3,985 Results Found

In any rock engineering project, the uniaxial compressive strength (UCS) is one of the most relevant parameters to be determined as it is used for a variety of purposes. Traditionally, the UCS of a rock sample is obtained by carrying out a uniaxial t...

The folding of the myosin head often requires a UCS (Unc45, Cro1, She4) domain-containing chaperone. Worms, flies, and fungi have just a single UCS protein. Vertebrates have two; one (Unc45A) which functions primarily in non-muscle cells and another...

Background. The role of the transcribed ultra-conserved regions (T-UCRs) has not yet been fully discovered, but the studies showed some indications that impaired expression of T-UCRS were present in malignant tumors, including breast cancer. Aim. The...

Lnc-uc.147, a long non-coding RNA derived from a transcribed ultraconserved region (T-UCR), was previously evidenced in breast cancer. However, the role of this region in other tumor types was not previously investigated. The present study aimed to i...

Sarcopenia is linked with an increased risk of falls, osteoporosis and mortality and is an increasing problem for healthcare systems. No satisfying biomarkers for sarcopenia diagnosis exist, connecting bone, fat and muscle. Matrix-GLA-protein (MGP) i...

Human umbilical cord mesenchymal stem cells (hUC-MSCs) are broadly applied in clinical treatment due to convenient accessibility, low immunogenicity, and the absence of any ethical issues involved. However, the microenvironment of inflammatory tissue...

A density functional theory-based study of UC₂ and Cr-doped UO₂ using the phono3py and VASP computational simulation packages is presented. Furthermore, the temperature-dependent thermal conductivities are compared to the traditional urania fuel. Dop...

The bHLH (basic helix–loop–helix) transcription factor AtCFLAP2 regulates epidermal wax accumulation, but the underlying molecular mechanism remains unknown. We obtained BnUC1^mut (BnaA05g18250D homologous to AtCFLAP2) from a Brassica napu...

This study aimed to investigate the potential mechanisms of action of total alkaloids from Portulaca oleracea L. (POL) on ulcerative colitis (UC) using a network pharmacology approach. Network pharmacology analysis identified two bioactive alkaloids...

Dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP) is considered a marker of vitamin K status and vascular calcification risk in chronic kidney disease. This study assessed the association of serum dp-ucMGP, alone and combined with albumin...

Duck Tembusu virus (DTMUV) is an emerging pathogenic flavivirus responsible for massive economic losses in the duck industry. However, commercially inactivated DTMUV vaccines have been ineffective at inducing protective immunity in ducks. The widely...

UC-II contains a patented form of undenatured type II collagen derived from chicken sternum. Previous preclinical and clinical studies support the safety and efficacy of UC-II in modulating joint discomfort in osteoarthritis and rheumatoid arthritis....

The potential benefits of drug repurposing have gained attention as an alternative to developing de novo drugs. The potential of using central nervous system (CNS) drugs as anticancer drugs has been explored in several types of human cancers, such as...

Vascular calcification and atherosclerotic arterial disease are complex processes involving multiple inhibitory and pro-calcific mechanisms. Matrix Gla protein (MGP) is an important inhibitor of vascular calcification, and its inactive dephosphorylat...

Bone health might be closely associated with male fertility, yet the molecular pathways remain poorly characterized. We demonstrate that undercarboxylated osteocalcin (ucOCN), a bone-derived hormone, initiates a signaling cascade that stimulates test...

Background/Objectives: High-altitude pulmonary edema (HAPE) remains a serious condition with limited preventive options. This study evaluated the prophylactic protective effects of nebulized human umbilical cord mesenchymal stem cell-derived extracel...

Background/Objectives: Uterine carcinosarcomas (UCSs) are rare and aggressive malignancies with limited epidemiological data. This study aims to evaluate the clinical and pathological features and prognostic factors of UCS in a retrospective cohort o...

This study investigated the mechanism of hydroxysafflor yellow A (HSYA) on senescent human umbilical cord mesenchymal stem cells (hUC-MSCs) through transcriptome sequencing. HSYA treatment identified 2377 differentially expressed genes (DEGs). Gene O...

Accurate estimation of uniaxial compressive strength (UCS) is essential in geotechnical engineering, but conventional UCS testing is destructive and time-consuming. This study investigates the effects of mild acid exposure and freeze–thaw (F&nd...

Rock mechanics and rock engineering projects require determining, among other parameters, the uniaxial compressive strength (UCS) of rock. For such a purpose, it is not uncommon to perform ultrasonic pulse laboratory tests. Many researchers have foun...

The geomechanical properties of rock materials, such as uniaxial compression strength (UCS), are the main requirements for geo-engineering design and construction. A proper understanding of UCS has a significant impression on the safe design of diffe...

Reliable construction-phase prediction of hard rock tunnel boring machine (TBM) rate of penetration (ROP) remains difficult because ground–machine interaction changes along the alignment and uniaxial compressive strength (UCS) is often incomple...

This study investigated the prediction of unconfined compressive strength (UCS), a common measure of soil’s undrained shear strength, using fundamental soil characteristics. While traditional pavement subgrade design often relies on parameters...

In the rock mechanics and rock engineering field, the strength parameter considered to characterize the rock is the uniaxial compressive strength (UCS). It is usually determined in the laboratory through a few statistically representative numbers of...

In this paper, to identify the roof unconfined compressive strength (UCS) in the process of coal mine roadway support in real-time and optimize the real-time drilling speed while drilling, this paper proposes and establishes a drilling test method fo...

Umbilical cord mesenchymal stromal cells (UC-MSCs) are a key element of regenerative medicine due to their ability to secrete growth factors that stimulate proliferation and angiogenesis, and modulate the inflammatory response. Despite their widespre...

The fundamental issue in designing encapsulation-based self-healing concrete structures is the design of microcapsules. However there are few studies in the literature on this topic; not only is the fracture of microcapsules crucial for releasing the...

Ulcerative colitis (UC) is a chronic inflammatory disease that affects the colon, triggering persistent inflammation and ulceration, resulting in a severe impact on patients’ quality of life. Currently, the standard diagnostic methods for UC in...

Accurate prediction of the 28-day unconfined compressive strength (UCS) of cemented backfill is essential for proportion design and quality control in mine backfill engineering. In this study, 119 groups of experimental data were used to develop a pr...

This study examines the efficacy of various machine learning models for predicting the uniaxial compressive strength (UCS) of rocks in oil and gas wells, which are essential for ensuring wellbore stability and optimizing drilling operations. The inve...

Electrical storage components such as ultracapacitors (UC) have received significant attention from various industrial sectors, from electric vehicles to renewable power plants. This article presents the investigations on dynamic properties of asymme...

Published laboratory data on soil stabilisation are abundant, yet they remain fragmented across studies and are often difficult to reuse because of inconsistent reporting formats, heterogeneous testing conditions, and incomplete metadata. This articl...

Background and Aim: Drug sustainability (DS) is a surrogate marker for treatment efficacy. We aimed to compare the DS of two main biologics used to treat moderate-to-severe ulcerative colitis (UC), infliximab (IFX) and vedolizumab (VDZ), in a real-wo...

Inflammatory bowel disease (IBD) is a chronic, autoimmune disorder of the gastrointestinal tract with numerous genetic and environmental risk factors. Patients with Crohn’s disease (CD) or ulcerative colitis (UC) often demonstrate marked disrup...

In order to establish an optimal model for reasonably predicting the uniaxial compressive strength (UCS) of rocks, a method based on feature optimization and SSA-XGBoost was proposed. Firstly, the UCS predictor system of rocks, considering petrograph...

This paper focuses on motion analysis of a coupled unmanned surface vehicle (USV)–umbilical cable (UC)–unmanned underwater vehicle (UUV) system to investigate the interaction behavior between the vehicles and the UC in the ocean environme...

It is of great significance to study the effect of solid contents (SC), binder-to-tailings (b/t) ratio, types and dosage of fly ash (FA) on the viscosity (V) and uniaxial compressive strength (UCS) of backfill. It can improve filling efficiency and r...

Ulcerative colitis (UC) belongs to the group of inflammatory bowel diseases (IBD). UC is an incurable, diffuse, and chronic inflammatory process of the colonic mucosa with alternating periods of exacerbation and remission. This review aimed to analyz...

In this study, the influence of fly ash (FA) content (0%, 10%, 20%, and 30%) on the alteration in the physical and mechanical parameters of loess is investigated. The influences of curing time (0, 14, and 28 days) and submergence and non-submergence...

Background: Ulcerative colitis (UC) is an idiopathic and heterogeneous large intestine disease, characterized by chronic mucosa and submucosa inflammation. Alteration of the intestinal microbiome in UC may be responsible for modifications in metaboli...

Background: A low vitamin K status is common in patients on haemodialysis, and this is considered one of the reasons for the accelerated atherosclerosis in these patients. The vitamin is essential in activation of the protein Matrix Gla Protein (MGP)...

Patients with active ulcerative colitis (UC) display a misalignment of the circadian clock, which plays a vital role in various immune functions. Our aim was to characterize the expression of clock and inflammation genes, and their mutual regulatory...

This paper reports a modeling methodology to predict the electrical and thermal behaviors of a 2.7 V/650 F ultracapacitor (UC) cell from LS Mtron Ltd. (Anyang, Korea). The UC cell is subject to the charge/discharge cycling with constant-current betwe...

Upconversion (UC) materials are promising for harvesting visual light. However, the efficiency of UC processes is very low when applied to practical devices. Therefore, we propose an array of UC nanocylinders on a gold substrate and induce electric d...

The oxidative stress induced by the accumulation of reactive oxygen species (ROS) can lead to cell aging and death. Equally, the skeletal muscle usually hosts enteroviral persistent infection in inflammatory muscle diseases. As excellent bioactive pr...

Ulcerative colitis (UC) is a chronic intestinal ailment which cannot be completely cured. The occurrence of UC has been on the rise in recent years, which is highly detrimental to patients. The effectiveness of conventional drug treatment is limited....

Background and Objectives: Immune check inhibitor (ICI) colitis is one of most common and adverse side effects of ICI. However, there was no case report of ulcerative colitis (UC)-mimicking colitis after atezolizumab use in hepatocellular carcinoma (...

Uniaxial compressive strength (UCS) is one of the most important parameters to characterize the rock mass in geotechnical engineering design and construction. In this study, a novel kernel extreme learning machine-grey wolf optimizer (KELM-GWO) model...

The described research focused on the diagnostic usefulness of sulfated glycosaminoglycans (sGAG), hyaluronan (HA), and extracellular part of syndecan-1 (sCD138) as new markers related to extracellular matrix (ECM) remodeling in the intestine during...

Hepatocellular carcinoma (HCC) is the most common form of liver cancer in humans, with an increasing incidence worldwide. The current study aimed to explore the molecular mechanisms that inhibit the proliferation of HepG2 cells, a hepatoblastoma-deri...