Designing Gels for Antibacterial and Antiviral Agents

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Analysis and Characterization".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 1637

Special Issue Editors


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Guest Editor
Department of Prosthodontics, “Iuliu Hațieganu” University of Medicine and Pharmacy, 32 Clinicilor Street, 400006 Cluj-Napoca, Romania
Interests: biomaterials; adhesion; dental erosion; tissue engineering; antibacterial gels

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Guest Editor
Department of Prosthodontics, “Iuliu Hațieganu” University of Medicine and Pharmacy, 32 Clinicilor Street, 400006 Cluj-Napoca, Romania
Interests: biomaterials; tissue engineering; adhesion; dental materials; drug delivery; hydrogels

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Guest Editor
Department of Polymer Composites, Institute of Chemistry “Raluca Ripan”, Babes-Bolyai University, 30 Fantanele street, 400294 Cluj-Napoca, Romania
Interests: biomaterials; inorganic fillers; nanomaterials; antibacterial effect; graphene; gels
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Prosthodontics, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca 400347, Romania
Interests: occlusion; temporomandibular disorders; aestethic dentistry; digital dentistry; CAD/CAM; digital occlusion; digital smile design; genetics and tissue engineering; novel dental materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Our efforts to stop the spread of antimicrobial agents depend on the discovery and development of novel antimicrobial soft materials (especially gels). Furthermore, gels and other soft materials must be understood from a molecular perspective, starting with the design process as well as how they interact with microbes and their antimicrobial and antiviral properties.

Recent advances in antimicrobial gels are the focus of this Special Issue on “Designing Gels for Antibacterial and Antiviral Agents”, which covers most aspects of antimicrobial gel fabrication, characterization, and applications. It will cover a broad range of topics, including the structure and behavior of antibacterial agents and gels, the antibacterial and antiviral mechanisms of gels, tissue regeneration, and antimicrobial gel applications.

Infections caused by bacteria pose one of the most serious threats to human health. In addition, a threat to human health worldwide has been posed by antibacterial-resistant bacteria (so-called “superbugs”) due to the widespread use of antibiotics. There are many clinical applications for antimicrobial gels, including wound healing. Further, antimicrobial gels are expected to stimulate new research and discoveries. To achieve progress in this field, an interdisciplinary approach is required to gain a deeper understanding of the structure of antibacterial gels and the mechanisms that underlie antimicrobial activity.

There can never be a complete coverage of antimicrobial gel science in a single issue. However, this Special Issue will include a variety of topics, including the molecular basis of soft materials’ antimicrobial activity, the mechanisms by which microbial agents interact with soft materials, characterization of soft materials and gels’ antimicrobial activity, and the adhesion of microbial agents to gels. There is also a focus on the synthesis, characterization, and processing of novel antimicrobial and antiviral gels, as well as synthetic and natural, hybrid, and composite gels that deliver antimicrobial agents effectively over long periods of time.

We hope that the topics will stimulate new research and discoveries in antimicrobial networks and gels.

Dr. Andrea Maria Chisnoiu
Dr. Andreea Iuliana Kui
Dr. Codruţa Saroși
Dr. Smaranda Buduru
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibacterial
  • antimicrobial activity
  • gels
  • hydrogels
  • adhesion
  • tissue engineering
  • synthesis and characterization

Published Papers (2 papers)

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Research

18 pages, 5122 KiB  
Article
Enhancing the Topical Antibacterial Activity of Fusidic Acid via Embedding into Cinnamon Oil Nano-Lipid Carrier
by Heba S. Elsewedy, Tamer M. Shehata, Shaymaa M. Genedy, Khuzama M. Siddiq, Bushra Y. Asiri, Rehab A. Alshammari, Sarah I. Bukhari, Adeola T. Kola-Mustapha, Heba A. Ramadan and Wafaa E. Soliman
Gels 2024, 10(4), 268; https://doi.org/10.3390/gels10040268 - 16 Apr 2024
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Abstract
Presently, antimicrobial resistance is of great risk to remarkable improvements in health conditions and infection management. Resistance to various antibiotics has been considered a great obstacle in their usage, necessitating alternative strategies for enhancing the antibacterial effect. Combination therapy has been recognized as [...] Read more.
Presently, antimicrobial resistance is of great risk to remarkable improvements in health conditions and infection management. Resistance to various antibiotics has been considered a great obstacle in their usage, necessitating alternative strategies for enhancing the antibacterial effect. Combination therapy has been recognized as a considerable strategy that could improve the therapeutic influence of antibacterial agents. Therefore, the aim of this study was to combine the antibacterial action of compounds of natural origin like fusidic acid (FA) and cinnamon essential oil (CEO) for synergistic effects. A distinctive nanoemulsion (NE) was developed using cinnamon oil loaded with FA. Applying the Box–Behnken design (BBD) approach, one optimized formula was selected and integrated into a gel base to provide an FA-NE-hydrogel for optimal topical application. The FA-NE-hydrogel was examined physically, studied for in vitro release, and investigated for stability upon storage at different conditions, at room (25 °C) and refrigerator (4 °C) temperatures, for up to 3 months. Ultimately, the NE-hydrogel preparation was inspected for its antibacterial behavior using multidrug-resistant bacteria and checked by scanning electron microscopy. The FA-NE-hydrogel formulation demonstrated a pH (6.32), viscosity (12,680 cP), and spreadability (56.7 mm) that are acceptable for topical application. The in vitro release could be extended for 6 h, providing 52.0%. The formulation was stable under both test conditions for up to 3 months of storage. Finally, the FA-NE-hydrogel was found to inhibit the bacterial growth of not only Gram-positive but also Gram-negative bacteria. The inhibition was further elucidated by a scanning electron micrograph, indicating the efficiency of CEO in enhancing the antibacterial influence of FA when combined in an NE system. Full article
(This article belongs to the Special Issue Designing Gels for Antibacterial and Antiviral Agents)
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17 pages, 2630 KiB  
Article
Development and Characterization of a Hand Rub Gel Produced with Artisan Alcohol (Puntas), Silver Nanoparticles, and Saponins from Quinoa
by Oscar Analuiza, Belen Paredes, Alejandra Lascano, Santiago Bonilla and José-Luis Martínez-Guitarte
Gels 2024, 10(4), 234; https://doi.org/10.3390/gels10040234 - 29 Mar 2024
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Abstract
The emergence of the global pandemic (COVID-19) has directed global attention towards the importance of hygiene as the primary defense against various infections. In this sense, one of the frequent recommendations of the World Health Organization (WHO) is regular hand washing and the [...] Read more.
The emergence of the global pandemic (COVID-19) has directed global attention towards the importance of hygiene as the primary defense against various infections. In this sense, one of the frequent recommendations of the World Health Organization (WHO) is regular hand washing and the use of alcohol-based hand sanitizers. Ethanol is the most widely used alcohol due to its effectiveness in eliminating pathogens, ease of use, and widespread production. However, artisanal alcohol, generally used as a spirit drink, could be a viable alternative for developing sanitizing gels. In this study, the use of alcohol “Puntas”, silver nanoparticles, and saponins from quinoa was evaluated to produce hand sanitizer gels. The rheological, physicochemical, and antimicrobial properties were evaluated. In the previous assays, the formulations were adjusted to be similar in visual viscosity to the control gel. A clear decrease in the apparent viscosity was observed with increasing shear rate, and an inversely proportional relationship was observed with the amount of ethyl alcohol used in the formulations. The flow behavior index (n) values reflected a pseudoplastic behavior. Oscillatory dynamic tests were performed to analyze the viscoelastic behavior of gels. A decrease in storage modulus (G′) and an increase in loss modulus (G″) as a function of the angular velocity (ω) was observed. The evaluation of pH showed that the gels complied with the requirements to be in contact with the skin of the people, and the textural parameters showed that the control gel was the hardest. The use of artisan alcohol could be an excellent alternative to produce sanitizer gel and contribute to the requirements of the population. Full article
(This article belongs to the Special Issue Designing Gels for Antibacterial and Antiviral Agents)
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