Next Article in Journal
Quantitative Proteomic Analysis Provides Insights into Rice Defense Mechanisms against Magnaporthe oryzae
Next Article in Special Issue
Genetics of Hypertension in African Americans and Others of African Descent
Previous Article in Journal
Improved General and Oral Health in Diabetic Patients by an Okinawan-Based Nordic Diet: A Pilot Study
Previous Article in Special Issue
Role of Cryptochrome-1 and Cryptochrome-2 in Aldosterone-Producing Adenomas and Adrenocortical Cells
Comment published on 24 January 2019, see Int. J. Mol. Sci. 2019, 20(3), 505.
Review

Endogenous Ouabain and Related Genes in the Translation from Hypertension to Renal Diseases

Genomics of Renal Disease and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Università Vita Salute San Raffaele, 20132 Milan, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(7), 1948; https://doi.org/10.3390/ijms19071948
Received: 22 May 2018 / Revised: 28 June 2018 / Accepted: 29 June 2018 / Published: 3 July 2018
(This article belongs to the Special Issue Role of Genomics in the Management of Hypertension)
The endogenous ouabain (EO) is a steroid hormone secreted by the adrenal gland with cardio-tonic effects. In this article, we have reviewed and summarized the most recent reports about EO, particularly with regard to how it may interact with specific genetic backgrounds. We have focused our attention on the EO’s potential pathogenic role in several diseases, including renal failure, essential hypertension and heart failure. Notably, these reports have demonstrated that EO acts as a pro-hypertrophic and growth-promoting hormone, which might lead to a cardiac remodeling affecting cardiovascular functions and structures. In addition, a possible role of EO in the development of acute kidney injury has been hypothesized. During the last decays, many important improvements permitted a deeper understanding of EO’s metabolisms and functions, including the characteristics of its receptor and the effects of its activation. Such progresses indicated that EO has significant implications in the pathogenesis of many common diseases. The patho-physiological role of EO in the development of hypertension and other cardiac and renal complications have laid the basis for the development of a new selective compound that could selectively modulate the genetic and molecular mechanisms involved in EO’s action. It is evident that the knowledge of EO has incredibly increased; however, many important areas remain to be further investigated. View Full-Text
Keywords: cardio-tonic steroids; endogenous ouabain; adducin; hypertension; renal damage cardio-tonic steroids; endogenous ouabain; adducin; hypertension; renal damage
Show Figures

Figure 1

MDPI and ACS Style

Simonini, M.; Casanova, P.; Citterio, L.; Messaggio, E.; Lanzani, C.; Manunta, P. Endogenous Ouabain and Related Genes in the Translation from Hypertension to Renal Diseases. Int. J. Mol. Sci. 2018, 19, 1948. https://doi.org/10.3390/ijms19071948

AMA Style

Simonini M, Casanova P, Citterio L, Messaggio E, Lanzani C, Manunta P. Endogenous Ouabain and Related Genes in the Translation from Hypertension to Renal Diseases. International Journal of Molecular Sciences. 2018; 19(7):1948. https://doi.org/10.3390/ijms19071948

Chicago/Turabian Style

Simonini, Marco, Paola Casanova, Lorena Citterio, Elisabetta Messaggio, Chiara Lanzani, and Paolo Manunta. 2018. "Endogenous Ouabain and Related Genes in the Translation from Hypertension to Renal Diseases" International Journal of Molecular Sciences 19, no. 7: 1948. https://doi.org/10.3390/ijms19071948

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop