Next Article in Journal
Targeting the Calcium Signalling Machinery in Cancer
Next Article in Special Issue
The Neurokinin-1 Receptor Antagonist Aprepitant: An Intelligent Bullet against Cancer?
Previous Article in Journal
Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1α S-Nitrosylation and Transcriptional Activity in Hypoxia
Previous Article in Special Issue
Inhibitors of Ceramide- and Sphingosine-Metabolizing Enzymes as Sensitizers in Radiotherapy and Chemotherapy for Head and Neck Squamous Cell Carcinoma
Open AccessReview

Molecular Targets for the Treatment of Metastatic Colorectal Cancer

Department of Medical Oncology, Hôpital Saint-Antoine, Sorbonne Université, Assistance Publique-Hôpitaux de Paris (AP-HP), F-75012 Paris, France
Author to whom correspondence should be addressed.
Cancers 2020, 12(9), 2350;
Received: 15 July 2020 / Revised: 6 August 2020 / Accepted: 10 August 2020 / Published: 20 August 2020
(This article belongs to the Special Issue Targeted Cancer Therapy)
Over the past years, colorectal cancer (CRC) was subtyped according to its molecular and genetic characteristics, allowing the development of therapeutic strategies, based on predictive biomarkers. Biomarkers such as microsatellite instability (MSI), RAS and BRAF mutations, HER2 amplification or NTRK fusions represent major tools for personalized therapeutic strategies. Moreover, the routine implementation of molecular predictive tests provides new perspectives and challenges for the therapeutic management of CRC patients, such as liquid biopsies and the reintroduction of anti-EGFR monoclonal antibodies. In this review, we summarize the current landscape of targeted therapies for metastatic CRC patients, with a focus on new developments for EGFR blockade and emerging biomarkers (MSI, HER2, NTRK). View Full-Text
Keywords: colorectal cancer; NTRK; HER2; BRAF; microsatellite instability; ctDNA colorectal cancer; NTRK; HER2; BRAF; microsatellite instability; ctDNA
Show Figures

Figure 1

MDPI and ACS Style

Cohen, R.; Pudlarz, T.; Delattre, J.-F.; Colle, R.; André, T. Molecular Targets for the Treatment of Metastatic Colorectal Cancer. Cancers 2020, 12, 2350.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop