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75,086 Results Found

  • Review
  • Open Access
12 Citations
6,625 Views
17 Pages

Cancer, Retrogenes, and Evolution

  • Klaudia Staszak and
  • Izabela Makałowska

19 January 2021

This review summarizes the knowledge about retrogenes in the context of cancer and evolution. The retroposition, in which the processed mRNA from parental genes undergoes reverse transcription and the resulting cDNA is integrated back into the genome...

(This article belongs to the Section Biodiversity, Ecology and Evolution)
  • Review
  • Open Access
49 Citations
10,103 Views
16 Pages

11 April 2020

Sex chromosome evolution remains an evolutionary puzzle despite its importance in understanding sexual development and genome evolution. The seemingly random distribution of sex-determining systems in reptiles offers a unique opportunity to study sex...

(This article belongs to the Special Issue Mechanisms Driving Karyotype Evolution and Genomic Architecture)
  • Article
  • Open Access
3 Citations
8,257 Views
15 Pages

17 April 2023

The evolution of the genus Homo can only be understood by considering both of the inheritance systems that interact to shape human nature: biology and culture. While growing intellectual abilities are a key factor of human evolution, they are rarely...

(This article belongs to the Section Biodiversity, Ecology and Evolution)
  • Protocol
  • Open Access
7 Citations
6,098 Views
23 Pages

Genomic Fishing and Data Processing for Molecular Evolution Research

  • Héctor Lorente-Martínez,
  • Ainhoa Agorreta and
  • Diego San Mauro

Molecular evolution analyses, such as detection of adaptive/purifying selection or ancestral protein reconstruction, typically require three inputs for a target gene (or gene family) in a particular group of organisms: sequence alignment, model of ev...

(This article belongs to the Section Omics and High Throughput)
  • Review
  • Open Access
15 Citations
15,143 Views
24 Pages

Evolution at the Origins of Life?

  • Ludo L. J. Schoenmakers,
  • Thomas A. C. Reydon and
  • Andreas Kirschning

24 January 2024

The role of evolutionary theory at the origin of life is an extensively debated topic. The origin and early development of life is usually separated into a prebiotic phase and a protocellular phase, ultimately leading to the Last Universal Common Anc...

(This article belongs to the Special Issue Feature Papers in Origins of Life)
  • Review
  • Open Access
19 Citations
12,376 Views
18 Pages

25 October 2012

How have animals evolved new body designs (morphological evolution)? This requires explanations both for simple morphological changes, such as differences in pigmentation and hair patterns between different Drosophila populations and species, and als...

(This article belongs to the Special Issue Gene Expression and Regulation)
  • Article
  • Open Access
3 Citations
3,953 Views
15 Pages

28 December 2021

There has been much theoretical work aimed at understanding the evolution of social learning; and in most of it, individual and social learning are treated as distinct processes. A number of authors have argued that this approach is faulty because th...

(This article belongs to the Section Learning and Evolution in Games)
  • Article
  • Open Access
3 Citations
1,699 Views
22 Pages

25 March 2026

Antimicrobial resistance has renewed interest in bacteriophage therapy, yet bacterial evolution frequently undermines treatment efficacy. Combination phage therapy is commonly implemented as simultaneous phage cocktails, but whether this is optimal r...

(This article belongs to the Special Issue Phage Cocktails: Promising Approaches Against Infections)
  • Review
  • Open Access
20 Citations
7,839 Views
19 Pages

10 October 2018

B chromosomes (Bs) revealed more than a hundred years ago remain to be some of the most mysterious elements of the eukaryotic genome. Their origin and evolution, DNA composition, transcriptional activity, impact on adaptiveness, behavior in meiosis,...

(This article belongs to the Special Issue Evolution, Composition and Regulation of Supernumerary B Chromosomes)
  • Review
  • Open Access
2 Citations
3,796 Views
15 Pages

We offer a detailed description of our previously published new concept of the evolution of the biosphere as an integral system of its states over time, united by development trends. The structure of the biosphere is considered as a hierarchical frac...

(This article belongs to the Section Biology & Life Sciences)
  • Feature Paper
  • Article
  • Open Access
8 Citations
8,012 Views
13 Pages

1 November 2018

Evolution of cooperation has traditionally been studied by assuming that individuals adopt either of two pure strategies, to cooperate or defect. Recent work has considered continuous cooperative investments, turning full cooperation and full defecti...

  • Article
  • Open Access
8 Citations
3,094 Views
15 Pages

Leishmania and the Model of Predominant Clonal Evolution

  • Michel Tibayrenc and
  • Francisco J. Ayala

As it is the case for other pathogenic microorganisms, the respective impact of clonality and genetic exchange on Leishmania natural populations has been the object of lively debates since the early 1980s. The predominant clonal evolution (PCE) model...

(This article belongs to the Section Parasitology)
  • Article
  • Open Access
1 Citations
5,803 Views
21 Pages

Today, graph theory represents one of the most important modeling techniques in biology. One of the most important applications is in the study of metabolic networks. During metabolism, a set of sequential biochemical reactions takes place, which con...

(This article belongs to the Special Issue 10th Anniversary of Computation—Computational Biology)
  • Review
  • Open Access
59 Citations
8,530 Views
21 Pages

Avian MHC Evolution in the Era of Genomics: Phase 1.0

  • Emily A. O’Connor,
  • Helena Westerdahl,
  • Reto Burri and
  • Scott V. Edwards

26 September 2019

Birds are a wonderfully diverse and accessible clade with an exceptional range of ecologies and behaviors, making the study of the avian major histocompatibility complex (MHC) of great interest. In the last 20 years, particularly with the advent of h...

(This article belongs to the Special Issue Major Histocompatibility Complex (MHC) in Health and Disease)
  • Article
  • Open Access
6 Citations
8,024 Views
42 Pages

On the Relationship between Design and Evolution

  • Stephen Dilley,
  • Casey Luskin,
  • Brian Miller and
  • Emily Reeves

28 June 2023

A longstanding question in science and religion is whether standard evolutionary models are compatible with the claim that the world was designed. In The Compatibility of Evolution and Design, theologian E. V. Rope Kojonen constructs a powerful argum...

(This article belongs to the Special Issue Exploring Science from a Biblical Perspective)
  • Article
  • Open Access
5 Citations
4,790 Views
23 Pages

An Evolutionary Computing Model for the Study of Within-Host Evolution

  • Antonio Gómez-Mompeán and
  • Rafael Lahoz-Beltra

Evolution of an individual within another individual is known as within-host dynamics (WHD). The most common modeling technique to study WHD involves ordinary differential equations (ODEs). In the field of biology, models of this kind assume, for exa...

(This article belongs to the Section Computational Biology)
  • Article
  • Open Access
7 Citations
4,221 Views
10 Pages

The NuGrid AGB Evolution and Nucleosynthesis Data Set

  • Umberto Battino,
  • Marco Pignatari,
  • Ashley Tattersall,
  • Pavel Denissenkov and
  • Falk Herwig

Asymptotic Giant Branch (AGB) stars play a key role in the chemical evolution of galaxies. These stars are the fundamental stellar site for the production of light elements such as C, N and F, and half of the elements heavier than Fe via the slow neu...

(This article belongs to the Special Issue AGB Stars—In Honor of Professor Maurizio Busso on the Occasion of His 70th Birthday)
  • Article
  • Open Access
46 Citations
5,473 Views
19 Pages

Trend Evolution of Vegetation Phenology in China during the Period of 1981–2016

  • Fusheng Jiao,
  • Huiyu Liu,
  • Xiaojuan Xu,
  • Haibo Gong and
  • Zhenshan Lin

8 February 2020

The trend of vegetation phenology dynamics is of crucial importance for understanding vegetation growth and its responses to climate change. However, it remains unclear how the trends of vegetation phenology changed over the past decades. By analyzin...

(This article belongs to the Special Issue Monitoring Vegetation Phenology: Trends and Anomalies)
  • Review
  • Open Access
30 Citations
9,718 Views
19 Pages

Current Progress in Understanding and Recovering the Wheat Genes Lost in Evolution and Domestication

  • Shanjida Rahman,
  • Shahidul Islam,
  • Zitong Yu,
  • Maoyun She and ,
  • Eviatar Nevo and
  • Wujun Ma
  • + 1 author+ 0 author

14 August 2020

The modern cultivated wheat has passed a long evolution involving origin of wild emmer (WEM), development of cultivated emmer, formation of spelt wheat and finally establishment of modern bread wheat and durum wheat. During this evolutionary process,...

(This article belongs to the Section Molecular Plant Sciences)
  • Review
  • Open Access
293 Views
18 Pages

13 October 2026

Root systems, the hidden half of terrestrial plants, have been a fundamental geological agent since the late Early Paleozoic, with their evolution preserved in a rich but underutilized archive of soils and sediments. This review adopts a rhizolith-ce...

(This article belongs to the Special Issue Rhizoliths in Paleoenvironmental Reconstruction)
  • Article
  • Open Access
6 Citations
2,311 Views
15 Pages

Entropy Treatment of Evolution Algebras

  • Farrukh Mukhamedov and
  • Izzat Qaralleh

24 April 2022

In this paper, by introducing an entropy of Markov evolution algebras, we treat the isomorphism of S-evolution algebras. A family of Markov evolution algebras is defined through the Hadamard product of structural matrices of non-negative real S-evolu...

(This article belongs to the Section Multidisciplinary Applications)
  • Article
  • Open Access
2 Citations
2,695 Views
10 Pages

Using the Evolution Operator to Classify Evolution Algebras

  • Desamparados Fernández-Ternero,
  • Víctor M. Gómez-Sousa and
  • Juan Núñez-Valdés

Evolution algebras are currently widely studied due to their importance not only “per se” but also for their many applications to different scientific disciplines, such as Physics or Engineering, for instance. This paper deals with these types of alg...

(This article belongs to the Special Issue Numerical and Symbolic Computation: Developments and Applications 2021)
  • Article
  • Open Access
9 Citations
3,749 Views
18 Pages

Multiple Instances of Adaptive Evolution in Aquaporins of Amphibious Fishes

  • Héctor Lorente-Martínez,
  • Ainhoa Agorreta,
  • Iker Irisarri,
  • Rafael Zardoya and ,
  • Scott V. Edwards and
  • Diego San Mauro
  • + 1 author+ 0 author

12 June 2023

Aquaporins (AQPs) are a highly diverse family of transmembrane proteins involved in osmotic regulation that played an important role in the conquest of land by tetrapods. However, little is known about their possible implication in the acquisition of...

(This article belongs to the Special Issue Evolution and Ecology of Phenotypes in Nature)
  • Article
  • Open Access
12 Citations
2,502 Views
15 Pages

22 June 2024

The process of grain refinement during welding significantly influences both the final microstructure and performance of the weld joint. In the present work, merits of acoustic addition in the conventional Frictions Stir Welding (FSW) process were ev...

(This article belongs to the Special Issue Welding and Joining Technologies: Processes, Parameters, Structures, Properties and Simulations)
  • Article
  • Open Access
13 Citations
8,767 Views
31 Pages

1 March 2021

As a worldwide sanitary insect pest, the housefly Musca domestica can carry and transmit more than 100 human pathogens without suffering any illness itself, indicative of the high efficiency of its innate immune system. Antimicrobial peptides (AMPs)...

  • Article
  • Open Access
30 Citations
16,396 Views
34 Pages

Total-Evidence Framework Reveals Complex Morphological Evolution in Nightbirds (Strisores)

  • Albert Chen,
  • Noor D. White,
  • Roger B.J. Benson,
  • Michael J. Braun and
  • Daniel J. Field

23 August 2019

Strisores is a clade of neoavian birds that include diurnal aerial specialists such as swifts and hummingbirds, as well as several predominantly nocturnal lineages such as nightjars and potoos. Despite the use of genome-scale molecular datasets, the...

(This article belongs to the Special Issue Origins of Modern Avian Biodiversity)
  • Article
  • Open Access
5 Citations
3,494 Views
13 Pages

Senecavirus A Enhances Its Adaptive Evolution via Synonymous Codon Bias Evolution

  • Simiao Zhao,
  • Huiqi Cui,
  • Zhenru Hu,
  • Li Du and ,
  • Xuhua Ran and
  • Xiaobo Wen
  • + 1 author+ 0 author

16 May 2022

Synonymous codon bias in the viral genome affects protein translation and gene expression, suggesting that the synonymous codon mutant plays an essential role in influencing virulence and evolution. However, how the recessive mutant form contributes...

(This article belongs to the Topic Veterinary Infectious Diseases)
  • Article
  • Open Access
9 Citations
6,251 Views
20 Pages

Karyotypic Evolution of Sauropsid Vertebrates Illuminated by Optical and Physical Mapping of the Painted Turtle and Slider Turtle Genomes

  • Ling Sze Lee,
  • Beatriz M. Navarro-Domínguez,
  • Zhiqiang Wu,
  • Eugenia E. Montiel and ,
  • Daleen Badenhorst,
  • Basanta Bista,
  • Thea B. Gessler and
  • Nicole Valenzuela
  • + 3 authors+ 0 author

12 August 2020

Recent sequencing and software enhancements have advanced our understanding of the evolution of genomic structure and function, especially addressing novel evolutionary biology questions. Yet fragmentary turtle genome assemblies remain a challenge to...

(This article belongs to the Special Issue Vertebrate Karyotype Evolution: How Far Have We Come, and Where Are We Going?)
  • Article
  • Open Access
1 Citations
1,159 Views
28 Pages

Galaxy Evolution with Manifold Learning

  • Tsutomu T. Takeuchi,
  • Suchetha Cooray and
  • Ryusei R. Kano

3 March 2026

Matter in the early Universe was nearly uniform, and galaxies emerged through the gravitational growth of small primordial density fluctuations. Astrophysics has been trying to unveil the complex physical phenomena that have caused the formation and...

(This article belongs to the Section Astrophysics, Cosmology, and Black Holes)
  • Article
  • Open Access
29 Citations
3,641 Views
19 Pages

Ecological Quality Evolution and Its Driving Factors in Yunnan Karst Rocky Desertification Areas

  • Shiwen Zhang,
  • Yan Wang,
  • Xuehua Wang,
  • Yang Wu and ,
  • Chengrong Li,
  • Chao Zhang and
  • Yuhang Yin
  • + 2 authors+ 0 author

Rocky desertification is a key element affecting regional ecological quality. Rocky desertification in Southwest China directly affects the ecological security of the Yangtze River and Pearl River basins and also restricts regional economic and socia...

(This article belongs to the Special Issue Ecological Environment Assessment Based on Remote Sensing)
  • Article
  • Open Access
61 Citations
18,963 Views
35 Pages

Venom Down Under: Dynamic Evolution of Australian Elapid Snake Toxins

  • Timothy N. W. Jackson,
  • Kartik Sunagar,
  • Eivind A. B. Undheim,
  • Ivan Koludarov and ,
  • Angelo H. C. Chan,
  • Kate Sanders,
  • Syed A. Ali,
  • Iwan Hendrikx,
  • Nathan Dunstan and
  • Bryan G. Fry
  • + 5 authors+ 0 author

18 December 2013

Despite the unparalleled diversity of venomous snakes in Australia, research has concentrated on a handful of medically significant species and even of these very few toxins have been fully sequenced. In this study, venom gland transcriptomes were se...

(This article belongs to the Collection Evolution of Venom Systems)
  • Review
  • Open Access
1 Citations
3,698 Views
17 Pages

Convergent Evolution and the Epigenome

  • Sebastian Gaston Alvarado,
  • Annaliese Chang and
  • Maral Tajerian

11 November 2025

Background: Trait convergence or parallelism is widely seen across the animal and plant kingdoms. For example, the evolution of eyes in cephalopods and vertebrate lineages, wings in bats and insects, or shark and dolphin body shapes are examples of c...

(This article belongs to the Collection Feature Papers in Epigenomes)
  • Article
  • Open Access
47 Citations
10,385 Views
44 Pages

Predicting Community Evolution in Social Networks

  • Stanisław Saganowski,
  • Bogdan Gliwa,
  • Piotr Bródka,
  • Anna Zygmunt and ,
  • Przemysław Kazienko and
  • Jarosław Koźlak
  • + 1 author+ 0 author

11 May 2015

Nowadays, sustained development of different social media can be observed worldwide. One of the relevant research domains intensively explored recently is analysis of social communities existing in social media as well as prediction of their future e...

(This article belongs to the Section Complexity)
  • Article
  • Open Access
11 Citations
6,843 Views
15 Pages

16 August 2020

Microsatellites are short, repetitive DNA sequences that can rapidly expand and contract due to slippage during DNA replication. Despite their impacts on transcription, genome structure, and disease, relatively little is known about the evolutionary...

(This article belongs to the Special Issue Causes and Consequences of Chromosomal Aberrations)
  • Review
  • Open Access
2 Citations
1,689 Views
24 Pages

Evolution from Composome to RNA Replicase

  • Shaojie Deng,
  • Doron Lancet and
  • Roy Yaniv

28 January 2026

This paper proposes a novel scheme for the origin of RNA replicase based on the replication-first stable complex evolution (SCE) model, also known as the stable complex encoding (SCE) model, and attempts to derive this scheme from the metabolism-firs...

(This article belongs to the Special Issue The 15th Anniversary of Life—Alternatives to RNA World)
  • Article
  • Open Access
12 Citations
3,203 Views
23 Pages

On S-Evolution Algebras and Their Enveloping Algebras

  • Farrukh Mukhamedov and
  • Izzat Qaralleh

25 May 2021

In the present paper, we introduce S-evolution algebras and investigate their solvability, simplicity, and semisimplicity. The structure of enveloping algebras has been carried out through the attached graph of S-evolution algebras. Moreover, we intr...

(This article belongs to the Section A: Algebra and Logic)
  • Article
  • Open Access
85 Citations
15,452 Views
24 Pages

Rapid Radiations and the Race to Redundancy: An Investigation of the Evolution of Australian Elapid Snake Venoms

  • Timothy N. W. Jackson,
  • Ivan Koludarov,
  • Syed A. Ali,
  • James Dobson and ,
  • Christina N. Zdenek,
  • Daniel Dashevsky,
  • Bianca Op den Brouw,
  • Paul P. Masci,
  • Amanda Nouwens and
  • Bryan G. Fry
  • + 12 authors+ 7 authors

26 October 2016

Australia is the stronghold of the front-fanged venomous snake family Elapidae. The Australasian elapid snake radiation, which includes approximately 100 terrestrial species in Australia, as well as Melanesian species and all the world's true sea sna...

(This article belongs to the Section Animal Venoms)
  • Review
  • Open Access
5 Citations
7,010 Views
15 Pages

Diet, Polyphenols, and Human Evolution

  • Patrizia Restani,
  • Francesca Colombo,
  • Simone Biella,
  • Corinne Bani and ,
  • Francesca Mercogliano and
  • Chiara Di Lorenzo
  • + 1 author+ 0 author

3 August 2022

Although diet has contributed significantly to the evolution of human beings, the composition of the diet that has most affected this phenomenon is still an open issue. Diet has undoubtedly participated in the acquisition of the skills that underlie...

(This article belongs to the Special Issue Functional Foods and Natural Products: Bioactive Compounds and Beneficial Effects on Health)
  • Opinion
  • Open Access
67 Citations
16,297 Views
16 Pages

Evolution of Tumor Metabolism might Reflect Carcinogenesis as a Reverse Evolution process (Dismantling of Multicellularity)

  • Khalid O. Alfarouk,
  • Mohammed E.A. Shayoub,
  • Abdel Khalig Muddathir,
  • Gamal O. Elhassan and
  • Adil H.H. Bashir

22 July 2011

Carcinogenesis occurs through a series of steps from normal into benign and finally malignant phenotype. This cancer evolutionary trajectory has been accompanied by similar metabolic transformation from normal metabolism into Pasteur and/or Crabtree-...

  • Article
  • Open Access
15 Citations
5,413 Views
20 Pages

The Evolution and Sources of Major Ions in Hot Springs in the Triassic Carbonates of Chongqing, China

  • Mingming Ta,
  • Xun Zhou,
  • Juan Guo,
  • Xinyun Wang and ,
  • Yuan Wang and
  • Yanqiu Xu
  • + 1 author+ 0 author

22 April 2020

Thermal groundwater in the Lower and Middle Triassic carbonates in Chongqing, China, is mainly concentrated in anticlines. Hot springs (32.9 to 57 °C) with SO4-Ca type waters and Total Dissolved Solids (TDS) of 1620 to 2929 mg/L emerge in the mid...

(This article belongs to the Special Issue Geochemistry of Groundwater)
  • Article
  • Open Access
13 Citations
4,797 Views
19 Pages

Retrogene Duplication and Expression Patterns Shaped by the Evolution of Sex Chromosomes in Malaria Mosquitoes

  • Duncan Miller,
  • Jianhai Chen,
  • Jiangtao Liang,
  • Esther Betrán and ,
  • Manyuan Long and
  • Igor V. Sharakhov
  • + 1 author+ 0 author

28 May 2022

Genes that originate during evolution are an important source of novel biological functions. Retrogenes are functional copies of genes produced by retroduplication and as such are located in different genomic positions. To investigate retroposition p...

(This article belongs to the Special Issue How Do New Genes Originate and Evolve?)
  • Article
  • Open Access
6 Citations
2,487 Views
13 Pages

26 May 2023

Understanding the evolution of pore-fracture networks in coal during loading is of paramount importance for coalbed methane exploration. To shed light on these dynamic changes, this study undertook uniaxial compression experiments on coal samples col...

(This article belongs to the Special Issue Advances in Numerical Modeling for Deep Water Geo-Environment)
  • Article
  • Open Access
14 Citations
8,382 Views
31 Pages

24 April 2013

We tested three predictions regarding the joint evolution of pollen performance and mating system. First, due to the potential for intense intrasexual competition in outcrossing populations, we predicted that outcrossers would produce faster-growing...

(This article belongs to the Special Issue Pollen Tube Growth)
  • Article
  • Open Access
14 Citations
3,790 Views
14 Pages

Determining When an Algebra Is an Evolution Algebra

  • Miguel D. Bustamante,
  • Pauline Mellon and
  • M. Victoria Velasco

12 August 2020

Evolution algebras are non-associative algebras that describe non-Mendelian hereditary processes and have connections with many other areas. In this paper, we obtain necessary and sufficient conditions for a given algebra A to be an evolution algebra...

  • Article
  • Open Access
6 Citations
11,357 Views
29 Pages

12 December 2019

In a changing digital world, organisations need to be effective information processing entities, in which people, processes, and technology together gather, process, and deliver the information that the organisation needs. However, like other informa...

(This article belongs to the Section Information Theory and Methodology)
  • Review
  • Open Access
11 Citations
6,370 Views
24 Pages

Mechanisms of Rapid Karyotype Evolution in Mammals

  • Emry O. Brannan,
  • Gabrielle A. Hartley and
  • Rachel J. O’Neill

31 December 2023

Chromosome reshuffling events are often a foundational mechanism by which speciation can occur, giving rise to highly derivative karyotypes even amongst closely related species. Yet, the features that distinguish lineages prone to such rapid chromoso...

(This article belongs to the Section Animal Genetics and Genomics)
  • Article
  • Open Access
5 Citations
6,039 Views
37 Pages

Root Operators and “Evolution” Equations

  • Giuseppe Dattoli and
  • Amalia Torre

13 August 2015

Root-operator factorization à la Dirac provides an effective tool to deal with equations, which are not of evolution type, or are ruled by fractional differential operators, thus eventually yielding evolution-like equations although for a multicompon...

(This article belongs to the Special Issue Recent Advances in Fractional Calculus and Its Applications)
  • Review
  • Open Access
28 Citations
6,025 Views
22 Pages

In Situ Surface Reconstruction of Catalysts for Enhanced Hydrogen Evolution

  • Yingbo Zhang,
  • Junan Pan,
  • Gu Gong,
  • Renxuan Song and ,
  • Ye Yuan,
  • Mengzhu Li,
  • Weifeng Hu,
  • Pengcheng Fan,
  • Lexing Yuan and
  • Longlu Wang
  • + 5 authors+ 0 author

5 January 2023

The in situ surface reconstitution of a catalyst for hydrogen evolution refers to its structure evolution induced by strong interactions with reaction intermediates during the hydrogen evolution reaction (HER), which eventually leads to the self-opti...

(This article belongs to the Special Issue Recent Progress in Development of Hydrogenation and Dehydrogenation Catalysts)
  • Article
  • Open Access
14 Citations
7,013 Views
9 Pages

Directed Evolution of a Mycobacteriophage

  • María Cebriá-Mendoza,
  • Rafael Sanjuán and
  • Pilar Domingo-Calap

Bacteriophages represent an alternative strategy to combat pathogenic bacteria. Currently, Mycobacterium tuberculosis infections constitute a major public health problem due to extensive antibiotic resistance in some strains. Using a non-pathogenic s...

(This article belongs to the Special Issue Bacteriophages: Alternatives to Antibiotics and Beyond)

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