Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Endothelial Health in Atherosclerosis: From Function to Dysfunction and Beyond
edited by and Zhenguo Liu
submission deadline 10 Aug 2025 | Viewed by 213 | Submission Open
Keywords: endothelial dysfunction; atherosclerosis; vascular inflammation; oxidative stress; nitric oxide signaling; cardiovascular biomarkers; endothelial repair; lipid metabolism; vascular homeostasis; therapeutic interventions
(This special issue belongs to the Section Molecular Biology)
Circular RNAs: Functions, Applications and Prospects: 2nd Edition
edited by and Feiya Li
submission deadline 15 Aug 2025 | 2 articles | Viewed by 5458 | Submission Open
Keywords: circular RNAs; circRNA; function; application; disease
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Inflammation—The Surprising Bridge between Diseases submission deadline 15 Aug 2025 | 1 articles | Viewed by 2307 | Submission Open
Keywords: low-grade inflammation; lung inflammation; atherosclerosis; ischemic heart disease; peripheral artery disease; inflammatory bowel disease; fatty liver disease; inflammatory rheumatic diseases; cancer
(This special issue belongs to the Section Molecular Biology)
New Tissue Substitutes and Bioactive Materials and Their Responses in Clinical Use
edited by
submission deadline 15 Aug 2025 | Viewed by 155 | Submission Open
Keywords: new tissue substitutes; bioactive materials; cellular response
TRP Channels in Cardiovascular and Inflammatory Disease, 2nd Edition
edited by and Soraia Katia Pereira Costa
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1069 | Submission Open
Keywords: TRP channels; TRP ligands; biological functions; new drugs; cardiovascular diseases; inflammation
(This special issue belongs to the Section Molecular Medicine)
Advances in Plasma Bioscience and Medicine: 2nd Edition submission deadline 20 Aug 2025 | 2 articles | Viewed by 969 | Submission Open
Keywords: non-thermal (cold) atmospheric pressure plasma; reactive oxygen and nitrogen species (RONSs); plasma– biomolecule interactions; plasma cancer treatment; plasma immunomodulation; plasma inactivation of viruses; fungi and bacteria; plasma– liquid interactions; computer simulations
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Biochemistry of Wine and Beer, 3rd Edition submission deadline 30 Aug 2025 | 4 articles | Viewed by 4357 | Submission Open
Keywords: grape biochemistry; barley and malt biochemistry; role of prefermentative enzymatic reactions; wine and beer’ s fermentation process; aging reactions; phenolic compounds; aroma compounds; protein and nitrogen compounds
(This special issue belongs to the Section Biological Factors)
Bioactive Molecules: Structures, Functions and Potential Uses for Cancer Prevention and Targeted Therapies (2nd Edition)
edited by
submission deadline 31 Aug 2025 | 10 articles | Viewed by 22059 | Submission Open
Keywords: small molecules; biomolecules; molecular targeting; natural products; cancer management
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Esophageal Diseases: Molecular Basis and Therapeutic Approaches
edited by and Amanda B. Muir
submission deadline 31 Aug 2025 | 6 articles | Viewed by 11876 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
State-of-the-Art of Myology 2024–2025 submission deadline 31 Aug 2025 | 3 articles | Viewed by 10922 | Submission Open
Keywords: embryonic myogenesis; adult myogenesis; exercise-induced muscle injury; muscular dystrophies and muscle diseases; sarcopenia; cachexia; rhabdomyosarcoma; muscle biophysics
(This special issue belongs to the Section Molecular Biology)
Recent Advances in the Isolation, Chemical and Biological Characterization and Synthesis of Bioactive Metabolites from Plants submission deadline 31 Aug 2025 | 5 articles | Viewed by 8602 | Submission Open
Keywords: plants; bioactive metabolite; natural analogues; chemical and biological characterization; synthesis; synthetic intermediates and derivatives
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Diet and Immune Response
edited by
submission deadline 31 Aug 2025 | 5 articles | Viewed by 6804 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
Nanomaterials and Their Applications in Biomedicine
edited by
submission deadline 31 Aug 2025 | 5 articles | Viewed by 6789 | Submission Open
Keywords: photothermal and photodynamic therapies and tumor ablation strategies; theranostics and image-guided drug delivery; biosensors; including surface-enhanced Raman scattering and metal-enhanced fluorescence; biosensors; point-of-care diagnostics and lateral-flow tests; controlled drug delivery; including delivery of RNA/DNA and other biologics; additive manufacturing and 3D/4D printing applications; antimicrobials; cell therapeutics and tissue regeneration
(This special issue belongs to the Section Bio-Engineered Materials)
Diabetic Retinopathy: From Pathophysiology to Therapeutic Perspectives
edited by Annayya R. Aroor, and Dean P. Hainsworth
submission deadline 31 Aug 2025 | 2 articles | Viewed by 5590 | Submission Open
Keywords: diabetic retinopathy; microvascular injury; neuronal dysfunction; mitochondrial dysfunction; oxidative stress; inflammation; biomarkers; signaling pathways; pharmacological interventions; anti-vegf; gene therapy; stem cell-based therapies; prevention strategies; patient education programs; patient-centered care
(This special issue belongs to the Section Molecular Medicine)
The Role of Astrocytes in Neurodegenerative Diseases
edited by
submission deadline 31 Aug 2025 | 4 articles | Viewed by 5422 | Submission Open
Keywords: astrocytes; neurodegeneration; neuroinflammation; neuroprotection; neuroregeneration
(This special issue belongs to the Section Cellular Biochemistry)
Chemoinformatics and Molecular Modeling of Pharmacologically Active Biomolecules: A Themed Issue in Honor of Prof. José L. Medina-Franco
edited by Carlos A. Velázquez-Martínez and
submission deadline 31 Aug 2025 | 1 articles | Viewed by 4941 | Submission Open
Keywords: drug design; molecular modelling; chemoinformatics; materials science; big data; machine learning; predictive modeling; toxicology
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Intracerebral Hemorrhage: Advances in Preclinical Studies: 2nd Edition submission deadline 31 Aug 2025 | 3 articles | Viewed by 4618 | Submission Open
Keywords: neuroinflammation; oxidative stress; neurodegeneration; neurological deficits; blood– brain barrier damage
(This special issue belongs to the Section Molecular Medicine)
The Role of CD36 in Human Health and Disease
edited by and Mihail E. Hinescu
submission deadline 31 Aug 2025 | 1 articles | Viewed by 3146 | Submission Open
Keywords: CD36; lipid scavenger; cell-to-matrix adhesion; metastasis; neoangiogenesis; biomarker
(This special issue belongs to the Section Molecular Medicine)
New Insights into Forensic Molecular Genetics
edited by
submission deadline 31 Aug 2025 | 2 articles | Viewed by 2792 | Submission Open
Keywords: forensic; DNA; RNA; protein; mtDNA; epigenetics; microbiome
(This special issue belongs to the Section Molecular Genetics)
Genomics in Biodiversity Conservation (Vertebrates and Invertebrates) submission deadline 31 Aug 2025 | 2 articles | Viewed by 2602 | Submission Open
Keywords: genomics; mitochondrial genome; genetic diversity; phylogenetic analyses; conservation genetics; gene arrangements; evolution
(This special issue belongs to the Section Molecular Genetics)
Heterocyclic Compounds as Novel Anti-Cancer Agents and Their Mechanisms of Action
edited by Chandra Mishra and
submission deadline 31 Aug 2025 | 2 articles | Viewed by 2536 | Submission Open
Keywords: heterocyclic compounds; anticancer; synthetic; natural
(This special issue belongs to the Section Molecular Medicine)
New Insights into RNA-Binding Proteins
edited by
submission deadline 31 Aug 2025 | 1 articles | Viewed by 2378 | Submission Open
Keywords: RNA-binding protein; RBP; RNA; riboregulation; RNA interactome; protein– RNA interaction; protein– RNA complex; ribonucleoprotein
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Glutamate and Glutamate Receptors in Health and Diseases, Second Edition submission deadline 31 Aug 2025 | 3 articles | Viewed by 2363 | Submission Open
Keywords: glutamate receptors; addiction; pain; learning and memory; anxiety; depression; autism; neurodegeneration
(This special issue belongs to the Section Molecular Biology)
Nerve Conduction Inhibition to Alleviate Disease Symptoms: Clinical Drugs and Medicinal Plant Compounds
edited by
submission deadline 31 Aug 2025 | 1 articles | Viewed by 2220 | Submission Open
Keywords: nerve conduction; action potential; clinical drug; medicinal plant compound; voltage-gated ion channel
(This special issue belongs to the Section Molecular Medicine)
Mechanisms of Schizophrenia: Insights to Unlock the Brain Puzzle and Generate Effective Antipsychotic Drugs
edited by Tatiana V. Lipina
submission deadline 31 Aug 2025 | 1 articles | Viewed by 2187 | Submission Open
Keywords: animal models of schizophrenia; antipsychotic drugs; brain; genes; D2R; neurodevelopment; neurotransmission; synaptic plasticity; neural circuits; genomics; proteomics; intracellular signalling; bioenergetics; prevention
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Novel Therapeutic Approaches of Neurodegenerative Diseases
edited by
submission deadline 31 Aug 2025 | 3 articles | Viewed by 1982 | Submission Open
Keywords: neurodegenerative disease; therapeutic approaches; molecular mechanisms; RNA-based therapies; gene therapy; small-molecule inhibitors; immunotherapy
(This special issue belongs to the Section Biological Factors)
Molecular Mechanisms and Pathophysiology of Gliomas
edited by Fengchao Lang
submission deadline 31 Aug 2025 | 1 articles | Viewed by 1493 | Submission Open
Keywords: gliomas; cell cycle; epigenetic modifications; metabolic reprogramming; tumor microenvironment; targeted therapies
(This special issue belongs to the Section Molecular Biology)
New Insights into Autacoids in Disease
edited by
submission deadline 31 Aug 2025 | Viewed by 1000 | Submission Open
Keywords: angiotensin; bradykinin; endothelin; prostaglandins; thromboxanes; leukotrienes; serotonin; histamine; angiotensin-converting enzyme; angiotensin receptor; renin; kininogen; kallikrein; cyclooxygenase; phospholipase A2
(This special issue belongs to the Section Molecular Medicine)
Cellular and Molecular Mechanisms of Endometriosis: 2nd Edition
edited by , Alessandra Andrisani and Chiara Sabbadin
submission deadline 31 Aug 2025 | 1 articles | Viewed by 1000 | Submission Open
Keywords: endocrine disfunction in endometriosis; glycosylphosphatidylinositols (GPIs) and GPI-anchored proteins; oxidative stress markers (glutathione; carbonic anhydrase; etc.); endometriosis and deep endometriosis; endometriosis-related immune system
(This special issue belongs to the Section Molecular Biology)
State-of-the-Art Protein X-Ray Crystallography
edited by Wu-Pei Su and
submission deadline 31 Aug 2025 | 1 articles | Viewed by 951 | Submission Open
Keywords: ab initio phasing methods; X-ray crystallography; protein structural determination; image reconstruction from Fourier amplitudes; iterative projection algorithms; phasing with deep learning methods
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Bioactive Compounds as Modifiers of Mitochondrial Function
edited by Mihail "Mike" Mitov
submission deadline 31 Aug 2025 | 1 articles | Viewed by 875 | Submission Open
Keywords: natural bioactive compounds; synthesized bioactive compounds; mitochondrial function; electron transport chain (ETC); ATP production rate; oxygen consumption rate (OCR); extracellular acidification rate (ECAR)
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Probiotics and Their Metabolites, 2nd Edition submission deadline 31 Aug 2025 | 1 articles | Viewed by 739 | Submission Open
Keywords: probiotics; metabolites; functionality; biochemical aspects; biophysical aspects; physicochemical approach; molecular mechanism; interaction; synergy; adhesion; colonization; stability; prebiotics; postbiotics; synbiotics; viability; formulation; rational design; human health; animal health; plant health
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Hyaluronic Acid and Proteoglycans: Basic and Biomedical Applications: 2nd Edition
edited by
submission deadline 31 Aug 2025 | 1 articles | Viewed by 623 | Submission Open
Keywords: hyaluronic acid; proteoglycans; GAGs; extracellular matrix; hyaluronic acid and proteoglycans in disease; cancer; inflammation; angiogenesis; vascular homeostasis and damage; arthritis and arthrosis; glycobiology
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Applications of NMR Spectroscopy in Structure-Based Drug Discovery
edited by Alexander L. Breeze and Reto Walser
submission deadline 31 Aug 2025 | Viewed by 496 | Submission Open
Keywords: NMR; structural biology; structure-based drug discovery; fragment screening; lead generation
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Advances in Purinergic Signaling Research: From Molecular Biology to Human Diseases
edited by Ricardo Rodrigues
submission deadline 31 Aug 2025 | Viewed by 340 | Submission Open
Keywords: ATP; adenosine; P1 receptors; P2 receptors; P2X receptors; P2Y receptors; ecto-nucleotidases
(This special issue belongs to the Section Molecular Biology)
Biomolecular Sciences and Precision Medicine in Vascular Disease
edited by
submission deadline 31 Aug 2025 | Viewed by 288 | Submission Open
Keywords: precision medicine; vascular disease; vascular surgery
(This special issue belongs to the Section Molecular Medicine)
Regenerative Medicine in Wound Healing and Tissue Engineering
edited by
submission deadline 31 Aug 2025 | Viewed by 189 | Submission Open
Keywords: wound healing; regeneration medicine; tissue engineering
Oxidative Stress and Ferroptosis in Health and Disease
edited by Udayakumar Karunakaran and Suma Elumalai
submission deadline 31 Aug 2025 | Viewed by 187 | Submission Open
Keywords: reactive oxygen species; antioxidants; glutathione; iron; H2S signaling; diabetes; metabolic disease; mitochondrial biology; ferroptosis; cell death; inflammation; aging; neurodegenerative diseases
(This special issue belongs to the Section Chemical Biology)
Small Aquatic Organisms as a Model for Predictive Toxicology and Stress Mechanisms
edited by Tetsuhiro Kudoh
submission deadline 31 Aug 2025 | Viewed by 134 | Submission Open
Keywords: fish model; zebrafish model; chemical toxicology
DNA Damage Response for Targeted Cancer Therapy: Molecular Basis and Mechanisms Pathways
edited by
submission deadline 31 Aug 2025 | Viewed by 118 | Submission Open
Keywords: DNA repair; targeted cancer therapy; DNA damage response; predictive factors; gene editing; personalized cancer therapy
(This special issue belongs to the Section Molecular Biology)
Updates on Molecular Mechanisms of Lysosomal Storage Disease submission deadline 31 Aug 2025 | Viewed by 109 | Submission Open
Keywords: lysosomal storage disease (LSD); molecular mechanisms of LSD; genetic analyses; genotype– phenotype correlation in LSD; molecular biomarkers in LSD; gene therapy in LSD
(This special issue belongs to the Section Biological Factors)
Advances in Antiviral Drug Development
edited by Angel S. Galabov
submission deadline 31 Aug 2025 | Viewed by 99 | Submission Open
Keywords: viral inhibitors; mechanism of action; antiviral tests
(This special issue belongs to the Section Molecular Medicine)
Genetics and Molecular Mechanisms of Parkinson's Disease
edited by
submission deadline 31 Aug 2025 | Viewed by 78 | Submission Open
Keywords: Parkinson’ s disease; genetics; molecular mechanisms; neurodegeneration
(This special issue belongs to the Section Molecular Genetics)
Advances in Nano-Based Drug Delivery: Unveiling the Next Frontier submission deadline 15 Sep 2025 | 1 articles | Viewed by 3053 | Submission Open
Keywords: targeted drug delivery; smart nanoformulation; controlled drug release; biocompatible nanocarriers; extracellular vesicles; immunotherapy
(This special issue belongs to the Section Bio-Engineered Materials)
Roles of Alpha-1 Antitrypsin in Human Health and Disease Models
edited by
submission deadline 15 Sep 2025 | 2 articles | Viewed by 2561 | Submission Open
Keywords: alpha-1 antitrypsin; serine proteinase inhibitor (SERPIN); autoimmunity; inflammation; aging; cancer
(This special issue belongs to the Section Molecular Medicine)
Molecular Insights into Treatment and Prognosis of Autoimmune Bullous Diseases
edited by Kristina Seiffert-Sinha and Animesh A. Sinha
submission deadline 15 Sep 2025 | Viewed by 393 | Submission Open
Keywords: autoimmunity; blistering; gene expression; immunome; keratinocyte; pathomechanism; proteome; skin
(This special issue belongs to the Section Molecular Medicine)
Recent Advances in Bioactive Compounds from Microalgae submission deadline 15 Sep 2025 | Viewed by 100 | Submission Open
Keywords: microalgae; bioactive compounds; biomolecules; innovations
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Dysregulated Cytokine Signals in Human Disease
edited by
submission deadline 25 Sep 2025 | Viewed by 332 | Submission Open
Keywords: cytokine; signaling; dysregulation; immunity; development; disease
(This special issue belongs to the Section Molecular Medicine)
Early Adversity and the Immune Hypothesis: Call for a Dialogue between Basic and Clinical Neuroscience
edited by Arie Kaffman, Kate Ryan Kuhlman, Bridget L. Callaghan and Christine Heim
submission deadline 30 Sep 2025 | 10 articles | Viewed by 23935 | Submission Open
Keywords: early adversity; microglia; neuroinflammation; microbiome; psychopathology
(This special issue belongs to the Section Molecular Biology)
Diabetes, Overweight and Obesity: From Molecular Mechanisms to Therapies Strategies
edited by and
submission deadline 30 Sep 2025 | 8 articles | Viewed by 22885 | Submission Open
Keywords: diabetes mellitus; overweight; obesity; molecular mechanisms; microbiome; liver metabolism; advanced therapy
(This special issue belongs to the Section Molecular Medicine)
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