PFAS Toxicology and Metabolism
A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Emerging Contaminants".
Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 48894
Special Issue Editors
Interests: PFAS health effects; biotransformations; lipidomics; metabolomics; bioanalytical chemistry method development
Interests: development, assessment, and integration of in vitro and in silico approaches to predict human exposures that can be applied to ensure protection of human health; toxicokinetics; in vitro-in vivo extrapolation (IVIVE); PFAS; metabolism; population variability; new approach methods
Interests: toxicology; obesity; fatty liver disease; PFAS; P450s; nuclear receptors
Special Issues, Collections and Topics in MDPI journals
Interests: flame retardants; PFAS; PAHs; neurotoxicity; nuclear receptors; epigenetics; non-ionising radiations; development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Per- and polyfluoroalkyl substances (PFAS) are seemingly everywhere: in our bodies, homes, clothes, food packaging, drinking water, rivers, soils, and carried across the globe in the atmosphere. Yet, despite their widespread occurrence and detection of a growing number of compounds, we know very little about the risks posed by our own and the environment’s exposure to these long-lived chemicals. Multiple studies have been published on the health effects of the first known PFAS, perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), but there are gaps in the data for other legacy and emerging chemicals in this structurally diverse class. Additionally, since we are likely exposed to multiple PFAS simultaneously, gaining an understanding of the potentially toxic effects of mixtures represents another critical data gap to fill.
This Special Issue of Toxics aims to expand knowledge of the health effects of per- and polyfluoroalkyl substances. We welcome original research, new methodologies and protocols, and reviews that evaluate the exposure, hazard, metabolism, and fate of legacy and emerging PFAS, PFAS mixtures, and resulting effects to humans and other organisms. Research may include in vivo, in vitro, and in silico studies in areas including, but not limited to, PFAS biomonitoring, bioaccumulation, biotransformation, dosimetry, exposure, toxicokinetics, lipidomics, metabolomics, integrated omics, neurotoxicity, endocrine disruption, developmental and reproductive toxicology, and cancer. In vivo dose–response studies that evaluate health effects related to sub-chronic and chronic exposure at environmentally relevant levels are welcome, as are those that employ new approach methodologies (NAMs), such as in vitro screening, microphysiologic systems, adverse outcome pathways, in vitro–in vivo extrapolation (IVIVE), computational modeling or other approaches.
Dr. Denise MacMillan
Dr. Barbara Wetmore
Prof. Dr. William S. Baldwin
Dr. Subham Dasgupta
Guest Editors
Manuscript Submission Information
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Keywords
- PFAS
- toxicity
- metabolism
- toxicokinetics
- adverse outcomes
- omics
- biotransformation
- biomonitoring
- new approach methodologies
- in vitro–in vivo extrapolation
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