The present paper concretizes the models proposed by S. Ri and N. Secelean. S. Ri proposed the construction of the fractal interpolation function (FIF) considering finite systems consisting of Rakotch contractions, but produced no concretization of t...
Currently, purification of antibodies is mainly carried out using a platform technology composed primarily of Protein A chromatography as a capture step, regardless of the scale. However, Protein A chromatography has a number of drawbacks, which are...
Since its introduction in the late 1970s, the non-affine or slip parameter,
As technology evolves, more complex non-affine systems are created. These complex systems are hard to model, whereas most controllers require information on systems to be designed. This information is hard to obtain for systems with varying control d...
A new fixed-time adaptive neural network control strategy is designed for pure-feedback non-affine nonlinear systems with state constraints according to the feedback signal of the error system. Based on the adaptive backstepping technology, the Lyapu...
This work introduces an identification scheme capable of obtaining the unknown dynamics of a nonlinear plant process. The proposed method employs an iterative algorithm that prevents confinement to a sole trajectory by fitting a neural network over a...
In this paper, an adaptive neural fault-tolerant tracking control scheme is presented for the yaw control of an unmanned-aerial-vehicle helicopter. The scheme incorporates a non-affine nonlinear system that manages actuator faults, input saturation,...
The drag-free satellite plays an important role in the space-based gravitational wave observatory. The capture control of test mass after release is a crucial technology that can affect the success of the mission. The test mass must be released to th...
A filter-based recursive tracker design approach is presented for the problem of unknown control directions of pure-feedback systems with completely unknown non-affine nonlinearities. In the controller design procedure, the first-order filters for er...
This paper studies the problem of the event-triggered control of nonaffine stochastic nonlinear systems with actuator hysteresis. The echo state network (ESN) is introduced to approximate an unknown nonlinear function. The command filtering technolog...
Ricin, derived from the castor bean plant Ricinus communis, is one of the most potent and lethal toxins known, against which there is no available antidote. To date, the use of neutralizing antibodies is the most promising post-exposure treatment for...
This paper considers tracking control of non-affine pure-feedback systems with uncertain disturbances. The “explosion of complexity” in the process of backstepping design is eliminated by introducing the output of first-order filter to re...
This paper investigates fault-tolerant tracking for continuous-time nonlinear systems subject to input nonaffinity and prescribed state inequality constraints. A slack-function-based transformation and a dynamic precompensator are adopted to handle s...
Modeling non-stationary systems with dynamically evolving data distributions remains a fundamental challenge in modern learning and optimization problems. In this work, we adopt a generalized notion of non-stationarity, where distribution shifts acro...
Utilizing large-scale epigenomics data, deep learning tools can predict the regulatory activity of genomic sequences, annotate non-coding genetic variants, and uncover mechanisms behind complex traits. However, these tools primarily rely on human or...
Taking the plant as a total uncertainty in a black box with measurable inputs and attainable outputs, this paper presents a constructive control design of agnostic nonlinear dynamic systems with discontinuous input (such as hard nonlinearities in the...
This paper presents a synthesis of higher-order control Lyapunov functions (HOCLFs) and higher-order control barrier functions (HOCBFs) capable of controlling nonlinear dynamic systems while maintaining safety. Building on previous Lyapunov and barri...
Structural open adoption has been beneficial to adoptees in integrating their birth heritage and identity. Adoptive parents also may sometimes seek out others who are neither related biologically nor through partnership to support their child in deve...
This paper is concerned with the problem of a full formal dynamic linearized model-free adaptive control scheme based on pattern class variable (P-FFDL-MFAC) for a class of unknown non-affine nonlinear discrete-time systems. The concept of pattern cl...
In this article, we employ a version of some fixed point theory (FPT) to obtain stability results for the symmetric functional equation (FE) of q-Wright affine functions in non-Archimedean
To address the performance degradation of traditional adaptive filtering algorithms in environments with correlated input signals and non-Gaussian noise, this paper proposes a complex-valued affine projection algorithm based on the
This paper addresses the asymptotic tracking control problem for a class of nonaffine pure-feedback nonlinear systems with partially unknown internal dynamics. Traditional backstepping control is plagued by the notorious complexity explosion arising...
An adaptive control scheme is proposed for a class of uncertain pure-feedback nonlinear systems preceded by asymmetric hysteresis nonlinearity. The asymmetric property is described by the modified Bouc-Wen model based on the proposed asymmetric facto...
Single-domain antibodies, including variable domains of the heavy chains of heavy chain-only antibodies (VHHs) from camelids and variable domains of immunoglobulin new antigen receptors (VNARs) from cartilaginous fish, show the therapeutic potential...
For many chronic fibrotic conditions, there is a need for local, sustained antifibrotic drug delivery. A recent trend in the pharmaceutical industry is the repurposing of approved drugs. This paper investigates drugs that are classically used for ant...
The selectivity of measurements by means of affinity sensors in (quasi)equilibrium conditions and in non-equilibrium conditions was compared. The results show that the measurements in non-equilibrium conditions can reduce or even eliminate a relative...
Miniaturized weak affinity chromatography is emerging as an interesting alternative to conventional biophysical tools for performing fragment-screening studies in the context of fragment-based drug discovery. In order to push back the analytical limi...
In silico studies were performed to assess the binding affinity of selected organophosphorus compounds toward the acetylcholinesterase enzyme (AChE). Quantum mechanical calculations, molecular docking, and molecular dynamics (MD) with molecular mecha...
One of the most important challenges in polymer science is a rigorous understanding of the molecular mechanisms of rubber elasticity by relating macroscopic deformation to molecular changes and deriving the constitutive stress–strain equation f...
Non-small cell lung cancer (NSCLC) is the predominant form of lung cancer and poses a significant public health challenge. Early detection is crucial for improving patient outcomes, with serum biomarkers such as carcinoembryonic antigen (CEA), squamo...
We present a unified framework for modelling the term structure of interest rates using affine term structure models (ATSMs) with jumps and regime switches. The novelty lies in combining affine jump diffusion models with regime switching dynamics wit...
Aimingat non-side-looking airborne radar, we propose a novel unsupervised affinity propagation (AP) clustering radar detection algorithm to suppress clutter and detect targets. The proposed method first uses selected power points as well as space-tim...
Cryptosporidium parvum is an important apicomplexan parasite that causes severe diarrheal disease in children and immunocompromised individuals. However, the structural basis for the limited immunogenicity of its T-cell epitopes remains poorly unders...
This study aimed to compare Utrerana native hen eggs’ sensory properties to Leghorn Lohmann LSL-Classic lineage’s commercial and ecological eggs through free-choice profiling. Second, affine and non-affine profiles were defined using the...
Characterizing biomolecular receptor–ligand interactions is critical for research and development. However, performing analyses in complex, biologically relevant matrices, such as serum, remains challenging due to non-specific binding that ofte...
Phosphonyl tyrosine is one of the main biomarkers to confirm exposure to highly lethal organophosphorus nerve agents (OPNAs) in vivo. However, a critical challenge remains unresolved: ionization suppression occurs during the analysis of phosphonyl ty...
Drug–targeted therapies are promising approaches to treating tumors, and research on receptor–ligand interactions for discovering high-affinity targeted drugs has been accelerating drug development. This study presents a mechanism-driven...
Damage to peripheral nerves can cause debilitating consequences for patients such as lifelong pain and disability. At present, no drug treatments are routinely given in the clinic following a peripheral nerve injury (PNI) to improve regeneration and...
Mesenchymal stromal cells (MSCs) were obtained from human bone marrow and amplified in cultures supplemented with human platelet lysate. Once semi-confluent, cells were seeded in solid collagen scaffolds that were rapidly colonized by the cells gener...
The outer contours of living trees are often considered as a standard circle during non-destructive testing (NDT) of internal defects using ground-penetrating radar (GPR). However, the detection of classical cross-sections (circular) lacks considerat...
This paper develops an adaptive model predictive control (AMPC) scheme for uncertain nonaffine nonlinear systems by integrating deep Koopman operator theory into a fully data-driven modeling framework. Complex nonlinear systems typically feature prom...
The formulation of the entropic statistical theory and the related neo-Hookean model has been a major advance in the modeling of rubber-like materials, but the failure to explain some experimental observations such as the slope in Mooney plots result...
The indispensable role of the SARS-CoV-2 main protease (Mpro) in the viral replication cycle and its dissimilarity to human proteases make Mpro a promising drug target. In order to identify the non-covalent Mpro inhibitors, we performed a comprehensi...
The nucleolus organizer regions (NORs) demonstrate differences in genomic dispersion and transcriptional activity among all organisms. I postulate that such differences stem from distinct genomic structures and their interactions from chromosome obse...
Background/Objectives: Granulicatella adiacens infective endocarditis is conventionally managed with penicillin, ampicillin, or ceftriaxone in combination with gentamicin, although double beta-lactam regiments have been proposed a safer alternative t...
For rapid and convenient detection of living endothelial cells (ECs) specifically without immunostaining, we developed a biosensor based on turn-on fluorescent protein, named LV-EcpG. It includes a high-affinity peptide E12P obtained through phage di...
Pollution of the Arctic Ocean by potentially toxic elements (PTEs) is a current environmental problem. Humic acids (HAs) play an important role in the regulation of PTE mobility in soil and water. The permafrost thaw releases ancient organic matter (...
This paper presents a unified Euler–Lagrange methodology for deriving the dynamic models of wheeled mobile robots (WMRs) across heterogeneous kinematic architectures. The work extends the authors’ previously developed kinematic methodolog...
A low-complexity global fault-tolerant control method is proposed to solve the tracking problem of uncertain pure-feedback systems in the presence of sensor faults. First, a novel modeling approach is introduced to reconstruct the non-affine term, wh...
Fluorophore (FD) labeling is widely used for detection and quantification of various compounds bound to nanocarriers. The systems, composed of gold nanoparticles (GNPs) and oligonucleotides (ONs) labeled with FDs, have wide applications. Our work was...
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