3,886 Results Found

Background: Pemetrexed is used for the chemotherapy of advanced thymoma. Exceptional responses of thymoma to pemetrexed treatment are not frequently observed. The underlying genetic mechanism of the exceptional responses remains unclear. We used whol...

Until recently, effective therapies for advanced endometrial cancer progressing to a platinum-based combination were lacking. In this setting, immunotherapy with anti PD-1/PDL-1 monoclonal antibodies is rising as a new paradigm in particular for pati...

Objectives: Endometrial cancer is the most common gynaecologic malignancy, and its mortality rate is rising. Advanced or recurrent disease remains challenging because historically there have been limited therapeutic options. We aim to describe a comp...

The acceleration of the climate crisis calls into question the effectiveness of traditional legal frameworks in addressing environmental emergencies. This article examines whether France should adopt an environmental state of exception, inspired by t...

The inhibitor cystine knot (ICK) is an unusual three-disulfide architecture in which one of the disulfide bonds bisects a loop formed by the two other disulfide bridges and the intervening sections of the protein backbone. Peptides containing an ICK...

We investigate the effect of geopolitical risk on the returns of firms in the Information Technology, Communication Services, and Consumer Staples sectors within the S&P 500 index. We use the event study methodology and perform more than 17,000 r...

In response to the COVID-19 pandemic, various preventive and controlling measures have been taken by host states but may damage the interests of foreign investors and consequently result in international investment disputes. Confronted with potential...

Amidst the mounting global challenges associated with climate change and resource depletion, achieving sustainable development is paramount. Focusing on cities as vital scenarios for pursuing sustainability, this research measured urban sustainabilit...

Ecological thresholds represent a critical tipping point along an environmental gradient that, once breached, can have irreversible consequences for species persistence and assemblage structure. Thresholds can also be used to identify species with th...

Background and Objectives: Among breast cancer molecular types, HER2 positive and triple negative (TN) subtypes have the highest likelihood of pathological complete response (pCR), which is a surrogate marker for reduced recurrence and improved patie...

Employed parents raising children with disabilities manage exceptional care responsibilities along with their work careers. This study examines the effects of targeted diversity training on human resource (HR) professionals’ knowledge of the wo...

Biofertilizers are considered as potential supplements or alternatives to fertilizers. The objective of the present study is to evaluate different biofertilizers in combination with synthetic fertilizers on the yields of maize and wheat in several st...

A crisis is an exceptional event that causes damage and negative impacts on organizations. For this reason, crisis management is considered as a significant action needed to follow crisis causes and consequences for preventing or avoiding these excep...

Twice-exceptional learners, students with both giftedness and disability (e.g., ADHD, ASD, dyslexia), face significant educational barriers in schools. This study examined stakeholder perspectives on the most pressing issues affecting twice-exception...

Insects in the same taxonomic group generally have similar responses to light at various wavelengths in the laboratory. However, there is lack of direct evidence of between-group differences in insect responses to various light wavelengths under fiel...

Inspired by exceptional point (EP) sensing in non-Hermitian systems, in this work, a label-free biosensor for detecting low-concentration analytes is proposed, via a special multilayer structure: a resonant optical tunneling resonator. Due to the squ...

Grazing is one of the most important land management activities worldwide, and cases of overgrazing increase erosion, land degradation, and plant invasion. The objective of this study was to assess the effect on individual species and species composi...

This paper documents the round robin testing campaign carried out on a floating wind turbine as part of the EU H2020 MaRINET2 project. A 1/60th scale model of a 10 MW floating platform was tested in wave basins in four different locations around Euro...

The emerging field of flexible tactile sensing systems, equipped with multi-physical tactile sensing capabilities, holds vast potential across diverse domains such as medical monitoring, robotics, and human–computer interaction. In response to...

The effects of Alnus sibirica (AS) extracts on cytokine expression induced by inflammatory stimulants were examined in human dermal fibroblasts (HDFs) and RAW264.7 cells. The anti-oxidative effect and effect on cell viability of AS extracts were eval...

Precision medicine approaches for solid tumors are mainly based on genomics. Its employment in clinical trials has led to somewhat underwhelming results, except for single responses. Moreover, several factors can influence the response, such as gene...

Background: This study aimed to evaluate short- and long-term humoral and T-cell-specific immune responses to SARS-CoV-2 vaccines in patients with multiple sclerosis (MS) treated with different disease-modifying therapies (DMTs). Methods: Single-cent...

This study aims to investigate the nature and intensity of the changes in corporate financial performance due to the corporate social responsibility (CSR) disclosures as a result of certain relationships between corporate governance and company perfo...

Photo-responsive microencapsulated phase-change materials (MEPCMs) are attracting growing interest for their significant potential in solar energy applications and advanced intelligent thermal management systems, owing to their exceptional capacity f...

In order to determine the humoral protective response against SARS-CoV-2, the vaccine-induced and naturally induced neutralizing antibodies (NtAbs) responses against SARS-CoV-2 variants circulating in Italy through in vitro live virus neutralization...

This systematic review and meta-analysis of randomized controlled trials (RCTs) compared the clinical efficacy and safety of anti-MRSA cephalosporin and vancomycin-based treatment in treating acute bacterial skin and skin structure infections (ABSSSI...

In a large, urban US public school district that began a new identification system for gifted education focused on the equity and inclusion of twice-exceptional (2e) students, a need for the further training of educators involved with assessment, ser...

Response functions completely define the constitutive equations for a hyperelastic material. A strain measure providing an orthogonal stress response, grants response functions directly from experimental curves. One of these strain measures is the La...

TGA transcription factor (TF) family genes play a major role in the regulation of plant growth and development as well as in the defense against pathogen attack. Little is known about the TGA family genes and their functions in sugarcane. Here, a tot...

Begonia semperflorens (B. semperflorens) is a popular ornamental plant widely used in landscapes such as plazas and flower beds, and it is also commonly grown as a potted plant indoors. It is known for its adaptability to high temperatures, drought,...

The aim of this study was to compare users’ and mental health workers’ (MHW) perception of respect of human rights and job/care satisfaction in mental health services in Italy during the COVID-19 pandemic. A sample of users and MHW of Sardinia, Italy...

Recent studies suggest that short pentraxins in fish might serve as biomarkers for not only bacterial infections, as in higher vertebrates including humans, but also for viral ones. These fish orthologs of mammalian short pentraxins are currently att...

Better mining corporations want to adopt “Responsible Mining”. This paper outlines the essentials of responsible mining and offers a guide to corporations who want become responsible. Eight principles are discussed: (1) Social and environmental asses...

Mast cells act as key effector cells of inflammatory responses through degranulation. Mast cell degranulation is induced by the activation of cell surface receptors, such as FcεRI, MRGPRX2/B2, and P2RX7. Each receptor, except FcεRI, v...

NAC (NAM, ATAF and CUC)-like transcription factors, a class of plant-specific transcription factors, play a pivotal role in plant growth, development, metabolism, and stress response. Notably, a specific subclass of NAC family, known as SNAC (stress-...

A highly sensitive ammonia-gas sensor based on a tungsten trioxide and polypyrrole (WO3/PPy) nanocomposite synthesized using pulsed-laser deposition (PLD) and matrix-assisted pulsed-laser evaporation (MAPLE) is presented in this study. The WO3/PPy na...

Perovskite oxide LaFeO3(LFO) emerges as a potential candidate for formaldehyde (HCHO) detection due to its exceptional electrical conductivity and abundant active metal sites. However, the sensitivity of the LFO sensor needs to be further enhanced. H...

The objective of this study was to validate and measure the internal reliability of the Baby and Child Eating Behavior Questionnaires for Toddlers (BEBQ-Mex and CEBQ-T-Mex), that evaluate appetitive trait (ATs). Mothers recruited from a public hospit...

This study used a thiolated calix[4]arene derivative modified on gold nanoparticles and a screen-printed carbon electrode (TC4/AuNPs/SPCE) for Pb2+ and Cu2+ determination. The surface of the modified electrode was characterised via Fourier-transform...

Siberian stone pine (Pinus sibirica Du Tour) is one of the keystone conifers in Siberian taiga, but its radial growth is complacent and thus rarely investigated. We studied its growth in subalpine stands near the upper timberline along the Western Sa...

Background: Tick-borne encephalitis virus (TBEV) is one of the most significant arboviruses affecting the human central nervous system (CNS) in Europe. Data on cytokine response in TBEV infection are limited. Methods: We analyzed the cytokine respons...

Training elite kayakers at a distance of 1000 m is associated with aerobic and anaerobic metabolism, while intermittent training, in a variety of forms, is one of the effective ways to improve cardiorespiratory and metabolic function. Thus, this stud...

The onset date of spring phenology (SOS) is regarded as a key parameter for understanding and modeling vegetation–climate interactions. Inner Mongolia has a typical temperate grassland vegetation ecosystem, and has a rich snow cover during wint...

Viruses are obligate intracellular parasites that alter host metabolic machinery to obtain energy and macromolecules that are pivotal for replication. Ranavirus, including the type species of the genus frog virus 3 (FV3), represent an ecologically im...

Little information is known about the effects of different fertilization practices on soil microbiome in intensively managed crop rotations. The objective of this research was to investigate the response of microbial community composition (phospholip...

Antibiotics are used in the treatment of bacterial diseases in commercial aquaculture. In this study, we the biological responses of Oreochromis niloticus juveniles upon dietary florfenicol (FFC) administration at 15 mg (1×) and 45 mg kg biomas...

Fogera cattle are among indigenous breeds of cattle in the northern part of Ethiopia. However, their response to heat stress (HS) under different seasonal variations has not been well investigated. This study was aimed to determine physiological, hem...

Combination antifungal therapy is widely used but not well understood. We analyzed the spectrophotometric readings from a multicenter study conducted by the New York State Department of Health to further characterize the in vitro interactions of the...

To ensure their survival, a number of bacterial and plant species have evolved a common strategy to capture energy from other biological systems. Being imperfect pathogens, organisms synthesizing multi-subunit AB toxins are responsible for the mortal...

Oncolytic viruses, colloquially referred to as “living drugs”, amplify themselves and the therapeutic transgenes that they carry to stimulate an immune response both locally and systemically. Remarkable exceptions aside, such as the recen...