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Molecular Research in Obesity and Obesity Related Disorders: 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 410

Special Issue Editor


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Guest Editor
1. Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland
2. Center for Preclinical Research, Medical University of Warsaw, 02-097 Warsaw, Poland
Interests: biochemistry and molecular medicine; molecular and cellular mechanisms of disease pathogenesis; pathogenesis of metabolic disorders; the role of interaction between genetic and environmental factors in the pathogenesis of non-communicable diseases; atherosclerosis; obesity; obesity-related metabolic diseases and cancers
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Special Issue Information

Dear Colleagues,

Obesity, a complex disease involving an excessive amount of body fat, significantly increases the risk of many metabolic diseases and various cancers. Although the main causes of excessive accumulation of adipose tissue are known and numerous efforts have been undertaken to fight the obesogenic environment, the number of overweight and obese people continues to grow. The obesity epidemic intensifies the need for research on the etiology of this disease, especially its molecular mechanisms. There is considerable evidence that supports the role of epigenetic mechanisms, as well as cross-talks between adipocytes and other cells, and between adipose tissue and other tissues in the development of obesity and obesity-related diseases.

For this Special Issue, we seek papers that focus on the molecular mechanisms associated with the development of obesity and obesity-related diseases, including adipocyte biology and adipose tissue disfunction, cell-to-cell metabolic cross-talk and cross-talk between microbiome and adipose tissue, and the molecular mechanisms underlying these processes. Data on specific molecular patterns of adipocytes and other cells involved in the development of adipose tissue dysfunction and its metabolic consequences are welcome. New insights into molecular mechanisms related to changes in eating behaviours that lead to obesity are also of importance.

Prof. Dr. Grażyna Nowicka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • biochemistry and molecular medicine
  • molecular and cellular mechanisms of disease pathogenesis
  • pathogenesis of metabolic disorders
  • the role of interaction between genetic and environmental factors in the pathogenesis of non-communicable diseases
  • atherosclerosis
  • obesity
  • obesity-related metabolic diseases and cancers

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Review

23 pages, 333 KiB  
Review
Incorporating Postbiotics into Intervention for Managing Obesity
by Emília Hijová, Izabela Bertková and Jana Štofilová
Int. J. Mol. Sci. 2025, 26(11), 5362; https://doi.org/10.3390/ijms26115362 - 3 Jun 2025
Viewed by 298
Abstract
Obesity is reaching global epidemic proportions worldwide, posing a significant burden on individual health and society. Altered gut microbiota is considered a key factor in the pathogenesis of many diseases, producing metabolites that contribute to the health-beneficial properties of postbiotics. Postbiotics, bioactive microbial [...] Read more.
Obesity is reaching global epidemic proportions worldwide, posing a significant burden on individual health and society. Altered gut microbiota is considered a key factor in the pathogenesis of many diseases, producing metabolites that contribute to the health-beneficial properties of postbiotics. Postbiotics, bioactive microbial components derived from probiotics, are emerging as a valuable strategy in modern medicine and a promising alternative for managing obesity without the need for live bacteria. This work provides a comprehensive overview of the potential health benefits of postbiotics, particularly in relation to obesity, which represents an important health challenge. Despite the encouraging insights into the health benefits of postbiotics, we highlight the need for further research to clarify the mechanisms and the specific roles of different postbiotic components. Integrating postbiotics into health interventions has the potential to enhance preventive care and significantly improve health outcomes in at-risk populations. Full article
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