Roles of Inflammasomes in Aging and Age-Related Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 46469
Special Issue Editor
Interests: inflammasomes; aging; autophagy; rare diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Inflammasomes are multiprotein complexes formed and activated after exposure to different danger signals that lead to the maturation of caspase-1 and the processing of its substrates, IL-1β and IL-18. In recent years, their implication in different diseases such as cardiovascular, neurodegenerative, psychiatric, and metabolic diseases has opened the door to developing new therapeutic perspectives. The NLRP3-inflammasome is the best-described complex which has also been shown to play a role in metabolic diseases such as obesity, diabetes, gout, and different age-associated diseases. Recently, the ablation of NLRP3 has been shown to prevent different aspects of aging and improve healthspan and lifespan in animal models.
In the Special Issue entitled “Inflammasomes in aging”, we welcome the submission of original and review articles covering a broad range of aspects related to the pathophysiological aspect of the inflammasomes in aging and age-related diseases. This may include topics related to cancer, cardiovascular, metabolic, neurodegenerative, and psychiatric diseases, bone disorder, and all disorder associated with aging. Furthermore, we may include biological topics associated with inflammasomes and aging; autophagy; AMPK; inflammation; stem cells; inmmunology; pathogens; oxidative stress; mitocondrial dysfunction; and celular stress.
Dr. Mario D. Cordero
Guest Editor
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Keywords
- inflammasomes
- NLRP3
- aging
- age-related diseases
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