171 Results Found

Optically active heterodimeric 5,5′-linked bis-isochromans, containing a stereogenic ortho-trisubstituted biaryl axis and up to four chirality centers, were synthesized stereoselectively by using a Suzuki–Miyaura biaryl coupling reaction...

The present article reviews the results on the application of vibrational circular dichroism (VCD) spectroscopy to the study of stereochemical properties of chiral metal complexes in solution. The chiral characters reflecting on the vibrational prope...

In this work we report our endeavors toward the development of an asymmetric synthesis of a 3,3-disubstituted isoindolinone, dimethyl 2-(1-methyl-3-oxoisoindolin-1-yl)malonate, via asymmetric cascade reaction of 2-acetylbenzonitrile with dimethylmalo...

The present article reports the application of vibrational circular dichroism (VCD) and temperature-dependent electronic circular dichroism (ECD) methods to reveal the dynamical aspects of a star-burst tetranuclear metal complex with a labile central...

While there has been a sufficient amount of research and empirical evidence on the factors that influence a company’s decisions to voluntarily disclose carbon information, little research has been done on the carbon disclosure practices of ETS-...

Bicyclo[3.3.1]nonane-2,6-dione (1) and bicyclo[3.3.1]nona-3,7-diene-2,6-dione (2) have been examined by vibrational circular dichroism (VCD), which, as for most C2-symmetric systems, exhibits strong VCD signals. In the case of 2, VCD signals are stro...

VCD analysis of 16 diastereomeric pairs of NHC precursors containing two isolated chirality centers and different substitution patterns identified VCD transitions characteristic of the chirality center in the imidazolium ring or in the side chain, wh...

The treatment landscape and clinical outcome of multiple myeloma (MM) patients have changed in the last decades, with an improved median survival of 8–10 years. This study aimed to evaluate the bortezomib, cyclophosphamide and dexamethasone (VCD) reg...

A whole series of [Ln(H2O)4(Ala)2]26+ dimeric cationic lanthanide complexes with both l- and d-alanine enantiomers was synthesized. The single-crystal X-ray diffraction at 100 and 292 K shows the formation of two types of dimers (I and II) in crystal...

Chirality plays a crucial role in drug discovery and development. As a result, a significant number of commercially available drugs are structurally dissymmetric and enantiomerically pure. The determination of the exact 3D structure of drug candidate...

Structural elucidation has always been challenging, and misassignment remains a stringent issue in the field of natural products. The growing interest in discovering unknown, complex natural structures accompanies the increasing awareness concerning...

An empirical model of global solar irradiance (EMGSI) under all sky conditions was developed by using solar radiation and meteorological parameters at Sodankylä. The calculated hourly global solar irradiance is in agreement with that observed at the...

Linear diterpenes that are commonly found in brown algae are of high chemotaxonomic and ecological importance. This study reports bifurcatriol (1), a new linear diterpene featuring two stereogenic centers isolated from the Irish brown alga Bifurcaria...

Radicinin and cochliotoxin (1 and 2) two phytotoxic pyranpyran-4,5-diones were isolated together with their close metabolites 3-epi-radicinin, radicinol, and its 3-epimer (3–5), from the culture filtrates of Cochliobolus australiensis, a fungus...

9-Hydroxynerolidol, 9-oxonerolidol, and chiliadenol B are three farnesane-type sesquiterpenoids isolated from Chiliadenus lopadusanus that have shown an interesting activity against human pathogens as Gram+ and Gram− bacteria resistant to antib...

Background and Clinical Significance: Kidney transplant recipients have a 2–4-fold higher cancer risk than the general population. The sequential occurrence of multiple myeloma (MM) and native-kidney renal cell carcinoma (RCC) is rare and creat...

Three new diketopiperazine alkaloids, including two oxepine-containing diketopiperazines, chrysopiperazines A and B (1 and 2), and one quinazoline-containing diketopiperazine, chrysopiperazine C (5), together with three known analogues (3, 4, and 6),...

Brown alga Bifurcaria bifurcata is a prolific source of bioactive acyclic (linear) diterpenes with high structural diversity. In the continuation of our investigations on Irish brown algae, we undertook an in-depth chemical study on the n-hexanes and...

We re-examine the theory of electronic and vibrational circular dichroism spectroscopy in terms of the formalism of frequency-dependent molecular polarizabilities. We show the link between Fermi’s gold rule in circular dichroism and the trace o...

Hydantoins, a class of five-membered heterocyclic compounds, exhibit diverse biological activities. The aim of this study was to synthesize and characterize a series of novel 3,5-disubstituted hydantoins and to investigate their antiproliferative act...

The TROPOMI instrument aboard Sentinel-5P is a relatively new, high-resolution source of information about atmosphere composition. One of the primary atmospheric trace gases that we can observe is nitrogen dioxide. Thanks to TROPOMI capabilities (hig...

Pollutants information can be retrieved from visible (VIS) and ultraviolet (UV) diffuse solar spectra exploiting Multi-AXis Differential Optical Absorption Spectroscopy (MAX-DOAS) instruments. In May 2021, the Italian research institute CNR-ISAC acqu...

Background/Objectives: Assessment of vitamin C status rarely occurs in hospital patients within high-income countries on the assumption that vitamin C deficiency (VCD) is rare, and evidence on prevalence, risk factors, and clinical outcomes of VCD is...

In this note, we report a correction to the published article, Molecules 2020, 25, 2272 [...]

Background and Objectives: Vaginal cuff dehiscence (VCD) represents a rare but relevant complication that occurs following minimally invasive hysterectomy. With the rising frequency of this procedure, it is crucial to continuously evaluate VCD incide...

Postmenopausal syndrome refers to symptoms caused by the gradual decrease in female hormones after mid-40 years. As a target organ of estrogen, decrease in estrogen causes various changes in brain function such as a decrease in choline acetyltransfer...

Background: The transfemoral (TF) approach is the most common route in TAVI, but it is still associated with a risk of bleeding and vascular complications. The aim of this study was to compare the clinical outcomes between surgical cut-down (SC) and...

This work describes the chromatographic fractionation of the aerial parts of Calea pinnatifida and the structural characterization and determination of the absolute configuration of the isolated compounds as well as their antitumor potential. The HPL...

Chiral natural product molecules are generally assumed to be biosynthesized in an enantiomerically pure or enriched fashion. Nevertheless, a significant amount of racemates or enantiomerically enriched mixtures has been reported from natural sources....

From the aerial parts of Salvia ballotiflora, eleven diterpenoids were isolated; among them, four icetexanes and one abietane (1–5) are reported for the first time. Their structures were established by spectroscopic means, mainly 1H- and 13C-NMR, inc...

Background: Large bore access procedures rely on vascular closure devices to minimize access site complications. Suture-based vascular closure devices (S-VCD) such as ProGlide and ProStar XL have been readily used, but recently, newer generation coll...

The long-term nature of and heterogeneity in industrialization has led to high formaldehyde (HCHO) concentrations with seasonal and regional variation in North China, and this is highly influenced by changes in meteorological and population condition...

Vibrational circular dichroism (VCD) enhancement by low-lying electronic states (LLESs) is a fascinating phenomenon, but accounting for it theoretically remains a challenge despite significant research efforts over the past 20 years. In this article,...

This paper investigates the temporal–spatial characteristics of column NO2 concentration and influence factors in Xinjiang based on the Tropospheric Monitoring Instrument (TROPOMI) aboard the EU/ESA Sentinel-5 Precursor satellite. The findings...

We report a facile method for the preparation of vesicle-like carbon dots (VCDs) via dry-heating of surfactant solutions. Like most reported CDs, the VCDs possess interesting fluorescence properties. Entrapment of enzymes and gold nanoclusters (AuNCs...

Parabens are widely used preservatives in basic necessities such as cosmetic and pharmaceutical products. In previous studies, xenoestrogenic actions of parabens were reported in an immature rat model and a rat pituitary cell line (GH3 cells). The re...

In order to investigate the abundance of and temporal variation in nitrogen dioxide (NO2) in the troposphere and validate the corresponding satellite products during a normal year and the lockdown period of coronavirus disease 2019 (COVID-19) in Lhas...

Magnoliae Flos (MF) is a medicinal herb widely employed in traditional medicine for relieving sinusitis, allergic rhinitis, headaches, and toothaches. Here, we investigated the potential preventive effects of MF extract (MFE) against 4-vinylcyclohexe...

Background and Objectives: Access-site complications (ASCs) remain clinically relevant after peripheral endovascular procedures, particularly with large femoral sheaths and complex anatomy. While randomized coronary trials show non-inferiority of vas...

Purpose: Bilateral vocal cord dysfunction (bVCD) is a rare but feared complication of thyroid surgery. This long term retrospective study determined the effect of intraoperative neuromonitoring (IONM) of the recurrent laryngeal nerve (RLN) during thy...

Objective: To compare the vaginal cuff dehiscence (VCD) rates using Vicryl (Poliglactyn 910) and Polydioxanone (PDS) in patients who underwent laparoscopic hysterectomy. Materials and methods: A retrospective, monocentric study was conducted, includi...

The tropospheric vertical column density of NO2 (Trop NO2 VCD) can be obtained using satellite remote sensing, but it has been discovered that the Trop NO2 VCD is affected by uncertainties such as the cloud fraction, terrain reflectivity, and aerosol...

Peyssonnoside A is an unusual natural product consisting of a diterpene unit and a sulfonated monosaccharide. The experimental and theoretical comparison of Optical Rotatory Dispersion (ORD) and quantitative Nuclear Magnetic Resonance (NMR) data prov...

The multifunctional platform response to the tumor microenvironment (TME) is critical for the high-precision diagnosis and treatment of cancer with low systemic toxicity. In this regard, vanadium-doped carbon dots (V−CDs) have been developed fo...

The Arctic stratospheric ozone depletion event in spring 2020 was the most severe compared with previous years. We retrieved the critical indicator ozone vertical column density (VCD) using zenith scattered light differential optical absorption spect...

Background: Preservation of kidney function in newly diagnosed (ND) multiple myeloma (MM) helps to prevent excess toxicity. Patients (pts) from two prospective trials were analyzed, provided postinduction (PInd) restaging was performed. Pts received...

Vibrational circular dichroism (VCD) is a widely used standard method for determination of absolute stereochemistry, and somewhat less so for biomolecule characterization and following dynamic processes. Over the last few decades, different VCD instr...

The Gas Absorption Spectrometer Correlating Optical Difference—New Generation 4 (GASCOD/NG4) is a multi-axis differential optical absorption spectroscopy (MAX-DOAS) instrument which measures diffuse solar spectra at the Environmental-Climate Ob...

Visual color determination (VCD) requires color competence and individual training. The aim of this study was to evaluate the deviations in students’ VCD with two different reference scales. The research hypothesis was that none of the color re...

In this paper we present a new method for retrieving tropospheric NO2 Vertical Column Density (VCD) from zenith-sky Differential Optical Absorption Spectroscopy (DOAS) measurements using mobile observations. This method was used during three days in...