The protocols in underwater acoustic wireless sensor networks (UAWSNs) that address reliability in packets forwarding usually consider the connectivity of the routing paths up to one- or two-hops. Since senor nodes are connected with one another usin...
Efficient metadata and page management are essential for sustaining database performance on modern flash-based storage. However, conventional SQLite configurations—rollback journal and WAL—often trigger excessive small writes and frequent...
Environmental stresses significantly influence crop growth and productivity, acting as powerful selective pressures in plant evolution. The AP2/ERF superfamily is crucial for plant development and stress responses, orchestrating key regulatory pathwa...
Background: Psychosomatic patients often complain of a variety of somatic symptoms. We sought to clarify the role of clinical predictors of complaints of somatic symptoms. Methods: We enrolled 604 patients visiting a psychosomatic outpatient clinic....
Loess–mudstone/soil-rock interfacial landslide is one of the prominent landslide hazards that occurs in soil rock contacting zones. It is necessary to develop sensors with high sensitivity to weak and low frequency vibrations for the early warn...
Impedance-based biosensing has emerged as a critical technology for high-sensitivity biomolecular detection, yet traditional approaches often rely on bulky, costly impedance analyzers, limiting their portability and usability in point-of-care applica...
Compound heat–drought (CHD) exposure poses a growing risk to grain production safety under climate change. Using a panel of Chinese cities from 2010 to 2024, we estimate its effects on grain yield anomalies. We also test whether the compound ef...
Overfitting remains a major difficulty in training deep neural networks, especially when attempting to achieve good generalization in complex classification tasks. Standard dropout is often employed to address this issue; however, its uniform random...
Human Ezrin Peptides (HEPs) are inhibitors of expression of IL-6 and other inflammatory cytokines, amplifiers of adaptive B cell and T cell immunity and enhancers of tissue repair. The mutation stable C-terminus of HIV gp120, mimics 69% of the “Hep-r...
Dryland grasslands face elevated risks of rapid threshold crossing under a regime of warming, precipitation redistribution, and intensified interannual hydrothermal variability. Using the Ebinur Lake Basin (ELB) as a case, we developed an integrated...
Protein synthesis (translation) is one of the fundamental processes occurring in the cells of living organisms. Translation can be divided into three key steps: initiation, elongation, and termination. In the yeast Saccharomyces cerevisiae, there are...
Reliable and robust multimodal crisis classification is challenged by degraded, corrupted, or missing image–text evidence, because reliability-blind fusion can propagate an unreliable modality and amplify local evidence failure into joint predi...
Background/Objectives: Hearing aids can be used as a treatment for tinnitus. There are indications that this treatment is most effective when the tinnitus pitch falls in the frequency range of amplification of the hearing aid. Then, the hearing aid p...
Isothermal amplification (IA) techniques like rolling circle amplification (RCA) and loop-mediated isothermal amplification (LAMP) have gained significant attention in recent years due to their ability to rapidly amplify DNA or RNA targets at a const...
The nucleic acid amplification reaction has extremely high requirements for the precision of temperature control. The conventional PID control algorithms exhibit limitations in nonlinear and time-varying PCR temperature control systems, including poo...
Circulating tumour DNA (ctDNA) is a promising biomarker for personalised oncology. However, its clinical utility is limited by detection sensitivity, particularly in early-stage disease. T-Oligo Primed Polymerase Chain Reaction (TOP-PCR) is a commerc...
Due to the contrast of X-ray images being low, significant elements including organs, bones, and nodules are very difficult to identify, so contrast enhancement is necessary. In this paper, an X-ray image enhancement algorithm based on adaptive gradi...
Genome sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is increasingly important to monitor the transmission and adaptive evolution of the virus. The accessibility of high-throughput methods and polymerase chain reaction (P...
Microfluidic (MF) advancements have been leveraged toward the development of state-of-the-art platforms for molecular diagnostics, where isothermal amplification schemes allow for further simplification of DNA detection and quantification protocols....
Isothermal amplification techniques such as recombinase polymerase amplification (RPA) and loop-mediated isothermal amplification (LAMP) for diagnosing Buruli ulcer, a necrotic skin disease caused by Mycobacterium ulcerans, have renewed hope for the...
Wireless sensor networks with a large number of cheap low-power interconnected devices bring up challenging tasks when considering the security of their communications. In our previous work, we presented two approaches for the design of dynamic proto...
Mature oak (Quercus spp.) leaves, although abundantly available during the plants’ developmental cycle, are rarely exploited as viable sources of genomic DNA. These leaves are rich in metabolites difficult to remove during standard DNA purification,...
In order to enhance the sensitivity of a Fabry–Perot (F-P) acoustic sensor without the need of fabricating complicated structures of the acoustic-sensitive diaphragm, a mini-type external sound pressure amplification structure (SPAS) with double 10 μ...
Deoxyribonucleic acid (DNA) is not only a fundamental biological molecule but also a versatile material for constructing sensitive and specific biosensing platforms. Its ability to undergo sequence-specific hybridization via Watson–Crick base p...
Nucleic acid amplification diagnostics offer outstanding features of sensitivity and specificity. However, they still lack speed and robustness, require extensive infrastructure, and are neither affordable nor user-friendly. Thus, they have not been...
The tunability of plasmonic resonances in gold and silver nanosphere arrays on a glass substrate, embedded in a liquid crystal matrix, was explored. The calculations involving the finite element method revealed that the optical properties of these ar...
Near full genome sequencing (NFGS) of HIV-1 is required to assess the genetic composition of HIV-1 strains comprehensively. Population-wide, it enables a determination of the heterogeneity of HIV-1 and the emergence of novel/recombinant strains, whil...
Vibrio parahaemolyticus (V. parahaemolyticus) is considered the most concerning pathogen for seafood. Like other pathogens in food samples, its gene detection suffers from a problem of background interference when isothermal detection methods are use...
Early detection protocols for the oak wilt fungal pathogen (Bretziella fagacearum) are crucial for forest health practitioners on the boundaries of the growing disease front. Established protocols use oak wilt-specific primers and gel electrophoresis...
The COVID-19 pandemic has made it abundantly clear that the state-of-the-art biosensors may not be adequate for providing a tool for rapid mass testing and population screening in response to newly emerging pathogens. The main limitations of the conv...
Digital microfluidics (DMF) arises as the next step in the fast-evolving field of operation platforms for molecular diagnostics. Moreover, isothermal schemes, such as loop-mediated isothermal amplification (LAMP), allow for further simplification of...
Phosphorus is critical for plant growth but often becomes less accessible due to its precipitation with cations in soil. Fabaceae, a diverse plant family, exhibits robust adaptability and includes species like Lupinus albus, known for its efficient p...
Currently, the treatment of pediatric high-grade osteosarcomas systematically includes one topoisomerase IIα inhibitor. This chemotherapy is usually adapted to the response to the neo-adjuvant therapy after surgery. The current and unique marker of c...
Isothermal amplification methods have become popular in research due to the simplicity of the technology needed to run the reactions. Specifically, loop-mediated isothermal amplification (LAMP) has been widely used for various applications since firs...
To the best of our knowledge, applying adaptive three-dimensional lookup tables (3D LUTs) to underwater image enhancement is an unprecedented attempt. It can achieve excellent enhancement results compared to some other methods. However, in the image...
Background: Extrachromosomal DNA (ecDNA) amplification represents a distinct mechanism of genomic instability in cancer, increasingly recognized for its role in aggressive disease progression. This review examines how ecDNA drives tumour evolution an...
Diagnostics often require specialized equipment and trained personnel in laboratory settings, creating a growing need for point-of-care tests (POCTs). Among the genetic testing methods available, Loop-mediated Isothermal Amplification (LAMP) offers a...
Early cancer detection is critical for improving patient outcomes, yet current diagnostic approaches often fail to identify malignancies when tumor-specific biomarkers are relatively scarce. Emerging CRISPR/Cas-based technologies have revolutionized...
In the rapid development of molecular biology, nucleic acid amplification detection technology has received more and more attention. The traditional polymerase chain reaction (PCR) instrument has poor refrigeration performance during its transition f...
Against the backdrop of global climate warming and rapid urbanization, urban thermal environments exhibit strong spatiotemporal heterogeneity and diurnal contrasts. Based on the high-resolution, seamless land surface temperature dataset (GSHTD), this...
This paper proposes a novel intelligent switching control strategy for a five-bar lower limb exoskeleton. First, during the support phase, terminal sliding mode control (TSMC) is employed to ensure robust stability and high-torque amplification capab...
Viral hemorrhagic fevers (VHFs) are highly lethal diseases that often present non-specific, influenza-like symptoms in their early stages, making clinical recognition and differentiation from other febrile illnesses difficult. This overlap underscore...
14 November 2026
Tidal propagation and flood-ebb current asymmetry influence inundation and sediment redistribution in coastal deltas, with considerable spatial variation across interconnected estuaries such as those of the Ganges–Brahmaputra–Meghna (GBM)...
Piezoelectric flexure micro-positioning stages are essential micromotion actuators for micro-assembly, atomic force microscopy and nano-manufacturing, but intrinsic hysteresis nonlinearity of piezoelectric stacks distorts the linear voltage-to-displa...
Background. SIOP PNET5 MB was initiated in 2014 as the first European trial using clinical, histological, and molecular parameters to stratify treatments for children and adolescents with standard-risk medulloblastoma. Methods. Stratification by upfr...
With the acceleration of industrialization, deformable mechanisms that can adapt to complex environments have gained widespread applications. Joints serve as carriers for transmitting forces and motions between components, and their stiffness signifi...
Modern cloud-based Internet of Things (IoT) infrastructures face increasingly sophisticated and diverse cyber threats that challenge traditional detection systems in terms of scalability, adaptability, and explainability. In this paper, we present (H...
Many tidal influenced estuaries and coastal basins feature tidal amplification because of, e.g., convergence and reflection. Increasing amplification rates were observed in the Elbe estuary, with consequences for construction measures, nautical manoe...
Salmonella poses a severe global threat to food safety and public health, necessitating rapid, sensitive, and reliable detection methods. Conventional techniques often suffer from complexity, time consumption, cost, or limited sensitivity. To address...
Signal amplification in biomolecular networks converts a linear input to a steeply sigmoid output and is central to a number of cellular functions including proliferation, differentiation, homeostasis, adaptation, and biological rhythms. One canonica...
of 11