Behavioral addiction in digital environments is an increasingly relevant neurobehavioral phenomenon characterized by persistent engagement with high-frequency, algorithmically optimized reward stimuli. Although neural correlates of addictive behavior...
Triple-negative breast cancer (TNBC) poses a significant challenge in terms of prognosis and disease recurrence. The limited treatment options and the development of resistance to chemotherapy make it particularly difficult to manage these patients....
This study aimed to comprehensively clarify the genomic landscape and its association with tumor mutational burden-high (TMB-H, ≥10 mut/Mb) and microsatellite instability-high (MSI-H) in endometrial, cervical, and ovarian cancers. We obtained geno...
Genome instability is a crucial and early event associated with an increased predisposition to tumor formation. In the absence of any exogenous agent, a single human cell is subjected to about 70,000 DNA lesions each day. It has now been shown that p...
The increasing anthropogenic impact on landscapes globally has increased interest in assessing landscape naturalness. This study assessed the changes in land cover in Lithuania and identified the most common reasons for land-use change. Coordination...
This article presents the main contents, methods, and results of the European project EDUSCAPE (Erasmus+) developed by a team of international researchers from four countries, just over a year and a half after its launch with a focus on SAAD/UNICAM c...
The generation of a complete and accurate copy of the genetic material during each cell cycle is integral to cell growth and proliferation. However, genetic diversity is essential for adaptation and evolution, and the process of DNA replication is a...
The landscape scaling relation challenges catchment ecological management; however, how the scaling relations change among naturally and anthropogenically differentiated catchments is still unknown. In this study, approximately 1500 soil samples were...
The rivers of south-eastern Australia flow within a complex meander tract (Coonambidgal Formation) formed by phases of Quaternary stream activity. Pumping tests, hydrochemistry and groundwater monitoring of the Campaspe, Loddon and Murray River Valle...
Climate change is resulting in significant transformations in mountain areas all over the world, causing the melting of glacier ice, reduction in snow accumulation, and permafrost loss. Changes in the mountain cryosphere are not only modifying flora...
Behavioural instability is a newly coined term used for measuring asymmetry of bilateral behavioural traits as indicators of genetic or environmental stress. However, this concept might also be useful for other types of data than bilateral traits. In...
Mountain landscapes are characterised by a very variable environment under different points of view (topography, geology, meteorological conditions), and they are frequently affected by mass wasting processes. A debris flow that occurred along the Cr...
Habitat loss and deforestation are among the main drivers of biodiversity decline in tropical ecosystems, yet their effects on developmental stability remain poorly understood in many insect groups. Orchid bees (Apidae: Euglossini) have been proposed...
Breast cancer is a diverse disease caused by mutations in multiple genes accompanying epigenetic aberrations of hazardous genes and protein pathways, which distress tumor-suppressor genes and the expression of oncogenes. Alteration in any of the seve...
In the past decade, defective DNA repair has been increasingly linked with cancer progression. Human tumors with markers of defective DNA repair and increased replication stress exhibit genomic instability and poor survival rates across tumor types....
High-grade serous ovarian carcinoma (HGSOC) is characterised by profound genomic instability and limited durable responses to standard therapy, leading to poor prognosis. The use of next-generation sequencing technologies has improved understanding o...
Monitoring dynamic post-catastrophic landscapes necessitates unsupervised classification approaches capable of incorporating newly emerging landscape-cover states without relying on predefined classes. Within this framework, the temporal corresponden...
Changes in the structure of ground beetle communities indicate environmental stability or instability influenced by, e.g., urbanization, agriculture, and forestry. It can affect flight capability and ellipsoid biovolume (EV) of ground beetles. Theref...
The Linghekou wetland is a rich repository of ecological resources and serves as an important habitat for numerous rare and protected animals. However, due to a confluence of natural and anthropogenic factors, the ecological environment of the Linghe...
The experience of adaptation and instability to a plurality of threats that question the life of human beings on the planet, from the post-pandemic to political conflicts, up to the danger looming in the background—the upheavals expected from c...
The barley chloroplast mutator (cpm) is a nuclear gene mutant that induces a wide spectrum of cytoplasmically inherited chlorophyll deficiencies. Plastome instability of cpm seedlings was determined by identification of a particular landscape of poly...
Monitoring deformation of architectural heritage sites is important for the quantitative evaluation of their stability. However, deformation monitoring of sites in mountainous areas remains challenging whether utilizing global navigation satellite sy...
High microsatellite instability (MSI-H) derives from genomic hypermutability due to deficient mismatch repair function. Colorectal (CRC) and endometrial cancers (EC) are the tumor types that more often present MSI-H. Anti-PD(L)-1 antibodies have been...
In Central America, Family Farming (FF) is characterized by the fostering of endogenous development, self-sustaining economies, food safety and upholding the values of the agricultural landscape. However, government agricultural policies have promote...
This article critically examines the evolving integration of urban and peri-urban agriculture (UPA) into green infrastructure (GI) concepts, a discussion gaining relevance amid geopolitical instability and global disruptions, such as the COVID-19 pan...
Derelict mining districts represent anthropogenically influenced landscapes that are often characterized by important geological, ecological, environmental, industrial, cultural, and archeological values. Nevertheless, after mining activities cease,...
The therapeutic landscape of several genitourinary malignancies has been revolutionized by the development of immune checkpoint inhibitors (ICIs); however, the utility of immunotherapies in prostate cancer has been limited, partly due to the immunolo...
Spatio-temporal analysis of land cover (LC) dynamics is essential for understanding landscape transformation in semi-arid woodland ecosystems. This study assessed historical and projected land cover changes in the Elnour Natural Forest Reserve (ENFR)...
Chromothripsis is a mutational mechanism leading to complex and relatively clustered chromosomal rearrangements, resulting in diverse phenotypic outcomes depending on the involved genomic landscapes. It may occur both in the germ and the somatic cell...
The replication-timing program constitutes a key element of the organization and coordination of numerous nuclear processes in eukaryotes. This program is established at a crucial moment in the cell cycle and occurs simultaneously with the organizati...
The study of Hodgkin lymphoma (HL), with its unique microenvironment and long-term follow-up, has provided exceptional insights into several areas of tumor biology. Findings in HL have not only improved our understanding of human carcinogenesis, but...
Over the past years, colorectal cancer (CRC) was subtyped according to its molecular and genetic characteristics, allowing the development of therapeutic strategies, based on predictive biomarkers. Biomarkers such as microsatellite instability (MSI),...
Deep-seated landslide complexes are widespread in soft-rock hill-country landscapes, yet their regional morphometric organisation and controlling factors remain insufficiently quantified. This study uses high-resolution (1 m) airborne LiDAR-derived t...
The school-to-work transition (STWT) represents a pivotal challenge in individual development, necessitating a global and interdisciplinary approach to address its inherent complexity. This article examines some key characteristics of the current lab...
Werner syndrome gene (WRN) contributes to DNA repair. In cancer, WRN mutations (WRN-mut) lead to genomic instability. Thus, WRN is a promising target in cancers with microsatellite instability (MSI). We assessed this study to investigate the molecula...
The yeast petite mutant was first discovered in the yeast Saccharomyces cerevisiae, which shows growth stress due to defects in genes encoding the respiratory chain. In a previous study, we described that deletion of the nuclear-encoded gene MRPL25 l...
Microsatellite instability (MSI), the spontaneous loss or gain of nucleotides from repetitive DNA tracts, is a diagnostic phenotype for gastrointestinal, endometrial, colorectal, and bladder cancers; yet a landscape of instability events across a wid...
The history of social housing in Spain over the last two centuries has been influenced by factors of political and economic instability that have affected the entire country. This research examines these factors through the analysis of official legis...
Genetic and epigenetic factors contribute to the development of cancer. Epigenetic dysregulation is common in gynaecological cancers and includes altered methylation at CpG islands in gene promoter regions, global demethylation that leads to genome i...
Chemically modified nucleic acid bases are sources of genomic instability and mutations but may also regulate gene expression as epigenetic or epitranscriptomic modifications. Depending on the cellular context, they can have vastly diverse impacts on...
Human activities play a key role in landscape evolution. Mining is one of the most important of these since it changes large parts of the Earth’s surface. In abandoned mines and quarries, pit lakes are quite common due to water table blocking....
Since their discovery, R-loops have been associated with both physiological and pathological functions that are conserved across species. R-loops are a source of replication stress and genome instability, as seen in neurodegenerative disorders and ca...
Understanding ecosystem response to drier climates calls for modeling the dynamics of dryland plant populations, which are crucial determinants of ecosystem function, as they constitute the basal level of whole food webs. Two modeling approaches are...
Membrane proteins are essential components of many biochemical processes and are important pharmaceutical targets. Membrane protein structural biology provides the molecular rationale for these biochemical process as well as being a highly useful too...
This study presents the first direct cosmogenic 36Cl-based chronology of landscape evolution and ground deformation in the Ionian Islands, focusing on the Thinia Valley in northern Kefalonia, western Greece. At the Zola site, exposure ages indicate t...
Therapeutic options for chemorefractory metastatic colorectal cancer (mcrc) have significantly expanded since 2009. The oral targeted therapies regorafenib and trifluridine/tipiracil have been established to be efficacious and safe in patients with m...
Ancient mining and quarrying activities left anthropogenic geomorphologies that have shaped the natural landscape and affected environmental equilibria. The artificial structures and their related effects on the surrounding environment are analyzed h...
Chromosomal rearrangement and genome instability are common features of cancer cells in human. Consequently, gene duplication and gene fusion events are frequently observed in human malignancies and many of the products of these events are pathogenic...
Acromegaly is caused by excessive secretion of GH and IGF-I mostly from somatotroph tumors. Various genetic and epigenetic factors are involved in the pathogenesis of somatotroph tumors. While somatic mutations of GNAS are the most prevalent cause of...
Entropy production (σ) is a measure of ecosystem and landscape stability in a changing environment. We calculated the σ in the radiation balance for a well-drained spruce forest, a paludified spruce forest, and a bog in the southern taiga of the Euro...
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