Resveratrol (RSV), a naturally occurring metabolite, is widely used in skincare products, but its hydrophobicity impairs its own incorporation into cosmetic formulations. RSV-GS is a synthetic hydrophilic sulfated glycosylated derivative inspired by...
Most food allergy cases are associated with a limited group of allergens. This could be attributed to an increased ability of some foods to sensitize and trigger allergic reactions. However, there are no validated animal models to evaluate the sensit...
Silica (SiO2), titanium dioxide (TiO2), and zinc oxide (ZnO) nanoparticles (NPs) are widely used in dermal products. Their skin sensitization potential, especially their effects in combination with known sensitizers, is poorly studied in vitro and th...
Polyethylene glycol (PEG) is a polymer used for surface modification of important substances in the modern pharmaceutical industry and biopharmaceutical fields. Despite the many benefits of PEGylation, there is also the possibility that the applicati...
Up to today, product safety evaluation in the EU is predominantly based on data/information on their individual ingredients. Consequently, the quality and reliability of individual ingredient data is of vital interest. In this context, the knowledge...
Nowadays, various industries using nanomaterials are growing rapidly, and in particular, as the commercialization and use of nanomaterials increase in the cosmetic field, the possibility of exposure of nanomaterials to the skin of product producers a...
The aim of the current study was to develop an in silico model to predict the sensitizing potential of cosmetic ingredients based on their physicochemical characteristics and to compare the predictions with historical animal data and results from &ld...
Potentially Polluting Wrecks (PPWs) represent a critical global threat to marine ecosystems, requiring proactive risk management aligned with the Precautionary Approach of international environmental law. However, standard multi-criteria risk assessm...
Individuals with different hypnotizability display different interoceptive sensitivity/awareness (IS) and accuracy (IA), likely sustained by morphofunctional differences in interoception-related brain regions and, thus, possibly also observable durin...
Heavy oil reservoirs often enter a high-water-cut and low-production stage after multiple cycles of steam stimulation. Converting to steam flooding can enhance recovery, yet the reliable prediction of incremental production potential and optimal desi...
Cortical auditory evoked potentials (CAEPs) are an emerging tool for hearing aid fitting evaluation in young children who cannot provide reliable behavioral feedback. It is therefore useful to determine the relationship between the sensation level of...
Endometriosis is a complicated, estrogen-dependent gynecological condition with a high morbidity rate. Pain, as the most common clinical symptom of endometriosis, severely affects women’s physical and mental health and exacerbates socioeconomic...
Carbon nanotubes (CNTs) are one of the major types of nanomaterials that have various industrial and biomedical applications. However, there is a risk of accidental exposure to CNTs in individuals involved in their large-scale production and in indiv...
The diagnosis and treatment of the possible visual sequelae in those with traumatic brain injury (TBI) represents an important area of health care in this special population. One of their most prevalent yet elusive visual symptoms is visual motion se...
As the largest “immune organ” of human beings, the gut microbiota is symbiotic and mutually beneficial with the human host, playing multiple physiological functions. Studies have long shown that dysbiosis of gut microbiota is associated w...
Assessing the propensity of ingredients to induce skin sensitization through in vitro testing is crucial for worker and consumer safety. This is particularly important for novel and high-performance ingredients with complex structures, such as rheolo...
Toluene diisocyanate (TDI) is a potent low molecular weight chemical sensitizer and a leading cause of chemical-induced occupational asthma. The regulatory potential of microRNAs (miRNAs) has been recognized in a variety of disease states, including...
Dust, both industrial and household, contains particulates that can reach the most distal aspects of the lung. Silica and nickel compounds are two such particulates and have known profiles of poor health outcomes. While silica is well-characterized,...
The skin sensitization potential of agrochemicals can be assessed using laboratory methods such as the keratinocyte activation assay so that their use in regulatory toxicology might replace experimental animal testing. Here, we evaluated the skin sen...
In recent years, a number of machine learning models for the prediction of the skin sensitization potential of small organic molecules have been reported and become available. These models generally perform well within their applicability domains but...
The birch pollen allergen Bet v 1 is believed to be the main sensitizer among PR-10 allergens. Recent data have shown that some other PR-10 allergens also display sensitization activities, and Bet v 1-based immunotherapy is not effective for blocking...
The soybean allergen Gly m 4 is known to cause severe allergic reactions including anaphylaxis, unlike other Bet v 1 homologues, which induce mainly local allergic reactions. In the present study, we aimed to investigate whether the food Bet v 1 homo...
The effect of SRB and applied potential on the stress corrosion sensitivity of X80 pipeline steel was analyzed in high-pH soil simulated solution under different conditions using a slow strain rate tensile test, electrochemical test, and electronic m...
Pyroelectric materials, with piezoelectricity and pyroelectricity, have been widely used in infrared thermal detectors. In this paper, a modified first-order plate theory is extended to analyze a pyroelectric sensitive element structure. The displace...
The prediction of ground-state redox potentials by quantum chemical methods has a prominent role in the rational design of novel organic photosensitizers both for dye-sensitized solar cells (DSSCs) and photocatalytic systems for the production of H2....
Identifying changes in rocky desertification sensitivity is an important basis for land degradation prevention and sustainable use in karst World Natural Heritage sites. This study incorporates recent sensitivity deterioration into zoning rules to di...
The etiopathogenesis and treatment response of sensitive skin remain poorly understood. We used 4-tert-butylcyclohexanol (4-TBLH) and 1% pimecrolimus ointment to treat sensitive skin in mice models constructed using tape stripping, propylene glycol,...
The ability to predict the skin sensitization potential of small organic molecules is of high importance to the development and safe application of cosmetics, drugs and pesticides. One of the most widely accepted methods for predicting this hazard is...
Gly m 4, a soybean PR-10 allergen, is known to trigger systemic allergic reactions. However, the intrinsic sensitizing potential of the allergen remains unclear. Adjuvant-free murine models of sensitization to Gly m 4 might help to investigate mechan...
Controlling the selectivity of a detonation initiation reaction of explosive is essential to reduce sensitivity, and it seems impossible to reduce it by strengthening the external electric field. To verify this, the effects of external electric field...
Optogenetics was developed in the field of neuroscience and is most commonly using light-sensitive rhodopsins to control the neural activities. Lately, we have expanded this technique into plant science by co-expression of a chloroplast-targeted β-ca...
Research on the development of plants grown for energy purposes is important for ensuring the global energy supply and reducing greenhouse gas emissions, and simulation is an important method to study its potential. This paper evaluated the marginal...
Surface ozone (O3), a key hurdle in air quality improvement in China, often displays regional pollution characteristics. This study investigated the influence of meteorological conditions and air mass transport on O3 and non-methane hydrocarbons (NMH...
Heat sensation and tolerance are crucial for determining species’ survival and distribution range of small mammals. As a member of the transmembrane proteins, transient receptor potential vanniloid 1 (TRPV1) is involved in the sensation and the...
This work aimed to quantitatively study the carbon emissions and carbon reduction potential of a nearly Zero Energy Building in a severe cold zone of China from the perspective of its life cycle. The methods were based on China’s “Standar...
A series of novel fluorescent 4H-1-benzopyrans was designed and developed as near-infrared fluorescent molecules with a compact donor–acceptor-donor architecture. Spectral intensity of the fluorescent molecules M-1, M-2, M-3 varied significantly with...
Groundwater is one of the most important natural resources, as it regulates the earth’s hydrological system. The Damghan sedimentary plain area, located in the region of a semi-arid climate of Iran, has very critical conditions of groundwater d...
Multipotent mesenchymal stromal cells (MSCs) integrate hormone and neuromediator signaling to coordinate tissue homeostasis, tissue renewal and regeneration. To facilitate the investigation of MSC biology, stable immortalized cell lines are created (...
Preparedness for oil spill response is a challenge for many coastal countries. Responders are unable to take effective action unless maps that indicate areas with different vulnerability to oil pollution are available. Such maps, developed in many co...
Due to the limited available envelope area, height-constrained buildings integrated with photovoltaics require that more attention be given to the effective use of roofs. Thus, it is crucial to study the energy savings potential of previously neglect...
In this study, we introduce a novel, functionally driven method for model pruning guided by sensitivity analysis. Conventional model compression techniques often rely on proxy metrics, such as weight magnitude, which may not accurately reflect a comp...
Microbially mediated soil organic matter is an extremely sensitive pool that indicates subtle changes in the quality parameters responsible for the soil’s ecological and productive functions. Fifty years of mineral fertilization of a wheat-corn cropp...
Potential evapotranspiration (PET), as an indicator of atmospheric evaporative demand, is a critical hydrological and meteorological factor to reflect regional and global hydrological cycles and environmental change. Understanding these nuanced respo...
Climate change refers to the statistically significant changes in the mean and dispersion values of meteorological factors. Characterizing potential evapotranspiration (ET0) and its climatic causes will contribute to the estimation of the atmospheric...
The Standardized Precipitation Evapotranspiration Index (SPEI) is widely used for climatological and hydrological studies, in which the estimation of potential evapotranspiration (PET) is of great importance. As many different models exist in estimat...
The cultivation of dry-season sorghum on residual moisture in West and Central Africa is highly affected by sowing dates and ecotypes used. Fifty-five dry-season sorghum ecotypes collected from three zones in southern Chadian were sown on two dates,...
Trends in streamflow, rainfall and potential evapotranspiration (PET) time series, from 1970 to 2017, were assessed for five important hydrological basins in Southeastern Brazil. The concept of elasticity was also used to assess the streamflow sensit...
“Koji” is one of the most well-known probiotic microorganisms in Japan that contribute to the maintenance of human health. Although the beneficial effects of some probiotics on ulcer healing have been demonstrated, there have been no repo...
Bacillus thuringiensis (Bt) Cry toxins from the Cry1A family demonstrate significantly different toxicities against members of the family Noctuidae for unknown reasons. In this study, membrane potential was measured and analyzed in freshly isolated m...
A disposable potentiometric sensor was newly developed for the amplification-coupled detection of nucleic acids. The hydrogen-ion is generally released during isothermal amplification of nucleic acids. The surface potential on the oxide-functionalize...
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