Bioactive Heterocyclic Compounds in Drug Design

Dear Colleagues,

Heterocycles are heavily involved in life processes. DNA, RNA, proteins, and coenzymes are common examples of fundamental biological macromolecules structured by heterocyclic nuclei.

The biomolecular standpoint of drug action confirms the broad biocompatibility and the versatile aptitude of heterocyclic compounds to mimic endogenous molecules and consequently to interact with biological entities. Moreover, heterocyclic chemistry provides useful tools to modulate polarity, solubility, and hydrogen bonding interactions of molecules, in order to develop improved physiochemical, pharmacological, and pharmacokinetic properties of new druggable candidates.

These features make heterocyclic chemistry one of the major pivots for the development of new drugs, justifying the intense interest of the scientific community in this field.

This Special Issue “Bioactive Heterocyclic Compounds in Drug Design” welcomes the submission of original research articles and reviews featuring recent developments in heterocyclic derivatives able to modulate biological pathways, designed by computational methodologies.

Prof. Antonino Lauria
Prof. Annamaria Martorana
Guest Editors

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