ROS-Mediated Nano Drug Delivery for Antitumor Therapy

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1352

Special Issue Editors


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Guest Editor
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China
Interests: antitumor nanomedicine; ROS-mediated tumor oxidation therapy; ROS-responsive prodrug/nanodrug delivery; ROS-mediated immunotherapy; ROS-mediated combination therapy; advanced targeted drug delivery system with nanomedicine or macrophage; ROS-responsive hydrogel

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Guest Editor
Department of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China
Interests: advanced drug delivery systems with bioactive materials; ROS-mediated combination therapy; nanomedicine; antitumor immunotherapy

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit original research papers and reviews in the field of ROS-mediated antitumor nanomedicine. ROS are a class of chemically reactive small molecules containing oxygen. Compared with normal cells, tumor cells generally have higher concentrations of ROS and are more susceptible to oxidative stress-induced cell death, which makes ROS-based therapies inherently tumor-selective. ROS-mediated tumor oxidation therapy and ROS-responsive drug delivery system are two key components of ROS-mediated therapies. Recently, ROS has emerged as an innovative and unique treatment mode as it can not only directly kill tumor cells but also induce immunogenic cell death (ICD) to activate the body’s immune responses. In addition, it can be easily generated and modulated by means of photodynamic therapy (PDT), sonodynamic therapy (SDT), chemodynamic therapy (CDT), radiodynamic therapy (RDT), microdynamic therapy (MDT), and electrodynamic therapy (EDT).

This Special Issue aims at gathering recent advancements in this field, encompassing topics such as PDT, SDT, CDT, RDT, MDT, EDT, ROS-mediated immunotherapy, ROS-responsive drug delivery system for anti-tumor nanomedicine, and other related topics.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: ROS-mediated tumor oxidation therapy/combination therapy, ROS-responsive anti-tumor drug delivery system, ROS-mediated tumor immunotherapy, and other related areas.

We look forward to receiving your contributions.

Dr. Yanjuan Huang
Dr. Xiaoyu Xu
Guest Editors

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Keywords

  • antitumor therapy
  • reactive oxygen species (ROS)
  • ROS-mediated biomedical nanotechnology
  • ROS-responsive nano drug delivery
  • ROS-mediated immunotherapy
  • ROS-mediated combination therapy
  • oxidation therapy
  • photodynamic therapy (PDT)
  • sonodynamic therapy (SDT)
  • chemodynamic therapy (CDT)
  • radiodynamic therapy (RDT)
  • microdynamic therapy (MDT)
  • electrodynamic therapy (EDT)

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Published Papers (1 paper)

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Research

16 pages, 6034 KiB  
Article
Precisely Tailoring Molecular Structure of Doxorubicin Prodrugs to Enable Stable Nanoassembly, Rapid Activation, and Potent Antitumor Effect
by Chengcheng Feng, Yuting Wang, Jiaxu Xu, Yanzi Zheng, Wenhu Zhou, Yuequan Wang and Cong Luo
Pharmaceutics 2024, 16(12), 1582; https://doi.org/10.3390/pharmaceutics16121582 - 11 Dec 2024
Cited by 3 | Viewed by 942
Abstract
Background: Achieving a balance between stable drug loading/delivery and on-demand drug activation/release at the target sites remains a significant challenge for nanomedicines. Carrier-free prodrug nanoassemblies, which rely on the design of prodrug molecules, offer a promising strategy to optimize both drug delivery efficiency [...] Read more.
Background: Achieving a balance between stable drug loading/delivery and on-demand drug activation/release at the target sites remains a significant challenge for nanomedicines. Carrier-free prodrug nanoassemblies, which rely on the design of prodrug molecules, offer a promising strategy to optimize both drug delivery efficiency and controlled drug release profiles. Methods: A library of doxorubicin (DOX) prodrugs was created by linking DOX to fatty alcohols of varying chain lengths via a tumor-responsive disulfide bond. In vitro studies assessed the stability and drug release kinetics of the nanoassemblies. In vivo studies evaluated their drug delivery efficiency, tumor accumulation, and antitumor activity in mouse models. Results: In vitro results demonstrated that longer fatty alcohol chains improved the stability of the nanoassemblies but slowed down the disassembly and drug release process. DSSC16 NAs (hexadecanol-modified DOX prodrug) significantly prolonged blood circulation time and enhanced tumor accumulation, with AUC values 14.2-fold higher than DiR Sol. In 4T1 tumor-bearing mouse models, DSSC16 NAs exhibited notably stronger antitumor activity, resulting in a final mean tumor volume of 144.39 ± 36.77 mm3, significantly smaller than that of all other groups (p < 0.05 by ANOVA at a 95% confidence interval). Conclusions: These findings underscore the critical role of prodrug molecule design in the development of effective prodrug nanoassemblies. The balance between stability and drug release is pivotal for optimizing drug delivery and maximizing therapeutic efficacy. Full article
(This article belongs to the Special Issue ROS-Mediated Nano Drug Delivery for Antitumor Therapy)
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