An asphalt mastic has thixotropic characteristics that significantly influence its fatigue and healing performance. Therefore, understanding the thixotropy of an asphalt mastic is clearly of great importance. However, research in this area is still i...
Background: Micronutrient abnormalities are frequent in critically ill patients and are associated with organ dysfunction, infection, and adverse outcomes. Yet randomized controlled trials of supplementation have largely failed to demonstrate a consi...
This study introduces the Failure Decision Function, a novel approach for evaluating the structural capacity of rectangular reinforced concrete columns under axial forces and moments, both uniaxial and biaxial. The method simplifies existing practice...
The aircraft landing gear system is vital in ensuring the aircraft’s functional completeness and operational safety. The mechanical structures of the landing gear must withstand significant operational forces, including repeated high-intensity...
18 January 2017
There are multiple lines of evidence of a strong link between obstructive sleep apnoea and heart failure. First, obstructive sleep apnoea is associated with cardiovascular risk factors (hypertension and diabetes) and cardiovascular diseases (coronary...
In mountain areas, long linear transport infrastructures (roads, motorways, railways, etc.) are exposed to numerous natural hazards, especially hydrological and gravity-driven events such as slope instabilities, rockfalls, or torrential hazards. Thes...
The main purpose of the article is to demonstrate how large language models (LLMs) can enhance and automate the Failure Modes and Effects Analysis (FMEA) method to improve the identification, assessment, and management of operational risk in modern t...
Heart failure (HF) is a complex clinical syndrome involving structural and/or functional abnormalities of the heart. Heart failure is often classified based on left ventricular ejection fraction, which serves as a predictor of mortality. The majority...
Obesity is strongly associated with an increased risk of heart failure. Recent studies indicate that epicardial adipose tissue plays a critical role in the development of obesity-related cardiomyopathy. This distinct visceral fat depot, located betwe...
Earthquake hazards, such as strong ground motion, liquefaction, and landslides, pose significant threats to structures built on seismically vulnerable, loose, and saturated sandy soils. Therefore, a structural failure evaluation method that accounts...
Stretchable electronics rely on sophisticated structural designs to allow brittle metallic conductors to adapt to curved or moving substrates. Patterns of soft islands and stable cracks in layered silver-PDMS composites provide exceptional stretchabi...
Shape memory alloy (SMA) micro cables have a wide potential for attenuation of vibrations and structural health monitoring due to energy dissipation. This work evaluates the effect of SMA thermomechanical coupling during dynamic cycling and the fatig...
Background/Objectives: Carvedilol is an adrenergic blocker FDA-approved to improve outcomes in heart failure with reduced ejection fraction. Clinical trials examining whether carvedilol may be cardioprotective in the setting of cancer therapy-induced...
Age-associated changes leading to a decline in cardiac structure and function contribute to the increased susceptibility and incidence of cardiovascular diseases (CVD) in elderly individuals. Indeed, age is considered a risk factor for heart failure...
Cartilage degeneration is a characteristic of osteoarthritis (OA), which is often observed in aging populations. This degeneration is due to the breakdown of articular cartilage (AC) mechanical and tribological properties primarily attributed to lubr...
The traditional route to achieving adequate structural performance in the event of fire is through ensuring that structural elements attain fire resistance ratings. The magnitude of these ratings typically varies in function of the building use, size...
Infiltrative cardiomyopathies comprise a heterogeneous spectrum of hereditary and acquired diseases characterised by the accumulation of pathological substrates within the myocardium, ultimately resulting in progressive impairment of cardiac function...
Hemodialysis is the most commonly used renal replacement therapy worldwide, and arteriovenous fistulas (AVFs) are the preferred vascular access. The functional patency of AVFs directly determines the dialysis efficiency and quality of life of patient...
This study proposed an optimization framework and methodologies to design edgeless lattice structures featuring fillet and multipipe functions. Conventional lattice structures typically experience stress concentration at the sharp edges of strut join...
This paper presents a novel meta-functional auxetic unit (MFAU) cell designed to improve performance and weight ratio for structural bridge bearing applications. Numerical investigations were conducted using three-dimensional finite element models va...
Standing Seam Metal Roofs (SSMRs) are widely used in the construction of industrial buildings, and their structural characteristics are rapidly being changed in order to improve the parameters of heat insulation and waterproofness. However, newly emp...
The paper provides findings on the technical efficiency of the European dairy processing industry, which is one of the most important subsectors of the food processing industry in the European Union (EU). The ability to efficiently use inputs in the...
In the present work, we study threshold reliability systems consisting of three different kinds of independent components. Within these structures, the components belonging to the same type, share a common reliability and the same weight. The reliabi...
Chronic heart failure (CHF) is a complex syndrome that results from structural and functional disturbances that affect the ability of the heart to supply oxygen to tissues. It largely affects and reduces the patient’s quality of life, socio-eco...
LNG storage tanks are essential facilities for large-scale storage and transportation of cryogenic energy. Because of the flammable, explosive, and ultra-low-temperature characteristics of liquefied natural gas, failures in such systems may result in...
Leucine supplementation potentiates the effects of aerobic exercise training (AET) on skeletal muscle; however, its potential effects associated with AET on cardiac muscle have not been clarified yet. We tested whether leucine supplementation would...
The heart is the most energy-consuming organ in the human body. In heart failure, the homeostasis of energy supply and demand is endangered by an increase in cardiomyocyte workload, or by an insufficiency in energy-providing processes. Energy metabol...
WEE2, an oocyte-specific kinase of the WEE family, is a core regulator of oocyte meiosis. It maintains germinal vesicle (GV) arrest and prevents premature meiotic resumption by phosphorylating cyclin-dependent kinase 1 (CDK1), thereby inhibiting matu...
Ventricular arrhythmias contribute significantly to morbidity and mortality in patients with heart failure (HF). Pathomechanisms underlying arrhythmogenicity in patients with structural heart disease and impaired cardiac function include myocardial f...
Due to their excellent mechanical properties, the carbon fiber-reinforced polymer composites (CFRPs) of thermoplastic resins are widely used, and an accurate constitutive model plays a pivotal role in structural design and service safety. A two-param...
Structural Health Monitoring (SHM) is essential to identifying problems that may cause human and material losses produced by disastrous and unexpected structural failures. The dynamic characterization of civil structures adopting SHM systems provides...
In cystic fibrosis (CF), pulmonary infection with Pseudomonas aeruginosa is a cause of increased morbidity and mortality, especially in patients for whom infection becomes chronic and there is reliance on long-term suppressive therapies. Current anti...
The Weibull distribution is a versatile probability distribution widely applied in modeling the failure times of objects or systems. Its behavior is shaped by two essential parameters: the shape parameter and the scale parameter. By manipulating thes...
Pathological cardiac hypertrophy is a critical factor leading to cardiomyopathy and ultimately heart failure. While several signaling pathways controlling cardiac hypertrophy have been identified, the molecular mechanisms underlying their precise reg...
Design-build contractors are challenged with the task of minimizing failure risks when introducing new technical solutions or adapting technical solutions to new conditions, e.g., climate change. They seem to have a disproportional trust in suppliers...
Coronary microvascular dysfunction (CMD) refers to a subset of structural and/or functional disorders of coronary microcirculation that lead to impaired coronary blood flow and eventually myocardial ischemia. Amid the growing knowledge of the pathoph...
Carbon fibre-reinforced polymers (CFRPs) are a lightweight alternative solution for various applications due to their mechanical and structural properties. However, debonding at the fibre–matrix interface is an important failure mechanism in co...
This study proposes an integrated framework that combines nonlinear stochastic vibration analysis with reliability assessment to address the safety issues of cable systems under damage conditions. First of all, a mathematical model of the damaged cab...
Maritime kill webs integrate heterogeneous platforms across air, surface, and underwater domains, with each platform potentially supporting multiple mission functions. Existing reliability models often represent attacks as complete node removals and...
Ischemia with nonobstructive coronary artery disease (INOCA) is increasingly recognized as a significant cause of angina, myocardial remodeling, and eventually heart failure (HF). Coronary microvascular dysfunction (CMD) is a major endotype of INOCA,...
The asphalt mixture splitting test is one of the most important methods for measuring asphalt’s tensile properties. To characterize the limitations of the traditional splitting test and the influence of the specimen size and loading conditions...
Gut-derived metabolites, particularly trimethylamine N-oxide (TMAO), have been implicated in the pathophysiology of heart failure (HF). This study investigated the associations between TMAO, cardiac function, and clinical parameters to evaluate TMAO&...
The endogenous ouabain (EO) is a steroid hormone secreted by the adrenal gland with cardio-tonic effects. In this article, we have reviewed and summarized the most recent reports about EO, particularly with regard to how it may interact with specific...
Diabetes mellitus (DM) and cardiovascular complications are two unmet medical emergencies that can occur together. The rising incidence of heart failure in diabetic populations, in addition to apparent coronary heart disease, ischemia, and hypertensi...
Heart failure (HF) is a leading cause of morbidity and mortality worldwide, representing a complex clinical syndrome in which the heart’s ability to pump blood efficiently is impaired. HF can be subclassified into heart failure with reduced eje...
Maritime Autonomous Surface Ships (MASSs) incorporate advanced digital technologies, thus rendering their systems more complex and diverse than those of conventional ships. Furthermore, the operation of MASSs, which introduces new risks not encounter...
Construction of rock-fill dams requires extensive preparatory work. The rationality of construction, ecological aspects, and flood safety must be considered. Potential catastrophic consequences of failure or collapse classify dam structures as high-r...
Background: Lead-related tricuspid valve dysfunction (LDTVD) has not been studied in a large population and its management remains controversial. Methods: An analysis of the clinical data of 2678 patients undergoing transvenous lead extraction (TLE)...
A decrease in the regenerative potential of the liver during the development of non-alcoholic fatty liver disease (NAFLD), which is observed in the vast majority of patients with diabetes mellitus type 1, significantly increases the risk of postopera...
Background/Objectives: Doxorubicin (DOX) is an effective chemotherapeutic agent whose clinical use is limited by dose-dependent cardiotoxicity that may progress to irreversible heart failure. Celastrol (Cel), a bioactive triterpenoid from Tripterygiu...
of 10