A kinetic model for the HIV-1 Rev protein is developed by drawing upon mechanistic information from the literature to formulate a set of differential equations modeling the behavior of Rev and its various associated factors over time. A set of result...
Reticuloendotheliosis virus (REV) is a retroviral pathogen capable of infecting several avian hosts and is associated with immunosuppression, anemia, proventriculitis, neoplasia, and runting–stunting syndrome. Its genome contains the three majo...
Moebius syndrome (MBS) is a rare disease consisting of uni-/bilateral palsy of CN VI and VII without impairment of vertical eye movements. Its uncommon nature means that the etiology is still uncertain. It is thought to be caused by vascular lesions...
Wind Farm Layout Optimization (WFLO) can be useful to minimize power losses associated with turbine wakes in wind farms. This work presents a new evolutionary WFLO methodology integrated with a recently developed and successfully validated Gaussian w...
In recent years, wind farm layout optimization (WFLO) has been extendedly developed to address the minimization of turbine wake effects in a wind farm. Considering that increasing the degrees of freedom in the decision space can lead to more efficien...
In this study, large-eddy simulations (LESs) were performed to investigate the effects of changing wind direction on the turbine wakes and associated power losses in the Horns Rev offshore wind farm. In the LES framework, the turbulent subgrid-scale...
Numerical simulation of the electrical conductivity of carbon fiber-reinforced asphalt concrete is essential for understanding its electrical behavior, yet research in this area remains limited. This study prepared six groups of Marshall specimens wi...
In the design of wind energy farms, the loss of power should be seriously considered for the second wind turbine located inside the wake region of the first one. The rotation of the first wind-front rotor generates a high-vorticity wake with turbulen...
18 September 2024
Cystic fibrosis (CF) is a monogenic syndrome caused by variants in the CF Transmembrane Conductance Regulator (CFTR) gene, affecting various organ and systems, in particular the lung, pancreas, sweat glands, liver, gastrointestinal tract, vas deferen...
Background/Objective: This study examines the composite influence of frailty, malnutrition, and anemia on postoperative outcomes for patients with adult spinal deformity (ASD). Methods: In this retrospective cohort study using the 2011–2022 NSQ...
Affected by discontinuities, the hydraulic properties of rock masses are characterized by significant scale dependency and anisotropy. Sampling a rock mass at any scale smaller than the representative elementary volume (REV) size may result in incorr...
DNA repair and cell cycle regulation are potential biological fields to develop molecular targeting therapies for cancer. Human REV7 was originally discovered as a homologous molecule to yeast Rev7, which is involved in DNA damage response and mutage...
Chimeric antigen receptor (CAR) therapies are emerging as promising strategies, particularly for metastatic castration-resistant prostate cancer (PCa), as they can act independently of the androgen receptor axis. Adapter CAR-T cell platforms, such as...
Obtaining the digital characterization and representative elementary volume (REV) of broken rock masses is an important foundation for simulating their mechanical properties and behavior. In this study, utilizing the broken surrounding rock of the ma...
Investigation of the change rate for contaminant parameters is important to characterize dense non-aqueous phase liquid (DNAPL) transport and distribution in groundwater systems. In this study, four experiments of perchloroethylene (PCE) migration ar...
Traumatic brain injury (TBI) is a significant cause of morbidity and mortality worldwide, and its pathophysiology is characterized by oxidative stress and inflammation. Despite extensive research, effective treatments for TBI remain elusive. Recent s...
Clinical translation of novel immunotherapeutic strategies such as chimeric antigen receptor (CAR) T-cells in acute myeloid leukemia (AML) is still at an early stage. Major challenges include immune escape and disease relapse demanding for further im...
Circadian rhythms significantly affect metabolism, and their disruption leads to cardiometabolic diseases and fibrosis. The clock repressor Rev-Erb is mainly expressed in the liver, heart, lung, adipose tissue, skeletal muscles, and brain, recognized...
Brucellosis is a bacterial zoonosis caused by the genus Brucella, which mainly affects domestic animals. In these natural hosts, brucellae display a tropism towards the reproductive organs, such as the placenta, replicating in high numbers and leadin...
The flow of water through a channel with a heterogeneous porous layer in its central core is simulated using the method of Smoothed-Particle Hydrodynamics (SPH). Three different porous substrates are considered that differ in the geometry of their gr...
Carbonate reservoirs commonly have significant heterogeneity and complex pore systems due to the multi-scale characteristic. Therefore, it is quite challenging to predict the petrophysical properties of such reservoirs based on restricted experimenta...
In this work, an equivalent continuum of a barrel gridshell is introduced. Constitutive identification procedures based on periodic homogenization are provided in the literature for this purpose, based on a flat Representative Element Volume (REV), n...
This study investigated the representative elementary volume (REV) for visible porosity in horticultural growing media (peat, commercial mixture, treated wood fibre/peat, pure wood fibre) using x-ray micro-computed tomography (µCT) with 2D and...
The Reticuloendotheliosis virus (REV) primarily causes avian severe immunosuppression, in addition to other symptoms, which include avian dwarfing syndrome and chronic tumors in lymphoid and other tissue. To date, REV’s molecular mechanisms leading t...
DNA polymerase ζ (pol ζ) plays a central role in replicating damaged genomic DNA. When DNA synthesis stalls at a lesion, it participates in translesion DNA synthesis (TLS), which helps replication proceed. TLS prevents cell death at the exp...
In this study, we present a novel comparison between pore-structure (PS) and representative elementary volume (REV) methods for modelling fluid flow through porous media using a second-order lattice Boltzmann method (LBM). We employ the LBM to demons...
Kirsten-RAS (KRAS) has been the target of drugs because it is the most mutated gene in human cancers. Because of the low affinity of drugs for KRAS mutations, it was difficult to target these tumor genes directly. We found a direct interaction betwee...
In this study, a method was introduced to validate the presence of a Representative Elementary Volume (REV) within marine clayey sediment containing cracks during cyclic loading and unloading of confinement pressure. Physical testing provided the bas...
The ability of lentiviruses to continually evolve and escape immune control is the central impediment in developing an effective vaccine for HIV-1 and other lentiviruses. Equine infectious anemia virus (EIAV) is considered a useful model for immune c...
To investigate the void mesostructure in porous asphalt mixtures (PA), computed tomography (CT) and Avizo were utilized to scan and reconstruct the three-dimensional (3D) void model of PA-16 specimens. The void mesostructure of the specimen was quant...
In the present study, a 3D finite element (FE) model for machining AISI-52100 steel was proposed, with respect to three levels of cutting speed (100 m/min, 150 m/min and 200 m/min), feed (0.08 mm/rev, 0.11 mm/rev and 0.14 mm/rev), depth of cut (0.20...
The circadian clock is closely linked to glucose regulation, but the dynamical consequences of specific metabolic feedback pathways on core clock regulation remain incompletely understood. In this study, we developed a theoretical metabolic-circadian...
The research into Corporate Social Responsibility (CSR) has been prolific in the last years, although few studies have focused their attention on studying its relationship with economic performance within the hotel industry, even less incorporating m...
Non-Newtonian fluids may cause nonlinear seepage even for a single-phase flow. Through digital rock technologies, the upscaling of this non-Darcy flow can be studied; however, the requirements for scanning resolution and sample size need to be clarif...
Friction stir lap welding of 1.5-mm thick 6082-T6 aluminum alloy to 2-mm thick galvanized DP800 steel (Zn-coated) was carried out. Optimal welding conditions were obtained aiming to defect-free joints with good mechanical properties. The interfacial...
Range-extended Electric Vehicles (REVs) have become popular due to their lack of emissions while driving in urban areas, and the elimination of range anxiety when traveling long distances with a combustion engine as the power source. The fuel consump...
This paper presents a method to estimate a representative element volume (REV) of a fractured rock mass based on the volumetric fracture intensity P32 and statistical tests. A 150 m 80 m 50 m 3D fracture network model was gene...
Hotel chains are reported as one of the most energy-intensive sectors and a growing number of international studies on this theme have been developed. This research aims to understand energy use and some of its key factors in hotel chains worldwide....
An important step towards understanding the working principles of the mammalian hearing sensor is the concept of an active cochlear amplifier. Theoretical arguments and physiological measurements suggest that the active cochlear amplifiers originate...
The most recent developments and applications in volume-averaged modeling of solidification processes have been reviewed. Since the last reviews of this topic by Beckermann and co-workers [Applied Mech. Rev. 1993, p. 1; Annual Rev. Heat Transfer 1995...
In the regenerative aluminum smelting process, the furnace temperature is critical for the quality and energy consumption of the product. However, the process requires protective sensors, making real-time furnace temperature measurement costly, while...
The alignment-dependent atomic model for treating electron transfer processes in ion-molecule collisions [Shingal and Lin, Phys. Rev. 1989, A40, 1302] is reviewed. This model has been applied to collisions between H+ and He2+ with H2, and recently al...
Lipoxygenases convert polyunsaturated fatty acids into biologically active metabolites such as inflammatory mediators—prostaglandins and leukotrienes. The inhibition of lipoxygenases is increasingly employed in the treatment of cancer. We evalu...
Brucellosis is a major economic and production-limiting disease for livestock owners and the community in Iraq. A cost–benefit analysis was conducted to evaluate the impact of an expanded annual mass vaccination programme of sheep and goats that invo...
Porous oil-containing polyimide cages are critical for ensuring long-life lubrication in momentum wheel bearings of spacecraft attitude control systems. However, the underlying microscopic seepage mechanisms governing lubricant release under operatio...
The pore structure and connectivity of coal directly control fluid storage and migration and provide an important basis for evaluating coal-seam permeability and gas-drainage performance. To quantitatively characterise the pore structure of anthracit...
This study investigates the turning performance of additive-manufactured polymer-based composite, with particular emphasis on the resulting dimensional error (DE) and surface roughness Ra. Cutting speed, feed rate, and depth of cut were selected as c...
Water availability is essential for the appropriate analysis of its sustainable management. We performed a comparative study of six hydrological balance models (Témez, ABCD, GR2M, AWBM, GUO-5p, and Thornthwaite-Mather) in several basins with d...
Neutrinoless double-beta decay is considered one of the most promising processes that would help clarify some of the symmetry-breaking problems in our understanding of the observable universe. Recent studies of neutrinoless double-beta decay matrix e...
This study performed a representative elementary volume (REV) and 3D equivalent continuum study of rock fractures based on fluid simulations of 3D discrete fracture networks (DFNs). A series of 3D DFNs with heterogeneous aperture distributions (the D...
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