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Volume 83
Issue 1
10.3797/scipharm.1406-09
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Article

Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione

by
Yuriy M. KONONEVICH
1,*,
Ludmila S. BOBKOVA
2,
Alexander S. SMOLSKI
3 and
Anatoly M. DEMCHENKO
2
1
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova str. 28, 119991, Moscow, Russian Federation
2
Institute of Pharmacology and Toxicology, National Academy of Medical Science of Ukraine, Ezhena Pot’je str. 14, 03680, Kyiv, Ukraine
3
T. G. Shevchenko Chernihiv National Pedagogical University, Het’mana Polubotka str. 53, 14013, Chernihiv, Ukraine
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2015, 83(1), 41-48; https://doi.org/10.3797/scipharm.1406-09
Submission received: 20 June 2014 / Accepted: 29 October 2014 / Published: 29 October 2014
Versions Notes

Abstract

New 7-thio derivatives of 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione have been synthesized by the reaction of 3-cyclohexyl-7-thio-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione with alkylhalogenides. The synthesized compounds were tested for antioxidant activity on the model of Fe2+-dependent oxidation of adrenaline in vitro. It was found that the antiradical activity of 7-thio derivatives of 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione significantly depends on the structure of the substituent which is part of the thioether fragment of the base molecule.
Keywords: 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione; Alkylation; Antioxidant activity; Fe2+-dependent oxidation of adrenaline 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione; Alkylation; Antioxidant activity; Fe2+-dependent oxidation of adrenaline

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MDPI and ACS Style

KONONEVICH, Y.M.; BOBKOVA, L.S.; SMOLSKI, A.S.; DEMCHENKO, A.M. Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione. Sci. Pharm. 2015, 83, 41-48. https://doi.org/10.3797/scipharm.1406-09

AMA Style

KONONEVICH YM, BOBKOVA LS, SMOLSKI AS, DEMCHENKO AM. Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione. Scientia Pharmaceutica. 2015; 83(1):41-48. https://doi.org/10.3797/scipharm.1406-09

Chicago/Turabian Style

KONONEVICH, Yuriy M., Ludmila S. BOBKOVA, Alexander S. SMOLSKI, and Anatoly M. DEMCHENKO. 2015. "Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione" Scientia Pharmaceutica 83, no. 1: 41-48. https://doi.org/10.3797/scipharm.1406-09

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