Announcements

As all articles published in our journal are open access, you have free, unlimited access to the full text. We invite you to read our most highly cited papers published in 2025 and 2026, which are listed below:

1. “HOXA10 and HOXA11 in Human Endometrial Benign Disorders: Unraveling Molecular Pathways and Their Impact on Reproduction”
by Lorin-Manuel Pîrlog, Andrada-Adelaida Pătrășcanu, Mara-Diana Ona, Andreea Cătană and Ioana Cristina Rotar
Biomolecules 2025, 15(4), 563; https://doi.org/10.3390/biom15040563
Full text available online: https://www.mdpi.com/2218-273X/15/4/563

2. “Molecular Biomarkers for Timely and Personalized Prediction of Maternal-Fetal Health Risk”
by Daniel Estrela, Rita F. Santos, Alice Masserdotti, Antonietta Silini, Ornella Parolini, Inês Mendes Pinto and Andrea Cruz
Biomolecules 2025, 15(3), 312; https://doi.org/10.3390/biom15030312
Full text available online: https://www.mdpi.com/2218-273X/15/3/312

3. “Revolutionizing Implantation Studies: Uterine-Specific Models and Advanced Technologies”
by Shu-Yun Li and Francesco John DeMayo
Biomolecules 2025, 15(3), 450; https://doi.org/10.3390/biom15030450
Full text available online: https://www.mdpi.com/2218-273X/15/3/450

4. “Blastocyst-Derived Lactate as a Key Facilitator of Implantation”
by Kathryn H. Gurner and David K. Gardner
Biomolecules 2025, 15(1), 100; https://doi.org/10.3390/biom15010100
Full text available online: https://www.mdpi.com/2218-273X/15/1/100

5. “Conceptus Elongation, Implantation, and Early Placental Development in Species with Central Implantation: Pigs, Sheep, and Cows”
by Gregory A. Johnson, Thainá Minela, Heewon Seo, Fuller W. Bazer, Robert C. Burghardt, Guoyao Wu, Ky G. Pohler, Claire Stenhouse, Joe W. Cain, Zachary K. Seekford et al.
Biomolecules 2025, 15(7), 1037; https://doi.org/10.3390/biom15071037
Full text available online: https://www.mdpi.com/2218-273X/15/7/1037

6. “LIFR-Mediated ERBB2 Signaling Is Essential for Successful Embryo Implantation in Mice”
by Jumpei Terakawa, Sakura Nakamura, Mana Ohtomo, Saki Uehara, Yui Kawata, Shunsuke Takarabe, Hibiki Sugita, Takafumi Namiki, Atsuko Kageyama, Michiko Noguchi et al.
Biomolecules 2025, 15(5), 698; https://doi.org/10.3390/biom15050698
Full text available online: https://www.mdpi.com/2218-273X/15/5/698

7. “Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration”
by Julia Delenko, Nathaniel Hyman, Prodyot K. Chatterjee, Polona Safaric Tepes, Andrew J. Shih, Xiangying Xue, Jane Gurney, Andrew G. Baker, Cheng Wei, Daniel Munoz Espin et al.
Biomolecules 2025, 15(6), 873; https://doi.org/10.3390/biom15060873
Full text available online: https://www.mdpi.com/2218-273X/15/6/873

8. “Unraveling the Multi-Omic Landscape of Extracellular Vesicles in Human Seminal Plasma”
by Laura Governini, Alesandro Haxhiu, Enxhi Shaba, Lorenza Vantaggiato, Alessia Mori, Marco Bruttini, Francesca Loria, Natasa Zarovni, Paola Piomboni, Claudia Landi et al.
Biomolecules 2025, 15(6), 836; https://doi.org/10.3390/biom15060836
Full text available online: https://www.mdpi.com/2218-273X/15/6/836

9. “The Role of Preconception Parental Health on Embryo Quality—Preliminary Results of a Prospective Study Using Non-Invasive Preimplantation Genetic Testing for Aneuploidy”
by Maja Tomic, Eda Bokal-Vrtacnik and Martin Stimpfel
Biomolecules 2025, 15(9), 1215; https://doi.org/10.3390/biom15091215
Full text available online: https://www.mdpi.com/2218-273X/15/9/1215

As all articles published in our journal are open access, you have free, unlimited access to the full text. We invite you to read our most highly cited papers published in 2025 and 2026, which are listed below:

1. “A Comprehensive Oncological Biomarker Framework Guiding Precision Medicine”
by Reza Bayat Mokhtari, Manpreet Sambi, Faezeh Shekari, Kosar Satari, Roya Ghafoury, Neda Ashayeri, Paige Eversole, Narges Baluch, William W. Harless, Lucia Anna Muscarella et al.
Biomolecules 2025, 15(9), 1304; https://doi.org/10.3390/biom15091304
Full text available online: https://www.mdpi.com/2218-273X/15/9/1304

2. “Epigenetic Biomarkers in Thoracic Aortic Aneurysm, Dissection, and Bicuspid Aortopathy: A Comprehensive Review”
by Dimitrios E. Magouliotis, Serge Sicouri, Noah Sicouri, Massimo Baudo, Francesco Cabrucci, Yoshiyuki Yamashita and Basel Ramlawi
Biomolecules 2025, 15(4), 568; https://doi.org/10.3390/biom15040568
Full text available online: https://www.mdpi.com/2218-273X/15/4/568

3. “The Impact of the Microbiota on the Immune Response Modulation in Colorectal Cancer”
by Ana Iulia Neagu, Marinela Bostan, Vlad Alexandru Ionescu, Gina Gheorghe, Camelia Mia Hotnog, Viviana Roman, Mirela Mihaila, Simona Isabelle Stoica, Camelia Cristina Diaconu, Carmen Cristina Diaconu et al.
Biomolecules 2025, 15(7), 1005; https://doi.org/10.3390/biom15071005
Full text available online: https://www.mdpi.com/2218-273X/15/7/1005

4. “Gene Expression Analysis and Validation of a Novel Biomarker Signature for Early-Stage Lung Adenocarcinoma”
by Sanjan S. Sarang, Catherine M. Cahill and Jack T. Rogers
Biomolecules 2025, 15(6), 803; https://doi.org/10.3390/biom15060803
Full text available online: https://www.mdpi.com/2218-273X/15/6/803

5. “Impact of Aging and Pathologies on Human Oral Mucosa: Preliminary Investigation of Biophysical Markers from Thermal and Vibrational Analyses”
by Valérie Samouillan, Camille Ober and Marie-Hélène Lacoste-Ferré
Biomolecules 2025, 15(7), 978; https://doi.org/10.3390/biom15070978
Full text available online: https://www.mdpi.com/2218-273X/15/7/978

6. “Growth Differentiation Factor 15 Predicts Cardiovascular Events in Peripheral Artery Disease”
by Ben Li, Farah Shaikh, Houssam Younes, Batool Abuhalimeh, Abdelrahman Zamzam, Rawand Abdin and Mohammad Qadura
Biomolecules 2025, 15(7), 991; https://doi.org/10.3390/biom15070991
Full text available online: https://www.mdpi.com/2218-273X/15/7/991

7. “The Prognostic, Predictive and Clinicopathological Implications of KRT81/HNF1A- and GATA6-Based Transcriptional Subtyping in Pancreatic Cancer”
by Michael Guenther, Sai Agash Surendran, Lea Margareta Steinke, Iduna Liou, Melanie Alexandra Palm, Volker Heinemann, Michael Haas, Stefan Boeck and Steffen Ormanns
Biomolecules 2025, 15(3), 426; https://doi.org/10.3390/biom15030426
Full text available online: https://www.mdpi.com/2218-273X/15/3/426

8. “Copeptin as a Biomarker in Chronic Kidney Disease—A Systematic Review and Meta-Analysis”
by Gabi Gazi, Robert Cristian Cruciat, Daniel-Corneliu Leucuta, Nahlah Al Srouji, Stefan-Lucian Popa, Mohamed Ismaiel, Dinu Iuliu Dumitrascu and Abdulrahman Ismaiel
Biomolecules 2025, 15(6), 845; https://doi.org/10.3390/biom15060845
Full text available online: https://www.mdpi.com/2218-273X/15/6/845

9. “Tauopathies: Calmodulin Regulates Tau Hyperphosphorylation and Its Transformation into Disease-Specific Aggregates”
by Danton H. O’Day
Biomolecules 2025, 15(8), 1133; https://doi.org/10.3390/biom15081133
Full text available online: https://www.mdpi.com/2218-273X/15/8/1133

As all articles published in our journal are open access, you have free, unlimited access to the full text. We invite you to read our most highly cited papers published in 2025 and 2026, which are listed below:

1. “The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease”
by Paola Zanfardino, Alessandro Amati, Mirko Perrone and Vittoria Petruzzella
Biomolecules 2025, 15(3), 433; https://doi.org/10.3390/biom15030433
Full text available online: https://www.mdpi.com/2218-273X/15/3/433

2. “Pathological and Inflammatory Consequences of Aging”
by Mario García-Domínguez
Biomolecules 2025, 15(3), 404; https://doi.org/10.3390/biom15030404
Full text available online: https://www.mdpi.com/2218-273X/15/3/404

3. “Calcium Signaling Dynamics in Vascular Cells and Their Dysregulation in Vascular Disease”
by Chang Dai and Raouf A. Khalil
Biomolecules 2025, 15(6), 892; https://doi.org/10.3390/biom15060892
Full text available online: https://www.mdpi.com/2218-273X/15/6/892

4. “Interplay Between Vascular Dysfunction and Neurodegenerative Pathology: New Insights into Molecular Mechanisms and Management”
by Avanthika Mekala and Hongyu Qiu
Biomolecules 2025, 15(5), 712; https://doi.org/10.3390/biom15050712
Full text available online: https://www.mdpi.com/2218-273X/15/5/712

5. “The Role of IL-6 in Ischemic Stroke”
by Hanna Pawluk, Alina Woźniak, Agnieszka Tafelska-Kaczmarek, Agnieszka Kosinska, Mateusz Pawluk, Krzysztof Sergot, Renata Grochowalska and Renata Kołodziejska
Biomolecules 2025, 15(4), 470; https://doi.org/10.3390/biom15040470
Full text available online: https://www.mdpi.com/2218-273X/15/4/470

6. “Thyroid Hormones and Metabolism Regulation: Which Role on Brown Adipose Tissue and Browning Process?”
by Laura Sabatino and Cristina Vassalle
Biomolecules 2025, 15(3), 361; https://doi.org/10.3390/biom15030361
Full text available online: https://www.mdpi.com/2218-273X/15/3/361

7. “β-Catenin: A Key Molecule in Osteoblast Differentiation”
by Edyta Wróbel, Piotr Wojdasiewicz, Agnieszka Mikulska and Dariusz Szukiewicz
Biomolecules 2025, 15(7), 1043; https://doi.org/10.3390/biom15071043
Full text available online: https://www.mdpi.com/2218-273X/15/7/1043

8. “Circadian Biomarkers in Humans: Methodological Insights into the Detection of Melatonin and Cortisol”
by Cene Skubic, Urša Zevnik, Katarina Nahtigal, Leja Dolenc Grošelj and Damjana Rozman
Biomolecules 2025, 15(7), 1006; https://doi.org/10.3390/biom15071006
Full text available online: https://www.mdpi.com/2218-273X/15/7/1006

9. “Unravelling the Connection Between Energy Metabolism and Immune Senescence/Exhaustion in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome”
by Jente Van Campenhout, Yanthe Buntinx, Huan-Yu Xiong, Arne Wyns, Andrea Polli, Jo Nijs, Joeri L. Aerts, Thessa Laeremans and Jolien Hendrix
Biomolecules 2025, 15(3), 357; https://doi.org/10.3390/biom15030357
Full text available online: https://www.mdpi.com/2218-273X/15/3/357

10. “Exploring the Antioxidant Roles of Cysteine and Selenocysteine in Cellular Aging and Redox Regulation”
by Marta Pace, Chiara Giorgi, Giorgia Lombardozzi, Annamaria Cimini, Vanessa Castelli and Michele d’Angelo
Biomolecules 2025, 15(8), 1115; https://doi.org/10.3390/biom15081115
Full text available online: https://www.mdpi.com/2218-273X/15/8/1115

11. “Immunohistochemical Detection of PIEZO Ion Channels in the Human Carotid Sinus and Carotid Body”
by Elda Alba, Yolanda García-Mesa, Ramón Cobo, Patricia Cuendias, José Martín-Cruces, Iván Suazo, Graciela Martínez-Barbero, José A. Vega, Olivia García-Suárez and Teresa Cobo
Biomolecules 2025, 15(3), 386; https://doi.org/10.3390/biom15030386
Full text available online: https://www.mdpi.com/2218-273X/15/3/386

12. “Neuroprotective Potential of Origanum majorana L. Essential Oil Against Scopolamine-Induced Memory Deficits and Oxidative Stress in a Zebrafish Model”
by Ion Brinza, Razvan Stefan Boiangiu, Iasmina Honceriu, Ahmed M. Abd-Alkhalek, Samir M. Osman, Omayma A. Eldahshan, Elena Todirascu-Ciornea, Gabriela Dumitru and Lucian Hritcu
Biomolecules 2025, 15(1), 138; https://doi.org/10.3390/biom15010138
Full text available online: https://www.mdpi.com/2218-273X/15/1/138

13. “Oxidative DNA Damage and Repair Dynamics in Multiple Sclerosis: Insights from Comet Assay Kinetics, Base Excision Repair Gene Expression, and Genotype Analysis”
by Beata Filipek, Anna Macieja, Aleksandra Binda, Rafal Szelenberger, Leslaw Gorniak, Elzbieta Miller, Mariola Swiderek-Matysiak, Mariusz Stasiolek, Ireneusz Majsterek and Tomasz Poplawski
Biomolecules 2025, 15(6), 756; https://doi.org/10.3390/biom15060756
Full text available online: https://www.mdpi.com/2218-273X/15/6/756

14. “Progressive Alcohol-Related Brain Atrophy and White Matter Pathology Are Linked to Long-Term Inhibitory Effects on mTOR Signaling”
by Ming Tong, Camilla Homans, William Pelit, Busra Delikkaya and Suzanne M. de la Monte
Biomolecules 2025, 15(3), 413; https://doi.org/10.3390/biom15030413
Full text available online: https://www.mdpi.com/2218-273X/15/3/413

MDPI will attend the ISSCR 2026 Annual Meeting taking place from 8 to 11 July 2026 in Montréal, Canada.

Leaders in stem cell research and regenerative medicine gather annually for the ISSCR Annual Meeting, and you are invited to be part of it! Join nearly 3500 scientists from across the world at ISSCR 2026 for a four-day event highlighting the most important breakthroughs in the field.

MDPI is excited to participate in this prestigious event. We welcome you to visit our booth, where you will be able to have face-to-face exchanges with our representatives, learn more about our open access publishing services, and receive gifts.

The following MDPI journals will be represented:

• Biomolecules;
• Cells;
• Biomedicines;
• Organoids;
• Current Issues in Molecular Biology;
• International Journal of Molecular Sciences;
• Methods and Protocols.

If you plan to attend this event, we encourage you to visit our booth and speak to our representatives. We are eager to meet you in person and assist you with any queries that you may have. For more information about the conference, please visit the official website: https://www.isscr2026.org/.

MDPI will be attending the international conference “ncRNA2026: From Molecular Mechanisms to Clinical Impact” in Leuven, Belgium, which will take place from 24 to 26 June 2026. In recent years, non-coding RNA studies have revolutionized our understanding of gene regulation, cellular networks, and disease mechanisms. ncRNA2026 will showcase the latest breakthroughs in ncRNA biology and technology through a program dedicated entirely to this field—from molecular mechanisms and clinical applications to data science and translational insights. The conference will feature distinguished international invited speakers, complemented by a strong selection of oral and poster presentations from submitted abstracts.

The following MDPI journals will be represented:

• Non-Coding RNA;
• Applied Biosciences;
• BioMed;
• BioMedInformatics;
• Biomolecules;
• Cells;
• Current Issues in Molecular Biology (CIMB);
• Current Oncology;
• Diagnostics;
• Epigenomes;
• International Journal of Molecular Sciences (IJMS);
• Targets.

If you are attending the conference, please feel free to visit our booth. Our delegates look forward to meeting you in person and answering any questions that you may have. For more information about the conference, please visit the following link: https://sciforum.net/event/ncRNA2026.

Conference: The American Society for Virology 45th Annual Meeting (ASV)
Date: 27–30 July 2026
Location: Minneapolis, USA

MDPI will attend the American Society for Virology 45th Annual Meeting (ASV) as an exhibitor. This meeting will be held in Minneapolis, USA, from 27 to 30 July 2026. 

ASV meetings are among the largest and most important virology conferences in the world. These meetings provide a forum to promote discussion and collaboration among scientists active in all aspects of virology, from basic research to vaccines and antiviral therapeutics. The meeting attracts 1400-1800 national and international scientists for a program crafted from over 1000 participant-submitted abstracts, 17 invited symposium speakers, and 6 distinctive state-of-the-art speakers.

The following open access journals will be represented:

• Viruses;
• Pathogens;
• Biomolecules;
• Vaccines;
• COVID;
• Microorganisms;
• Immuno;
• BioMed;
• Germs;
• Microbiology Research.

If you are attending this conference, please feel free to start an online conversation with us. Our delegates look forward to meeting you in person at our booth and answering any questions you may have. For more information about the conference, please visit the following website: https://www.asv.org/asv2026.

Conference: National Congress of Plant Biology 2026
Organization: Chinese Society for Plant Biology
Date: 6–10 November 2026
Place: Hangzhou, China

With the vigorous development of plant science in China over the past fifteen years, the National Congress of Plant Biology has been continuously strengthened in terms of organizational scale and influence and has become the largest event in the field of plant science in China.

This conference covers topics including plant metabolism and synthesis, cell and development, genetics and genome, light signaling and photosynthesis, evolution and conservation, molecular breeding, plant–microbe interactions, abiotic stress biology, interdisciplinary studies and AI design, and smart agriculture. The conference will also feature a special forum on youth development and journal development, a graduate student forum, and a poster fund. These initiatives aim to foster new academic growth points, promote interdisciplinary integration and industry–academia research collaboration, strengthen the training of young talents, and encourage plant biology researchers to reach new academic heights, thus injecting momentum into the development of plant biology in China and internationally.

The following MDPI journals will be represented:

• Plants;
• International Journal of Molecular Sciences (IJMS);
• Biomolecules;
• Life;
• Stresses;
• Epigenomes;
• International Journal of Plant Biology (IJPB);
• AgriEngineering;
• Genes;
• Agronomy;
• Phycology.

If you attend this conference, please feel free to visit our booth. Our delegates look forward to meeting you in person and answering any questions that you may have.

As all the articles published in our journal are open access, you have free and unlimited access to the full texts. We encourage you to read our most highly cited papers published in 2025 and 2026, which are listed below.

1. “Dual Therapy in Inflammatory Bowel Disease”
by Gabriele Altieri, Alessandra Zilli, Tommaso Lorenzo Parigi, Mariangela Allocca, Federica Furfaro, Gionata Fiorino, Clelia Cicerone, Laurent Peyrin-Biroulet, Silvio Danese and Ferdinando D’Amico
Biomolecules 2025, 15(2), 222; https://doi.org/10.3390/biom15020222
Full text available online: https://www.mdpi.com/2218-273X/15/2/222

2. “Past, Present and Future Perspectives of Forensic Genetics”
by Itzae Adonai Gutiérrez-Hurtado, Mayra Elizabeth García-Acéves, Yolanda Puga-Carrillo, Mariano Guardado-Estrada, Denisse Stephania Becerra-Loaiza, Víctor Daniel Carrillo-Rodríguez, Reynaldo Plazola-Zamora, Juliana Marisol Godínez-Rubí, Héctor Rangel-Villalobos and José Alonso Aguilar-Velázquez
Biomolecules 2025, 15(5), 713; https://doi.org/10.3390/biom15050713
Full text available online: https://www.mdpi.com/2218-273X/15/5/713

3. “The Role of Long Non-Coding RNAs in Modulating the Immune Microenvironment of Triple-Negative Breast Cancer: Mechanistic Insights and Therapeutic Potential”
by Yongcheng Su, Qingquan Bai, Wenqing Zhang, Beibei Xu and Tianhui Hu
Biomolecules 2025, 15(3), 454; https://doi.org/10.3390/biom15030454
Full text available online: https://www.mdpi.com/2218-273X/15/3/454

4. “Unveiling Pharmacogenomics Insights into Circular RNAs: Toward Precision Medicine in Cancer Therapy”
by Saud Alqahtani, Taha Alqahtani, Krishnaraju Venkatesan, Durgaramani Sivadasan, Rehab Ahmed, Hassabelrasoul Elfadil, Premalatha Paulsamy and Kalaiselvi Periannan
Biomolecules 2025, 15(4), 535; https://doi.org/10.3390/biom15040535
Full text available online: https://www.mdpi.com/2218-273X/15/4/535

5. “Circulating microRNAs and Plasma Gelsolin as Biomarkers of Sepsis: Molecular Insights and Prospects for Precision Medicine”
by Mircea Stoian, Leonard Azamfirei, Sergio Rares Bandila, Adina Stoian, Dragoș-Florin Babă and Claudia Bănescu
Biomolecules 2025, 15(11), 1621; https://doi.org/10.3390/biom15111621
Full text available online: https://www.mdpi.com/2218-273X/15/11/1621

6. “Integrated Multi-Omics of the Longissimus Dorsal Muscle Transcriptomics and Metabolomics Reveals Intramuscular Fat Accumulation Mechanism with Diet Energy Differences in Yaks”
by Jingying Deng, Pengjia Bao, Ning Li, Siyuan Kong, Tong Wang, Minghao Zhang, Qinran Yu, Xinyu Cao, Jianlei Jia and Ping Yan
Biomolecules 2025, 15(7), 1025; https://doi.org/10.3390/biom15071025
Full text available online: https://www.mdpi.com/2218-273X/15/7/1025

7. “Insights into Solea senegalensis Reproduction Through Gonadal Tissue Methylation Analysis and Transcriptomic Integration”
by Daniel Ramírez, Marco Anaya-Romero, María Esther Rodríguez, Alberto Arias-Pérez, Robert Mukiibi, Helena D’Cotta, Diego Robledo and Laureana Rebordinos
Biomolecules 2025, 15(1), 54; https://doi.org/10.3390/biom15010054
Full text available online: https://www.mdpi.com/2218-273X/15/1/54

8. “Differential Expression of miR-223-3p and miR-26-5p According to Different Stages of Mastitis in Dairy Cows”
by Eleonora Dall’Olio, Fabio De Rensis, Eugenio Martignani, Silvia Miretti, Ugo Ala, Valeria Cavalli, Claudio Cipolat-Gotet, Melania Andrani, Mario Baratta and Roberta Saleri
Biomolecules 2025, 15(2), 235; https://doi.org/10.3390/biom15020235
Full text available online: https://www.mdpi.com/2218-273X/15/2/235

9. “Identification of Quantitative Trait Loci and Analysis of Novel Candidate Genes for Resistance to False Smut of Rice Based on SSR Molecular Markers”
by Rongtao Fu, Liyu Zhao, Cheng Chen, Jian Wang, Yu Chen and Daihua Lu
Biomolecules 2025, 15(2), 186; https://doi.org/10.3390/biom15020186
Full text available online: https://www.mdpi.com/2218-273X/15/2/186

10. “Absolute Quantitative Metagenomic Analysis Provides More Accurate Insights for the Anti-Colitis Effect of Berberine via Modulation of Gut Microbiota”
by Jiaguo Zhan, Jiale Cheng, Wenhui Chang, Yuying Su, Xixin Yue and Chongming Wu
Biomolecules 2025, 15(3), 400; https://doi.org/10.3390/biom15030400
Full text available online: https://www.mdpi.com/2218-273X/15/3/400

11. “The Inhibition of Bromodomain and Extraterminal Domain (BET) Proteins Protects Against Microglia-Mediated Neuronal Loss In Vitro”
by Marta Matuszewska, Anna Wilkaniec, Magdalena Cieślik, Marcin Strawski and Grzegorz A. Czapski
Biomolecules 2025, 15(4), 528; https://doi.org/10.3390/biom15040528
Full text available online: https://www.mdpi.com/2218-273X/15/4/528

12. “Complete Mitochondrial Genome of Niphon spinosus (Perciformes: Niphonidae): Genome Characterization and Phylogenetic Analysis”
by Maheshkumar Prakash Patil, Jong-Oh Kim, Seung Hyun Yoo, Jiyoung Shin, Ji-Young Yang, Kyunghoi Kim and Gun-Do Kim
Biomolecules 2025, 15(1), 52; https://doi.org/10.3390/biom15010052
Full text available online: https://www.mdpi.com/2218-273X/15/1/52

13. “Evaluation of the Effects of Thymoquinone on RAGE/NOX4 Expressions and Brain Tissue Morphometry in Experimental Alzheimer’s Disease Induced by Amyloid Beta 1–42 Peptide”
by Şükrü Ateş, Harun Ülger, Sümeyye Uçar, Aslı Okan, Mert Ocak, Ecma Güvenilir, Zeynep Yılmaz Şükranlı, Emin Kaymak, Züleyha Doğanyiğit, Serpil Taheri et al.
Biomolecules 2025, 15(4), 543; https://doi.org/10.3390/biom15040543
Full text available online: https://www.mdpi.com/2218-273X/15/4/543

14. “The Critical Balance Between Quiescence and Reactivation of Neural Stem Cells”
by Adam M. Elkin, Sarah Robbins, Claudia S. Barros and Torsten Bossing
Biomolecules 2025, 15(5), 672; https://doi.org/10.3390/biom15050672
Full text available online: https://www.mdpi.com/2218-273X/15/5/672

15. “Spatial Transcriptomics Decodes Breast Cancer Microenvironment Heterogeneity: From Multidimensional Dynamic Profiling to Precision Therapy Blueprint Construction”
by Aolong Ma, Lingyan Xiang, Jingping Yuan, Qianwen Wang, Lina Zhao and Honglin Yan
Biomolecules 2025, 15(8), 1067; https://doi.org/10.3390/biom15081067
Full text available online: https://www.mdpi.com/2218-273X/15/8/1067

As all the articles published in our journal are open access, you have free and unlimited access to the full texts. We encourage you to read our most highly cited papers published in 2025 and 2026, which are listed below.

1. “Functional Characterization of the SHIP1-Domains Regarding Their Contribution to Inositol 5-Phosphatase Activity”
by Spike Murphy Müller, Nina Nelson and Manfred Jücker
Biomolecules 2025, 15(1), 105; https://doi.org/10.3390/biom15010105
Full text available online: https://www.mdpi.com/2218-273X/15/1/105

2. “Time-Dependent Kinetic Complexities in Enzyme Assays: A Review”
by Juan Luis Rendón and Juan Pablo Pardo
Biomolecules 2025, 15(5), 641; https://doi.org/10.3390/biom15050641
Full text available online: https://www.mdpi.com/2218-273X/15/5/641

3. “PERK-Olating Through Cancer: A Brew of Cellular Decisions”
by Laurent Mazzolini and Christian Touriol
Biomolecules 2025, 15(2), 248; https://doi.org/10.3390/biom15020248
Full text available online: https://www.mdpi.com/2218-273X/15/2/248

4. “β-Galactosidase-Catalyzed Transglycosylation of Tyrosol: Substrates and Deep Eutectic Solvents Affecting Activity and Stability”
by Alžbeta Koššuthová, Monika Antošová, Vladena Bauerová-Hlinková, Jacob A. Bauer and Milan Polakovič
Biomolecules 2025, 15(6), 801; https://doi.org/10.3390/biom15060801
Full text available online: https://www.mdpi.com/2218-273X/15/6/801

5. “Beyond Processing: Furin as a Central Hub in Viral Pathogenesis and Genetic Susceptibility”
by Adrián Alejandro Silva-Ríos, Carlos Ernesto Mora-Ornelas, Luna Galilea Flores-Medina, José Francisco Muñoz-Valle, Carlos Daniel Díaz-Palomera, Mariel García-Chagollan, Alexis Missael Vizcaíno-Quirarte and Oliver Viera-Segura
Biomolecules 2025, 15(11), 1530; https://doi.org/10.3390/biom15111530
Full text available online: https://www.mdpi.com/2218-273X/15/11/1530

6. “AlphaFold-Guided Semi-Rational Engineering of an (R)-Amine Transaminase for Green Synthesis of Chiral Amines”
by Xiaole Yang, Xia Tian, Ruizhou Tang, Jiahuan Li, Xuning Zhang and Tingting Li
Biomolecules 2025, 15(10), 1435; https://doi.org/10.3390/biom15101435
Full text available online: https://www.mdpi.com/2218-273X/15/10/1435

7. “A Highly Active Keratinase from Bacillus sp. FJ-3-16 for Sustainable Feather Waste Valorization and Eco-Friendly Industrial Applications”
by Fei Bian, Hailun He, Gao Chen, Shousong Yue, Yaoxia Zhu, Xiaowei Zhang and Bin-Bin Xie
Biomolecules 2025, 15(10), 1389; https://doi.org/10.3390/biom15101389
Full text available online: https://www.mdpi.com/2218-273X/15/10/1389

8. “Cell-Penetrating Peptide Based on Myosin Phosphatase Target Subunit Sequence Mediates Myosin Phosphatase Activity”
by Andrea Kiss, Mohamad Mahfood, Zsófia Bodogán, Zoltán Kónya, Bálint Bécsi and Ferenc Erdődi
Biomolecules 2025, 15(5), 705; https://doi.org/10.3390/biom15050705
Full text available online: https://www.mdpi.com/2218-273X/15/5/705

9. “Membrane-Type 5 Matrix Metalloproteinase (MT5-MMP): Background and Proposed Roles in Normal Physiology and Disease”
by Deepak Jadhav, Anna M. Knapinska, Hongjie Wang and Gregg B. Fields
Biomolecules 2025, 15(8), 1114; https://doi.org/10.3390/biom15081114
Full text available online: https://www.mdpi.com/2218-273X/15/8/1114

10. “Characterization and Engineering of Two Novel Strand-Displacing B Family DNA Polymerases from Bacillus Phage SRT01hs and BeachBum”
by Yaping Sun, Kang Fu, Wu Lin, Jie Gao, Xianhui Zhao, Yun He and Hui Tian
Biomolecules 2025, 15(8), 1126; https://doi.org/10.3390/biom15081126
Full text available online: https://www.mdpi.com/2218-273X/15/8/1126

11. “Cold-Active Starch-Degrading Enzymes from a Cold and Alkaline Greenland Environment: Role of Ca2+ Ions and Conformational Dynamics in Psychrophilicity”
by Malthe Kjær Bendtsen, Jan Stanislaw Nowak, Pedro Paiva, Marcos López Hernández, Pedro Ferreira, Jan Skov Pedersen, Nicolai Sundgaard Bekker, Elia Viezzi, Francesco Bisiak, Ditlev E. Brodersen et al.
Biomolecules 2025, 15(3), 415; https://doi.org/10.3390/biom15030415
Full text available online: https://www.mdpi.com/2218-273X/15/3/415

12. “From Corncob By-Product to Functional Lignins: Comparative Analysis of Alkaline and Organosolv Extraction Followed by Laccase Treatment”
by Elise Martin, Swarnima Agnihotri, Fabrice Audonnet, Eric Record, Pascal Dubessay, Mohammad J. Taherzadeh and Philippe Michaud
Biomolecules 2025, 15(9), 1226; https://doi.org/10.3390/biom15091226
Full text available online: https://www.mdpi.com/2218-273X/15/9/1226

13. “Sustainable, Targeted, and Cost-Effective Laccase-Based Bioremediation Technologies for Antibiotic Residues in the Ecosystem: A Comprehensive Review”
by Rinat Ezra, Gulamnabi Vanti and Segula Masaphy
Biomolecules 2025, 15(8), 1138; https://doi.org/10.3390/biom15081138
Full text available online: https://www.mdpi.com/2218-273X/15/8/1138

14. “Biochemical Consequences of a Leucine-to-Cysteine Clamp Substitution in Lipoxygenases”
by Samuel G. Hill, Katherine DeFeo and Adam R. Offenbacher
Biomolecules 2025, 15(8), 1153; https://doi.org/10.3390/biom15081153
Full text available online: https://www.mdpi.com/2218-273X/15/8/1153

15. “Biochemical and Functional Characterization of E. coli Aminopeptidase N: A New Role as a 6-Monoacetylmorphine Hydrolase”
by Xiabin Chen, Yishuang Li, Jianzhuang Yao, Xiaoxuan Li, Hualing Li, Zelin Wu, Qi Hu, Nuo Xu, Tingjun Hou, Jiye Wang and Shurong Hou
Biomolecules 2025, 15(6), 822; https://doi.org/10.3390/biom15060822
Full text available online: https://www.mdpi.com/2218-273X/15/6/822

As all the articles published in our journal are open access, you have free and unlimited access to the full texts. We encourage you to read our most highly cited papers published in 2025 and 2026, which are listed below.

1. “Organocyclophosphazenes and Materials Based on Them for Pharmaceuticals and Biomedicine”
by Pavel Yudaev, Anton Tupikov and Evgeniy Chistyakov
Biomolecules 2025, 15(2), 262; https://doi.org/10.3390/biom15020262
Full text available online: https://www.mdpi.com/2218-273X/15/2/262

2. “Overcoming Immune Barriers in Allogeneic CAR-NK Therapy: From Multiplex Gene Editing to AI-Driven Precision Design”
by Hyunyoung Kim
Biomolecules 2025, 15(7), 935; https://doi.org/10.3390/biom15070935
Full text available online: https://www.mdpi.com/2218-273X/15/7/935

3. “Biological Nanocarriers in Cancer Therapy: Cutting Edge Innovations in Precision Drug Delivery”
by Ramesh Ganpisetti, Sanjay Giridharan, G. S. Sainaga Jyothi Vaskuri, Nikesh Narang, Pratap Basim, Mehmet Remzi Dokmeci, Menekse Ermis, Satish Rojekar, Amol D. Gholap and Nagavendra Kommineni
Biomolecules 2025, 15(6), 802; https://doi.org/10.3390/biom15060802
Full text available online: https://www.mdpi.com/2218-273X/15/6/802

4. “Advances in Local Drug Delivery for Periodontal Treatment: Present Strategies and Future Directions”
by Mayuka Nakajima, Mayuko Yanagawa, Honoka Takikawa, Truong Tran Thien, Lorena Zegarra-Caceres, Chunyang Yan and Koichi Tabeta
Biomolecules 2025, 15(6), 903; https://doi.org/10.3390/biom15060903
Full text available online: https://www.mdpi.com/2218-273X/15/6/903

5. “Revolutionizing mRNA Vaccines Through Innovative Formulation and Delivery Strategies”
by Munazza Fatima, Timothy An and Kee-Jong Hong
Biomolecules 2025, 15(3), 359; https://doi.org/10.3390/biom15030359
Full text available online: https://www.mdpi.com/2218-273X/15/3/359

6. “Silver Nanoparticles (AgNPs) from Lysinibacillus sp. Culture Broths: Antibacterial Activity, Mechanism Insights, and Synergy with Classical Antibiotics”
by Carlos Pernas-Pleite, Amparo M. Conejo-Martínez, Irma Marín and José P. Abad
Biomolecules 2025, 15(5), 731; https://doi.org/10.3390/biom15050731
Full text available online: https://www.mdpi.com/2218-273X/15/5/731

7. “FmocFF Peptide Hydrogel Is a Promising Matrix for Encapsulation and Controlled Release of the Anticancer Peptide Drug Bortezomib”
by Peter Divanach, Antzela Noti, Panagiotis Vouvopoulos, Thanasis Athanasiou, Nikos Kountourakis, Vagelis Harmandaris, Anastassia N. Rissanou and Anna Mitraki
Biomolecules 2025, 15(6), 839; https://doi.org/10.3390/biom15060839
Full text available online: https://www.mdpi.com/2218-273X/15/6/839

8. “Biochar Utilization in Antimicrobial, Anticancer, and Biosensing Applications: A Review”
by Ki Ha Min, Koung Hee Kim, Joo-Hyung Seo and Seung Pil Pack
Biomolecules 2025, 15(6), 760; https://doi.org/10.3390/biom15060760
Full text available online: https://www.mdpi.com/2218-273X/15/6/760

9. “Applications of Isothermal Titration Calorimetry in Studying Biomimetic Nanocarriers”
by Martin Guerrero, Colby Braden and Yuping Bao
Biomolecules 2025, 15(10), 1349; https://doi.org/10.3390/biom15101349
Full text available online: https://www.mdpi.com/2218-273X/15/10/1349

10. “Recent Stem-Cell-Based and Stem-Cell-Free Possibilities for the Therapeutic Management of the Osteonecrosis of the Jaw”
by Merita Mazreku, L’uboš Danišovič, Martin Klein and Mária Kleinová
Biomolecules 2025, 15(4), 595; https://doi.org/10.3390/biom15040595
Full text available online: https://www.mdpi.com/2218-273X/15/4/595

11. “Biological Behavior of Bioactive Glasses SinGlass (45S5) and SinGlass High (F18) in the Repair of Critical Bone Defects”
by Dayane Maria Braz Nogueira, Marcelie Priscila de Oliveira Rosso, Paulo Sérgio da Silva Santos, Manoel Damião Sousa-Neto, Alice Corrêa Silva-Sousa, Cleverson Teixeira Soares, Carlos Henrique Bertoni Reis, Jéssica de Oliveira Rossi, Cleuber Rodrigo de Souza Bueno, Daniela Vieira Buchaim et al.
Biomolecules 2025, 15(1), 112; https://doi.org/10.3390/biom15010112
Full text available online: https://www.mdpi.com/2218-273X/15/1/112

12. “Evaluation of Biocompatible Materials for Enhanced Mesenchymal Stem Cell Expansion: Collagen-Coated Alginate Microcarriers and PLGA Nanofibers”
by Manuel Jaime-Rodríguez, María Luisa Del Prado-Audelo, Norma Angélica Sosa-Hernández, Dulce Patricia Anaya-Trejo, Luis Jesús Villarreal-Gómez, Ángel Humberto Cabrera-Ramírez, Jesus Augusto Ruiz-Aguirre, Israel Núñez-Tapia, Marek Puskar, Emily Marques dos Reis et al.
Biomolecules 2025, 15(3), 345; https://doi.org/10.3390/biom15030345
Full text available online: https://www.mdpi.com/2218-273X/15/3/345

13. “Aptamer-Coated PLGA Nanoparticles Selectively Internalize into Epithelial Ovarian Cancer Cells In Vitro and In Vivo”
by Gregory Benedetto, Anthony Fowler, Dan Langdon, Maya Raine, Molly Lynne White, Joshua Ogle, Corey Garmon, Craig Ogle and Christine Richardson
Biomolecules 2025, 15(8), 1123; https://doi.org/10.3390/biom15081123
Full text available online: https://www.mdpi.com/2218-273X/15/8/1123

14. “Tailored Iron Oxide Nanoparticles as Potential Cannabinoid Carriers for Anti-Cancer Treatment”
by Jan Taudul, Joanna Celej, Kinga Żelechowska-Matysiak, Daria Kępińska, Agnieszka Majkowska-Pilip, Marcin Strawski, Paweł Krysiński and Dorota Nieciecka
Biomolecules 2025, 15(2), 230; https://doi.org/10.3390/biom15020230
Full text available online: https://www.mdpi.com/2218-273X/15/2/230