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Genes 2019, 10(4), 252; https://doi.org/10.3390/genes10040252

Insights into the Link between the Organization of DNA Replication and the Mutational Landscape

CNRS, University of Rennes, Institute of Genetics and Development of Rennes, 35043 Rennes, France
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Received: 1 March 2019 / Revised: 21 March 2019 / Accepted: 21 March 2019 / Published: 27 March 2019
(This article belongs to the Special Issue DNA Replication Timing: Where, When, How and Why?)
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Abstract

The generation of a complete and accurate copy of the genetic material during each cell cycle is integral to cell growth and proliferation. However, genetic diversity is essential for adaptation and evolution, and the process of DNA replication is a fundamental source of mutations. Genome alterations do not accumulate randomly, with variations in the types and frequencies of mutations that arise in different genomic regions. Intriguingly, recent studies revealed a striking link between the mutational landscape of a genome and the spatial and temporal organization of DNA replication, referred to as the replication program. In our review, we discuss how this program may contribute to shaping the profile and spectrum of genetic alterations, with implications for genome dynamics and organismal evolution in natural and pathological contexts. View Full-Text
Keywords: DNA replication; replication program; mutational landscape; genome dynamics; genome instability DNA replication; replication program; mutational landscape; genome dynamics; genome instability
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Gaboriaud, J.; Wu, P.-Y.J. Insights into the Link between the Organization of DNA Replication and the Mutational Landscape. Genes 2019, 10, 252.

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