle

Quantitative Analysis of Effects of a Single 60Co Gamma Ray Point Exposure on Time-Dependent Change in Locomotor Activity in Rats

1
The Center for Peace, Hiroshima University, Hiroshima 730-0053, Japan
2
Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan
3
Maxillo-facial and facial plastic surgery, Semey Medical University, Semey 071400, Kazakhstan
4
Public health, Medical University, Semey 071400, Kazakhstan
5
Board of Directors, Astana Medical University, Astana 010000, Kazakhstan
6
Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki 300-0394, Japan
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(16), 5638; https://doi.org/10.3390/ijerph17165638
Received: 6 June 2020 / Revised: 25 July 2020 / Accepted: 31 July 2020 / Published: 5 August 2020
Investigating initial behavioral changes caused by irradiation of animals might provide important information to aid understanding of early health effects of radiation exposure and clinical features of radiation injury. Although previous studies in rodents suggested that radiation exposure leads to reduced activity, detailed properties of the effects were unrevealed due to a lack of proper statistical analysis, which is needed to better elucidate details of changes in locomotor activity. Ten-week-old male Wistar rats were subjected to single point external whole-body irradiation with 60Co gamma rays at 0, 2.0, 3.5, and 5.0 Gy (four rats per group). Infrared sensors were used to continuously record the locomotor activity of each rat. The cumulative number of movements during the night was defined as “activity” for each day. A non-linear mixed effects model accounting for individual differences and daily fluctuation of activity was applied to analyze the rats’ longitudinal locomotor data. Our statistical method revealed characteristics of the changes in locomotor activity after radiation exposure, showing that (1) reduction in activity occurred immediately—and in a dose-dependent manner—after irradiation and (2) recovery to pre-irradiation levels required almost one week, with the same recovery rate in each dose group. View Full-Text
Keywords: external irradiation; locomotor activity; individual differences; non-linear mixed effects model; time-dependency external irradiation; locomotor activity; individual differences; non-linear mixed effects model; time-dependency
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Otani, K.; Ohtaki, M.; Fujimoto, N.; Saimova, A.; Chaizhunusova, N.; Rakhypbekov, T.; Sato, H.; Kawano, N.; Hoshi, M. Quantitative Analysis of Effects of a Single 60Co Gamma Ray Point Exposure on Time-Dependent Change in Locomotor Activity in Rats. Int. J. Environ. Res. Public Health 2020, 17, 5638.

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