Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Unraveling the Complexity of the Human Spliceosome and RNA Splicing
edited by Liliana Florea
submission deadline 30 Jul 2024 | Viewed by 229 | Submission Open
Keywords: spliceosome; splicing regulation; RNA splicing in human physiology and development; computational modelling
(This special issue belongs to the Section Biomacromolecules: Nucleic Acids)
Pathogenesis and Potential Treatments of Neurointestinal Diseases submission deadline 31 Jul 2024 | 10 articles | Viewed by 15968 | Submission Open
Keywords: enteric nervous system; gastrointestinal motility; enteric neuropathies; neurogenesis; regeneration; brain– gut axis; development
(This special issue belongs to the Section Molecular Medicine)
Stress, Aging and Metabolism
edited by
submission deadline 31 Jul 2024 | 3 articles | Viewed by 10066 | Submission Open
Keywords: DNA damage; oxidative stress; aging; lifespan; healthspan; metabolism; stress-induced molecules and their functions; autophagy; exercise; nutritional restriction
(This special issue belongs to the Section Molecular Medicine)
Defects in the Transport Mechanism of Membrane Proteins and Related Diseases submission deadline 31 Jul 2024 | 5 articles | Viewed by 8011 | Submission Open
Keywords: function; structure and folding of membrane transport proteins; pathological mutations; mechanism of transport; neurological and metabolic disease; transport of nanoparticles; organelle membranes; cellular function and signaling; bioenergetics; neuroinflammation; nanoformulations for drug targets
(This special issue belongs to the Section Cellular Biochemistry)
The Role of Tumor Microenvironment in the Pathogenesis and Progression of Hematological Malignancies
edited by
submission deadline 31 Jul 2024 | 3 articles | Viewed by 7131 | Submission Open
Keywords: inflammation; metabolic rewiring; epigenetics; mesenchymal stromal cells; immune cells; immune-escape
(This special issue belongs to the Section Molecular Medicine)
Molecular Research in Uterine Physiology and Pathology submission deadline 31 Jul 2024 | 3 articles | Viewed by 5393 | Submission Open
Keywords: endometrium; myometrium; endometriosis; uterine disorders; uterine molecular alterations; reproduction; implantation; endometrial cancer; uterine fluid; adenomyosis; leiomyoma; endometritis
(This special issue belongs to the Section Molecular Medicine)
NMDA Receptor in Health and Diseases: 2nd Edition
edited by
submission deadline 31 Jul 2024 | 3 articles | Viewed by 5299 | Submission Open
(This special issue belongs to the Section Molecular Biology)
The Value of Natural Compounds as Therapeutic Agents II submission deadline 31 Jul 2024 | 3 articles | Viewed by 4780 | Submission Open
Keywords: natural compound; acute and chronic conditions; cell proliferation; cell death; cell differentiation
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Biomarkers in Renal Diseases Ⅱ submission deadline 31 Jul 2024 | 2 articles | Viewed by 4574 | Submission Open
Keywords: biomarkers; acute kidney injury; chronic kidney disease; microvesicles; exosomes
(This special issue belongs to the Section Molecular Biomarkers)
H2S, Polysulfides, and Enzymes: Physiological and Pathological Aspects: 2nd Edition submission deadline 31 Jul 2024 | 2 articles | Viewed by 4042 | Submission Open
Keywords: H2S  and polysulfide; H2S  in inflammation; H2S  in brain; heart; liver; kidney; and pulmonary diseases; H2S  in cancer cells; H2S  in the pathogenesis of diabetes; H2S  and polysulfides biosynthetic enzymes; H2S  precursors
(This special issue belongs to the Section Molecular Medicine)
Mitochondrial Proteins: From Import and Biogenesis to Complex Functional Network submission deadline 31 Jul 2024 | 1 articles | Viewed by 3904 | Submission Open
Keywords: mitochondrial proteins; import; biogenesis; metabolism; functional network; oxidative stress; small molecules; mitochondrial protein quality control; mitophagy
(This special issue belongs to the Section Biomacromolecules: Proteins)
Advanced Glycation End-Products (AGEs): Receptors, Signalling Pathways, and Anti-AGE Therapies
edited by Maria Koziołkiewicz and Aleksandra Twarda-Clapa
submission deadline 31 Jul 2024 | 2 articles | Viewed by 3652 | Submission Open
Keywords: advanced glycation end-products; AGEs; AGE receptors; anti-AGE therapies; RAGE; scavenger receptors; AGE-related diseases; signalling pathways
(This special issue belongs to the Section Biomacromolecules: Carbohydrates)
Molecular Aspects of Diseases Origin and Development
edited by
submission deadline 31 Jul 2024 | 2 articles | Viewed by 2994 | Submission Open
Emerging Biomarkers Discovery for Molecular Diagnostics
edited by , Masaki Shimizu and
submission deadline 31 Jul 2024 | 2 articles | Viewed by 1919 | Submission Open
Keywords: emerging biomarkers; pre-clinical; molecular diagnostics; deep sequencing; omics; personalized medicine; precision medicine; targeted therapy; prognosis
(This special issue belongs to the Section Molecular Biomarkers)
Esophageal Diseases: Molecular Basis and Therapeutic Approaches
edited by and Amanda B. Muir
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1526 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
The Genomics Era: From Reference Genomes to Pan-Genomic Approach II
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1444 | Submission Open
Keywords: pangenome; genome evolution; graph-based pangenome; core and dispensable genomes; human genomics; metagenomics; transcriptome; structural variation
(This special issue belongs to the Section Molecular Genetics)
Recent Advances in the Isolation, Chemical and Biological Characterization and Synthesis of Bioactive Metabolites from Plants submission deadline 31 Jul 2024 | 1 articles | Viewed by 1264 | Submission Open
Keywords: plants; bioactive metabolite; natural analogues; chemical and biological characterization; synthesis; synthetic intermediates and derivatives
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Molecular Mechanisms and Biomedical Applications of Virus Entry
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 600 | Submission Open
Keywords: heparan sulfate; virus entry; virus– host cell interactions; virus cell-to-cell fusion
New Insights into Diseases with Cognitive Impairment: Development, Genesis, and Treatment
edited by
submission deadline 31 Jul 2024 | Viewed by 331 | Submission Open
Keywords: dementia; brain; biomarkers
Natural Products in Chemo- or Hormone Therapy: 2nd Edition
edited by
submission deadline 31 Jul 2024 | Viewed by 286 | Submission Open
Keywords: natural compounds; chemotherapy; hormone therapy; cancer; phytochemicals; combination
(This special issue belongs to the Section Natural and Bio-derived Molecules)
The Role of Oxidative Stress in Ovarian Cancer submission deadline 31 Jul 2024 | Viewed by 198 | Submission Open
Keywords: ovarian cancer; reactive oxygen species (ROS); metastasis; antioxidant; oxidative stress; chemotherapeutic resistance; inflammation
(This special issue belongs to the Section Molecular Medicine)
Advances in Cancer and Glycosylation
edited by
submission deadline 31 Jul 2024 | Viewed by 191 | Submission Open
Keywords: glycosylation; glycobiology; N-glycans; O-glycans; glycosyltransferases; glycosidases
(This special issue belongs to the Section Molecular Medicine)
Role of the Immune System in Mycobacterial Infection
edited by Auriol Purdie
submission deadline 31 Jul 2024 | Viewed by 182 | Submission Open
Keywords: mycobacterial infections; host immune response; livestock species; zoonotic transmission; cross-species dynamics; macrophages; dendritic cells; T lymphocytes; pro-inflammatory signals; anti-inflammatory signals; immunomodulation; host genetic factors; veterinary immunology; animal health; tuberculosis in livestock; Johne’ s disease (Mycobacterium avium subsp. paratuberculosis); bovine tuberculosis (Mycobacterium bovis); avian tuberculosis (Mycobacterium avium); immune evasion mechanisms; comparative immunology; innate immunity; adaptive immunity; one health approach
Neurocognitive Disorders: From Molecular Mechanisms to Therapeutic Strategies
edited by Mbemba Jabbi
submission deadline 31 Jul 2024 | Viewed by 178 | Submission Open
Keywords: neurocognition; molecular mechanisms; brain anatomy; disease
(This special issue belongs to the Section Molecular Medicine)
Role of the ABI1 Gene in Cancers
edited by Leszek Kotula
submission deadline 31 Jul 2024 | Viewed by 141 | Submission Open
Keywords: ABI1 cancer EMT cell signaling actin cytoskeleton 
(This special issue belongs to the Section Molecular Genetics)
Exploring the Dynamics of Protein Lysine Methylation and Its Implication in Disease
edited by Kyle K. Biggar
submission deadline 1 Aug 2024 | 3 articles | Viewed by 1459 | Submission Open
Keywords: protein regulation; disease mechanisms; biomarkers and therapeutic targets; cellular signaling; mass spectrometry
(This special issue belongs to the Section Biomacromolecules: Proteins)
DNA Methylation in Human Diseases submission deadline 15 Aug 2024 | 6 articles | Viewed by 9795 | Submission Open
Keywords: DNA methylation alterations; DNA methylation profiling; DNMT aberrations; TET aberrations; DNA methylation machinery; DNA methylation biomarkers; DNA methylation reprogramming
(This special issue belongs to the Section Biomacromolecules: Nucleic Acids)
Extracellular Vesicles as Biomarkers of Diseases submission deadline 15 Aug 2024 | 4 articles | Viewed by 6205 | Submission Open
Keywords: extracellular vesicles; metabolic syndrome; cancer; cardiovascular diseases; neurodegenerative diseases; biomarkers
(This special issue belongs to the Section Molecular Biomarkers)
What Is the Weight of Epigenetic Inheritance over Generations? submission deadline 15 Aug 2024 | 2 articles | Viewed by 4183 | Submission Open
Keywords: genetic; epigenetic; transcripts variation; diseases; model organisms
(This special issue belongs to the Section Molecular Genetics)
The Role of Metals Ions in Neurodegenerative Diseases
edited by Imre Sòvágó
submission deadline 15 Aug 2024 | 1 articles | Viewed by 783 | Submission Open
Keywords: Alzheimer’ s disease; Parkinson’ s disease; metal complexes; amyloid-beta; peptide fragments of prion and tau proteins
The Role of Scaffold Proteins in Human Diseases
edited by László Buday and
submission deadline 15 Aug 2024 | Viewed by 226 | Submission Open
Keywords: scaffold proteins; cellular signalling; protein– protein interactions; protein domains; human diseases; drug targets; protein complex formation; pathogenic alterations
Mechanisms of Schizophrenia: Insights to Unlock the Brain Puzzle and Generate Effective Antipsychotic Drugs
edited by Tatiana V. Lipina
submission deadline 15 Aug 2024 | Viewed by 34 | Submission Open
Keywords: animal models of schizophrenia; antipsychotic drugs; brain; genes; D2R
Advances in Melanoma Targeted Therapy
edited by
submission deadline 20 Aug 2024 | 2 articles | Viewed by 4846 | Submission Open
Keywords: melanoma; drug discovery; new targets; target discovery
(This special issue belongs to the Section Molecular Medicine)
Advances in the Molecular Mechanisms of Inflammatory Arthritis and Inflammation-Related Bone Changes submission deadline 20 Aug 2024 | 2 articles | Viewed by 3401 | Submission Open
Keywords: inflammatory arthritis; molecular mechanisms; bone changes; osteoimmunology; autoimmunity
(This special issue belongs to the Section Molecular Medicine)
Biotechnological and Biomedical Applications of Enzymes Involved in the Synthesis of Nucleosides and Nucleotides—2nd Edition submission deadline 20 Aug 2024 | 5 articles | Viewed by 2555 | Submission Open
Keywords: biotransformations; biomedicine; enzyme technology; biochemistry; organic chemistry
(This special issue belongs to the Section Enzymology)
Tryptophan-Kynurenine Pathway in Health and Disease submission deadline 20 Aug 2024 | 1 articles | Viewed by 854 | Submission Open
Keywords: tryptophan; kynurenine pathway; kynurenic acid; neuropsychiatric disorders; metabolic disorders
(This special issue belongs to the Section Molecular Medicine)
The Role of Microglia in Aging and Neurodegenerative Disease
edited by
submission deadline 25 Aug 2024 | 2 articles | Viewed by 1186 | Submission Open
Keywords: microglia; neurodegenerative diseases; disease-associated  microglia (DAM); microglia activation; Alzheimer's disease; Parkinson’ s disease; ischemic stroke
(This special issue belongs to the Section Molecular Medicine)
Plant Polyphenols in the Immune and Inflammatory Responses, 2nd Edition 
edited by
submission deadline 25 Aug 2024 | 1 articles | Viewed by 1165 | Submission Open
Keywords: plant polyphenol; bioactivity; immunity; inflammation; molecular mechanism; structure-function relationship
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Role of Thiols in Oxidant-Induced Injuries
edited by
submission deadline 25 Aug 2024 | Viewed by 243 | Submission Open
Keywords: cysteine; sulfhydryl; thiol; antioxidants; reactive oxygen species; free radicals; oxidant-induced injuries
(This special issue belongs to the Section Molecular Biology)
Wnt Pathway Regulation in Development, Stem Cells and Cancer
edited by Marc De La Roche
submission deadline 25 Aug 2024 | Viewed by 241 | Submission Open
Keywords: Wnt pathway regulation and function; metazoan development; stem cells; Wnt pathway driven cancer
(This special issue belongs to the Section Biological Factors)
Connexins, Pannexins, and Homologous Channel-Forming Proteins submission deadline 30 Aug 2024 | 2 articles | Viewed by 3530 | Submission Open
Keywords: gap junctions; hemichannels; connexins; pannexins; innexins; unnexins; paracrine; autocrine
(This special issue belongs to the Section Biomacromolecules: Proteins)
Non-coding RNAs in Human Diseases: Roles and Mechanisms of Action
edited by Lei Jin
submission deadline 30 Aug 2024 | Viewed by 299 | Submission Open
Keywords: non-coding RNAs; human diseases; diagnostic markers; therapeutic targets; prognostic indicators
(This special issue belongs to the Section Molecular Genetics)
Mitochondrial Quality Control in Aging and Neurodegeneration
edited by Sofie Lautrup
submission deadline 31 Aug 2024 | 5 articles | Viewed by 11593 | Submission Open
Keywords: mitochondria; quality control; mitochondrial biogenesis; mitochondrial dynamics; fission; fusion; mitophagy; mitochondrial degradation; cellular metabolism; aging; neurodegeneration; neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease
(This special issue belongs to the Section Cellular Biochemistry)
Advances in Neuroproteomics submission deadline 31 Aug 2024 | 6 articles | Viewed by 11323 | Submission Open
Keywords: discovery mass spectrometry; neuroproteomics; mass spectrometry; quantitative proteomics; targeted mass spectrometry
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Synuclein Proteins II submission deadline 31 Aug 2024 | 6 articles | Viewed by 10414 | Submission Open
Keywords: synuclein native structures & functions; synuclein genetics; tissue expression and regulation of synucleins; synuclein aggregates; animal models of synucleinopathies; synuclein interacting partners; synuclein and neurotransmission; synuclein and neurodegeneration; synuclein and immune responses
(This special issue belongs to the Section Molecular Biology)
Hormonal Control of Plant Growth and Development
edited by
submission deadline 31 Aug 2024 | 2 articles | Viewed by 3698 | Submission Open
Keywords: plant hormones; auxins; cytokinin; gibberellins; ethylene; abscisic acid; jasmonic acid; salicylic acid; peptide hormones; growth and development
(This special issue belongs to the Section Biological Factors)
Advances in Metabolites Produced by Microbiota submission deadline 31 Aug 2024 | 2 articles | Viewed by 2931 | Submission Open
Keywords: microbiota; metabolites; short-chain fatty acids; amino acids; vitamins
(This special issue belongs to the Section Cellular Biochemistry)
Advances in the Pathology of Prostate Cancer
edited by
submission deadline 31 Aug 2024 | 2 articles | Viewed by 2820 | Submission Open
Keywords: prostate cancer; molecular pathology; biomarker; chemoprevention; therapy
(This special issue belongs to the Section Molecular Biology)
New Insight into the Molecular Genetics of Neurodevelopmental Disorders
edited by and Flavio Faletra
submission deadline 31 Aug 2024 | 2 articles | Viewed by 2216 | Submission Open
Keywords: neurodevelopmental disorders; next generation sequencing; pathomechanisms; phenotypic spectra; phenotype-genotype correlation
(This special issue belongs to the Section Molecular Genetics)
Current Advances in ABC Transporters in Physiology and Disease
edited by
submission deadline 31 Aug 2024 | 1 articles | Viewed by 2131 | Submission Open
Keywords: functions; structure; regulation; genetic polymorphisms
(This special issue belongs to the Section Molecular Biology)
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