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Molecular Targets for the Treatment of Metastatic Colorectal Cancer

Department of Medical Oncology, Hôpital Saint-Antoine, Sorbonne Université, Assistance Publique-Hôpitaux de Paris (AP-HP), F-75012 Paris, France
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Cancers 2020, 12(9), 2350; https://doi.org/10.3390/cancers12092350
Received: 15 July 2020 / Revised: 6 August 2020 / Accepted: 10 August 2020 / Published: 20 August 2020
(This article belongs to the Special Issue Targeted Cancer Therapy)
Over the past years, colorectal cancer (CRC) was subtyped according to its molecular and genetic characteristics, allowing the development of therapeutic strategies, based on predictive biomarkers. Biomarkers such as microsatellite instability (MSI), RAS and BRAF mutations, HER2 amplification or NTRK fusions represent major tools for personalized therapeutic strategies. Moreover, the routine implementation of molecular predictive tests provides new perspectives and challenges for the therapeutic management of CRC patients, such as liquid biopsies and the reintroduction of anti-EGFR monoclonal antibodies. In this review, we summarize the current landscape of targeted therapies for metastatic CRC patients, with a focus on new developments for EGFR blockade and emerging biomarkers (MSI, HER2, NTRK). View Full-Text
Keywords: colorectal cancer; NTRK; HER2; BRAF; microsatellite instability; ctDNA colorectal cancer; NTRK; HER2; BRAF; microsatellite instability; ctDNA
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Cohen, R.; Pudlarz, T.; Delattre, J.-F.; Colle, R.; André, T. Molecular Targets for the Treatment of Metastatic Colorectal Cancer. Cancers 2020, 12, 2350.

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