Causes and Consequences of Chromosomal Aberrations

Dear Colleagues,

The maintenance of a proper chromosome structure is important for the functions of cells. It has been revealed that chromosomal aberrations in eukaryotic organisms may lead to changes in metabolism, secretory phenotype, lifespan, and/or fitness. Furthermore, the chromosomal aberrations may also promote cellular heterogenization, leading to premature senescence, cancer development, and/or drug resistance. Thus, it seems important to address the question about the mechanisms and factors regulating the chromosomal integrity of cells, including the mechanisms responsible for the control of variability in the length of repetitive DNA sequences. In this Special Issue of Genes, we welcome reviews, mini-reviews, new methods, original research articles, and short communications that advance our understanding of the causes and consequences of chromosomal aberrations in eukaryotic microorganisms, plants, animals, and humans using current and emerging high-throughput approaches. While the mechanisms involved in the maintenance of telomere, rDNA, centromere, and heterochromatin will be of special interest, we will also be open to any advancement exploring the chromosomal instability or genome plasticity and consequences of chromosomal aberrations on a cellular, organism, or population level.

Dr. Maciej Wnuk
Guest Editor

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