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Pharmaceutics
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ROS-Mediated Nano Drug Delivery for Antitumor Therapy
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ROS-Mediated Nano Drug Delivery for Antitumor Therapy

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1754

Special Issue Editors

Dr. Yanjuan Huang

E-Mail Website
Guest Editor
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China
Interests: antitumor nanomedicine; ROS-mediated tumor oxidation therapy; ROS-responsive prodrug/nanodrug delivery; ROS-mediated immunotherapy; ROS-mediated combination therapy; advanced targeted drug delivery system with nanomedicine or macrophage; ROS-responsive hydrogel
Dr. Xiaoyu Xu

E-Mail Website
Guest Editor
Department of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China
Interests: advanced drug delivery systems with bioactive materials; ROS-mediated combination therapy; nanomedicine; antitumor immunotherapy

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit original research papers and reviews in the field of ROS-mediated antitumor nanomedicine. ROS are a class of chemically reactive small molecules containing oxygen. Compared with normal cells, tumor cells generally have higher concentrations of ROS and are more susceptible to oxidative stress-induced cell death, which makes ROS-based therapies inherently tumor-selective. ROS-mediated tumor oxidation therapy and ROS-responsive drug delivery system are two key components of ROS-mediated therapies. Recently, ROS has emerged as an innovative and unique treatment mode as it can not only directly kill tumor cells but also induce immunogenic cell death (ICD) to activate the body’s immune responses. In addition, it can be easily generated and modulated by means of photodynamic therapy (PDT), sonodynamic therapy (SDT), chemodynamic therapy (CDT), radiodynamic therapy (RDT), microdynamic therapy (MDT), and electrodynamic therapy (EDT).

This Special Issue aims at gathering recent advancements in this field, encompassing topics such as PDT, SDT, CDT, RDT, MDT, EDT, ROS-mediated immunotherapy, ROS-responsive drug delivery system for anti-tumor nanomedicine, and other related topics.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: ROS-mediated tumor oxidation therapy/combination therapy, ROS-responsive anti-tumor drug delivery system, ROS-mediated tumor immunotherapy, and other related areas.

We look forward to receiving your contributions.

Dr. Yanjuan Huang
Dr. Xiaoyu Xu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antitumor therapy
  • reactive oxygen species (ROS)
  • ROS-mediated biomedical nanotechnology
  • ROS-responsive nano drug delivery
  • ROS-mediated immunotherapy
  • ROS-mediated combination therapy
  • oxidation therapy
  • photodynamic therapy (PDT)
  • sonodynamic therapy (SDT)
  • chemodynamic therapy (CDT)
  • radiodynamic therapy (RDT)
  • microdynamic therapy (MDT)
  • electrodynamic therapy (EDT)

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Published Papers (2 papers)

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Research

17 pages, 5473 KiB  
Article
Sivelestat-Loaded Neutrophil-Membrane-Coated Antioxidative Nanoparticles for Targeted Endothelial Protection in Sepsis
by Juexian Wei, Aijia Zhong, Yuting Zhang, Ehua Deng, Hengzong Mo, Hongyu Zhao, Jiayu Huang, Huaidong Peng, Kaiyin Zhang, Xiaohui Chen, Haifeng Mao, Yixin Chen and Yongcheng Zhu
Pharmaceutics 2025, 17(6), 766; https://doi.org/10.3390/pharmaceutics17060766 - 10 Jun 2025
Viewed by 178
Abstract
Background/Objectives: This study aims to develop and evaluate neutrophil-membrane-coated nanoparticles (Siv@NMs) encapsulating sivelestat for the treatment of sepsis-induced endothelial injury. Leveraging the intrinsic chemotactic properties of neutrophil membranes, Siv@NMs are engineered to achieve site-specific delivery of sivelestat to damaged endothelia, thereby overcoming [...] Read more.
Background/Objectives: This study aims to develop and evaluate neutrophil-membrane-coated nanoparticles (Siv@NMs) encapsulating sivelestat for the treatment of sepsis-induced endothelial injury. Leveraging the intrinsic chemotactic properties of neutrophil membranes, Siv@NMs are engineered to achieve site-specific delivery of sivelestat to damaged endothelia, thereby overcoming the limitations of conventional therapies in mitigating endothelial dysfunction and multiorgan failure associated with sepsis. Methods: Siv@NMs were synthesized through a combination of ultrasonication and extrusion techniques to encapsulate sivelestat within neutrophil-membrane-derived vesicles. Comprehensive physicochemical characterization included analysis of particle size distribution, zeta potential, and encapsulation efficiency. Stability profiles and controlled release kinetics were systematically evaluated under simulated conditions. In vitro investigations encompassed (1) endothelial cell biocompatibility assessment via cytotoxicity assays, (2) investigation of the targeting efficiency in suppressing endothelial neutrophil extracellular trap generation during inflammation, and (3) ROS-scavenging capacity quantification using flow cytometry with DCFH-DA fluorescent probes. In vivo therapeutic efficacy was validated using a cecal ligation and puncture (CLP) sepsis mouse model, with multiparametric monitoring of endothelial function, inflammatory markers, ROS levels, and survival outcomes. Results: The optimized Siv@NMs exhibited an average particle size of approximately 150 nm, and a zeta potential of −10 mV was achieved. Cellular studies revealed that (1) Siv@NMs selectively bound to inflammatory endothelial cells with minimal cytotoxicity, and (2) Siv@NMs significantly reduced ROS accumulation in endothelial cells subjected to septic stimuli. In vitro experiments demonstrated that Siv@NMs treatment markedly attenuated endothelial injury biomarkers’ expression (ICAM-1 and iNOS), suppressed formation of neutrophil extracellular traps, and improved survival rates compared to treatment with free sivelestat. Conclusions: The neutrophil-membrane-coated nanoparticles loaded with sivelestat present a breakthrough strategy for precision therapy of sepsis-associated endothelial injury. This bioengineered system synergistically combines targeted drug delivery with multimodal therapeutic effects, including ROS mitigation, anti-inflammatory action, and endothelial protection. These findings substantiate the clinical translation potential of Siv@NMs as a next-generation nanotherapeutic for sepsis management. Full article
(This article belongs to the Special Issue ROS-Mediated Nano Drug Delivery for Antitumor Therapy)
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16 pages, 6034 KiB  
Article
Precisely Tailoring Molecular Structure of Doxorubicin Prodrugs to Enable Stable Nanoassembly, Rapid Activation, and Potent Antitumor Effect
by Chengcheng Feng, Yuting Wang, Jiaxu Xu, Yanzi Zheng, Wenhu Zhou, Yuequan Wang and Cong Luo
Pharmaceutics 2024, 16(12), 1582; https://doi.org/10.3390/pharmaceutics16121582 - 11 Dec 2024
Cited by 23 | Viewed by 1071
Abstract
Background: Achieving a balance between stable drug loading/delivery and on-demand drug activation/release at the target sites remains a significant challenge for nanomedicines. Carrier-free prodrug nanoassemblies, which rely on the design of prodrug molecules, offer a promising strategy to optimize both drug delivery efficiency [...] Read more.
Background: Achieving a balance between stable drug loading/delivery and on-demand drug activation/release at the target sites remains a significant challenge for nanomedicines. Carrier-free prodrug nanoassemblies, which rely on the design of prodrug molecules, offer a promising strategy to optimize both drug delivery efficiency and controlled drug release profiles. Methods: A library of doxorubicin (DOX) prodrugs was created by linking DOX to fatty alcohols of varying chain lengths via a tumor-responsive disulfide bond. In vitro studies assessed the stability and drug release kinetics of the nanoassemblies. In vivo studies evaluated their drug delivery efficiency, tumor accumulation, and antitumor activity in mouse models. Results: In vitro results demonstrated that longer fatty alcohol chains improved the stability of the nanoassemblies but slowed down the disassembly and drug release process. DSSC16 NAs (hexadecanol-modified DOX prodrug) significantly prolonged blood circulation time and enhanced tumor accumulation, with AUC values 14.2-fold higher than DiR Sol. In 4T1 tumor-bearing mouse models, DSSC16 NAs exhibited notably stronger antitumor activity, resulting in a final mean tumor volume of 144.39 ± 36.77 mm3, significantly smaller than that of all other groups (p < 0.05 by ANOVA at a 95% confidence interval). Conclusions: These findings underscore the critical role of prodrug molecule design in the development of effective prodrug nanoassemblies. The balance between stability and drug release is pivotal for optimizing drug delivery and maximizing therapeutic efficacy. Full article
(This article belongs to the Special Issue ROS-Mediated Nano Drug Delivery for Antitumor Therapy)
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