Metal Ions in Health and Diseases: Current Progress and Future Challenges

Topic Information

Dear Colleagues,

Metal ions play a pivotal role in numerous physiological processes within the human body, ranging from enzyme activation to cellular signaling. However, dysregulation in metal ion homeostasis has been implicated in various health conditions and diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. The study of metal ions in health and diseases represents a burgeoning field of research, with significant implications for both diagnosis and treatment.

Recent advances in analytical techniques have facilitated the detection and quantification of metal ions in biological samples, enabling researchers to better understand their roles in disease pathogenesis and the underlying molecular mechanisms involved. Moreover, studies exploring the therapeutic potential of metal ion chelators and modulators have provided promising avenues for the development of novel treatments.

Despite these advancements, numerous challenges persist. For instance, elucidating precise mechanisms of metal ion dysregulation, developing effective targeting and modulation strategies, overcoming analytical limitations, discovering reliable biomarkers, and translating findings into clinically viable treatments. Additionally, understanding interactions with other biological factors and bridging the gap between basic research and clinical applications are key challenges in this field. The current topic aims to provide a platform for researchers to disseminate their findings and insights into the role of metal ions in health and diseases. We invite manuscripts that delve into the multifaceted realm of metal ion biology, spanning from the intricate coordination chemistry of metal ions within biological systems to their pivotal roles in disease pathogenesis, diagnostic modalities, and therapeutic strategies. Furthermore, we encourage submissions that explore emerging research frontiers, including the utilization of metal nanoparticles in cutting-edge biomedical applications like targeted drug delivery and advanced imaging techniques.

Dr. Massimiliano F. Peana
Prof. Dr. Carlo Santini
Dr. Maura Pellei
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Chemistry chemistry	2.4	3.2	2019	17.2 Days	CHF 1800	Submit
Molecules molecules	4.2	7.4	1996	15.1 Days	CHF 2700	Submit
International Journal of Molecular Sciences ijms	4.9	8.1	2000	16.8 Days	CHF 2900	Submit
Biomolecules biomolecules	4.8	9.4	2011	18.4 Days	CHF 2700	Submit
Inorganics inorganics	3.1	2.8	2013	15.8 Days	CHF 2200	Submit

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Open AccessArticle

New Cu(II), Cu(I) and Ag(I) Complexes of Phenoxy-Ketimine Schiff Base Ligands: Synthesis, Structures and Antibacterial Activity

by Miriam Caviglia, Zhenzhen Li, Carlo Santini, Jo’ Del Gobbo, Cristina Cimarelli, Miao Du, Alessandro Dolmella and Maura Pellei

Molecules 2025, 30(9), 1893; https://doi.org/10.3390/molecules30091893 - 24 Apr 2025

Viewed by 159

Abstract

Two phenoxy-ketimines ligands, 2-(1-(benzylimino)ethyl)phenol (HL^BSMe) and 2-((benzylimino)(phenyl)methyl)phenol (HL^BSPh), were synthesized and used as supporting ligands of new copper(II), copper(I), and silver(I) complexes. In order to confer different solubility properties to the metal complexes and to stabilize Cu and Ag [...] Read more.

Two phenoxy-ketimines ligands, 2-(1-(benzylimino)ethyl)phenol (HL^BSMe) and 2-((benzylimino)(phenyl)methyl)phenol (HL^BSPh), were synthesized and used as supporting ligands of new copper(II), copper(I), and silver(I) complexes. In order to confer different solubility properties to the metal complexes and to stabilize Cu and Ag in their +1 oxidation state, the lipophilic triphenylphosphine (PPh₃) and the hydrophilic 1,3,5-triaza-7-phosphaadamantane (PTA) were selected as co-ligands in the syntheses of the Cu(I) and Ag(I) complexes. All compounds were characterized by CHN analysis, NMR, FT-IR spectroscopy, and electrospray ionization mass spectrometry (ESI-MS); the molecular structure of the copper(II) complex [Cu(L^BSPh)₂] was also determined by single-crystal X-ray diffraction. Finally, the antibacterial activity of the metal complexes, the Schiff base ligands and phosphane co-ligands, were assessed by determining the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Gram-negative (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus). Full article

(This article belongs to the Topic Metal Ions in Health and Diseases: Current Progress and Future Challenges)

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