17 July 2021
Acute high-altitude illnesses are of great concern for physicians and people traveling to high altitude. Our recent article “Acute Mountain Sickness, High-Altitude Pulmonary Edema and High-Altitude Cerebral Edema, a View from the High Andes” was ques...
Excessive erythrocytosis (EE) is a preclinical form of chronic mountain sickness (CMS). The dysregulation of iron metabolism in high-altitude hypoxia may induce EE. The intestinal hypoxia-inducible factor 2 alpha (HIF2a) regulates the genes involved...
High-altitude environments, characterized by hypoxia, low temperature, and intense ultraviolet radiation, profoundly disrupt host intestinal homeostasis and reshape the gut microbiota, thereby influencing immune regulation and acclimatization. This r...
The Qinghai–Tibetan Plateau is characterized by persistent hypobaric hypoxia, and Tibetan antelopes (Pantholops hodgsonii) exhibit exceptional athletic performance under extreme oxygen-deficient conditions. This study conducted a comparative an...
High-altitude hypoxia is associated with sleep disruption, affective fluctuation, and changes in cognitive performance, yet prior findings remain markedly heterogeneous in both direction and magnitude. To clarify this variability, this structured nar...
13 January 2022
Background: Despite a potential high risk of acute mountain sickness (AMS) in the Swiss Alps, there is a lack of analyses concerning its relevance over longer periods. In consequence, the aim of this study is to analyze the prevalence of AMS in compa...
(1) Background: High-altitude hypoxia has been shown to affect the pharmacokinetic properties of drugs. Although there is a high incidence of cardiovascular disease among individuals living in high-altitude areas, studies on the effect of high-altitu...
High altitude can be a hostile environment and a paradigm of how environmental factors can determine illness when human biological adaptability is exceeded. This paper aims to provide a comprehensive review of high-altitude sickness, including its ep...
The Qinghai–Tibet Plateau, famously known as the “Roof of the World”, has witnessed a surge in individuals traveling or working there. However, a considerable percentage of these individuals may suffer from acute mountain sickness (...
20 January 2023
The hypobaric-hypoxia environment at high-altitude (HA, >2500 m) may influence DNA damage due to the production of reactive molecular species and high UV radiation. The telomere system, vital to chromosomal integrity and cellular viability, is pro...
5 August 2021
Humans on earth inhabit a wide range of environmental conditions and some environments are more challenging for human survival than others. However, many living beings, including humans, have developed adaptive mechanisms to live in such inhospitable...
As a kind of large-scale unmanned aerial vehicle, a high-altitude balloon can carry a large load up to tens of kilometers in the near space for a long time, which brings a new way for the stratosphere atmospheric detection. In order to provide a suit...
The results of the observations of atmospherics and whistlers initiated by high-altitude electrical discharges that occurred during the eruption of the Kamchatka volcanoes (Bezymianny and Shiveluch (Russia)) on 7 and 10 April 2023 are presented. Reco...
11 February 2023
This report aims to summarise the scientific knowledge around hydration, nutrition, and metabolism at high altitudes and to transfer it into the practical context of extreme altitude alpinism, which, as far as we know, has never been considered befor...
To study the influence of tip clearance on the working characteristics of high-altitude fans, this paper takes the MIX-140 high-altitude fan as the research object. Five different tip clearance (TC) models are selected. The CFD method is used to anal...
14 March 2023
Background: Nowadays, with the convenience of international traveling and driven by many individuals’ fond dreams of challenging high-altitude exercises, high-altitude mountaineering is becoming increasingly popular worldwide. Therefore, we per...
The aim of this review is to identify a preventive strategy in order to minimize the risk of adverse events in patients with coronary syndromes and acute exposure to high-altitude. For this purpose we searched the electronic database of PubMed, EMBAS...
Altitude travelers are exposed to high-altitude pathologies, which can be potentially serious. Individual susceptibility varies widely and this makes it difficult to predict who will develop these complications. The assessment of physiological adapta...
22 December 2015
The low atmospheric pressure and low oxygen content in high-altitude environment have great impacts on the functions of human body. Especially for the personnel engaged in complicated physical labor such as tunnel construction, high altitude can caus...
High-altitude relight is a critical challenge for aero-engines, directly impacting the safety and emergency response capabilities of aircraft. This paper systematically reviews the physical mechanisms, key factors, and relevant prediction models of h...
The external insulation strength of the power equipment sleeve in the substation and converter station will be reduced with the increase in altitude and atmosphere pollution. The weakness of external insulation seriously threatens the safe operation...
Natural plants from plateaus have been the richest source of secondary metabolites extensively used in traditional and modern health care systems. They were submitted to years of natural selection, co-evolved within that habitat, and show significant...
High-altitude diseases, including acute mountain sickness (AMS), high-altitude cerebral edema (HACE), and high-altitude pulmonary edema (HAPE), are closely related to an individual’s ability to adapt to hypoxic environments. However, specific r...
To study the landslide risk of high-altitude and cold stope slopes, the slope deformation index and landslide risk standards at home and abroad for many years were analyzed and summarized. Using the unascertained measurement model, combined with the...
The species living in the Qinghai-Tibet Plateau provide an excellent model system for studying the relationship between molecular convergent evolution and adaptation. Distant species experiencing the same selection pressure (i.e., hypoxia, low temper...
In order to study the strong electromagnetic pulse effect of critically vulnerable equipment in power systems and evaluate the survivability under high-altitude electromagnetic pulses, it is necessary to study the characteristics of the transient res...
When ground observation or signal relaying in the vicinity of an unfriendly operative scenario are of interest, such as for military actions or disaster relief, high-altitude airships (HAA) offer some technical benefits. Featuring a milder cost and h...
The Tibetan Plateau’s distinctive high-altitude environment, marked by extreme cold and reduced oxygen levels, presents considerable survival challenges for both humans and mammals. Natural selection has led to the accumulation of adaptive muta...
Analyzing flight data from high-altitude unmanned aerial vehicles (UAVs) is an essential approach to anomaly detection and early warning. However, flight data collected during the climb, cruise, and descent phases of high-altitude UAV missions exhibi...
Overhead transmission lines are critical carriers for power delivery, directly influencing the security of the power system. In high-altitude areas, special environmental conditions such as low air pressure and intense solar radiation significantly c...
High-altitude work poses significant safety risks, and wearing safety belts is crucial to prevent falls and ensure worker safety. However, manual monitoring of safety belt usage is time consuming and prone to errors. In this paper, we propose an impr...
High-altitude wind energy offers a vast and comparatively stable renewable resource, yet its development in China lacks systematic assessment that integrates generation system characteristics. This study establishes a multi-scale evaluation framework...
As a result of ease of travel, a rising number of individuals, including many patients with pre-existing cardiovascular disease, visit high-altitude locations (>2500 m). Exposure to high altitude triggers a series of physiological responses intend...
High-altitude environments dramatically influenced the genetic evolution of vertebrates. However, little is known about the role of RNA editing on high-altitude adaptation in non-model species. Here, we profiled the RNA editing sites (RESs) of heart,...
Background: The illnesses associated with changes in barometric pressure can be classified into three types: acute mountain sickness, high-altitude pulmonary edema (HAPE), and high-altitude cerebral edema. HAPE is a rare form of pulmonary edema that...
Understanding how species adapt to extreme environments is an extension of the main goals of evolutionary biology. While alpine plants are an ideal system for investigating the genetic basis of high-altitude adaptation, genomic resources in these spe...
To further investigate altitude-associated variations in gut microbiota and serum metabolites of plateau zokors (Eospalax baileyi) and elucidate their adaptive mechanisms to high-altitude environments, we performed fecal metagenomic sequencing and se...
High-altitude long-duration (HALE) flight capability is one of the ultimate goals pursued by human aviation technology, and the high-altitude solar-powered aircraft (SPA) is the most promising technical approach to achieve this target as well as wide...
With the significant increase in the number of motor vehicles in plateau regions, the adaptability and reliability requirements of diesel engines operating under high-altitude and cold conditions have become increasingly critical. In this study, a on...
The Tibetan sheep is an indigenous animal of the Tibetan plateau, and after a long period of adaptation have adapted to high-altitude hypoxia. Many physiological changes occur in Tibetan sheep as they adapt to high-altitude hypoxia, especially in the...
The power attenuation of internal combustion engines in high-altitude environments restricts the performance of unmanned aerial vehicles. Herein, a single-zone model of a hydrogen-doped high-efficiency hybrid cycle rotary engine that considers high-a...
In high-altitude highway tunnels, the efficiency of jet fans significantly impacts the performance and energy consumption of ventilation systems. To optimize jet fan efficiency under such conditions, this study combines outdoor model experiments with...
Railway system insulators are affected by pollution, altitude, and other environmental situations during operation, which causes reduced electrical performance or even flashover accidents. These factors threaten the safety of railway operations in hi...
High-altitude exposure poses significant health challenges to mountaineers, military personnel, travelers, and indigenous residents. Altitude-related illnesses encompass acute conditions such as acute mountain sickness (AMS), high-altitude pulmonary...
High-altitude stress threatens the survival rate of Tibetan sheep and reduces their fertility. However, the molecular basis of this phenomenon remains elusive. Here, we used RNA-seq to elucidate the transcriptome dynamics of high-altitude stress in T...
Tropical high-altitude lakes are vital freshwater reservoirs in the Andean regions. They are heavily threatened by human activities that may alter their functioning and hamper the provisioning of key ecosystem services such as water supply. Despite t...
Nowadays there are several transmission lines projected to be operating in high-altitude regions. It is well known that the installation altitude has an impact on the dielectric behavior of air-insulated systems. As a result, atmospheric and voltage...
As global demand for renewable energy continues to grow, high-altitude wind energy, characterized by high speed, wide distribution, and strong stability, has emerged as a promising alternative to low-altitude wind energy. Airborne Wind Energy systems...
Environmental stress at high altitudes drives the development of distinct adaptive mechanisms in plants. However, studies exploring the genetic adaptive mechanisms of high-altitude plant species are scarce. In the present study, we explored the high-...
Near space, as a critical atmospheric domain with unique physical, electromagnetic, and biological characteristics, remains a frontier with extensive unresolved scientific questions in atmospheric physics, electromagnetic environment dynamics, and bi...
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