866 Results Found

Mercury as one of the most toxic elements can be present in organic or inorganic form in marine fishes, which may cause a potential threat to public health. In this study, we investigated to determine the dietary organic (O-Hg) and inorganic (I-Hg) m...

Chromium (Cr) is a highly toxic heavy metal, yet its effects on soil invertebrates—particularly Caenorhabditis elegans (C. elegans)—remain insufficiently understood, especially regarding how soil properties and Cr speciation change regula...

Atmospheric deposition brings both nutrients and toxic components to the surface ocean, resulting in important impacts on phytoplankton. Field and lab studies have been done on the iron (Fe) fertilization on marine phytoplankton. However, studies on...

Soil toxicity resulting from either natural or anthropogenic heavy metal contamination was evaluated through a nitrifying bacteria bioassay focused on the inhibition of oxygen consumption. Every contaminated soil sample inhibited the nitrifying bacte...

Dietary assessment reports and population surveillance programs show that chronic exposure to low levels of environmental cadmium (Cd) is inevitable for most people, and adversely impacts the health of children and adults. Based on a risk assessment...

Cultivation of L. platensis under elevated CO₂ ensures CO₂ biofixation, while adding Na₂SeO₃ to the culture medium, produces valuable Se-enriched biomass. This study evaluated the effect of Na₂SeO₃ supplementation (20–640 mg/L) on the growth of...

Nickel (Ni) is a ubiquitous trace metal, yet its physiological dynamics and dose-dependent roles in skeletal biology remain unclear. Here we combined elemental mapping, cellular assays, multi-omics and mouse models to define how Ni availability modul...

The uncertainty in the risk assessment of trace metal elements in soils when total metal contents are used can be decreased by assessing their availability and/or extractability when the soils have a high background value or different sources of trac...

The use of mercury in industry causes its continuous increase in nature. A pro-ecological technology that can reduce mercury levels in aquatic environments is phytoremediation using the plant Salvinia natans. The study aimed to determine the maximum...

An increased level of cadmium (Cd) in food crops, especially rice is concerning because rice is a staple food for over half of the world’s population. In some regions, rice contributes to more than 50% of the total Cd intake. Low environmental...

We retrospectively analyzed data on the excretion of cadmium (E_Cd), β₂-microglobulin (E_β2M) and N-acetyl-β-D-glucosaminidase (E_NAG), which were recorded for 734 participants in a study conducted in low- and high-exposure areas of Thail...

The frequently observed association between kidney toxicity and long-term cadmium (Cd) exposure has long been dismissed and deemed not to be of clinical relevance. However, Cd exposure has now been associated with increased risk of developing chronic...

Background/Objectives: 5-fluorouracil (5-FU) is used in the treatment of solid cancer types. Because of its narrow therapeutic window, drug monitoring is recommended. We were confronted to answer a question on the relevance of concentration as oppose...

Radiation-induced keratoconjunctivitis sicca (KCS) is a significant late complication in dogs receiving radiation therapy for intranasal tumors, particularly with hypofractionated intensity-modulated radiation therapy (IMRT). This retrospective case-...

Although it has been reported that fluorescent quantum dots (QDs) have obvious acute toxic effects in vitro, their toxic effects at low doses or threshold doses are still unknown. Therefore, we evaluated the biological histocompatibility and in vitro...

Background: Amoxicillin (AMX)-induced neurotoxicity is well described and may be associated with AMX overexposure. No neurotoxic concentration threshold has been determined thus far. A better knowledge of maximum tolerable AMX concentrations is of im...

Nickel (Ni) metal and Ni compounds are widely used in applications like stainless steel, alloys, and batteries. Nickel is a naturally occurring element in water, soil, air, and living organisms, and is essential to microorganisms and plants. Thus, hu...

Perfluorooctane sulfonate (PFOS) is a persistent contaminant that has been found globally within the environment. Key data gaps exist in the toxicity of PFOS to marine organisms, especially estuarine species that are crucial to the food web: fish, sh...

Trichogramma dendrolimi, a key egg parasitoid for lepidopteran pest control, faces potential risks from neonicotinoid insecticides like acetamiprid used in integrated pest management (IPM). This study evaluated acetamiprid’s acute and sublethal...

In the FIGHTDIGO study, digestive cancer patients with dynapenia experienced more chemotherapy-induced neurotoxicities. FIGHTDIGOTOX aimed to evaluate the relationship between pre-therapeutic handgrip strength (HGS) and chemotherapy-induced dose-limi...

Natural and artificial heavy metal exposure to the environment requires finding thresholds to protect aquatic ecosystems from the toxicity of heavy metals. The threshold is commonly called a predicted no effect concentration (PNEC) and is thought to...

(1) Background: Polycyclic aromatic hydrocarbons (PAHs) are important components of petroleum and pose a serious threat to the soil environment of oil production well sites. Therefore, scientific risk thresholds and ecological risk assessment methods...

The threat posed by water pollutants to aquatic ecosystems and human health cannot be overlooked, and the assessment of the toxicity of these contaminants is paramount to understanding their risks and formulating effective control measures. Luminesce...

The concentration of trace toxic metals (Cr, Zn, As, Pb, Cd, Cu, and Ni) in soil and rice plants, including the stems, leaves, and grain, from the main rice-producing provinces in Ecuador, was determined. Additionally, the soils were analyzed to dete...

Licorice (Glycyrrhiza uralensis) contains bioactive flavonoids and saponins, primarily liquiritin and glycyrrhizin, which exhibit pharmacological activities but also potential dose-dependent toxicity. This study aimed to establish an integrative work...

Mycotoxins in agriculturally used plants can cause intoxication in animals and can lead to severe financial losses for farmers. The endophytic fungus Epichloë festucae var. lolii living symbiotically within the cool season grass species Lolium p...

Tephritid fruit flies are economically important orchard pests globally. While much effort has focused on controlling individual species with a combination of pesticides and biological control, less attention has been paid to managing assemblages of...

Mineral imbalances in sheep can have significant health and economic consequences, yet regional assessments of trace mineral and toxic element status are limited. Oregon is an endemically selenium (Se)-deficient region, but a statewide evaluation has...

Background: Deferasirox (DFX) is commonly used to reduce the chronic iron overload (IO) in pediatric patients. However, the drug is characterized by a large pharmacokinetic variability and approximately 10% of patients may discontinue the treatment d...

Factors associated with olaparib toxicity remain unknown in ovarian cancer patients. The large inter-individual variability in olaparib pharmacokinetics could contribute to the onset of early significant adverse events (SAE). We aimed to retrospectiv...

2-(Methylthio) benzothiazole (MTBT) is widely used in the industrial and pharmaceutical fields, but limited research has been conducted on its aquatic toxicity. In this study, we established a zebrafish model to systematically evaluate its developmen...

Cadmium (Cd) is a food-chain contaminant that has high rates of soil-to-plant transference. This phenomenon makes dietary Cd intake unavoidable. Although long-term Cd intake impacts many organ systems, the kidney has long been considered to be a crit...

Background/Objectives: Ropivacaine is primarily metabolized by the liver. High doses of ropivacaine, combined with altered pharmacokinetics due to hepatectomy, raise concerns about potential drug toxicity. We investigated the impact of LMH (laparosco...

Toxic trace elements in farmland soils are potential threats to human health. In this study, we collected soil samples from the farmlands of southern Guangzhou. We used a sequential indicator simulation (SIS) to deal with the problem of skewed distri...

Deoxynivalenol (DON), a toxic secondary metabolite produced by Fusarium graminearum in infected cereal crops, has emerged as a major global contaminant in food and feed due to its stable physicochemical properties and resistance to degradation during...

Few studies have explored the holistic public health risk assessment associated with toxic elements (TEs) and their bioaccessibility in integrated urban environmental media including soils, vegetables, atmospheric particles, dust, etc. Urban industri...

Long-term variations of ecological status in a Mediterranean coastal lagoon (Sacca di Goro, Northern Adriatic) were investigated, combining data on the concentration of surface sediment contaminants and on the structure of the macrobenthic community....

The ecotoxicity of a set of 30 ionic liquids, namely 23 aprotic compounds (APILs) and 7 protic compounds (PILs), was analyzed in this work by monitoring the inhibition of the bioluminescence of the bacteria Aliivibrio fischeri with varying concentrat...

This study employed an integrated field monitoring approach, combining chemical analysis and ecotoxicity testing of multiple environmental matrices—water, sediment, and sediment elutriates—to comprehensively assess the environmental healt...

Limited by flammability, wood and wood-based materials face challenges in distinguishing themselves as structural materials or finishing materials. Once burning, they can produce toxic gases detrimental to humans and the environment. Therefore, it is...

We investigated the role of the selective avoidance of haematopoietically active pelvic bone marrow (BM), with a targeted intensity-modulated radiotherapy (IMRT) approach, to reduce acute hematologic toxicity (HT) in anal cancer patients undergoing c...

This study aims to quantitatively analyze choriocapillaris (CC) alterations using swept-source optical coherence tomography angiography (SS-OCTA) in eyes presenting with hydroxychloroquine (HCQ) toxic retinopathy and to compare it to patients under H...

Potential drug toxicities and drug interactions of redundant compounds of plant complexes may cause unexpected clinical responses or even severe adverse events. On the other hand, super-additivity of drug interactions between natural products and syn...

Heavy metal (HM) toxicity has become a global concern in recent years and is imposing a severe threat to the environment and human health. In the case of plants, a higher concentration of HMs, above a threshold, adversely affects cellular metabolism...

Globally, many shallow lakes have shifted from a clear macrophyte-dominated state to a turbid phytoplankton-dominated state due to eutrophication. Such shifts are often accompanied by toxic cyanobacterial blooms, with specialized traits including buo...

Background/Objectives: The combination of chemotherapy and radiotherapy represents a standard adjuvant treatment for patients with high-risk endometrial cancer. However, limited access to radiotherapy in many healthcare systems frequently results in...

Heavy metal contamination in urban topsoil is one of the most serious environmental threats to children’s health, particularly through ingestion, dermal contact, and inhalation exposure routes. The objectives of this study were: (1) to assess t...

Human exposure to arsenic and other toxic elements such as cadmium, lead and mercury may lead to a wide range of adverse health effects. In relation to this, it is well established that the diet is the main route of exposure to both essential and tox...

Toxicological investigations of pesticides largely focus on the declared active ingredient, which constitutes only between a few percent to around 50% of the total formulation. The complete formulations are unknown. For each declared active ingredien...

As listed by the European Chemicals Agency, the three elements in evaluating the hazards of engineered nanomaterials (ENMs) include the integration and evaluation of toxicity data, categorization and labeling of ENMs, and derivation of hazard thresho...