Metal Ions in Health and Diseases: Current Progress and Future Challenges

Dear Colleagues,

Metal ions play a pivotal role in numerous physiological processes within the human body, ranging from enzyme activation to cellular signaling. However, dysregulation in metal ion homeostasis has been implicated in various health conditions and diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. The study of metal ions in health and diseases represents a burgeoning field of research, with significant implications for both diagnosis and treatment.

Recent advances in analytical techniques have facilitated the detection and quantification of metal ions in biological samples, enabling researchers to better understand their roles in disease pathogenesis and the underlying molecular mechanisms involved. Moreover, studies exploring the therapeutic potential of metal ion chelators and modulators have provided promising avenues for the development of novel treatments.

Despite these advancements, numerous challenges persist. For instance, elucidating precise mechanisms of metal ion dysregulation, developing effective targeting and modulation strategies, overcoming analytical limitations, discovering reliable biomarkers, and translating findings into clinically viable treatments. Additionally, understanding interactions with other biological factors and bridging the gap between basic research and clinical applications are key challenges in this field. The current topic aims to provide a platform for researchers to disseminate their findings and insights into the role of metal ions in health and diseases. We invite manuscripts that delve into the multifaceted realm of metal ion biology, spanning from the intricate coordination chemistry of metal ions within biological systems to their pivotal roles in disease pathogenesis, diagnostic modalities, and therapeutic strategies. Furthermore, we encourage submissions that explore emerging research frontiers, including the utilization of metal nanoparticles in cutting-edge biomedical applications like targeted drug delivery and advanced imaging techniques.

Dr. Massimiliano F. Peana
Prof. Dr. Carlo Santini
Dr. Maura Pellei
Topic Editors