Structural Biology & Structure-Function Relationships of Membrane Proteins

Dear Colleaues,

To understand life and its biological complexity, one needs to investigate how biomolecules behave and interact with each other at a molecular level. A major goal in structural biology has been the study and understanding of the relationships between protein structure, dynamics, and function. Membrane proteins are fundamental biomolecules responsible for many important functions and processes in cellular physiology. Signal transduction, transport of ions and molecules, regulation of electrical signals, and enzymatic catalysis are just a few of the many pivotal responsibilities. Consequently, they make import pharmaceutical drug targets, either directly due to genetic mutations or indirectly as drug transporters or modulators of infection.

Modern pharmaceutical discovery has benefited from the many recent breakthroughs in membrane protein structural biology. Nevertheless, many questions remain. An improved understanding of the relationship between membrane protein structure and function will help unravel the mechanisms behind signal transduction, drug/solute transport, and channel gating. Essentially, the study of the structure–function relationships of membrane proteins is central to our understanding of cellular biology.

This Special Issue welcomes the submission of original research and review manuscripts focusing on membrane protein structural biology, including methods and developments that have made contributions to field development.

Dr. Isabel Moraes
Dr. Andrew Quigley
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.