New Insights into Diagnosis and Therapeutic Strategies for Chronic Liver Diseases
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 59
Special Issue Editor
Interests: internal medicine; gastroenterology; gastrointestinal disorders; chronic liver disease; irritable bowel syndrome; gut microbiome; clinical research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic liver diseases (CLDs) have emerged as a significant cause of hepatic-related morbidity and mortality worldwide in recent years. MASLD is a complex pathology, and is considered to be the hepatic expression of metabolic syndrome (MetS). It is likely to become the main indication for liver transplantation in the coming years, as it is estimated to affect 57.5–74.0% of obese people and 52.8% of obese children, with 50% of individuals with type 2 diabetes being diagnosed with MASLD. Moreover, alcoholic liver disease (ALD) and drug-induced liver injury (DILI) result from one or a combination of genetic, environmental, and lifestyle-associated factors, such as diet-induced obesity, metabolic dysfunction, alcohol use, or drug toxicity. A late diagnosis of CLD, due to its insidious evolution and heterogeneous pathophysiology, significantly limits the use of therapeutic options that aim to improve the prognosis of disease. Therefore, the identification of disease-specific biomarkers that are related to the early detection of these conditions is crucial. We welcome the submission of articles that highlight new insights into the pathophysiologic mechanisms of CLDs and examine novel pathogenic pathways, new biomarkers, imaging diagnosis tools, and future therapies. In addition, we particularly welcome the submission of articles that analyze the influence of lifestyle and environmental factors on CLD progression. This Special Issue aims to present recent advances in research that enable the early diagnosis and personalized treatment of CLD, thus improving patient outcomes. The dissemination of current research regarding CLDs and collaboration between physicians, gastroenterologists, internists, cardiologists, diabetologists, nutritionists and endocrinologists is also required to ensure that we possess the knowledge and resources necessary to address this public health challenge.
Prof. Dr. Cristina Marginean
Guest Editor
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Keywords
- chronic liver disease
- metabolic dysfunction-associated steatotic liver disease (MASLD)
- metabolic dysfunction-associated steatohepatitis (MASH)
- drug-induced liver injury (DILI)
- hepatocellular carcinoma
- biomarkers of liver fibrosis
- imaging of liver fibrosis
- CEUS
- novel therapeutic strategies for CLDs
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