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Hematology Reports
Volume 13
Issue 3
10.4081/hr.2021.8361
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

The Correlation between Hemostatic Parameters and Mortality Rate in Patients with Non-Small Cell Lung Cancer

by
Noni Novisari Soeroso
1,*,
Fannie Rizki Ananda
1,
Ganda Samosir
1,
Herman Hariman
2 and
Putri Chairani Eyanoer
3
1
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Sumatera Utara, Universitas Sumatera Utara Hospital, Dodik Road No. 11, Medan Helvetia, North Sumatera 20126, Indonesia
2
Department of Clinical Pathology, Faculty of Medicine Universitas Sumatera Utara, Adam Malik General Hospital, Sumatera Utara 20136, Indonesia
3
Department of Community Medicine, Faculty of Medicine Universitas Sumatera Utara, Sumatera Utara 20222, Indonesia
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2021, 13(3), 8361; https://doi.org/10.4081/hr.2021.8361
Submission received: 31 October 2019 / Revised: 13 April 2020 / Accepted: 10 July 2020 / Published: 6 September 2021

Abstract

The increasing level of hemostatic parameters and tumor markers were associated with cancer progression and poor prognosis, particularly in NSCLC. The objective of this study is to determine whether there was a correlation between hemostatic parameters and mortality rate in patients with NSCLC. This was a prospective analytical study with a pretest-posttest design which included 41 patients with diagnosis of NSCLC. Plasma levels of PT, APTT, TT, D-dimer, and fibrinogen were measured before initiation of chemotherapy and remeasured after 4 cycles or 6 cycles of chemotherapy, based on the clinical condition of patients. Then, patients were followed up for 1 year to evaluate the mortality rate. The majority of subjects were male (85.4%) with adenocarcinoma (75.6%). There was no significant difference in mean between adenocarcinoma and squamous cell carcinoma (p > 0.05). Most patients died after one month of follow up (61%). The parameters which could predict high mortality rate in NSCLC were prolonged PT and the increased of D-dimer with RR > 1, although they had not significant in statistical analysis (p > 0.05). There is no correlation between hemostatic parameters and mortality rate in patients with NSCLC.
Keywords: hemostatic parameters; mortality rate; non-small cell lung cancer; chemotherapy hemostatic parameters; mortality rate; non-small cell lung cancer; chemotherapy

Share and Cite

MDPI and ACS Style

Soeroso, N.N.; Rizki Ananda, F.; Samosir, G.; Hariman, H.; Chairani Eyanoer, P. The Correlation between Hemostatic Parameters and Mortality Rate in Patients with Non-Small Cell Lung Cancer. Hematol. Rep. 2021, 13, 8361. https://doi.org/10.4081/hr.2021.8361

AMA Style

Soeroso NN, Rizki Ananda F, Samosir G, Hariman H, Chairani Eyanoer P. The Correlation between Hemostatic Parameters and Mortality Rate in Patients with Non-Small Cell Lung Cancer. Hematology Reports. 2021; 13(3):8361. https://doi.org/10.4081/hr.2021.8361

Chicago/Turabian Style

Soeroso, Noni Novisari, Fannie Rizki Ananda, Ganda Samosir, Herman Hariman, and Putri Chairani Eyanoer. 2021. "The Correlation between Hemostatic Parameters and Mortality Rate in Patients with Non-Small Cell Lung Cancer" Hematology Reports 13, no. 3: 8361. https://doi.org/10.4081/hr.2021.8361

APA Style

Soeroso, N. N., Rizki Ananda, F., Samosir, G., Hariman, H., & Chairani Eyanoer, P. (2021). The Correlation between Hemostatic Parameters and Mortality Rate in Patients with Non-Small Cell Lung Cancer. Hematology Reports, 13(3), 8361. https://doi.org/10.4081/hr.2021.8361

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