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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Endothelial Health in Atherosclerosis: From Function to Dysfunction and Beyond

edited by

Yuqi Cui

and Zhenguo Liu

submission deadline 10 Aug 2025 | Viewed by 214 | Submission Open

Keywords: endothelial dysfunction; atherosclerosis; vascular inflammation; oxidative stress; nitric oxide signaling; cardiovascular biomarkers; endothelial repair; lipid metabolism; vascular homeostasis; therapeutic interventions

(This special issue belongs to the Section Molecular Biology)

Circular RNAs: Functions, Applications and Prospects: 2nd Edition

edited by

William W. Du

and Feiya Li

submission deadline 15 Aug 2025 | 2 articles | Viewed by 5468 | Submission Open

Keywords: circular RNAs; circRNA; function; application; disease

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Inflammation—The Surprising Bridge between Diseases

edited by

Manuela Ciocoiu

Minerva Codruta Badescu

and

Iris Bararu-Bojan

submission deadline 15 Aug 2025 | 1 articles | Viewed by 2317 | Submission Open

Keywords: low-grade inflammation; lung inflammation; atherosclerosis; ischemic heart disease; peripheral artery disease; inflammatory bowel disease; fatty liver disease; inflammatory rheumatic diseases; cancer

(This special issue belongs to the Section Molecular Biology)

New Tissue Substitutes and Bioactive Materials and Their Responses in Clinical Use

edited by

Rodolfo Reda

submission deadline 15 Aug 2025 | Viewed by 155 | Submission Open

Keywords: new tissue substitutes; bioactive materials; cellular response

TRP Channels in Cardiovascular and Inflammatory Disease, 2nd Edition

edited by

Susan D. Brain

and Soraia Katia Pereira Costa

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1072 | Submission Open

Keywords: TRP channels; TRP ligands; biological functions; new drugs; cardiovascular diseases; inflammation

(This special issue belongs to the Section Molecular Medicine)

Advances in Plasma Bioscience and Medicine: 2nd Edition

edited by

Yuantao Zhang

and

Maksudbek Yusupov

submission deadline 20 Aug 2025 | 2 articles | Viewed by 980 | Submission Open

Keywords: non-thermal (cold) atmospheric pressure plasma; reactive oxygen and nitrogen species (RONSs); plasma– biomolecule interactions; plasma cancer treatment; plasma immunomodulation; plasma inactivation of viruses; fungi and bacteria; plasma– liquid interactions; computer simulations

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Biochemistry of Wine and Beer, 3rd Edition

edited by

Encarna Gómez-Plaza

and

Rocio Gil-Muñoz

submission deadline 30 Aug 2025 | 4 articles | Viewed by 4372 | Submission Open

Keywords: grape biochemistry; barley and malt biochemistry; role of prefermentative enzymatic reactions; wine and beer’ s fermentation process; aging reactions; phenolic compounds; aroma compounds; protein and nitrogen compounds

(This special issue belongs to the Section Biological Factors)

Bioactive Molecules: Structures, Functions and Potential Uses for Cancer Prevention and Targeted Therapies (2nd Edition)

edited by

Qingping Dou

submission deadline 31 Aug 2025 | 10 articles | Viewed by 22198 | Submission Open

Keywords: small molecules; biomolecules; molecular targeting; natural products; cancer management

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Esophageal Diseases: Molecular Basis and Therapeutic Approaches

edited by

Hiroshi Nakagawa

and Amanda B. Muir

submission deadline 31 Aug 2025 | 6 articles | Viewed by 11957 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

State-of-the-Art of Myology 2024–2025

edited by

Guglielmo Sorci

and

Francesca Riuzzi

submission deadline 31 Aug 2025 | 3 articles | Viewed by 10957 | Submission Open

Keywords: embryonic myogenesis; adult myogenesis; exercise-induced muscle injury; muscular dystrophies and muscle diseases; sarcopenia; cachexia; rhabdomyosarcoma; muscle biophysics

(This special issue belongs to the Section Molecular Biology)

Recent Advances in the Isolation, Chemical and Biological Characterization and Synthesis of Bioactive Metabolites from Plants

edited by

Antonio Evidente

and

Stefano Superchi

submission deadline 31 Aug 2025 | 5 articles | Viewed by 8630 | Submission Open

Keywords: plants; bioactive metabolite; natural analogues; chemical and biological characterization; synthesis; synthetic intermediates and derivatives

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Diet and Immune Response

edited by

Hanne Frøkiær

submission deadline 31 Aug 2025 | 5 articles | Viewed by 6840 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Nanomaterials and Their Applications in Biomedicine

edited by

George Pasparakis

submission deadline 31 Aug 2025 | 5 articles | Viewed by 6811 | Submission Open

Keywords: photothermal and photodynamic therapies and tumor ablation strategies; theranostics and image-guided drug delivery; biosensors; including surface-enhanced Raman scattering and metal-enhanced fluorescence; biosensors; point-of-care diagnostics and lateral-flow tests; controlled drug delivery; including delivery of RNA/DNA and other biologics; additive manufacturing and 3D/4D printing applications; antimicrobials; cell therapeutics and tissue regeneration

(This special issue belongs to the Section Bio-Engineered Materials)

Diabetic Retinopathy: From Pathophysiology to Therapeutic Perspectives

edited by Annayya R. Aroor,

Puttur Santhoshkumar

and Dean P. Hainsworth

submission deadline 31 Aug 2025 | 2 articles | Viewed by 5610 | Submission Open

Keywords: diabetic retinopathy; microvascular injury; neuronal dysfunction; mitochondrial dysfunction; oxidative stress; inflammation; biomarkers; signaling pathways; pharmacological interventions; anti-vegf; gene therapy; stem cell-based therapies; prevention strategies; patient education programs; patient-centered care

(This special issue belongs to the Section Molecular Medicine)

The Role of Astrocytes in Neurodegenerative Diseases

edited by

Nima Sanadgol

submission deadline 31 Aug 2025 | 4 articles | Viewed by 5463 | Submission Open

Keywords: astrocytes; neurodegeneration; neuroinflammation; neuroprotection; neuroregeneration

(This special issue belongs to the Section Cellular Biochemistry)

Chemoinformatics and Molecular Modeling of Pharmacologically Active Biomolecules: A Themed Issue in Honor of Prof. José L. Medina-Franco

edited by Carlos A. Velázquez-Martínez and

Martín González-Andrade

submission deadline 31 Aug 2025 | 1 articles | Viewed by 4949 | Submission Open

Keywords: drug design; molecular modelling; chemoinformatics; materials science; big data; machine learning; predictive modeling; toxicology

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Intracerebral Hemorrhage: Advances in Preclinical Studies: 2nd Edition

edited by

Sangeetha Sukumari-Ramesh

submission deadline 31 Aug 2025 | 3 articles | Viewed by 4637 | Submission Open

Keywords: neuroinflammation; oxidative stress; neurodegeneration; neurological deficits; blood– brain barrier damage

(This special issue belongs to the Section Molecular Medicine)

The Role of CD36 in Human Health and Disease

edited by

Laura Cristina Ceafalan

and Mihail E. Hinescu

submission deadline 31 Aug 2025 | 1 articles | Viewed by 3151 | Submission Open

Keywords: CD36; lipid scavenger; cell-to-matrix adhesion; metastasis; neoangiogenesis; biomarker

(This special issue belongs to the Section Molecular Medicine)

New Insights into Forensic Molecular Genetics

edited by

Erin K. Hanson

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2815 | Submission Open

Keywords: forensic; DNA; RNA; protein; mtDNA; epigenetics; microbiome

(This special issue belongs to the Section Molecular Genetics)

Genomics in Biodiversity Conservation (Vertebrates and Invertebrates)

edited by

Shantanu Kundu

and

Hyun-Woo Kim

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2613 | Submission Open

Keywords: genomics; mitochondrial genome; genetic diversity; phylogenetic analyses; conservation genetics; gene arrangements; evolution

(This special issue belongs to the Section Molecular Genetics)

Heterocyclic Compounds as Novel Anti-Cancer Agents and Their Mechanisms of Action

edited by Chandra Mishra and

Dnyaneshwar N. Garad

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2547 | Submission Open

Keywords: heterocyclic compounds; anticancer; synthetic; natural

(This special issue belongs to the Section Molecular Medicine)

Glutamate and Glutamate Receptors in Health and Diseases, Second Edition

edited by

Jolanta H. Kotlińska

and

Marta Marszalek-Grabska

submission deadline 31 Aug 2025 | 3 articles | Viewed by 2405 | Submission Open

Keywords: glutamate receptors; addiction; pain; learning and memory; anxiety; depression; autism; neurodegeneration

(This special issue belongs to the Section Molecular Biology)

New Insights into RNA-Binding Proteins

edited by

Marko Noerenberg

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2382 | Submission Open

Keywords: RNA-binding protein; RBP; RNA; riboregulation; RNA interactome; protein– RNA interaction; protein– RNA complex; ribonucleoprotein

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Nerve Conduction Inhibition to Alleviate Disease Symptoms: Clinical Drugs and Medicinal Plant Compounds

edited by

Eiichi Kumamoto

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2229 | Submission Open

Keywords: nerve conduction; action potential; clinical drug; medicinal plant compound; voltage-gated ion channel

(This special issue belongs to the Section Molecular Medicine)

Mechanisms of Schizophrenia: Insights to Unlock the Brain Puzzle and Generate Effective Antipsychotic Drugs

edited by Tatiana V. Lipina

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2192 | Submission Open

Keywords: animal models of schizophrenia; antipsychotic drugs; brain; genes; D2R; neurodevelopment; neurotransmission; synaptic plasticity; neural circuits; genomics; proteomics; intracellular signalling; bioenergetics; prevention

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Novel Therapeutic Approaches of Neurodegenerative Diseases

edited by

Zhidong Zhou

submission deadline 31 Aug 2025 | 3 articles | Viewed by 2163 | Submission Open

Keywords: neurodegenerative disease; therapeutic approaches; molecular mechanisms; RNA-based therapies; gene therapy; small-molecule inhibitors; immunotherapy

(This special issue belongs to the Section Biological Factors)

Molecular Mechanisms and Pathophysiology of Gliomas

edited by Fengchao Lang

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1503 | Submission Open

Keywords: gliomas; cell cycle; epigenetic modifications; metabolic reprogramming; tumor microenvironment; targeted therapies

(This special issue belongs to the Section Molecular Biology)

Cellular and Molecular Mechanisms of Endometriosis: 2nd Edition

edited by

Luciana Bordin

, Alessandra Andrisani and Chiara Sabbadin

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1008 | Submission Open

Keywords: endocrine disfunction in endometriosis; glycosylphosphatidylinositols (GPIs) and GPI-anchored proteins; oxidative stress markers (glutathione; carbonic anhydrase; etc.); endometriosis and deep endometriosis; endometriosis-related immune system

(This special issue belongs to the Section Molecular Biology)

New Insights into Autacoids in Disease

edited by

Katsutoshi Yayama

submission deadline 31 Aug 2025 | Viewed by 1001 | Submission Open

Keywords: angiotensin; bradykinin; endothelin; prostaglandins; thromboxanes; leukotrienes; serotonin; histamine; angiotensin-converting enzyme; angiotensin receptor; renin; kininogen; kallikrein; cyclooxygenase; phospholipase A2

(This special issue belongs to the Section Molecular Medicine)

State-of-the-Art Protein X-Ray Crystallography

edited by Wu-Pei Su and

Hongxing He

submission deadline 31 Aug 2025 | 1 articles | Viewed by 964 | Submission Open

Keywords: ab initio phasing methods; X-ray crystallography; protein structural determination; image reconstruction from Fourier amplitudes; iterative projection algorithms; phasing with deep learning methods

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Bioactive Compounds as Modifiers of Mitochondrial Function

edited by Mihail "Mike" Mitov

submission deadline 31 Aug 2025 | 1 articles | Viewed by 949 | Submission Open

Keywords: natural bioactive compounds; synthesized bioactive compounds; mitochondrial function; electron transport chain (ETC); ATP production rate; oxygen consumption rate (OCR); extracellular acidification rate (ECAR)

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Probiotics and Their Metabolites, 2nd Edition

edited by

Hary Razafindralambo

submission deadline 31 Aug 2025 | 1 articles | Viewed by 750 | Submission Open

Keywords: probiotics; metabolites; functionality; biochemical aspects; biophysical aspects; physicochemical approach; molecular mechanism; interaction; synergy; adhesion; colonization; stability; prebiotics; postbiotics; synbiotics; viability; formulation; rational design; human health; animal health; plant health

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Hyaluronic Acid and Proteoglycans: Basic and Biomedical Applications: 2nd Edition

edited by

Michele Scuruchi

submission deadline 31 Aug 2025 | 1 articles | Viewed by 641 | Submission Open

Keywords: hyaluronic acid; proteoglycans; GAGs; extracellular matrix; hyaluronic acid and proteoglycans in disease; cancer; inflammation; angiogenesis; vascular homeostasis and damage; arthritis and arthrosis; glycobiology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Applications of NMR Spectroscopy in Structure-Based Drug Discovery

edited by Alexander L. Breeze and Reto Walser

submission deadline 31 Aug 2025 | Viewed by 496 | Submission Open

Keywords: NMR; structural biology; structure-based drug discovery; fragment screening; lead generation

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Advances in Purinergic Signaling Research: From Molecular Biology to Human Diseases

edited by Ricardo Rodrigues

submission deadline 31 Aug 2025 | Viewed by 340 | Submission Open

Keywords: ATP; adenosine; P1 receptors; P2 receptors; P2X receptors; P2Y receptors; ecto-nucleotidases

(This special issue belongs to the Section Molecular Biology)

Biomolecular Sciences and Precision Medicine in Vascular Disease

edited by

Raffaele Serra

submission deadline 31 Aug 2025 | Viewed by 289 | Submission Open

Keywords: precision medicine; vascular disease; vascular surgery

(This special issue belongs to the Section Molecular Medicine)

Regenerative Medicine in Wound Healing and Tissue Engineering

edited by

Jie Ding

submission deadline 31 Aug 2025 | Viewed by 190 | Submission Open

Keywords: wound healing; regeneration medicine; tissue engineering

Oxidative Stress and Ferroptosis in Health and Disease

edited by Udayakumar Karunakaran and Suma Elumalai

submission deadline 31 Aug 2025 | Viewed by 188 | Submission Open

Keywords: reactive oxygen species; antioxidants; glutathione; iron; H2S signaling; diabetes; metabolic disease; mitochondrial biology; ferroptosis; cell death; inflammation; aging; neurodegenerative diseases

(This special issue belongs to the Section Chemical Biology)

Small Aquatic Organisms as a Model for Predictive Toxicology and Stress Mechanisms

edited by Tetsuhiro Kudoh

submission deadline 31 Aug 2025 | Viewed by 134 | Submission Open

Keywords: fish model; zebrafish model; chemical toxicology

DNA Damage Response for Targeted Cancer Therapy: Molecular Basis and Mechanisms Pathways

edited by

Renata Krupa

submission deadline 31 Aug 2025 | Viewed by 119 | Submission Open

Keywords: DNA repair; targeted cancer therapy; DNA damage response; predictive factors; gene editing; personalized cancer therapy

(This special issue belongs to the Section Molecular Biology)

Updates on Molecular Mechanisms of Lysosomal Storage Disease

edited by

Anna Tylki-Szymanska

and

Patryk Lipiński

submission deadline 31 Aug 2025 | Viewed by 109 | Submission Open

Keywords: lysosomal storage disease (LSD); molecular mechanisms of LSD; genetic analyses; genotype– phenotype correlation in LSD; molecular biomarkers in LSD; gene therapy in LSD

(This special issue belongs to the Section Biological Factors)

Advances in Antiviral Drug Development

edited by Angel S. Galabov

submission deadline 31 Aug 2025 | Viewed by 100 | Submission Open

Keywords: viral inhibitors; mechanism of action; antiviral tests

(This special issue belongs to the Section Molecular Medicine)

Genetics and Molecular Mechanisms of Parkinson's Disease

edited by

Hugo Fernandes

submission deadline 31 Aug 2025 | Viewed by 79 | Submission Open

Keywords: Parkinson’ s disease; genetics; molecular mechanisms; neurodegeneration

(This special issue belongs to the Section Molecular Genetics)

Advances in Nano-Based Drug Delivery: Unveiling the Next Frontier

edited by

Yuping Bao

and

Jessica M. Larsen

submission deadline 15 Sep 2025 | 1 articles | Viewed by 3058 | Submission Open

Keywords: targeted drug delivery; smart nanoformulation; controlled drug release; biocompatible nanocarriers; extracellular vesicles; immunotherapy

(This special issue belongs to the Section Bio-Engineered Materials)

Roles of Alpha-1 Antitrypsin in Human Health and Disease Models

edited by

Sihong Song

submission deadline 15 Sep 2025 | 2 articles | Viewed by 2566 | Submission Open

Keywords: alpha-1 antitrypsin; serine proteinase inhibitor (SERPIN); autoimmunity; inflammation; aging; cancer

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Treatment and Prognosis of Autoimmune Bullous Diseases

edited by Kristina Seiffert-Sinha and Animesh A. Sinha

submission deadline 15 Sep 2025 | Viewed by 396 | Submission Open

Keywords: autoimmunity; blistering; gene expression; immunome; keratinocyte; pathomechanism; proteome; skin

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in Bioactive Compounds from Microalgae

edited by

Giuseppe Martelli

and

Rosa Paola Radice

submission deadline 15 Sep 2025 | Viewed by 101 | Submission Open

Keywords: microalgae; bioactive compounds; biomolecules; innovations

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Dysregulated Cytokine Signals in Human Disease

edited by

Alister C. Ward

submission deadline 25 Sep 2025 | Viewed by 333 | Submission Open

Keywords: cytokine; signaling; dysregulation; immunity; development; disease

(This special issue belongs to the Section Molecular Medicine)

Early Adversity and the Immune Hypothesis: Call for a Dialogue between Basic and Clinical Neuroscience

edited by Arie Kaffman, Kate Ryan Kuhlman, Bridget L. Callaghan and Christine Heim

submission deadline 30 Sep 2025 | 10 articles | Viewed by 23981 | Submission Open

Keywords: early adversity; microglia; neuroinflammation; microbiome; psychopathology

(This special issue belongs to the Section Molecular Biology)

Diabetes, Overweight and Obesity: From Molecular Mechanisms to Therapies Strategies

edited by

Othmar Moser

and

Harald Sourij

submission deadline 30 Sep 2025 | 8 articles | Viewed by 23106 | Submission Open

Keywords: diabetes mellitus; overweight; obesity; molecular mechanisms; microbiome; liver metabolism; advanced therapy

(This special issue belongs to the Section Molecular Medicine)

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