Heterocyclic Compounds in Medicinal Chemistry

Dear Colleagues,

The development of new medicinal agents is pivotal for the maintenance of a high quality of life as well as a healthy and productive society. Heterocycles play a key role in the biological activity of many small molecule drugs due to their capability of forming hydrogen bond, altering the polarity and modulating lipophilicity at specific sites in the pathogen or host with the overall effect of inhibiting the biological processes that lead to the progression of diseases. Indeed, most of the organic compounds used as therapeutics or intermediates utilized for their synthesis contain heterocyclic motifs that can improve pharmacological, pharmacokinetic, toxicological and physicochemical properties of compounds, making them more effective as therapeutic agents. heterocycles endowed with any biological action. Contributions that highlight the importance of heterocycles that are widely found in: agrochemicals, dyes, cosmetics and functional materials are also welcome. The aim of the present Special Issue is Heterocycle is a ring with at least one atom that is not carbon. Nitrogen, oxygen, and sulfur are the primary elements seen in common heterocycles, which play a critical role in drug discovery. Based on the size of the ring, there are three, four, five, six, seven or more membered rings, as well as fused, bicyclic and macrocyclic heterocycles. Furthermore, they are grouped as aromatic, saturated or unsaturated. Depending on the structure and on the type of bonds, such compounds show different acid-base properties and they can contain one, two or more heteroatoms.

This Special Issue will acknowledge research papers with topics including, but not limited to, the preparation of aromatic and non-aromatic also an overview primarily of the state of the art of synthetic methods and recent advances in the synthesis of heterocycles.

Dr. Valentina Noemi Madia
Dr. Davide Ialongo
Guest Editors

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