Clinical decision-making may be enhanced when combining psychophysiological sensors with computerized neuropsychological tests. The current study explored the utility of integrating an eye tracker with a commercially available continuous performance...
Background/Objectives: Randomized clinical trials (RCTs) suggest that n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) and high-dose vitamin D supplementation during pregnancy may protect against childhood asthma. However, the underlying mecha...
This study employs a 3D discrete element method (DEM) to simulate cone penetration tests (CPTs) in granular soils, taking into account the effect of temperature. A coupled thermal mechanical model is developed to allow for heat transfer and storage i...
The biologically active form of vitamin D, calcitriol (VD3), has received great attention for its extraskeletal effects, such as a protective role on the cardiovascular system. The aim of the present work is to test the capacity of VD3 to affect lipi...
This study proposes a hybrid wireless power transfer (WPT) coupler that integrates a Double-D (DD) coil and a Split Capacitive Plate (SCP) for unmanned aerial vehicle (UAV) near-field charging stations. The proposed structure arranges the DD coil and...
Fatty acid oxidation disorders (FAODs) are inborn errors of metabolism (IEMs) caused by defects in the fatty acid (FA) mitochondrial β-oxidation. The most common FAODs are characterized by the accumulation of medium-chain FAs and long-chain (3-h...
Camptothecin (CPT) shows potent anticancer activity through inhibition of topoisomerase I. However, its water insolubility and severe toxicity limit its clinical application. Coupling with bile acid moieties is a promising method for liver-targeted d...
Hypoxia and hypoxia-related biomarkers are the major determinants of prostate cancer (PCa) aggressiveness. Therefore, a better understanding of molecular players involved in PCa cell survival under hypoxia could offer novel therapeutic targets. We pr...
Camptothecin (CPT) is a potent anticancer drug, and its putative oral administration is envisioned although difficult due to physiological barriers that must be overcome. A comprehensive biophysical analysis of CPT interaction with biointerface model...
Background and Objectives: Osteoarthritis (OA) of the knee and hip is a major cause of pain and functional impairment. This study evaluated the effects of non-immersive virtual reality (NIVR) combined with conventional physical therapy (CPT) on pain...
To accelerate maturation of intestinal function and promote growth and development, the effect of maternal clofibrate on intestinal fatty acid (FA) metabolism was investigated in suckling piglets. Twenty-seven pregnant sows were fed either 0, 0.25, o...
The medicinal plant, Ophiorrhiza pumila, naturally grows on the floors of humid inland forests in subtropical areas. It accumulates camptothecin (CPT), which is used as an anti-tumor agent, in all organs. We investigated the optimal hydroponic root-z...
Bisphenol S (BPS) is an environmental pollutant that can accumulate in the human body and cause harm. Puerarin (PUE) is a flavonoid with anti-inflammatory and antioxidant effects. In this study, we used 50 mg/kg/d BPS as a poison and PUE as an interv...
Benzo[c]phenanthridine (BCP) derivatives were identified as topoisomerase I (TOP-I) targeting agents with pronounced antitumor activity. In this study, hologram-QSAR, 2D-QSAR and 3D-QSAR models were developed for BCPs on topoisomerase I inbibitory ac...
Background/Objectives: Reactive oxygen species (ROS)-responsive polymeric drug conjugates (PDCs) can enable oxidative stress-triggered drug release, but their activation may be limited by heterogeneous or insufficient intracellular ROS. Herein, we sy...
Objectives: This study investigated how polysorbate 80 (Tween 80; TW80) loading affects the biopharmaceutical performance of curcumin (CUR) amorphous solid dispersions (ASDs), focusing on the relationship between apparent dissolution and oral exposur...
This paper was prepared based on in situ measurements carried out by the authors using the CPTu and DMT static penetration probes. The list of study sites includes seven specific locations in the northern parts of Croatia and one study site on the so...
With the aim to investigate the role of chirality and helicity between d- and l-valine crystal lattices under Debye temperature 2–20 K, magnetic field dependence of zero-field and 1, 3 and 5 Tesla on the heat capacity were measured. The heat ca...
Background/Objectives: Although increased nociceptive excitability and deficient endogenous pain modulation are considered key features of pronociception and central sensitization, their contribution to neuropathic pain (NP) characteristics in SCI is...
The concrete prism test (CPT) retains the aggregate size and specimen configuration of concrete and is widely used to evaluate measures for mitigating alkali–silica reaction (ASR). However, it requires a long test period, and stable control of...
6 January 2023
Background: Explosive strength is essential for rhythmic gymnasts’ performance. It has been suggested that core stability (CS) and plyometric training can enhance athletes’ explosive strength. Nevertheless, there is some uncertainty about...
This study aimed to investigate the effects of resveratrol (RES) and carboplatin (CPT), alone and in combination, on cell viability, apoptosis, cell cycle progression, mitochondrial function, and oxidative stress in Y79 retinoblastoma (RB) cells. Par...
Background/Objectives: The purpose of the present study was to assess the relationships between attention level and personality traits among 44 older adults aged from 65 to 75 in the Israeli population. The participants were 19 females and 25 males,...
The combination of unmanned aerial vehicles and atomic magnetometers can be used for detection applications such as mineral resource exploration, environmental protection, and earthquake monitoring, as well as the detection of sunken ships and unexpl...
23 April 2020
Chronic exposure to lead is neurotoxic to the human peripheral sensory system. Variant vitamin D receptor (VDR) genes and polymorphisms of metallothioneins (MTs) are associated with different outcomes following lead toxicity. However, no evidence of...
3D printing (3DP) of cement-based systems (CBSs) is a highly demanded technology in the construction field. Material requirements include specific rheological conditions for proper extrusion, followed by fast stiffening and strength gain to allow the...
Background/Objectives: Peritoneal micrometastases (micromets) remain a major barrier to durable cytoreduction in ovarian and other intra-abdominal cancers because lesions are difficult to visualize and are often resistant to systemic therapy. Liposom...
With the rapid development of the economy, data have become a new production factor and strategic asset, enhancing efficiency and energy for technological innovation and industrial upgrading in enterprises. The evaluation of enterprise digital asset...
Background: Clinical practice suggests that objective assessment tools are needed to assess adults with inattention or hyperactivity, informed by the underlying pathophysiology of attention-deficit and hyperactivity disorder (ADHD). This systematic r...
In continuation of our program aimed at the development of natural product-based pesticidal agents, three series of novel camptothecin derivatives were designed, synthesized, and evaluated for their biological activities against T. Cinnabarinus, B. b...
Background: Metabolic reprogramming and mitochondrial dysfunction are central features of acute kidney injury (AKI), yet their temporal relationship with proximal tubular cell-state remodeling remains incompletely understood. This study aimed to char...
27 June 2014
Although there is some evidence supporting the existence of an association between prenatal maternal or postnatal child’s urine phthalate metabolite concentrations and poor attentional performances, the interaction between urine phthalate metabolite...
11 October 2021
Delivering metaphors experientially has been emphasized in several psychotherapies, such as acceptance and commitment therapy. However, few research has analyzed the variables involved in the efficacy of metaphors. This experimental analog study aims...
Azadirachta indica was designated the “Tree of the 21st century” by the United Nations, as it is believed to be the largest natural depository of bioactive phytochemicals. This study investigates genetic variability among 152 Candidate Pl...
In cone penetration test (CPT) based on submarine drilling rigs, encountering harder soil layers requires drill-bit rotation. During this process, the flow noise generated by seawater flushing the drill bit propagates along the drill pipe with the de...
A series of eight new alkyl-7,8,9-trichloro-6,7,8,9-tetrahydro-5-oxopyrido[2,3-a]-indolizine-10-carboxylates (OPIC), analogues of camptothecin (CPT), were prepared in a one-pot reaction of 2,2'-bipyridine-3,3'-dicarboxylic acid (BPA) with a mixture o...
Background/Objectives: Subtle cognitive alterations have been described in children with type 1 diabetes (T1D), but the association between cognition and real-time glycemia during cognitive testing remains unclear. This study aimed to investigate whe...
Objective: Tranexamic acid (TXA) is widely used in rhinoplasty to minimize intraoperative bleeding and improve visualization; however, its effect on postoperative bleeding remains unclear. This study aimed to evaluate whether intravenous TXA reduces...
Aging is an irreversible pathophysiological process for all organisms. The accumulation of senescent cells in pathological sites or tissues is recognized as the major cause of diseases and disorders during the aging process. Small molecules that redu...
17 October 2023
Melatonin, a hormone secreted by the pineal gland of vertebrates, regulates sleep, blood pressure, and circadian and seasonal rhythms, and acts as an antioxidant and anti-inflammatory agent. We investigated the protective effects of melatonin against...
An experimental study was conducted to evaluate the printability of cement–lime mortars designed for 3D printing applications, incorporating a microencapsulated phase-change material (PCM) and cellulose microfibers (CMFs). The influence of both...
Artificial night light (ALAN) could lead to circadian rhythm disorders and disrupt normal lipid metabolism, while time-restricted feeding (TRF) could maintain metabolic homeostasis. In mammals, TRF has been demonstrated to have extraordinary effects...
We investigated an exact solution in a conformal invariant Randall-Sundrum 5D warped brane world model on a time dependent Kerr-like spacetime. The singular points are determined by a quintic polynomial in the complex plane and fulfills Cauchy’...
Delphinidin-3-O-β-glucoside (D3G) is a health-promoting anthocyanin whose anti-obesity activity has not yet been thoroughly investigated. We examined the effects of D3G on adipogenesis and lipogenesis in 3T3-L1 adipocytes and primary white adipo...
The classification of soils into categories with a similar range of properties is a fundamental geotechnical engineering procedure. At present, this classification is based on various types of cost- and time-intensive laboratory and/or in situ tests....
Compact wireless electronic devices require charging interfaces that can support different receiver positions and orientations within limited spaces. In this context, a double-sided mixed-coupling structure can provide independent magnetic- and elect...
Type-2 diabetes mellitus (T2D) is one of the leading non-communicable diseases of global concern. Knowing the exact mechanism of action of available antidiabetic agents, particularly natural products, may assist in providing effective therapeutic sol...
Obesity is recognized as a state of chronic low-grade systemic inflammation due to adipose tissue macrophage infiltration and production of proinflammatory adipokines. Decreased vitamin D status is associated with obesity. The specific aim of the pre...
Left ventricular (LV) function is normally improved after renal transplant; however, cardiovascular mortality remains elevated. Moderate physical activity has a positive impact on myocardial function; however, few data are available about the role of...
The effects of chronic coffee exposure in models of type 2 diabetes mellitus (T2D) is scarcely studied, and the efficacy of the main coffee species has never been compared. We tested the hypothesis that long-term consumption of arabica and robusta co...
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