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Announcements
11 November 2025
Biomolecules | Highly Cited Papers in 2024–2025 in the “Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates” Section
We welcome you to read our most highly cited papers published in 2024 and 2025, which are listed below. As all of the articles published in Biomolecules (ISSN: 2218-273X) are open access, you have free and unlimited access to the full text.
1. “LL-37: Structures, Antimicrobial Activity, and Influence on Amyloid-Related Diseases”
by Surajit Bhattacharjya, Zhizhuo Zhang and Ayyalusamy Ramamoorthy
Biomolecules 2024, 14(3), 320; https://doi.org/10.3390/biom14030320
Full text available online: https://www.mdpi.com/2218-273X/14/3/320
2. “Morphological and Biophysical Study of S100A9 Protein Fibrils by Atomic Force Microscopy Imaging and Nanomechanical Analysis”
by Ana P. Carapeto, Carlos Marcuello, Patrícia F. N. Faísca and Mário S. Rodrigues
Biomolecules 2024, 14(9), 1091; https://doi.org/10.3390/biom14091091
Full text available online: https://www.mdpi.com/2218-273X/14/9/1091
3. “The RAGE Axis: A Relevant Inflammatory Hub in Human Diseases”
by Armando Rojas, Cristian Lindner, Ivan Schneider, Ileana Gonzalez and Jaime Uribarri
Biomolecules 2024, 14(4), 412; https://doi.org/10.3390/biom14040412
Full text available online: https://www.mdpi.com/2218-273X/14/4/412
4. “Inhibitors of SARS-CoV-2 Main Protease (Mpro) as Anti-Coronavirus Agents”
by Agnieszka Zagórska, Anna Czopek, Monika Fryc and Jakub Jończyk
Biomolecules 2024, 14(7), 797; https://doi.org/10.3390/biom14070797
Full text available online: https://www.mdpi.com/2218-273X/14/7/797
5. “Current Technologies Unraveling the Significance of Post-Translational Modifications (PTMs) as Crucial Players in Neurodegeneration”
by Saima Zafar, Shehzadi Irum Fatima, Matthias Schmitz and Inga Zerr
Biomolecules 2024, 14(1), 118; https://doi.org/10.3390/biom14010118
Full text available online: https://www.mdpi.com/2218-273X/14/1/118
6. “The Metabolism of Creatinine and Its Usefulness to Evaluate Kidney Function and Body Composition in Clinical Practice”
by Marcela Ávila, Mariana G. Mora Sánchez, Alma Sofía Bernal Amador and Ramón Paniagua
Biomolecules 2025, 15(1), 41; https://doi.org/10.3390/biom15010041
Full text available online: https://www.mdpi.com/2218-273X/15/1/41
7. “Enkephalins and Pain Modulation: Mechanisms of Action and Therapeutic Perspectives”
by Mario García-Domínguez
Biomolecules 2024, 14(8), 926; https://doi.org/10.3390/biom14080926
Full text available online: https://www.mdpi.com/2218-273X/14/8/926
8. “Structures of Toxic Advanced Glycation End-Products Derived from Glyceraldehyde, A Sugar Metabolite”
by Akiko Sakai-Sakasai, Kenji Takeda, Hirokazu Suzuki and Masayoshi Takeuchi
Biomolecules 2024, 14(2), 202; https://doi.org/10.3390/biom14020202
Full text available online: https://www.mdpi.com/2218-273X/14/2/202
9. “Role of the Receptor for Advanced Glycation End Products (RAGE) and Its Ligands in Inflammatory Responses”
by Kaylen Cross, Stefan W. Vetter, Yousuf Alam, Md. Zahidul Hasan, Anupom Deb Nath and Estelle Leclerc
Biomolecules 2024, 14(12), 1550; https://doi.org/10.3390/biom14121550
Full text available online: https://www.mdpi.com/2218-273X/14/12/1550
10. “Advancements in the Application of Ribosomally Synthesized and Post-Translationally Modified Peptides (RiPPs)”
by Sang-Woo Han and Hyung-Sik Won
Biomolecules 2024, 14(4), 479; https://doi.org/10.3390/biom14040479
Full text available online: https://www.mdpi.com/2218-273X/14/4/479
11 November 2025
Biomolecules | Highly Cited Papers in 2024–2025 in the “Bioinformatics and Systems Biology” Section
We welcome you to read our most highly cited papers published in 2024 and 2025, which are listed below. As all of the articles published in Biomolecules (ISSN: 2218-273X) are open access, you have free and unlimited access to the full text.
1. “Advances in AI for Protein Structure Prediction: Implications for Cancer Drug Discovery and Development”
by Xinru Qiu, Han Li, Greg Ver Steeg and Adam Godzik
Biomolecules 2024, 14(3), 339; https://doi.org/10.3390/biom14030339
Full text available online: https://www.mdpi.com/2218-273X/14/3/339
2. “SynerGNet: A Graph Neural Network Model to Predict Anticancer Drug Synergy”
by Mengmeng Liu, Gopal Srivastava, J. Ramanujam and Michal Brylinski
Biomolecules 2024, 14(3), 253; https://doi.org/10.3390/biom14030253
Full text available online: https://www.mdpi.com/2218-273X/14/3/253
3. “The Historical Evolution and Significance of Multiple Sequence Alignment in Molecular Structure and Function Prediction”
by Chenyue Zhang, Qinxin Wang, Yiyang Li, Anqi Teng, Gang Hu, Qiqige Wuyun and Wei Zheng
Biomolecules 2024, 14(12), 1531; https://doi.org/10.3390/biom14121531
Full text available online: https://www.mdpi.com/2218-273X/14/12/1531
4. “Structure-Based Approaches for Protein–Protein Interaction Prediction Using Machine Learning and Deep Learning”
by Despoina P. Kiouri, Georgios C. Batsis and Christos T. Chasapis
Biomolecules 2025, 15(1), 141; https://doi.org/10.3390/biom15010141
Full text available online: https://www.mdpi.com/2218-273X/15/1/141
5. “Serum Biomarker Signatures of Choroid Plexus Volume Changes in Multiple Sclerosis”
by Dejan Jakimovski, Robert Zivadinov, Ferhan Qureshi, Murali Ramanathan, Bianca Weinstock-Guttman, Eleonora Tavazzi, Michael G. Dwyer and Niels Bergsland
Biomolecules 2024, 14(7), 824; https://doi.org/10.3390/biom14070824
Full text available online: https://www.mdpi.com/2218-273X/14/7/824
6. “BSA Binding and Aggregate Formation of a Synthetic Amino Acid with Potential for Promoting Fibroblast Proliferation: An In Silico, CD Spectroscopic, DLS, and Cellular Study”
by Hayarpi Simonyan, Rosanna Palumbo, Satenik Petrosyan, Anna Mkrtchyan, Armen Galstyan, Ashot Saghyan, Pasqualina Liana Scognamiglio, Caterina Vicidomini, Marta Fik-Jaskólka and Giovanni N. Roviello
Biomolecules 2024, 14(5), 579; https://doi.org/10.3390/biom14050579
Full text available online: https://www.mdpi.com/2218-273X/14/5/579
7. “Novel Insights into the Antimicrobial and Antibiofilm Activity of Pyrroloquinoline Quinone (PQQ); In Vitro, In Silico, and Shotgun Proteomic Studies”
by Mai M. Labib, Alaa M. Alqahtani, Hebatallah H. Abo Nahas, Rana M. Aldossari, Bandar Fahad Almiman, Sarah Ayman Alnumaani, Mohammad El-Nablaway, Ebtesam Al-Olayan, Maha Alsunbul and Essa M. Saied
Biomolecules 2024, 14(8), 1018; https://doi.org/10.3390/biom14081018
Full text available online: https://www.mdpi.com/2218-273X/14/8/1018
8. “In Silico Investigation of Parkin-Activating Mutations Using Simulations and Network Modeling”
by Naeyma N. Islam, Caleb A. Weber, Matt Coban, Liam T. Cocker, Fabienne C. Fiesel, Wolfdieter Springer and Thomas R. Caulfield
Biomolecules 2024, 14(3), 365; https://doi.org/10.3390/biom14030365
Full text available online: https://www.mdpi.com/2218-273X/14/3/365
9. “GTADC: A Graph-Based Method for Inferring Cell Spatial Distribution in Cancer Tissues”
by Tianjiao Zhang, Ziheng Zhang, Liangyu Li, Jixiang Ren, Zhenao Wu, Bo Gao and Guohua Wang
Biomolecules 2024, 14(4), 436; https://doi.org/10.3390/biom14040436
Full text available online: https://www.mdpi.com/2218-273X/14/4/436
10. “A Review for Artificial Intelligence Based Protein Subcellular Localization”
by Hanyu Xiao, Yijin Zou, Jieqiong Wang and Shibiao Wan
Biomolecules 2024, 14(4), 409; https://doi.org/10.3390/biom14040409
Full text available online: https://www.mdpi.com/2218-273X/14/4/409
6 November 2025
Meet Us at the Multiomics and Precision Medicine Joint Conference 2025 (MOPM2025), 8–9 November 2025, Taipei, Taiwan
Conference: Multiomics and Precision Medicine Joint Conference 2025
Date: 8–9 November 2025
Place: Taipei, Taiwan
We are excited to announce that MDPI will be attending the Multiomics and Precision Medicine Joint Conference 2025 (MOPM 2025) as an exhibitor and proud sponsor of the Special Poster Award Sponsorship, which will recognize six recipients of the MDPI Rising Star Poster Awards.
Now in its seventh edition, MOPM serves as Taiwan’s leading academic platform dedicated to integrative multiomics and precision medicine research. Organized jointly by six major scientific societies, the conference promotes interdisciplinary collaboration across life sciences, medicine, and data science.
This year’s theme, “Big Data and AI Revolution for Next-Generation Precision Medicine”, will highlight cutting-edge applications of artificial intelligence and big data in biotechnology and healthcare. The program will feature plenary talks from international experts, poster presentations, industry showcases, and exhibitions of the latest research and technologies — fostering dialogue and collaboration among scholars and professionals across disciplines.
The following MDPI journals will be represented:
- Proteomes;
- Sclerosis;
- Metabolites;
- Biomolecules;
- Cancers;
- Cells;
- Journal of Clinical Medicine (JCM);
- Journal of Personalized Medicine (JPM);
- Pharmaceuticals.
If you will be attending this conference, our delegates look forward to meeting you in person and answering any questions you may have. For more information about the conference, please visit the following website: https://www.mopmtaiwan.com.
4 November 2025
MDPI INSIGHTS: The CEO's Letter #28 - WSF11, Nobel Laureates, Proofig AI, Romania Summit, STM and FBF
Welcome to the MDPI Insights: The CEO's Letter.
In these monthly letters, I will showcase two key aspects of our work at MDPI: our commitment to empowering researchers and our determination to facilitating open scientific exchange.
Opening Thoughts

Highlights from the 11th World Sustainability Forum in Barcelona
I’m pleased to share some highlights from the 11th World Sustainability Forum (WSF 11), held in Barcelona on 2–3 October 2025 under the theme Sustainable and Resilient Cities.
Why WSF matters
The WSF series is a flagship initiative for MDPI and is supported by the MDPI Sustainability Foundation. It serves as a transdisciplinary platform for researchers, policymakers, and stakeholders to engage on sustainability challenges. WSF is now held annually as part of our commitment to maintain momentum in the sustainability discourse.
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This year’s Barcelona edition focused on urban resilience, landscape design, and social community impact in the sustainability space. Over 48 hours of sessions, we brought together leading minds across disciplines to translate vision into practice. With participants from 53 countries across all continents, WSF 11 was truly global in scope.

“WSF is now held annually as part of our commitment to maintain momentum in the sustainability discourse”
What made WSF 11 especially successful (from my vantage point) was the level of positive engagement with our participants. Chief editors, researchers, and attendees repeatedly told me how professionally executed the event was, highlighting the high energy, logistical smoothness and quality of MDPI’s event management. That kind of recognition from peers really builds our reputation as more than just a publisher, but as a convener of meaningful scientific dialogue.
Our conferences are a form of experiential marketing as they create memorable and immersive connections between a brand and attendees. These positive associations build promotion and brand loyalty, ultimately impacting the MDPI’s trust and reputation for the better.
WSF 11: By the numbers
Here’s a quick snapshot of WSF 11’s scale and reach:
- 181 registrations across global participants.
- 8 keynote speakers and 5 invited speakers.
- 144 abstracts accepted (over 355 submitted), resulting in 75 short talks and 69 posters.
- 53 countries were represented across all continents, making it a truly international event.
- First time that we ran parallel sessions for WSF (an ambitious program).
- A dedicated awards ceremony to honour outstanding sustainability research: World Sustainability Award (WSA) x 2 winners, and Emerging Sustainability Leader Award (ESLA) x 3 winners.
Interviews with our World Sustainability Award Winners
One of the most rewarding parts of WSF is recognizing researchers whose work advances sustainability in powerful ways. In our Blog series, Daniella Maritan-Thomson (Content Specialist, MDPI) interviewed the two winners of the World Sustainability Award, Professor Dr. Stuart Pimm and Dr. Abdelbagi M. Ismail, who offered insights to the human side of sustainability research, the people behind the data, and the stories behind the science.
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Prof. Stuart Pimm, whose decades of conservation work make him a leader in biodiversity preservation, reflected on his WSF Award experience and research in this interview: [Interview: Prof Stuart Pimm] |
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Dr. Abdelbagi M. Ismail, an expert in crop improvement and winner of the WSF Award, shares his journey and perspectives here: [Interview: Dr Abdelbagi M. Ismail] |
“Our conferences create memorable and immersive connections”
Emerging Sustainability Leader Award winners

Stefan Tochev (CEO, MDPI), Prof. Dr. Vhahangwele Masindi, Dr. Katya Rhodes, and Prof. Dr. Myriam Ertz (left to right).
We also recognized three recipients of the Emerging Sustainability Leader Award: Prof. Dr. Vhahangwele Masindi, Dr. Katya Rhodes, and Prof. Dr. Myriam Ertz, for their contributions as early-career researchers advancing sustainability through innovation, impact, and academic excellence across the field.
What this means for MDPI
- Building our global identity in events
WSF is a marquee MDPI event, not just a gathering, but a statement of how we wish to position ourselves in the global sustainability ecosystem. The positive feedback helps us build on our approach for future editions, so that we remain a reference point for quality, relevance, and engagement. - Expanding capacity across offices
The success of WSF 11 in Barcelona’s would not have happened without great teamwork from Basel, Barcelona, Romania, the UK, and the APAC Conference team. Thanks to everyone for their work to bring this ambitious event to life. - Supporting MDPI’s mission
At this event, I had the opportunity to present on MDPI's role in Open Access, sustainability publishing, and the intersection of science and policy. WSF is not only about the science; it’s also a platform for us to position MDPI as a thought leader and a collaborator in shaping the future of sustainable research.
I look forward to the WSF momentum as we work towards WSF 12 in Hong Kong, which is scheduled for August 2026.

MDPI Colleagues at the 11th World Sustainability Forum in Barcelona, Spain, 2–3 October 2025.
Impactful Research

Celebrating 2025 Nobel Laureates who have published with MDPI
October is always an inspiring month in science. It’s when the world turns its attention to the Nobel Prize announcements, recognizing discoveries that have changed how we understand the world.
Over the years, many distinguished researchers who have received the Nobel Prize have chosen to publish their work with MDPI. These are scientists whose breakthroughs have shaped entire fields of research, and who have entrusted our Open Access journals to share their findings with the world.
“The work we support can be world-class and world-changing”
Congratulations to the 2025 Laureates
Dozens of Nobel Laureates have published in our journals: as at 2024, more than 40 laureates had contributed over 115 articles across more than 35 MDPI journals. Congratulations to the three 2025 Nobel prize-winners who have published with MDPI during their careers. Below are links to their MDPI publications and announcements for further reading:
- Omar M. Yaghi (Chemistry)
- Awarded for his pioneering work on metal-organic frameworks (MOFs). MDPI published his article “Covalent Organic Frameworks: Organic Chemistry Beyond the Molecule” in Molecules (2017).
- MDPI Announcement: https://www.mdpi.com/news/13455
- Nobel Prize in Chemistry – The Science Behind the Prize
- Shimon Sakaguchi (Medicine)
- Recognized for discoveries in immune-system self-tolerance and regulatory T-cells. Published in Cancers (2021).
- MDPI Announcement: https://www.mdpi.com/news/13443
- Nobel Prize in Physiology or Medicine – The Science Behind the Prize
- John M. Martinis (Physics)
- Recognized for quantum tunnelling in electrical circuits. MDPI’s Journal of Nuclear Engineering (2025) includes his co-authored work.
- MDPI Announcement: https://www.mdpi.com/news/13450
- Nobel Prize in Physics – The Science Behind the Prize
These connections strengthen our mission to make research freely available and ensure that transformative ideas reach the widest possible audience.
Publishing at the leading edge of knowledge
The privilege of hosting such contributors resonates deeply with our editorial teams. It shows that top-tier scientific work has a home at MDPI, which builds our visibility in the research community. It signals that our publishing model, our editorial workflows, and our commitment to Open Access are respected at the very highest levels of science. It also gives our authors, reviewers, editors and staff the message that the work we support can be world-class and world-changing.
Publishing at the leading edge of knowledge isn’t just about individual papers – it’s about the ecosystem of support, transparency, and accessibility that makes discovery possible. Let’s continue to build a publishing platform and provide a service that attracts and enables both everyday research and the breakthroughs of tomorrow.
Inside MDPI

Strengthening Research Integrity: MDPI partners with Proofig AI
I’m pleased to share that MDPI has entered a multi-year partnership with Proofig AI, a leader in AI-driven proofing and integrity software for scientific publishing. This follows the success of our pilot program, in which Proofig AI proved highly effective in detecting duplicated, altered, and manipulated images across biomedical submissions.
Safeguarding the credibility of the research we publish
Research integrity is at the core of MDPI’s mission. The life sciences, in particular, face increasing risks of image-related issues due to advanced editing tools and generative AI. By integrating Proofig AI into our workflows, we improve our ability to detect issues early, reduce post-publication corrections, and safeguard the credibility of the research we publish.
Pilot outcomes
- Successful detection of duplicated confocal and histology images, even when altered to disguise similarities.
- Early results showed a significant drop in post-publication image manipulation flags year-on-year.
- Positive feedback from editors and staff highlighted the tool’s ease of use and reliability.

Dr. Dror Kolodkin-Gal (co-founder and CEO of Proofig AI) said:
“The MDPI team conducted a highly professional and carefully monitored pilot, achieving excellent results in detecting problematic images.
Their fast and effective integration process was impressive, and we are excited to contribute to this important collaboration.”

Sanita Meijere (IT Product and Project Manager, MDPI), shared:
“For more than a year, we’ve tested all the available image manipulation detection tools. Proofig AI’s quality and ease of use, alongside positive feedback from our internal users, made their software a clear stand-out.
We’re thrilled to be moving forward with this partnership, ensuring we do our utmost to protect MDPI’s biomedical journals. Using this advanced image proofing software reaffirms MDPI’s commitment to maintaining the highest standards in research integrity.”
Raising the bar for integrity
This partnership sets a new benchmark for quality control in biomedical publishing.

As Tim Tait-Jamieson (Head of Publication Ethics, MDPI), explains:
“The life sciences are disproportionately affected by research integrity issues, making vigilance in this field especially critical. This is driven, in part, by the increasing sophistication of image editing software and generative AI.
Whether accidental or deliberate, image manipulation can have a lasting impact on credibility. By integrating Proofig AI into our editorial workflows, we strengthen our ability to detect scientific misconduct early and reduce post-publication amendments.”
Faster and more accurate quality control
Proofig will automatically flag potentially problematic images during submission checks, giving our editors more confidence in the integrity of manuscripts and freeing up time to focus on editorial decisions. The tool will also reduce the burden of manual checks, while supporting faster and more accurate quality control. This partnership reinforces MDPI's reputation as a publisher that takes integrity seriously and continues to invest in tools to support authors, editors, and reviewers alike.
A big thank-you to all colleagues who supported the pilot and rollout. You can read more in our MDPI Blog post.
Coming Together for Science

The MDPI Romania Summit 2025
On 21–22 October, I had the pleasure of joining our colleagues in Bucharest for the MDPI Romania Summit 2025. The event was organized by our Romania Marketing team, with support from colleagues across our Romanian offices. It brought together academics, policymakers, and collaborators to discuss the country’s evolving research landscape.
Over two days, we welcomed more than 30 participants, including Editorial Board Members, Guest Editors, and policy-makers from the Romanian research and education sectors, including representatives from the Romanian Academy and the National Commission for the Accreditation of Academic Titles (CNATDCU).
The discussions and presentations reflected the strength and growth of Romania’s research community and its active engagement in Open Access publishing.
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“The discussions and presentations reflected the strength and growth of Romania’s research community”
Romania’s role in Open Access
Romania loves Open Access and has emerged as one of MDPI’s most engaged national research communities. The numbers speak for themselves:
- 67% of all publications in Romania were Open Access in 2024.
- MDPI accounts for 39% of the country’s total OA publications (14,779 in 2024).
- Over the last five years (2020–2024), Romanian institutions published over 33,000 papers with MDPI.
- There are 460 active Editorial Board Members from Romania, including 8 Chief Editors.
- 29 institutions are part of our Institutional Open Access Program (IOAP), with 8 new members joining in 2025.
These numbers reflect the trust and reliable partnership we have built with the Romanian academic community.
Highlights from the Summit
The program covered a wide range of topics from MDPI’s achievements and updates to our editorial processes, peer-review quality, AI in publishing, IOAP and Open Access funding models, and publication ethics.
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Agenda Highlights:
- MDPI Introduction, Performance & Achievements, and Collaboration with Romania – Stefan Tochev (CEO, MDPI).
- Trust the Process: Editorial Workflow and Quality in Publishing – Dr. Liliane Auwerter (Scientific Review Group).
- Publication Ethics at MDPI: Safeguarding the Integrity of the Published Scholarly Record – Diana Cristina Apodaritei (Research Integrity Specialist).
- Institutional Partnerships – Becky Castellon (Institutional Partnerships Manager, MDPI).
- AI in Publishing and MDPI's Actions – Sanita Meijere (AI Product Manager).
- Closing Remarks – Stefan Tochev (CEO, MDPI).
Participants shared feedback and ideas for future collaborations, including organizing author workshops, possible conference collaborations, and strengthening our engagement with national institutions such as the Ministry of Education and Research and the National Council of Romanian Rectors.
As Acad. Dr. Nicolae-Victor Zamfir, Vice President of the Romanian Academy, noted during the discussions:
“The organization of the event is very timely, because MDPI is a publishing house in full development and expansion. The opinion of researchers is important for increasing the quality of published works.”
A collaborative future
Events like this remind us how essential it is to engage locally and listen directly to the voices of our editors, authors, and institutional partners. They help us build relationships, improve our understanding of the local market, and align our shared goals in advancing Open Access and research quality.
Thank you to everyone involved, especially our Romania Marketing team, who organized the event, and to all colleagues who continue to build relationships with our academic communities around the world.

Thank you!
A special thank-you to the Romanian Marketing team and all colleagues behind the scenes who made this Summit such a success. Your efforts are greatly appreciated. We look forward to building on this momentum with future Summits in Europe and beyond.
Closing Thoughts

STM and FBF 2025: Connecting Through Science and Publishing

Stefan Tochev (CEO, MDPI), Constanze Schelhorn (Head of Indexing, MDPI) at STM Conference, Frankfurt, 14 October 2025.
On 13–14 October, I attended the STM Frankfurt Conference 2025, my fourth visit to the Frankfurt event, and it continues to be one of the most valuable gatherings in our industry.
The STM meeting brings together the publishing community and key opinion leaders to speak on current trends and challenges shaping our industry.
This year’s theme – “Science Diplomacy: What is it and How Does it Work?” – unpacked the growing intersection of science, policy, and publishing.
Discussion topics ranged from what is science diplomacy and how publishers can contribute to global collaboration to how science communication can help maintain trust during an era of disruption.
I was joined by Dr. Constanze Schelhorn, our Head of Indexing, who met with representatives from Scopus, Web of Science, Digital Science, ProQuest, and other partners. These meetings give us a chance to share feedback on our collaborations, learn about new updates being developed, and build our relationships with indexing bodies.
“The STM meeting brings together the publishing community and key opinion leaders”
STM also provides a space to connect with industry peers, as I did with colleagues from Elsevier, Frontiers, Clarivate, Sage, and STM itself, reinforcing MDPI’s engagement within the broader publishing community. It was also nice to bump into some former colleagues and see them continuing to grow in their publishing careers.
At the Frankfurt Book Fair

The MDPI booth at the 2025 Frankfurt Book Fair.
Following STM, I spent the next day at the Frankfurt Book Fair (15–19 October) – one of the largest and most influential events in the publishing world.
It’s always inspiring to see the scale and energy of this global gathering, which spans everything from books and education to digital innovation and academic publishing.
We set up an MDPI booth to host discussions with partners, vendors, and researchers.
The Fair ran into the weekend, with colleagues from several MDPI departments attending to represent the company and connect with the scholarly community.
Events like STM and FBF are a nice reminder of how dynamic and interconnected our industry is, and how important it is for MDPI to continue taking part in global conversations about science, communication, and the future of publishing.
Chief Executive Officer
MDPI AG
3 November 2025
Meet Us at the 48th Annual Meeting of the Molecular Biology Society of Japan, 3–5 December 2025, Yokohama, Japan
MDPI will attend the 48th Annual Meeting of the Molecular Biology Society of Japan which will be held from 3 to 5 December 2025 in Yokohama, Japan. This is an annual conference organized by the Molecular Biology Society of Japan covering themes such as molecular, cell, development and regeneration, animal and plant physiology, and diseases.
We are excited to participate in this prestigious event and welcome you to visit MDPI’s booth. The booth number is #145, where you will be able to have face-to-face exchanges with our representatives, learn more about our open access publishing services, and acquire gifts.
The following MDPI journals will be represented:
- CIMB;
- IJMS;
- BioChem;
- Biomolecules;
- Clocks & Sleep;
- SynBio;
- Antioxidants;
- Biologics;
- Epigenomes;
- IJTM;
- JMP;
- JDB.
If you plan to attend this event, we encourage you to visit our booth and speak to our representatives. We are eager to meet you in person and assist you with any queries that you may have. For more information about the conference, please visit the official website: https://www.aeplan.jp/mbsj2025/en-index.html.
30 October 2025
Biomolecules | Highly Cited Papers in 2024–2025 in the “Molecular Reproduction” Section
All of the articles published in our journal are open access, granting our readers free and unlimited access to the full texts. We welcome you to read our most highly cited papers published in 2024 and 2025, which are listed below:
1. “Current Status and Future Prospects of Stem Cell Therapy for Infertile Patients with Premature Ovarian Insufficiency”
by Hye Kyeong Kim and Tae Jin Kim
Biomolecules 2024, 14(2), 242; https://doi.org/10.3390/biom14020242
Full text available online: https://www.mdpi.com/2218-273X/14/2/242
2. “Adenomyosis and Abnormal Uterine Bleeding: Review of the Evidence”
by Marwan Habiba, Sun-Wei Guo and Giuseppe Benagiano
Biomolecules 2024, 14(6), 616; https://doi.org/10.3390/biom14060616
Full text available online: https://www.mdpi.com/2218-273X/14/6/616
3. “Potential Causal Association between Plasma Metabolites, Immunophenotypes, and Female Reproductive Disorders: A Two-Sample Mendelian Randomization Analysis”
by Hui-Hui Shen, Yang-Yang Zhang, Xuan-Yu Wang, Cheng-Jie Wang, Ying Wang, Jiang-Feng Ye and Ming-Qing Li
Biomolecules 2024, 14(1), 116; https://doi.org/10.3390/biom14010116
Full text available online: https://www.mdpi.com/2218-273X/14/1/116
4. “Endometrial Receptivity–Lessons from “Omics”
by Louie Ye and Evdokia Dimitriadis
Biomolecules 2025, 15(1), 106; https://doi.org/10.3390/biom15010106
Full text available online: https://www.mdpi.com/2218-273X/15/1/106
5. “Mechanisms of Hormonal, Genetic, and Temperature Regulation of Germ Cell Proliferation, Differentiation, and Death During Spermatogenesis”
by María Maroto, Sara N. Torvisco, Cristina García-Merino, Raúl Fernández-González and Eva Pericuesta
Biomolecules 2025, 15(4), 500; https://doi.org/10.3390/biom15040500
Full text available online: https://www.mdpi.com/2218-273X/15/4/500
6. “Investigation of Uterine Fluid Extracellular Vesicles’ Proteomic Profiles Provides Novel Diagnostic Biomarkers of Bovine Endometritis”
by Johanna Piibor, Andres Waldmann, Madhusha Prasadani, Ants Kavak, Aneta Andronowska, Claudia Klein, Suranga Kodithuwakku and Alireza Fazeli
Biomolecules 2024, 14(6), 626; https://doi.org/10.3390/biom14060626
Full text available online: https://www.mdpi.com/2218-273X/14/6/626
7. “Protective Role of Physical Activity and Antioxidant Systems During Spermatogenesis”
by Cristina Antinozzi, Luigi Di Luigi, Laura Sireno, Daniela Caporossi, Ivan Dimauro and Paolo Sgrò
Biomolecules 2025, 15(4), 478; https://doi.org/10.3390/biom15040478
Full text available online: https://www.mdpi.com/2218-273X/15/4/478
8. “Molecular Mechanism of Oocyte Activation in Mammals: Past, Present, and Future Directions”
by Hibiki Sugita, Shunsuke Takarabe, Atsuko Kageyama, Yui Kawata and Junya Ito
Biomolecules 2024, 14(3), 359; https://doi.org/10.3390/biom14030359
Full text available online: https://www.mdpi.com/2218-273X/14/3/359
9. “Single-Nucleus RNA-Seq Reveals Spermatogonial Stem Cell Developmental Pattern in Shaziling Pigs”
by Xiangwei Tang, Chujie Chen, Saina Yan, Anqi Yang, Yanhong Deng, Bin Chen and Jingjing Gu
Biomolecules 2024, 14(6), 607; https://doi.org/10.3390/biom14060607
Full text available online: https://www.mdpi.com/2218-273X/14/6/607
10. “Aflatoxin Exposure-Caused Male Reproductive Toxicity: Molecular Mechanisms, Detoxification, and Future Directions”
by Dongyun Ye, Zhihui Hao, Shusheng Tang, Tony Velkov and Chongshan Dai
Biomolecules 2024, 14(11), 1460; https://doi.org/10.3390/biom14111460
Full text available online: https://www.mdpi.com/2218-273X/14/11/1460
30 October 2025
Biomolecules | Highly Cited Papers in 2024–2025 in the “Molecular Biophysics: Structure, Dynamics, and Function” Section
All of the articles published in our journal are open access, granting our readers free and unlimited access to the full texts. We welcome you to read our most highly cited papers published in 2024 and 2025, which are listed below:
1. “Phenotypic Heterogeneity, Bidirectionality, Universal Cues, Plasticity, Mechanics, and the Tumor Microenvironment Drive Cancer Metastasis”
by Claudia Tanja Mierke
Biomolecules 2024, 14(2), 184; https://doi.org/10.3390/biom14020184
Full text available online: https://www.mdpi.com/2218-273X/14/2/184
2. “Epigenetic Properties of Compounds Contained in Functional Foods Against Cancer”
by Giulia Casari, Brenda Romaldi, Andrea Scirè, Cristina Minnelli, Daniela Marzioni, Gianna Ferretti and Tatiana Armeni
Biomolecules 2025, 15(1), 15; https://doi.org/10.3390/biom15010015
Full text available online: https://www.mdpi.com/2218-273X/15/1/15
3. “Integrating Computational Design and Experimental Approaches for Next-Generation Biologics”
by Ahrum Son, Jongham Park, Woojin Kim, Wonseok Lee, Yoonki Yoon, Jaeho Ji and Hyunsoo Kim
Biomolecules 2024, 14(9), 1073; https://doi.org/10.3390/biom14091073
Full text available online: https://www.mdpi.com/2218-273X/14/9/1073
4. “Recent Advances in Metalloproteomics”
by James P. C. Coverdale, Sirilata Polepalli, Marco A. Z. Arruda, Ana B. Santos da Silva, Alan J. Stewart and Claudia A. Blindauer
Biomolecules 2024, 14(1), 104; https://doi.org/10.3390/biom14010104
Full text available online: https://www.mdpi.com/2218-273X/14/1/104
5. “Structure and Dynamics of the Bacterial Flagellar Motor Complex”
by Shuichi Nakamura and Tohru Minamino
Biomolecules 2024, 14(12), 1488; https://doi.org/10.3390/biom14121488
Full text available online: https://www.mdpi.com/2218-273X/14/12/1488
6. “Bacterial Decontamination of Water-Containing Objects Using Piezoelectric Direct Discharge Plasma and Plasma Jet”
by Evgeny M. Konchekov, Victoria V. Gudkova, Dmitriy E. Burmistrov, Aleksandra S. Konkova, Maria A. Zimina, Mariam D. Khatueva, Vlada A. Polyakova, Alexandra A. Stepanenko, Tatyana I. Pavlik, Valentin D. Borzosekov et al.
Biomolecules 2024, 14(2), 181; https://doi.org/10.3390/biom14020181
Full text available online: https://www.mdpi.com/2218-273X/14/2/181
7. “Ion Signaling in Cell Motility and Development in Dictyostelium discoideum”
by Yusuke V. Morimoto
Biomolecules 2024, 14(7), 830; https://doi.org/10.3390/biom14070830
Full text available online: https://www.mdpi.com/2218-273X/14/7/830
8. “Computational Methods to Predict Conformational B-Cell Epitopes”
by M. Carroll, E. Rosenbaum and R. Viswanathan
Biomolecules 2024, 14(8), 983; https://doi.org/10.3390/biom14080983
Full text available online: https://www.mdpi.com/2218-273X/14/8/983
9. “Chaga Mushroom Triterpenoids Inhibit Dihydrofolate Reductase and Act Synergistically with Conventional Therapies in Breast Cancer”
by Junbiao Wang, Daniela Beghelli, Augusto Amici, Stefania Sut, Stefano Dall’Acqua, Giulio Lupidi, Diego Dal Ben, Onelia Bistoni, Daniele Tomassoni, Barbara Belletti et al.
Biomolecules 2024, 14(11), 1454; https://doi.org/10.3390/biom14111454
Full text available online: https://www.mdpi.com/2218-273X/14/11/1454
10. “Ubiquitin-Specific Protease Inhibitors for Cancer Therapy: Recent Advances and Future Prospects”
by Mohamad Bakkar, Sara Khalil, Komal Bhayekar, Narva Deshwar Kushwaha, Amirreza Samarbakhsh, Sadaf Dorandish, Holly Edwards, Q. Ping Dou, Yubin Ge and Navnath S. Gavande
Biomolecules 2025, 15(2), 240; https://doi.org/10.3390/biom15020240
Full text available online: https://www.mdpi.com/2218-273X/15/2/240
30 October 2025
Biomolecules | Highly Cited Papers in 2024–2025 in the “Molecular Biomarkers” Section
All of the articles published in our journal are open access, granting our readers free and unlimited access to the full texts. We welcome you to read our most highly cited papers published in 2024 and 2025, which are listed below:
1. “Extracellular Vesicles as Delivery Vehicles for Non-Coding RNAs: Potential Biomarkers for Chronic Liver Diseases”
by Arianna Ferro, Gabriele Saccu, Simone Mattivi, Andrea Gaido, Maria Beatriz Herrera Sanchez, Shafiul Haque, Lorenzo Silengo, Fiorella Altruda, Marilena Durazzo and Sharmila Fagoonee
Biomolecules 2024, 14(3), 277; https://doi.org/10.3390/biom14030277
Full text available online: https://www.mdpi.com/2218-273X/14/3/277
2. “Unravelling the Gut Microbiome Role in Cardiovascular Disease: A Systematic Review and a Meta-Analysis”
by Diana Martins, Cláudia Silva, António Carlos Ferreira, Sara Dourado, Ana Albuquerque, Francisca Saraiva, Ana Beatriz Batista, Pedro Castro, Adelino Leite-Moreira, António S. Barros et al.
Biomolecules 2024, 14(6), 731; https://doi.org/10.3390/biom14060731
Full text available online: https://www.mdpi.com/2218-273X/14/6/731
3. “Oxidative Stress and Cataract Formation: Evaluating the Efficacy of Antioxidant Therapies”
by Merve Kulbay, Kevin Y. Wu, Gurleen K. Nirwal, Paul Bélanger and Simon D. Tran
Biomolecules 2024, 14(9), 1055; https://doi.org/10.3390/biom14091055
Full text available online: https://www.mdpi.com/2218-273X/14/9/1055
4. “Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death”
by Shudan Wang, Francesca Kahale, Amirreza Naderi, Pier Luigi Surico, Jia Yin, Thomas Dohlman, Yihe Chen and Reza Dana
Biomolecules 2024, 14(2), 169; https://doi.org/10.3390/biom14020169
Full text available online: https://www.mdpi.com/2218-273X/14/2/169
5. “Toward Precision Medicine: Exploring the Landscape of Biomarkers in Acute Kidney Injury”
by Nicole Nourie, Rita Ghaleb, Carmen Lefaucheur and Kevin Louis
Biomolecules 2024, 14(1), 82; https://doi.org/10.3390/biom14010082
Full text available online: https://www.mdpi.com/2218-273X/14/1/82
6. “Advances in Sjögren’s Syndrome Dry Eye Diagnostics: Biomarkers and Biomolecules beyond Clinical Symptoms”
by Kevin Y. Wu, Olivia Serhan, Anne Faucher and Simon D. Tran
Biomolecules 2024, 14(1), 80; https://doi.org/10.3390/biom14010080
Full text available online: https://www.mdpi.com/2218-273X/14/1/80
7. “LILRB4 Checkpoint for Immunotherapy: Structure, Mechanism and Disease Targets”
by Zhiqing Xiang, Xiangli Yin, Leiyan Wei, Manqing Peng, Quan Zhu, Xiaofang Lu, Junshuang Guo, Jing Zhang, Xin Li and Yizhou Zou
Biomolecules 2024, 14(2), 187; https://doi.org/10.3390/biom14020187
Full text available online: https://www.mdpi.com/2218-273X/14/2/187
8. “Biomarkers in Cerebrospinal Fluid for the Diagnosis and Monitoring of Gliomas”
by Dimosthenis Papadimitrakis, Miltiadis Perdikakis, Antonios N. Gargalionis and Athanasios G. Papavassiliou
Biomolecules 2024, 14(7), 801; https://doi.org/10.3390/biom14070801
Full text available online: https://www.mdpi.com/2218-273X/14/7/801
9. “Molecular Challenges and Opportunities in Climate Change-Induced Kidney Diseases”
by Eder Luna-Cerón, Alfredo Pherez-Farah, Indumathi Krishnan-Sivadoss and Carlos Enrique Guerrero-Beltrán
Biomolecules 2024, 14(3), 251; https://doi.org/10.3390/biom14030251
Full text available online: https://www.mdpi.com/2218-273X/14/3/251
10. “Advances and Challenges in Pediatric Sepsis Diagnosis: Integrating Early Warning Scores and Biomarkers for Improved Prognosis”
by Susanna Esposito, Benedetta Mucci, Eleonora Alfieri, Angela Tinella and Nicola Principi
Biomolecules 2025, 15(1), 123; https://doi.org/10.3390/biom15010123
Full text available online: https://www.mdpi.com/2218-273X/15/1/123
29 October 2025
Welcoming the New Early Career Editorial Board Members of Biomolecules
Biomolecules (ISSN: 2218-273X) is pleased to announce the addition of the following 45 researchers to the 2025 Early Career Editorial Board. We would like to congratulate them on becoming part of the Biomolecules community!
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Name: Dr. Angela-Patricia Hernández |
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Name: Dr. Carla Vitorino |
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Name: Dr. Andrea Angeletti |
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Name: Dr. Zhidong Zhou |
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Name: Dr. Manikandan Selvaraj |
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Name: Dr. Adriana Georgescu |
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Name: Dr. Sean Chia |
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Name: Dr. Marco Casciaro |
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Name: Dr. Anna Cieślińska |
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Name: Dr. Maroula Kokotou |
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Name: Dr. Xavier Gallart-Palau |
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Name: Dr. Michele Scuruchi |
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Name: Dr. Chi Keung Lam |
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Name: Dr. Carmen Cerchia |
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Name: Dr. Camilla Russo |
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Name: Prof. Dr. Grzegorz Janusz |
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Name: Dr. Amarylis Wanschel |
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Name: Dr. Xingbo Xu |
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Name: Dr. Xianrui Yang |
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Name: Dr. Jure Knez |
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Name: Dr. Peng Shao |
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Name: Dr. Franck Chiappini |
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Name: Dr. Beatrice Mihaela Radu |
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Name: Dr. Silvia Nuzzo |
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Name: Dr. Massimo Tusconi |
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Name: Dr. Joy Mitra |
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Name: Dr. Giorgia Miolo |
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Name: Dr. Qiuhua Yang |
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Name: Dr. Clement Agoni |
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Name: Dr. Bala Moku |
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Name: Dr. Marco Piccoli |
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Name: Dr. Avisek Majumder |
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Name: Dr. Tony Z. Jia |
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Name: Dr. Niraj Lodhi |
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Name: Dr. Benesh Joseph |
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Name: Dr. Makram Merimi |
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Name: Dr. Udayakumar Karunakaran |
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Name: Dr. Eleni Tsakiri |
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Name: Dr. Camilla Bean |
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Name: Dr. Mathieu Schwartz |
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Name: Dr. Hongxia Ren |
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Name: Dr. Bi Zhao |
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Name: Dr. Shantanu Kundu |
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Name: Dr. Hewang Lee |
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Name: Dr. Helena Felgueiras |
21 October 2025
Meet Us at the 17th Stem Cell Society Singapore Symposium, 11–14 November 2025, Singapore
MDPI will be exhibiting at the 17th Stem Cell Society Singapore Symposium 2025.
The 17th Stem Cell Society Singapore Symposium 2025 (SCSS 2025) will be held from 11 to 14 November 2025 at Matrix Building, Biopolis, Singapore. The conference is organized by the Stem Cell Society Singapore (SCSS).
This exciting event will bring together leading experts, researchers, and professionals in the biological science field to share their knowledge, present their latest discoveries, and provide valuable networking opportunities.
The following MDPI journals will be represented:
If you are planning to attend the conference, please do not hesitate to start an online conversation with us. Our delegates look forward to meeting you in person and answering any questions that you may have. For more information about the conference, please visit the following website: https://www.stemcell.org.sg/symposium2025.html.




















































