Bleeding is a potentially life-threatening emergency that can result in severe complications or death regardless of the cause of bleeding. The development of hemostatic materials has been a long-standing concern for emergency treatment in surgery and...
Background/Objectives: Achieving effective hemostasis is a vital step in wound healing, particularly in cases of severe bleeding caused by surgical procedures or trauma. This study focuses on the development of chitosan-based dressings enriched with...
Hemostasis plays an essential role in all surgical procedures. Uncontrolled hemorrhage is the primary cause of death during surgeries, and effective blood loss control can significantly reduce mortality. For modern surgeons to select the right agent...
Background: the aim of this study was to describe the ultrasound appearance of topical hemostatics after thyroidectomy. Methods: we enrolled 84 patients who were undergoing thyroid surgery and were treated with two types of topical hemostats, 49 with...
In contrast to hemostatic fabrics, foams, and gels, hemostatic spray powders may be conveniently applied on narrow and complex bleeding sites. However, powdered hemostatic agents are easily desorbed from the bleeding surface because of blood flow, wh...
The recognition of trauma-induced coagulopathy (TIC) as an endogenous response to traumatic injuries rather than a consequence of therapeutic interventions has shifted the clinical approach toward an early and physiologically based hemostatic resusci...
Surgicel® (regenerated oxidized cellulose) is a bio-absorbable hemostatic material widely applied to prevent surgery-derived adhesions. Some critical issues have been reported associated with this biomaterial, which we aimed to overcome by producing...
Hemorrhage is a detrimental event present in traumatic injury, surgery, and disorders of bleeding that can become life-threatening if not properly managed. Moreover, uncontrolled bleeding can complicate surgical interventions, altering the outcome of...
Background: The selection of the optimal hemostatic agent for surgical procedures remains a subject of ongoing debate. Among topical hemostatic agents, cellulose-based hemostats constitute a significant class of biocompatible and bioabsorbable polyme...
Wounds caused by trauma and/or surgery represent a significant challenge in contemporary medical practice, requiring innovative approaches to promote optimal healing and reduce the risk of bleeding and complications resulting from it. In this context...
Bleeding remains a leading cause of death in trauma and surgery, which drives the search for effective local hemostatic materials. Chitosan is a promising candidate because of its biocompatibility, biodegradability, and intrinsic hemostatic activity,...
Bleeding resulting from surgical procedures or trauma, including gunshot wounds, represents a life-threatening health issue. Therefore, the development of safe, effective, and convenient hemostatic agents is critical in securing the “golden tim...
Massive blood loss is responsible for numerous causes of death. Hemorrhage may occur on the battlefield, at home or during surgery. Commercially available biomaterials may be insufficient to deal with excessive bleeding. Therefore novel, highly effic...
In the current study, hemostatic compositions including a combination of chitosan and kaolin have been developed. Chitosan is a marine polysaccharide derived from chitins, a structural component in the shells of crustaceans. Both chitosan and kaolin...
In recent years, the coagulation properties of inorganic minerals such as kaolin and zeolite have been demonstrated. This study aimed to assess the hemostatic properties of three local clays from China: natural kaolin from Hainan, natural halloysite...
Using ammonium bicarbonate (AB) particles as a porogen, chitosan (CS)-based hemostatic porous sponges were prepared in supercritical carbon dioxide due to its low viscosity, small surface tension, and good compatibility with organic solvent. Fourier...
Multiple hemostatic abnormalities are associated with paraneoplastic syndrome and some malignant tumors. Lymphoma is the most common hematopoietic neoplasm in dogs, sometimes associated with hemostatic changes. The objectives of this study were to ev...
To accelerate healing of severe hemorrhagic wounds, a novel highly absorbent hemostatic dressing composed of a Tencel®/absorbent-cotton/polylactic acid nonwoven base and chitosan/nanosilver antibacterial agent was fabricated by using a nonwoven proce...
Background/Objectives: This study evaluated the hemostatic efficacy of a chitosan-based field hemostatic sponge (FHS), the first hemostatic product of this type manufactured in Vietnam, across bleeding models of varying injury severity under both nor...
Despite the importance of the hemostatic properties of reconstituted freeze-dried plasma (FDP) for trauma resuscitation, few studies have been conducted to determine its post-reconstitution hemostatic stability. This study aimed to assess the short-...
Absorbable hemostatic materials have great potential in clinical hemostasis. However, their single coagulation mechanism, long degradation cycles, and limited functionality mean that they have restricted applications. Here, we prepared a sodium hyalu...
Hemostasis is vital to save lives, reducing risks of organ failure and hemorrhagic shock. Exploring novel hemostatic materials and precise monitoring of the hemostatic status is of great importance for efficient hemostasis. We present the development...
A hemostatic sponge prototype was successfully synthesized from fish gelatin as an alternative to mammalian gelatin; it was mixed with alginate in certain combinations, double cross-linked with calcium ions, and gamma irradiated at a dose of 20 kGy t...
Thermosensitive biopolymer gelatin–alginate hydrogels are promising for use as dressings for wound healing and drug delivery. This work presents fluorescence arising from the internal fluorophores of alginate and gelatin biopolymers in thermose...
Hemostatic powder (HP) is a relatively recent addition to the arsenal of hemostatic endoscopic procedures (HEPs) for gastrointestinal bleeding (GIB) due to benign and malignant lesions. Five types of HP are currently available: TC-325 (Hemospray&trad...
Hemorrhea is one of the major problems in war, trauma care, and surgical operation that threaten the life of the injured and patients. As a novel polymeric hemostatic agent, biodegradable chitosan can stop bleeding through a variety of approaches. In...
The physicochemical properties and potential hemostatic application of Wenchang kaolin and Maoming kaolin were inspected and evaluated. Chemical composition analysis, Fourier transform infrared (FTIR) spectroscopy, surface area determination, X-ray d...
Background/Objectives: Cirrhosis is characterized by a fragile and unstable hemostatic balance, predisposing patients to both hemorrhagic and thrombotic complications, particularly in the context of chronic liver disease (CLD). This dual risk present...
The effectiveness of Floseal, a thrombin-based hemostatic matrix, in total knee arthroplasty (TKA) in minimizing blood loss and transfusion requirements remains a topic of debate. This meta-analysis aims to evaluate the up-to-date randomized controll...
Hemostatic powder, which can absorb large amounts of water and tends to produce repeated hydration with tissue, has been clinically proven as an ideal engineering material for treating wounds and tissues. We herein designed a polypeptide-based hemost...
In this study, an improved PVA/PLA fibrous hemostatic membrane was prepared by electrospinning technology combined with air plasma modification. The plasma treatment was used to modify PLA to enhance the interlayer bonding between the PVA and PLA fib...
A biodegradable micro/nano-structured porous hemostatic gelatin-based sponge as a dentistry surgery foam was prepared using a freeze-drying method. In vitro function evaluation tests were performed to ensure its hemostatic effect. Biocompatibility te...
Background: For over a decade, endoscopic hemostatic powders have been used to manage upper gastrointestinal bleeding (UGIB). Various preclinical benchtop and animal models have been developed to evaluate these devices. Multiple companies have releas...
The inevitable bleeding and infections caused by disasters and accidents are the main causes of death owing to extrinsic trauma. Hemostatic agents are often used to quickly suppress bleeding and infection, and they can solve this problem in a short t...
Uncontrollable bleeding continues to stand as the primary cause of fatalities globally following surgical procedures, traumatic incidents, disasters, and combat scenarios. The swift and efficient management of bleeding through the application of hemo...
Background and Objectives: Traumatic hemorrhage remains the leading cause of preventable death following major injury, with most hemorrhage-related fatalities occurring within the first hours after trauma. During this early phase, trauma-induced coag...
Platelet dysfunction plays a critical role in the pathogenesis of various disorders affecting the hemostatic-coagulant system. This review aims to explore the mechanisms by which platelet dysfunctions contribute to the disruption of hemostasis, leadi...
Uncontrolled hemorrhage remains a major challenge in trauma care and surgical interventions, where rapid hemostasis and wound sealing are essential for improving patient survival. Natural polymer-based hydrogels have emerged as promising hemostatic m...
The use of glycerolates of biogenic elements as biocompatible precursors in sol–gel synthesis is an innovative direction and opens up new scientific and practical prospects in chemistry and technology of producing practically important biomedic...
In our search for a biocompatible composite hemostatic dressing, we focused on the design of a novel biomaterial composed of two natural biological components, collagen and sodium alginate (SA), cross-linked using 1-ethyl-3-(3-dimethylaminopropyl) ca...
Previous studies have reported that dogs with neoplasms had elevated D-dimer levels. However, few studies have addressed whether D-dimer could be an indicator of tumor burden. The clinical significance of paired analysis of pre- and post-operation of...
Hemostatic particles have specific advantages when applied to narrow and complicated bleeding sites with convenient usage compared to other types of hemostatic agents such as fabrics, foams, and pastes. However, powdery hemostatic agents are easy to...
Pediatric extracorporeal membrane oxygenation (ECMO) is associated with complex hemostatic disturbances arising from interactions among blood–circuit interfaces, developmental hemostasis, endothelial dysfunction, coagulation, fibrinolysis, infl...
The increasing level of hemostatic parameters and tumor markers were associated with cancer progression and poor prognosis, particularly in NSCLC. The objective of this study is to determine whether there was a correlation between hemostatic paramete...
Two hemostatic bionanocomposite dressings were developed using natural, semi-natural (or semi-synthetic) and synthetic polymers. The first system consisted of chitosan (CS), polyvinyl alcohol (PVA), and carboxymethyl cellulose (CMC) (CS/PVA/CMC), whi...
Background: Rapid hemostasis is essential in oral surgery to minimize blood loss, prevent postoperative complications, and promote early wound healing. This study developed freeze-dried fish-derived gelatin–chitosan composite sponges with diffe...
Cuttlefish ink sac is an underutilized marine processing by-product with considerable potential for value-added conversion into functional ingredients. In this study, high-purity cuttlefish melanin (HCM) was isolated from cuttlefish ink sacs, and its...
Hemostatic agents are frequently used during pediatric dental procedures and may inadvertently contact restorative materials. This study evaluated the fracture-load and surface roughness of contemporary pediatric restorative materials following expos...
Chitosan and gelatin were the most widely used natural materials in pharmaceutical and medical fields, especially as local hemostatic agents, independently or as a composite material with the addition of other active substances. Chitosan and gelatin...
Objective: Unilateral biportal endoscopic (UBE) lumbar decompression is an effective minimally invasive spine surgery, but postoperative spinal epidural hematoma (PSEH) remains a practical concern. This study evaluated the clinical necessity of routi...
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