The identification of structural variants (SVs) in genomic data represents an ongoing challenge because of difficulties in reliable SV calling leading to reduced sensitivity and specificity. We prepared high-quality DNA from 9 parent–child trio...
Background: Population-specific reference genomes are essential for improving the accuracy and reliability of genomic analyses across diverse human populations. Although Vietnam ranks as the 16th most populous country in the world, with more than 86%...
In late 2023, the image-reading capability added to a Generative Pre-trained Transformer (GPT) framework provided the opportunity to potentially revolutionize the way we view and understand geographic maps, the core component of cartography, geograph...
A school world atlas is likely the first systematic cartographic product which students encounter in their lives. However, only a few empirical studies have analysed school atlases in the context of map reading and learning geographical curricula. Th...
Map reading is an important skill for acquiring spatial information. Previous studies have mainly used results-based assessments to learn about map-reading skills. However, how to model the relationship between map-reading skills and eye movement met...
As a reading comprehension strategy, mind mapping has a positive influence on the development of students’ reading ability. However, how mind mapping affects reading ability has not been well documented. In this study, we used eye tracking sens...
Misinterpreting maps can have serious consequences, especially in situations requiring quick decisions like using car navigation systems. Studies indicate that a map reader’s experience is crucial for understanding maps, but factors such as age...
Reading and interpreting a map represents an essential part of daily life, enabling appropriate orientation and navigation through space. Based on the idea that perceptual analogical reasoning is critical in aligning the spatial structure of the map...
Automatic reading of analog pointer meters is affected by complex backgrounds, illumination changes, and camera viewpoints. This study implements and evaluates a template-calibrated reading procedure that integrates established detection and image-pr...
Enhancing spatial orientation and map-reading skills is a cornerstone of geography education, yet the comparative efficacy of physical versus virtual reality learning environments (VRLEs) remains a subject of ongoing debate. This study evaluates the...
Ever since the introduction of high-throughput sequencing following the human genome project, assembling short reads into a reference of sufficient quality posed a significant problem as a large portion of the human genome—estimated 50–69...
For gene expression analysis in complex microbiomes, utilizing both metagenomic and metatranscriptomic reads from the same sample enables advanced functional analysis. Due to their diversity, metagenomic contigs are often used as reference sequences...
Quantification of gene expression is crucial to connect genome sequences with phenotypic and physiological data. RNA-Sequencing (RNA-Seq) has taken a prominent role in the study of transcriptomic reactions of plants to various environmental and genet...
High-throughput sequence data retrieved from ancient or other degraded samples has led to unprecedented insights into the evolutionary history of many species, but the analysis of such sequences also poses specific computational challenges. The most...
Recent technological advancements in many areas have changed the way that individuals interact with the world. Some daily tasks require visualization skills, especially when in a map-reading context. Augmented Reality systems could provide substantia...
While conventional physical maps helped build most of the reference genomes we use today, generating the maps was prohibitively expensive, and the technology was abandoned in favor of whole-genome shotgun sequencing (WGS). However, genome assemblies...
How does a child learn to read a map? In 2007, the authors of an article in the Journal of Geography proposed a tentative list of eight “modes of spatial reasoning” that children may use to organize their perceptions of information on a m...
During the last decade, genetic testing has emerged as an important etiological diagnostic tool for Mendelian diseases, including pediatric neurological conditions. A genetic diagnosis has a considerable impact on disease management and treatment; ho...
This study aimed to design a virtual reality (VR)–based mountaineering education system and examined its effects on junior high school students’ learning outcomes, motivation, and cognitive load in compass operation and map reading. The s...
Visual search is a core component of map reading, influenced by both cartographic design and human perceptual processes. This study investigates whether the location of a target cartographic symbol—central or peripheral—can be predicted using eye-tra...
29 April 2022
Advances in Next Generation Sequencing technologies allow us to inspect and unlock the genome to a level of detail that was unimaginable only a few decades ago. Omics-based studies are casting a light on the patterns and determinants of disease condi...
The emergence of pangenome graphs represents a paradigm shift in genomics, moving beyond linear reference genomes to embrace the full spectrum of genetic diversity within and across species. These graph-based models provide a unified framework for re...
Duchenne muscular dystrophy (DMD) is a severe progressive muscle disease that mainly affects boys due to X-linked recessive inheritance. In most affected individuals, MLPA or sequencing-based techniques detect deletions, duplications, or point mutati...
High-throughput sequencing technologies have rapidly developed during the past years and have become an essential tool in plant sciences. However, the analysis of genomic data remains challenging and relies mostly on the performance of automatic pipe...
As the development of small-scale thematic cartography continues, there is a growing interest in simple graphic solutions, e.g., in the form of numerical values presented on maps to replace or complement well-established quantitative cartographic met...
Recently, due to Web 2.0 and neocartography, heat maps have become a popular map type for quick reading. Heat maps are graphical representations of geographic data density in the form of raster maps, elaborated by applying kernel density estimation w...
This study investigates how expert and novice map users’ attention is influenced by the map design characteristics of 2D web maps by building and sharing a framework to analyze large volumes of eye tracking data. Our goal is to respond to the f...
A computer vision method for measuring multiple pointer meters is proposed based on the inverse perspective mapping. First, the measured meter scales are used as the calibration objects to obtain the extrinsic parameters of the meter plane. Second, n...
The identification of mRNA isoforms in biological samples is crucial for studying tissue- and cell-specific isoform expression, activity of tissue-specific promoters, alternative splicing events, and alternative polyadenylation signals in genes. For...
(1) Background: This study assessed the spatial position and anatomical features associated with impacted third molars through a map-reading strategy employing cone-beam computed tomography (CBCT). (2) Methods: The positioning of impacted third molar...
Venoms are evolutionary key adaptations that species employ for defense, predation or competition. However, the processes and forces that drive the evolution of venoms and their toxin components remain in many aspects understudied. In particular, the...
Entropy can be defined as the antithesis of well-formed true reports that agree with each other and with the material facts accessible through the experience of one or more competent observers. The abstract convergence (strictly formal, logical agree...
The Bemisia tabaci complex of whiteflies contains globally important pests thought to contain cryptic species corresponding to geographically structured phylogenetic clades. Although mostly morphologically indistinguishable, differences have been sho...
The characteristics of modern science, i.e., data-intensive, multidisciplinary, open, and heavily dependent on Internet technologies, entail the creation of a linked scholarly record that is online and open. Instrumental in making this vision happen...
Small supernumerary marker chromosomes (sSMCs) are additional chromosomal elements smaller than or equal to chromosome 20, with a prevalence of ~0.044% in the population. Their clinical impact ranges from asymptomatic carriage to severe congenital, n...
6 February 2022
Background: High-altitude mountaineering is becoming more popular. Despite technical developments such as global positioning systems, mountaineers still lose their way. This study aimed to analyze characteristics of alpinists that lost their way whil...
Viral CD8 T-cell epitopes, represented by viral peptides bound to major histocompatibility complex class-I (MHC-I) glycoproteins, are often identified by “reverse immunology”, a strategy not requiring biochemical and structural knowledge of the actua...
In a two-system theory for mind-reading, a flexible system (FS) enables full-blown mind-reading, and an efficient system (ES) enables early mind-reading. Efficient processing differs from flexible processing in terms of restrictions on the kind of in...
Much of today’s molecular science revolves around next-generation sequencing. Frequently, the first step in analyzing such data is aligning sequencing reads to a reference genome. This step is often taken for granted, but any analysis downstrea...
Visual attention plays a crucial role in the map-reading process and is closely related to the map cognitive process. Eye-tracking data contains a wealth of visual information that can be used to identify cognitive behavior during map reading. Nevert...
It is acknowledged that various types of thematic maps emphasize different aspects of mapped phenomena and thus support different map users’ tasks. To provide empirical evidence, a user study with 366 participants was carried out comparing three map...
Since the time of the HGP, research into next-generation sequencing, which can reduce the cost and time of sequence analysis using computer algorithms, has been actively conducted. Mapping is a next-generation sequencing method that identifies sequen...
This study compares adjacent and bivariate maps in communicating variance-based global sensitivity analysis (GSA) results for a geodiversity assessment spatial multi-criteria model and examines the influence of prior exposure to geodiversity and map...
Estimating the taxonomic composition of viral sequences in a biological samples processed by next-generation sequencing is an important step in comparative metagenomics. Mapping sequencing reads against a database of known viral reference genomes, ho...
This study presents a new computer program for assessing the effects of different factors and sequencing strategies on de novo sequence assembly. The program uses reads from actual sequencing studies or from simulations with a reference genome that m...
DNA viruses that produce persistent infections have been proposed as potential causes for the extinction of Neanderthals, and, therefore, the identification of viral genome remnants in Neanderthal sequence reads is an initial step to address this hyp...
Non-coding RNA fragments (ncRFs) are processed from various non-coding RNAs (ncRNAs), with the most abundant being those produced from tRNAs. ncRFs were reported in many animal and plant species. Many ncRFs exhibit tissue specificity or/and are affec...
In recent years, the use of Cloud infrastructures for data processing has proven useful, with a computing potential that is not affected by the limitations of a local infrastructure. In this context, Serverless computing is the fastest-growing Cloud...
Mobile map applications are increasingly used in various aspects of our lives, leading to an increase in different map use situations and, therefore, map use contexts. Several empirical usability studies have identified how map design is associated w...
Integrating CAD-based mine maps with GIS through ETL tools requires an intermediate spatial data format suitable for a range of applications. This industrial case study compares GeoJSON, GeoPackage and GML, each uncompressed and in ZIP archives, usin...
of 22