Redox Regulation of Immune and Inflammatory Responses
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 25 February 2026 | Viewed by 903
Special Issue Editor
Interests: IL-1 signaling; NF-κB; particulate matter; neutrophil
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleague,
The immune system and inflammatory responses are indispensable processes at the forefront of host defense. Recent research has illuminated the central role of strict redox (oxidation–reduction) state control within these complex biological reactions. Once considered merely cytotoxic agents, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are now recognized as crucial intracellular signaling molecules, fine-tuning immune cell activation, differentiation, and the production of inflammatory cytokines. Crucially, these redox signals often converge on key transcription factors like NF-κB (Nuclear Factor kappa light chain enhancer of activated B cells), directly influencing gene expression, which is critical for inflammatory and immune responses.
This Special Issue, "Redox Regulation of Immune and Inflammatory Responses", aims to explore how the balance between oxidative stress and antioxidant defense optimizes hosts’ protective mechanisms or, conversely, contributes to pathological conditions. We focus on the functions of key antioxidant pathways like NADPH oxidase (NOX) and mitochondrial ROS production in immune cells, and the glutathione and thioredoxin systems. Particular attention will be given to how their dysregulation, often mediated through altered NF-κB activation, is implicated in the onset and progression of a wide range of diseases, including autoimmune disorders, chronic inflammation, and infections.
Deepening our understanding in this field will not only lead to the development of novel therapeutic strategies for inflammatory diseases, but also re-emphasize the importance of redox balance in maintaining overall health. We hope that this Special Issue serves as a bridge between redox biology and immunology, contributing to future advancements in research.
Dr. Yasuhiro Yoshida
Guest Editor
Manuscript Submission Information
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Keywords
- immune system
- inflammatory responses
- cytokines
- immune cells
- autoimmune disorders
- chronic inflammation
- and infections
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