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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular and Molecular Biology of Neurodevelopment

edited by

David M. Feliciano

submission deadline 15 Jul 2026 | 5 articles | Viewed by 12588 | Submission Open

Keywords: neural stem cells; neuroblasts; neurons; glia; microglia; molecular pathways; genes; mutations; pharmacology; toxicology; neurodevelopment; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Biology)

The Role of Calcium Signaling in Cardiac and Skeletal Muscle

edited by

Andreas Rinne

and

Florentina Pluteanu

submission deadline 15 Jul 2026 | 4 articles | Viewed by 10711 | Submission Open

Keywords: striated muscle; Ca2+ signaling; excitation–contraction coupling; remodeling; inflammation

(This special issue belongs to the Section Molecular Biology)

Advances in Computational Biology of Intrinsically Disordered Proteins

edited by

Paul Harrison

submission deadline 15 Jul 2026 | 1 articles | Viewed by 3295 | Submission Open

Keywords: intrinsic disorder; compositional bias; prions; protein annotation; protein simulation

(This special issue belongs to the Section Bioinformatics and Systems Biology)

The Role of DNA Methylation, Histone Modifications and MicroRNA in Cancer

edited by

Joanna Szczepanek

submission deadline 15 Jul 2026 | Viewed by 353 | Submission Open

Keywords: epigenetic regulation; DNA methylation; histone modifications; microRNA; cancer progression; therapeutic resistance; tumor suppressor genes; oncogenic reprogramming; personalized cancer therapy; epigenetic therapy

(This special issue belongs to the Section Molecular Genetics)

Molecular Regulation of Biomaterials and Engineering for Skeletal and Cartilage Regeneration

edited by

Young Yul Kim

submission deadline 15 Jul 2026 | Viewed by 205 | Submission Open

Keywords: biomaterials; molecular regulation; skeletal regeneration; cartilage regeneration; cell–matrix interaction; osteogenesis and chondrogenesis; mechanotransduction; immunomodulation; translational regenerative medicine

(This special issue belongs to the Section Bio-Engineered Materials)

Mechanisms of RNA Regulation in Inflammation

edited by

Roopa Biswas

submission deadline 17 Jul 2026 | 1 articles | Viewed by 2111 | Submission Open

Keywords: inflammation; inflammatory diseases; non-coding RNAs; microRNAs (miRNAs); circular RNAs; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Genetics)

Regulation of Synapses in the Brain

edited by

Kunwei Wu

and Guohao Wang

submission deadline 17 Jul 2026 | 1 articles | Viewed by 1815 | Submission Open

Keywords: synaptic plasticity; neurodevelopmental disorders; glial cells; synaptic formation; learning and memory; neuroinflammation; neurodegenerative diseases; extracellular matrix; synaptic dysfunction; therapeutic interventions

(This special issue belongs to the Section Molecular Biology)

Protein Acetylation and Methylation—from Gene Regulation to Epigenetics, Metabolism, and Beyond

edited by

Kangling Zhang

submission deadline 17 Jul 2026 | Viewed by 287 | Submission Open

Keywords: protein acetylation; protein methylation; histone modification; epigenetics; gene regulation; chromatin remodeling; metabolism; signal transduction; post-translational modification (PTM); proteomics; cancer biology; systems biology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Mechanisms of Metabolic Regulation Used by G Protein-Coupled Receptors

edited by

Hongxia Ren

and Jason M. Conley

submission deadline 20 Jul 2026 | 5 articles | Viewed by 16412 | Submission Open

Keywords: diabetes; obesity; metabolism; GPCR; signaling

(This special issue belongs to the Section Molecular Biology)

Skeletal Muscle in Health, Exercise and Aging

edited by Barbara Munz

submission deadline 20 Jul 2026 | 3 articles | Viewed by 12416 | Submission Open

Keywords: skeletal muscle; molecular mechanisms of exercise adaptation; aging; cachexia; sarcopenia

(This special issue belongs to the Section Molecular Biology)

Barrier Formation and Homeostasis in the Vertebrate Brain

edited by

Ramani Ramchandran

Karthikeyan Thirugnanam

and

Ankan Gupta

submission deadline 20 Jul 2026 | 3 articles | Viewed by 10425 | Submission Open

Keywords: brain endothelial cell; pericytes; choroid plexus; retina; lymphatic; blood; astrocytes; oligodendrocytes; brain ventricle; microglia

(This special issue belongs to the Section Cellular Biochemistry)

Recent Advances in Cellular and Non-Cellular Treatment of Stroke

edited by

David T. Harris

submission deadline 20 Jul 2026 | 1 articles | Viewed by 6583 | Submission Open

Keywords: stroke; treatment; therapy; biomolecules; stem cells

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in Chromatin and Chromosome Molecular Research

edited by Xin Bi

submission deadline 20 Jul 2026 | 3 articles | Viewed by 5762 | Submission Open

Keywords: chromatin; chromosome; genome; molecular mechanisms; regulation

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Wound Repair and Regeneration: From Molecular and Cellular Mechanisms to New Approaches

edited by Elia Ranzato

submission deadline 20 Jul 2026 | 3 articles | Viewed by 3090 | Submission Open

Keywords: wound repair; tissue regeneration; molecular mechanisms; cellular mechanisms; chronic wounds; fibrosis/scarring; biomaterials; stem cells; translational therapies

(This special issue belongs to the Section Molecular Medicine)

Advances in Type 2 Diabetes: Molecular Mechanisms and Therapeutic Innovations

edited by Orien L. Tulp

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1538 | Submission Open

Keywords: type 2 diabetes (T2DM); insulin resistance; GLUT4; sirtuins; epigenetic expression; nutrition; pharmacotherapeutics

(This special issue belongs to the Section Molecular Medicine)

Protein Structure Prediction in Drug Discovery, 3rd Edition

edited by

Alessandro Paiardini

submission deadline 20 Jul 2026 | Viewed by 356 | Submission Open

Keywords: protein structure prediction; drug design; docking; virtual screening; drug discovery; machine learning; alphafold

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Signaling Pathways of 5-HT Receptors in Neuropsychiatric Disorders

edited by

Abdeslam Chagraoui

and

Philippe De Deurwaerdère

submission deadline 20 Jul 2026 | Viewed by 324 | Submission Open

Keywords: serotonin; 5-HT Receptors; allostery; allosteric modulators; synaptic plasticity; psychedelics; non-hallucinogenic agonists; RNA editing; Akt; GSK3; ERK; PI3K; mTOR; microglia; neuroinflammation; dopamine; glutamate; prefrontal cortex; hippocampus; nucleus accumbens; depression; schizophrenia; anxiety; addictions; cognition; biosensors; cryo-EM; phospho-proteomics

(This special issue belongs to the Section Molecular Medicine)

Multi-Scale Integrative Radiobiology

edited by

Nicolas Foray

submission deadline 20 Jul 2026 | Viewed by 284 | Submission Open

Keywords: integrative radiobiology; radiosensitivity; radiosusceptibility; radiodegeneration; radiation-induced energy microdepositions; radiation-induced radical oxygen species; radiation-induced DNA damage; DNA damage recognition and repair; radiation-induced tissue injuries; radiation-induced risks

(This special issue belongs to the Section Molecular Biology)

p53 Family: The Molecular Landscape in Cancer and Beyond

edited by

Paola Tucci

and Michele Pellegrino

submission deadline 24 Jul 2026 | 1 articles | Viewed by 1683 | Submission Open

Keywords: p53 family; microRNA; tumorigenesis; aging; neurodegenerative diseases; immune regulation; biomarkers; therapy

(This special issue belongs to the Section Molecular Biology)

Computational Analysis and Conformational Modeling for Protein Structure and Interaction: Second Edition

edited by

Clement Agoni

and

Indrani Bera

submission deadline 24 Jul 2026 | 1 articles | Viewed by 829 | Submission Open

Keywords: protein structure prediction; drug discovery targeting proteins; structural bioinformatics; molecular dynamics simulations; protein–protein interactions; protein–ligand binding; conformational dynamics; molecular docking studies

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Insights into Retinal Biology: Focus on Inflammation, Metabolism, and Retinal Dysfunction

edited by

, Qiuhua Yang,

and

submission deadline 24 Jul 2026 | Viewed by 412 | Submission Open

Keywords: inflammation; metabolism; neovascularization; retinal degeneration; photoreceptors; Muller glia; RPE

(This special issue belongs to the Section Molecular Medicine)

New Insights into Integrins: 2nd Edition

edited by

Yoshikazu Takada

submission deadline 25 Jul 2026 | 2 articles | Viewed by 1315 | Submission Open

Keywords: integrins; growth factors; ligands; allosteric binding; inflammation-induced activation

(This special issue belongs to the Section Biological Factors)

Biomaterial Innovations for Tissue Engineering and Regeneration

edited by

Maria Chatzinikolaidou

submission deadline 30 Jul 2026 | 2 articles | Viewed by 4187 | Submission Open

Keywords: biomaterials; tissue engineering; regenerative medicine; cellular responses; 3D pathophysiological tissue models

(This special issue belongs to the Section Bio-Engineered Materials)

Biomarkers in Musculoskeletal and Orthopedic Disorders

edited by

Elena De Vecchi

submission deadline 30 Jul 2026 | 1 articles | Viewed by 1168 | Submission Open

Keywords: musculo-skeletal pathologies; orthopaedic infections; synovial fluid analysis

(This special issue belongs to the Section Molecular Biomarkers)

Cardiometabolic Disease: Molecular Basis and Therapeutic Approaches

edited by

Nikolaos Theodorakis

and Maria Nikolaou

submission deadline 31 Jul 2026 | 5 articles | Viewed by 36513 | Submission Open

Keywords: cardiometabolic medicine; preventive cardiology; cardiovascular endocrinology and metabolism; obesity; diabetes mellitus; cardiovascular disease

(This special issue belongs to the Section Molecular Medicine)

The Role of Mechanotransduction in Cellular Biology

edited by

Frederick H. Silver

submission deadline 31 Jul 2026 | 4 articles | Viewed by 18174 | Submission Open

Keywords: cell membrane; cytosol; nuclear membrane; integrin; mechanotransduction; map kinase pathway; ERKs; JNKs; p38/SAPKs; YAP/TAZ; Hippo pathway

(This special issue belongs to the Section Cellular Biochemistry)

Cysteine and Selenocysteine in Antioxidant Defense, Protein Synthesis and Signaling Pathways

edited by

Maria Wrobel

and

Halina Jurkowska

submission deadline 31 Jul 2026 | 4 articles | Viewed by 12615 | Submission Open

Keywords: cysteine; selenocysteine; taurine; hydrogen sulfide; hydrogen selenide; selenoproteins; sulfurtransferases; H2S precursors; antioxidants; diseases related to sulfur metabolism

(This special issue belongs to the Section Molecular Biology)

Molecular Basis of Mast Cells Activation and Medical Implications

edited by

Grzegorz Porebski

and

Matija Rijavec

submission deadline 31 Jul 2026 | 5 articles | Viewed by 9904 | Submission Open

Keywords: mast cells; allergy; immediate hypersensitivity; molecular mechanisms

(This special issue belongs to the Section Biological Factors)

Molecular Advances in Platelet Disease, Thrombosis and Hemostasis

edited by

José Rivera

submission deadline 31 Jul 2026 | 3 articles | Viewed by 9432 | Submission Open

Keywords: platelets; hemostasis and thrombosis; inherited platelet disorders; coagulation; immunothrombosis; miRNA; GPVI; Runx1; antiplatelet therapy

(This special issue belongs to the Section Molecular Biology)

Exerkines as Mediators of Exercise Benefits: Mechanisms, Functions and Applications

edited by

Sara Missaglia

and Eleonora Martegani

submission deadline 31 Jul 2026 | 7 articles | Viewed by 8154 | Submission Open

Keywords: exerkines; myokines; adipokines; cytokines; exercise-induced benefits

(This special issue belongs to the Section Molecular Biology)

Non-Invasive Biomarkers in Saliva or Urine: Technical and Biological Variability

edited by

Peter Celec

submission deadline 31 Jul 2026 | 2 articles | Viewed by 7796 | Submission Open

Keywords: saliva; urine; non-invasive diagnostics; screening; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Novel Mechanisms of Bacterial Antibiotic Resistance

edited by

Dorothea K. Thompson

submission deadline 31 Jul 2026 | 3 articles | Viewed by 6045 | Submission Open

Keywords: molecular mechanisms of antibiotic resistance; bacterial resistome acquired and intrinsic; drug resistance antibiotic modification/degradation; antibiotic efflux; antibiotic target modification antibiotic permeability; antibiotic sequestration proteins; beta-lactamases; bioinformatic and phylogenetic approaches

(This special issue belongs to the Section Biological Factors)

Updates on Mitochondria and Cancer

edited by

Antonella Cormio

and

Clara Musicco

submission deadline 31 Jul 2026 | 3 articles | Viewed by 5982 | Submission Open

Keywords: mitochondrial dysfunction in cancer; mitochondrial metabolomics; mitochondria and cancer therapy; mitochondria and cancer drug resistance; prognostic/predictive mitochondrial markers in cancer tissues and body fluids

(This special issue belongs to the Section Biological Factors)

Functional Peptides and Their Interactions (3rd Edition)

edited by

Mikhail Soloviev

and

Simon M. Cutting

submission deadline 31 Jul 2026 | 3 articles | Viewed by 5496 | Submission Open

Keywords: peptides; antimicrobial peptides; immunomodulatory peptides; neuropeptides; signaling peptides; regulatory peptides; cyclic peptides; peptidomics; peptide profiling; peptoids; peptide engineering; peptide docking; peptide therapeutics; peptide self-assembly; biomaterials; biocatalysts; small proteins

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Function and Regulation of Hyaluronan and Hyalectins in Disease

edited by

Edward N. Harris

and

Michele T. Pritchard

submission deadline 31 Jul 2026 | 5 articles | Viewed by 4936 | Submission Open

Keywords: hyaluonan; glycosaminoglycan; hyalectan; cancer; extracellular matrix; cellular signaling

(This special issue belongs to the Section Chemical Biology)

Epigenetic Programming of Cellular States

edited by

Benjamin Carone

submission deadline 31 Jul 2026 | 2 articles | Viewed by 3019 | Submission Open

Keywords: iPSCs; stem cells; reprogramming; chromatin; epigenetics

Ion Channels in Cardiovascular and Metabolic Diseases

edited by

Shang-Zhong Xu

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2764 | Submission Open

Keywords: Na+ channel; Ca2+ channel; K+ channel; TRP channel; store-operated channel; Cl− channel; cation channel; ryanodine receptor; mechanosenstive channels; piezo channels; SGLT-1 transporters; membrane transporters

(This special issue belongs to the Section Biological Factors)

Heterocyclic Compounds: Synthesis, Characterization, and Validation

edited by

Monika Pitucha

submission deadline 31 Jul 2026 | 3 articles | Viewed by 2502 | Submission Open

Keywords: heterocyclic compounds; synthesis; spectroscopy; molecular modeling; biological activity; radiopharmaceuticals

(This special issue belongs to the Section Chemical Biology)

Molecular Mechanism and Regulation of Adipogenesis, Adipose Tissue Inflammation and Metabolism

edited by Udai P. Singh

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1922 | Submission Open

Keywords: immunometabolism; obesity; adipogenesis; adipose tissue inflammation; adipose immune microenvironment; immune-adipose tissue cross-talk; hormones; high-fat diet; metabolic disease

(This special issue belongs to the Section Biological Factors)

Alcohol Consumption as a Cardiovascular Risk Factor: Focusing on Molecular Mechanisms

edited by

Ichiro Wakabayashi

and

Klaus Groschner

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1663 | Submission Open

Keywords: alcohol; ethanol metabolism; ethanol–protein interactions; ethanol–membrane interactions; cardiovascular health and disease

(This special issue belongs to the Section Molecular Medicine)

VDAC1 as a Hub Protein–Modulation of VDAC1-Mediated Prograde Cell Death, Metabolism, Inflammation and Immunity via Interacting Proteins, Metabolites and Small Molecules

edited by Jay H. Chung and

Vito De Pinto

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1355 | Submission Open

Keywords: apoptosis; binding sites; ferroptosis; inflammation; metabolism; mitochondria; oxidative strass; pyroptosis; small molecules; VDAC

(This special issue belongs to the Section Cellular Biochemistry)

Immunofluorescent Techniques in Animal Stem Cell Research

edited by

Jaromír Vašíček

and Andrea Svoradová

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1339 | Submission Open

Keywords: animal stem cells; fluorescence/confocal microscopy; flow cytometry; fluorescence-activated cell sorting; fluorescent protein assay; stem cell markers; cell therapy; drug screening; exosomes; DNA analysis

(This special issue belongs to the Section Molecular Biology)

Genetic and Epigenetic Mechanisms Underlying Neurodevelopmental Disorders

edited by

Andrea L. Gropman

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1213 | Submission Open

Keywords: neurodevelopmental disorders; epigenetics; gene–environment interaction; chromatin remodeling; neurogenomics

(This special issue belongs to the Section Molecular Genetics)

CRISPR-Directed Gene Editing: Molecular Approaches to Cancer Therapeutics

edited by

Eric B. Kmiec

and

Kelly Banas

submission deadline 31 Jul 2026 | 1 articles | Viewed by 898 | Submission Open

Keywords: CRISPR; gene editing; genome engineering; cancer therapy; solid tumors; precision medicine; translational research; functional genomics; tumor-specific targeting; CRISPR diagnostics; off-target effects

(This special issue belongs to the Section Molecular Medicine)

Exploration of Drug Targets for Liver Fibrosis Based on Hepatic Stellate Cells and Extracellular Matrix Remodeling

edited by

Nadezda Apostolova

submission deadline 31 Jul 2026 | 1 articles | Viewed by 780 | Submission Open

Keywords: liver fibrosis; collagen; hepatic stellate cells; senescence; animal models; extracellular matrix; hepatitis; cytokines; biomarkers; MASH; MASLD; cirrhosis; hepatocellular carcinoma

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms of Skeletal Muscle Growth and Loss in Health, Aging, and Disease

edited by

Khaled Kamal

submission deadline 31 Jul 2026 | Viewed by 695 | Submission Open

Keywords: skeletal muscle; muscle growth and atrophy; metabolic signaling (anabolic/catabolic); mechanotransduction; redox biology and oxidative stress; inflammation and immune signaling; obesity and metabolic disease; sarcopenia and aging; cachexia and neuromuscular disease; extracellular vesicles and exosomes

(This special issue belongs to the Section Molecular Biology)

Therapeutics Targeting Pathogenic Mechanisms of Leishmaniasis

edited by

Kwang Poo Chang

submission deadline 31 Jul 2026 | Viewed by 597 | Submission Open

Keywords: leishmaniasis; host–parasite interactions; pathogenicity; precision medicine; AI-assisted development of therapeutics

Advances in Molecular Therapy Targeting DNA Damage and Repair Systems

edited by

Joy Mitra

Anirban Chakraborty

and Anahita Mojiri

submission deadline 31 Jul 2026 | Viewed by 551 | Submission Open

Keywords: DNA repair; DNA repair inhibitors; homologous recombination; genome instability; inflammation; DNA damage; cell death; apoptosis

(This special issue belongs to the Section Biological Factors)

Molecular Biology and Therapy of Breast Cancer

edited by

Norbert Nass

submission deadline 31 Jul 2026 | Viewed by 441 | Submission Open

Keywords: breast cancer; molecular pathology; biomarkers; novel therapy targets; personalized therapy; immunotherapy; tumor microenvironment; tumor stem cells; therapy resistance; non-coding RNA

Nanotechnology in Agriculture and the Environment: From Molecular Mechanisms to Sustainable Applications

edited by

Nubia Zuverza-Mena

and Luis Hernandez-Adame

submission deadline 31 Jul 2026 | Viewed by 385 | Submission Open

Keywords: nanotechnology; molecular mechanisms; biomolecules; environment; sustainable agriculture

(This special issue belongs to the Section Bio-Engineered Materials)

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